To elucidate the pattern of progression in multiple system atrophy

• Project/Area Number: 25461313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: Ito Mizuki 名古屋大学, 医学部附属病院, 助教 (50437042)
• Co-Investigator(Kenkyū-buntansha): WATANABE Hirohisa 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177) ; SOBUE Gen 名古屋大学, 医学系研究科, 特任教授 (20148315) ; SENDA Joe 名古屋大学, 医学部附属病院, 医員 (80569781) ; ATSUTA Naoki 名古屋大学, 医学部附属病院, 病院講師 (90547457)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 多系統萎縮症（MSA） / VBM / TBSS / 安静時機能MRI / バイオマーカー / 安静時脳機能MRI / 多系統萎縮症 / Mean diffusivity / fractional anisotropy / voxel-based morphometry

Outline of Final Research Achievements

Although the patients with multiple system atrophy (MSA) had decreased scores of Addenbrooke’s Cognitive Examination Revised (ACE-R), MRI showed atrophy of the cerebellum, not the cerebral cortex. By contrast, the MSA patients with low scores of ACE-R showed broad anatomical impairments of neural circuits in the frontal lobe, especially the superior longitudinal fasciculus, in the analysis using the tract-based spatial statistics technique, compared with those with normal scores of ACE-R and normal controls.
Together, MSA showed the anatomical atrophy of white matter earlier than that of the cerebral cortex. These results suggested a decline of cognitive function in MSA might be associated with these anatomical damages of neural circuits.

Research Products

• [Journal Article] Impaired peripheral vasoconstrictor response to orthostatic stress in patients with multiple system atrophy (2015)
  • Author(s): Suzuki, J. Nakamura, T. Hirayama, M. Mizutani, Y. Okada, A. Ito, M. Watanabe, H. Sobue, G.
  • Journal Title: Parkinsonism Relat Disord Volume: 21 Issue: 8 Pages: 917-22
  • DOI: 10.1016/j.parkreldis.2015.05.023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Variants associated with Gaucher disease in multiple system atrophy. (2015)
  • Author(s): Mitsui J, Matsukawa T, Sasaki H, Yabe I, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Tsuji S, et al.
  • Journal Title: Ann Clin Transl Neurol. Volume: 2 Issue: 4 Pages: 417-426
  • DOI: 10.1002/acn3.185
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder (2015)
  • Author(s): Tsuboi, T. Watanabe, H. Tanaka, Y. Ohdake, R. Yoneyama, N. Hara, K. Ito, M. Hirayama, M. Yamamoto, M. Fujimoto, Y. Kajita, Y. Wakabayashi, T. Sobue, G.
  • Journal Title: J Neural Transm (Vienna) Volume: 122 Issue: 12 Pages: 1663-72
  • DOI: 10.1007/s00702-015-1436-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy. (2014)
  • Author(s): Hara K, Watanabe H, Ito M, Tsuboi T, Watanabe H, Nakamura R, Senda J, Atsuta N, Adachi H, Aiba I, Naganawa S, Sobue G.
  • Journal Title: Parkinsonism Relat Disord. Volume: 20(2) Issue: 2 Pages: 157-161
  • DOI: 10.1016/j.parkreldis.2013.10.007
  • Peer Reviewed
• [Journal Article] Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation. (2014)
  • Author(s): Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Nakamura R, Watanabe H, Senda J, Atsuta N, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: Epub Issue: 8 Pages: 856-64
  • DOI: 10.1136/jnnp-2014-308043
  • Peer Reviewed / Open Access
• [Journal Article] Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination (2013)
  • Author(s): Watanabe, H. Senda, J. Kato, S. Ito, M. Atsuta, N. Hara, K. Tsuboi, T. Katsuno, M. Nakamura, T. Hirayama, M. Adachi, H. Naganawa, S. Sobue, G.
  • Journal Title: Mov Disord Volume: 28 Issue: 12 Pages: 1732-6
  • DOI: 10.1002/mds.25641
  • Peer Reviewed
• [Journal Article] Clinical and radiological impact of liver transplantation for brain in cirrhosis patients without hepatic encephalopathy. (2013)
  • Author(s): Ishihara T, Ito M, Niimi Y, Tsujimoto M, Senda J, Kawai Y, Watanabe H, Ishigami M, Ito T, Kamei H, Onishi Y, Nakamura T, Goto H, Naganawa S, Kiuchi T, Sobue G.
  • Journal Title: Clin Neurol Neurosurg Volume: 115 Issue: 11 Pages: 2341-2347
  • DOI: 10.1016/j.clineuro.2013.08.015
  • Peer Reviewed
• [Presentation] 多系統萎縮症の脳内神経回路解析 (2015)
  • Author(s): 原 一洋, 渡辺 宏久, 今井 和憲, 川畑 和也, 桝田 道人, 大嶽 れい子, 伊藤 瑞規, バガリナオ・エピファニオチラ , 勝野 雅央, 祖父江 元
  • Organizer: 第33回日本神経治療学会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-11-26
• [Presentation] 脳容積・拡散テンソル画像を用いた前頭側頭型認知症とアルツハイマー型認知症における大脳病変の比較検討 (2015)
  • Author(s): 桝田 道人, 今井 和憲, 大嶽 れい子, 田中 康博, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 勝野 雅央, 祖父江 元
  • Organizer: 第33回日本神経治療学会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-11-26
• [Presentation] tract-based spatial statisticsを用いた多系統萎縮症の画像解析 (2015)
  • Author(s): 原一洋，渡辺宏久，今井和憲，川畑和也，米山典孝，桝田道人，坪井崇，渡邉はづき，中村亮一，伊藤瑞規，熱田直樹，バガリナオエピファニオジュニア，辻河高陽，加藤重典，安井敬三，長谷川康博，祖父江元
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ(新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] MMSEが正常のパーキンソン病に対するACE-Rを用いた高次機能の検討 (2015)
  • Author(s): 川畑和也，渡辺宏久，米山典孝，原一洋，大嶽れい子，田中康博，坪井崇，渡辺はづき，中村亮一，伊藤瑞規，熱田直樹，祖父江元
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ(新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] パーキンソン病における重度嗅覚低下と安静時脳機能MRIの検討 (2015)
  • Author(s): 米山典孝，渡辺宏久，原一洋，川畑和也，平山正昭，今井和憲，坪井崇，桝田道人，横井大知，渡辺はづき，熱田直樹，伊藤瑞規，田中康博，大嶽れい子，祖父江元
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ(新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] 脳容積・拡散テンソル解析での筋萎縮性側索硬化症と前頭側頭葉変性症の共通性障害 (2014)
  • Author(s): 千田 譲, 桝田 道人, 陸 雄一, 今井 和憲, 川畑 和也, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 祖父江 元
  • Organizer: 第33回日本認知症学会学術大会
  • Place of Presentation: 神奈川県横浜市(パシフィコ横浜)
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] MRI大脳容積画像を用いた前頭側頭型認知症とアルツハイマー型認知症の鑑別 (2014)
  • Author(s): 桝田 道人, 今井 和憲, 陸 雄一, 千田 譲, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 祖父江 元
  • Organizer: 第33回日本認知症学会学術大会
  • Place of Presentation: 神奈川県横浜市(パシフィコ横浜)
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] MRI脳容積・拡散テンソル画像を用いた前頭側頭型認知症における大脳病変の解析 (2014)
  • Author(s): 桝田道人、陸雄一、坪井崇、原一洋、渡辺はづき、中村亮一、千田譲、伊藤瑞規、熱田直樹、渡辺宏久、祖父江元
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡県福岡市(福岡国際会議場)
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] RESOLVEを用いた進行性核上性麻痺に おける上小脳脚病変の検討 (2013)
  • Author(s): 原一洋、渡辺宏久、伊藤瑞規、祖父江元他
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京都千代田区、国際フォーラム