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personally customized photodynamic therapy for oral cancer patients using porphyrin synthesis protein as a biomarker

Research Project

Project/Area Number 25460680
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Nagata Tetsuji  浜松医科大学, 医学部附属病院, 講師 (60264058)

Co-Investigator(Kenkyū-buntansha) 守本 祐司  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 分子生体制御学, 准教授 (10449069)
増本 一真  浜松医科大学, 医学部附属病院, 講師 (50464136)
加藤 文度  浜松医科大学, 医学部, 教授 (60204492)
小倉 俊一郎  東京工業大学, 生命理工学院, 准教授 (90343160)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords口腔がん / プロトポルフィリン / プロトポルフィリンIX / アミノリブリン酸 / 口腔癌 / 光線力学療法
Outline of Final Research Achievements

It is known that the oral cancer lesion is activated by blue-light irradiation and emits red fluorescence. We focused on efficacy of the photodynamic therapy using 5-aminolevulinic acid (ALA), and analyzed the red fluorescent expression by protoporphyrin IX(PpIX) in the tumor of of the oral cavity. As a result, approximately 40% of the tumors of oral cavity lesion emitted red fluorescence. The red fluorescence was distributed over the tumor region heterogeneously, and there was no association with the differentiation nor the histologic type of the tumor. We need to investigate a red fluorescent origin, and seek a factor to raise the effect of photodynamic therapy.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Three-dimensional computed tomographic analysis of variations of the carotid artery2016

    • Author(s)
      Tetsuji Nagata , Kazuma Masumoto, Yutaro Hayashi, Yoshiko Watanabe, Yuta Kato,Fuminori Katou
    • Journal Title

      Journal of Cranio-Maxillofacial Surgery

      Volume: 44 Issue: 6 Pages: 734-742

    • DOI

      10.1016/j.jcms.2016.02.011

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 口腔がん組織由来の赤色蛍光:かん検知の可能性2016

    • Author(s)
      守本祐司、増本一真、長田哲次ら
    • Organizer
      題5回日本生体医工学大会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔がん組織由来の赤色蛍光:がん検知の可能性2016

    • Author(s)
      鬼木玲奈、寺原航、小島涼、長井健一郎、仲谷将隆、江南慧、増本一真、長田哲次、小倉俊一郎、四ノ宮成祥、守本祐司
    • Organizer
      第55回日本生体医工学会大会(旧日本エム・イー学会)
    • Place of Presentation
      富山国際会議場、富山市民プラザ
    • Year and Date
      2016-04-26
    • Related Report
      2015 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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