Improvement of image quality using estimated filters and physical filters in image-guided radiation therapy

• Project/Area Number: 25461907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Japanese Foundation for Cancer Research (2015-2016); The University of Tokyo (2013-2014)
• Principal Investigator: Sakumi Akira 公益財団法人がん研究会, 有明病院 放射線治療部, その他 (30360556)
• Co-Investigator(Kenkyū-buntansha): 芳賀 昭弘 東京大学, 医学部附属病院, 助教 (30448021) ; 白石 憲史郎 帝京大学, 医学部, 准教授 (40447404) ; 山下 英臣 東京大学, 医学部附属病院, 講師 (70447407) ; 中川 恵一 東京大学, 医学部附属病院, 准教授 (80188896) ; 井垣 浩 国立研究開発法人国立がん研究センター, 中央病院, 医長 (90361344)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: コーンビームCT画質改善 / 画像誘導放射線治療 / 実線量分布 / 治療中の腫瘍移動、変化 / 逐次放射線治療 / 治療中の腫瘍異動・変形 / 治療中の腫瘍移動・変形

Outline of Final Research Achievements

Although the image quality of the cone beam CT (CBCT) with a radiation therapy accelerator can be used as position matching, it is necessary to improve the image quality for a dose reconstruction in CBCT, also tumor shift. In this study, at first, we obtained scattering phenomena from experiments using a physical collimator and obtained a database of representative scattering components from the Monte Carlo simulation. We also focused attention on detection saturation of excessive X-rays into the detector, and obtained correction functions.
These data were used together with the iterative reconstruction method. Then the image quality was improved and seems to use for dose reconstructions and adaptive therapy.

Research Products

• [Journal Article] Comparison of gadolinium-enhanced magnetic resonance imaging with pathological findings in brain metastases after gamma knife radiosurgery; case series with autopsy cases (2017)
  • Author(s): M. Sakuramachi, H. Igaki, M. Ikemura, H. Yamashita, K. Okuma, N. Sekiya, Y. Hayakawa, A. Sakumi, W. Takahashi, H. Hasegawa, M. Fukayama, K. Nakagawa
  • Journal Title: Oncology Letters Volume: 印刷中
  • Peer Reviewed
• [Journal Article] External effective radiation dose dose to workers in the restricted area of the Fukushima Daiichi Nuclear Power Plant during the third year after the Great East Japan Earthquake (2016)
  • Author(s): Sakumi A., Miyagawa R., Tamari Y., Nawa K., Sakura O., Nakagawa K.
  • Journal Title: Journal of Radiation Research Volume: 57 Issue: 2 Pages: 178-181
  • DOI: 10.1093/jrr/rrv073
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A report that Fukushima residents are concerned about radiation from Land, Food and Radon. (2016)
  • Author(s): Tamari Y, Kuroda Y, Miyagawa R, Nawa K, Sakumi A, Sakata N, Mizushima N, Sakura O, Iwamitsu Y, Takemura K, Nakagawa K.
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 4 Pages: 1-4
  • DOI: 10.1093/jrr/rrw017
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of motion of the rectum and bladder during preoperative intensity modulated radiation therapy for rectal cancer using cone-beam computed tomography (2015)
  • Author(s): Hideomi Yamashita, Ryousuke Takenaka, Akira Sakumi, Akihiro Haga, Kuni Otomo and Keiichi Nakagawa
  • Journal Title: Radiation Oncology Volume: 10 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s13014-014-0311-6
  • Peer Reviewed / Open Access
• [Journal Article] Quality assurance of volumetric modulated arc therapy for a prostate cancer patient with a hip prosthesis (2015)
  • Author(s): Ikeda T., Moriwaki H., Sakumi A
  • Journal Title: Radiotherapy and Oncology, Volume: 115
  • Peer Reviewed / Open Access
• [Journal Article] Corticospinal tract-sparing intensity-modulated radiotherapy treatment planning. (2014)
  • Author(s): Igaki H, Sakumi A, Mukasa A, Saito K, Kunimatsu A, Masutani Y, Hanakita S, Ino K, Haga A, Nakagawa K, Ohtomo K.
  • Journal Title: Report Practical Oncology of Radiotherapy. Volume: 19 Issue: 5 Pages: 310-6
  • DOI: 10.1016/j.rpor.2014.01.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Validation of Planning Target Volume Margins by Analyzing Intrafractional Localization Errors for 14 Prostate Cancer Patients Based on Three-Dimensional Cross-Correlation between the Prostate Images of Planning CT and Intrafraction Cone-Beam CT during Volumetric Modulated Arc Therapy (2014)
  • Author(s): Kenshiro Shiraishi, Masahiko Futaguchi, Akihiro Haga, Akira Sakumi, Katsutake Sasaki, Kentaro Yamamoto, Hiroshi Igaki, Kuni Ohtomo, Kiyoshi Yoda, and Keiichi Nakagawa
  • Journal Title: BioMed Research International Volume: ID960928 Pages: 1-5
  • DOI: 10.1155/2014/960928
  • Peer Reviewed / Open Access
• [Journal Article] Lung tumor motion reproducibility for five patients who received four-fraction VMAT stereotactic ablative body radiotherapy under constrained breathing conditions: a preliminary study. (2014)
  • Author(s): Nakagawa K, Haga A, Sasaki K, Kida S, Masutani Y, Yamashita H, Takahashi W,Igaki H, Sakumi A, Ohtomo K, Yoda K.
  • Journal Title: J Radiat Res Volume: 55 Issue: 6 Pages: 1199-201
  • DOI: 10.1093/jrr/rru055
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Volumetric Modulated Arc Therapy (VMAT) in the Treatment of Localized Prostate Cancer: Initial Experience in 200 Patients (2014)
  • Author(s): K. Shiraishi, K. Yamamoto, A. Haga, A. Sakumi, K. Nakagawa
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 90
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of a Low Transmission Multileaf Collimator on the Parotid Grand Dose in Head and Neck Volumetric Modulated Arc Therapy Planning: A Dose-Volume Histogram Comparison Between 2-Step Adaptive and Simultaneously Integrated Boost Techniques (2014)
  • Author(s): A. Sakumi, K. Yamamoto, A. Haga, K. Okuma, H. Igaki, Y. Iwai, K. Yoda, K. Nakagawa
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 90
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Patterns of Recurrence in Malignant Glioma Patients: Association With Neurogenic Niche and Radiation Therapy Dose (2014)
  • Author(s): H. Igaki, T. Magome, M. Sakuramachi, A. Nomoto, A. Sakumi, M. Kitaguchi, A. Haga, J. Itami, and others
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 90
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prospective Phase 1/2 Trial of Carbon Ion Radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer (NSCLC) (2014)
  • Author(s): W. Takahashi, N. Yamamoto, M. Nakajima, A. Sakumi, H. Yamashita, K. Nakagawa, H. Tsuji, T. Kamada
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 90
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Individually wide range of renal motion evaluated by four-dimensional computed tomography. (2014)
  • Author(s): Yamashita H, Yamashita M, Futaguchi M, Takenaka R, Shibata S, Yamamoto K, Nomoto A, Sakumi A, Kida S, Kaneko Y, Takenaka S, Shiraki T, Nakagawa K.
  • Journal Title: Springerplus Volume: 3 Issue: 1 Pages: 131-137
  • DOI: 10.1186/2193-1801-3-131
  • Peer Reviewed
• [Journal Article] Impact of flattening-filter-free techniques on delivery time for lung stereotactic volumetric modulated arc therapy and image quality of concurrent kilovoltage cone-beam computed tomography: a preliminary phantom study (2014)
  • Author(s): Nakagawa K, Haga A, Sakumi A, Yamashita H, Igaki H, Shiraki T, Ohtomo K, Iwai Y, Yoda K.
  • Journal Title: Journal of Radiation Research Volume: 55 Pages: 200-202
  • Peer Reviewed
• [Journal Article] Independent absorbed-dose calculation using the Monte Carlo algorithm in volumetric modulated arc therapy (2014)
  • Author(s): Haga A , Magome T , Takenaka S , Imae T , Sakumi A , Nomoto A , Igaki H , Shiraishi K , Yamashita H , Ohtomo K , Nakagawa K.
  • Journal Title: Radiation Oncology Volume: 9 Pages: 75-75
  • Peer Reviewed
• [Journal Article] The feasibility and efficacy of stereotactic body radiotherapy for centrally-located lung tumors. (2013)
  • Author(s): Takahashi W, Yamashita H, Omori M, Kitaguchi M, Shibata-Kobayashi S, Sakumi A, Nakagawa K.
  • Journal Title: Anticancer Research Volume: 33 Pages: 4959-4964
  • Peer Reviewed
• [Journal Article] 4D registration and 4D verification of lung tumor position for stereotactic volumetric modulated arc therapy using respiratory-correlated cone-beam CT. (2013)
  • Author(s): Nakagawa K, Haga A, Kida S, Masutani Y, Yamashita H, Takahashi W, Sakumi A, Saotome N, Shiraki T, Ohtomo K, Iwai Y, Yoda K.
  • Journal Title: Journal of Radiation Research Volume: 54 Pages: 152-156
  • Peer Reviewed
• [Journal Article] Verification of planning target volume settings in volumetric modulated arc therapy for stereotactic body radiation therapy by using in-treatment 4-dimensional cone beam computed tomography. (2013)
  • Author(s): Takahashi W, Yamashita H, Kida S, Masutani Y, Sakumi A, Ohtomo K, Nakagawa K, Haga A.
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 86 Pages: 426-431
  • Peer Reviewed
• [Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters (2013)
  • Author(s): Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
  • Journal Title: Radiol Phys Technol Volume: 6(2) Issue: 2 Pages: 335-42
  • DOI: 10.1007/s12194-013-0205-6
  • Peer Reviewed
• [Journal Article] Evaluation of an intrafraction 4D cone-beam CT(CBCT) imaging system using a 4D lung tumor phantom driven by measured tumor motions for a lung cancer patient (2013)
  • Author(s): A. Sakumi, K. Mizuno, M. Uesaka, A. Haga, K. Yoda, K. Nakagawa
  • Journal Title: Medical Physics International Volume: 2 Pages: 222-222
  • Peer Reviewed
• [Journal Article] PO-0873 Evaluation of an intrafraction 4D cone-beam CT (CBCT) imaging system (2013)
  • Author(s): A. Sakumi, K. Mizuno, Y. Nishijima, M. Uesaka, A. Haga, Y. Iwai, K. Yoda, K. Nakagawa,
  • Journal Title: Radiotherapy and Oncology Volume: 106 Supplement 2
  • Peer Reviewed
• [Presentation] Exposure dose of workers in the restricted area; Iitate Village in in 2013 (2015)
  • Author(s): Sakumi A., Miyagawa R., Tamari Y., Nawa K., Sakura O., Nakagawa K.
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Quality assurance of volumetric modulated arc therapy for a prostate cancer patient with a hip prosthesis (2015)
  • Author(s): Sakumi A, Ikeda T., Moriwaki H
  • Organizer: 3rd ESTRO Forum
  • Place of Presentation: バルセロナ
  • Year and Date: 2015-04-24
  • Int'l Joint Research
• [Presentation] Agilityを用いた頭頸部高精度放射線治療 (2014)
  • Author(s): 作美 明、芳賀昭弘、山本健太郎、中川恵一、岩井良夫、依田潔
  • Organizer: 日本放射線腫瘍学会第27回大会
  • Place of Presentation: パシフィコ横浜会議センター
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] 飯舘村村内で操業を継続している企業の従業員を対象とした2013年の被曝線量の評価 (2014)
  • Author(s): 作美 明、玉利祐樹、坂田尚子、中川恵一、佐倉統、水島希
  • Organizer: 日本放射線影響学会第57回大会
  • Place of Presentation: かごしま県民交流センター
  • Year and Date: 2014-10-01 – 2014-10-03
• [Presentation] Impact of a Low Transmission Multileaf Collimator on the Parotid gland Dose in Head And Neck Volumetric Modulated Arc Therapy Planning - A Dose Volume Histogram Comparison between Two-step Adaptive and Simultaneously Integrated Boost Techniques (2014)
  • Author(s): A. Sakumi, K. Yamamoto, A. Haga, K. Okuma, H. Igaki, Y. Iwai, K. Yoda, K. Nakagawa
  • Organizer: American Society for Radiation Oncology' 56th Meeting
  • Place of Presentation: Moscone Center, San Francisco
  • Year and Date: 2014-09-14 – 2014-09-16
• [Presentation] 飯舘村で操業中の企業従業員を対象とした個人被曝積算線量調査 (2014)
  • Author(s): 作美 明、黒田佑次郎、坂田尚子、中川恵一、佐倉統、水島希、加瀬郁子
  • Organizer: 第107回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜会議センター
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Dosimetric comparison between Agility and MLCi heads for nasopharyngeal IMRT plans created by two different treatment planning systems (2014)
  • Author(s): A. Sakumi, A. Haga, K. Yamamoto, Y. Iwai, K. Yoda, K. Nakagawa
  • Organizer: ICTR-PHE 2014
  • Place of Presentation: Geneva. Switzerland.
• [Presentation] Accuracy comparison of 3D and 4D CBCT based lung tumor registrations by way of in-treatment 4D CBCT analysis (2013)
  • Author(s): A. Sakumi, K. Nakagawa, A. Haga, W. Takahashi, H. Yamashita, T. Imae, S.Kida, Y. Masutani, K. Ohtomo
  • Organizer: 2nd ESTRO Forum 2013,
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Evaluation of an intrafraction 4D cone-beam CT(CBCT) imaging system using a 4D lung tumor phantom driven by measured tumor motions for a lung cancer patient (2013)
  • Author(s): A. Sakumi, K. Mizuno, M. Uesaka, A. Haga, K. Yoda, K. Nakagawa,
  • Organizer: IOMP2013
  • Place of Presentation: Brighton, United Kingdom
• [Presentation] Agilityを用いた頭頸部高精度放射線治療 (2013)
  • Author(s): 作美 明、芳賀昭弘、山本健太郎、中川恵一、岩井良夫、依田潔
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 青森
• [Presentation] Dose calculation using in-treatment 4D kilovoltage CBCT and in-treatment linac parameters during VMAT for a lung tumor (2013)
  • Author(s): A. Sakumi, N. Saotome, A. Haga, S. Kida, H. Y., K. Nakagawa
  • Organizer: 日本医学物理学会
  • Place of Presentation: 横浜