| Project/Area Number |
25462091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MORINE Yuji 徳島大学, 大学院医歯薬学研究部, 講師 (60398021)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Mitsuo 徳島大学, 大学院医歯薬学研究部, 教授 (10216070)
IMURA Satoru 徳島大学, 病院, 特任教授 (90380021)
IKEMOTO Tetsuya 徳島大学, 大学院医歯薬学研究部, 助教 (20398019)
UTSUNOMIYA Toru 徳島大学, 大学院医歯薬学研究部, 准教授 (30304801)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Epigenetics / HDAC / 肝再生 / 加齢 / 肝切除 |
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| Outline of Final Research Achievements |
Mechanism of the decreased regenerative capacity of aged liver after hepatectemy and its regulation focused on epigenetic changes were elucidated in this study. In aged liver, the down-regulated of cell cycle and up -regulated of apoptosis-related genes during liver regeneration after hepatectomy were demonstrated. Also the epigenetic regulation with HDAC inhibitor up-regulated cell cycle related genes and differentiation related genes, after hepatectomy resulted in increase of liver regeneration and decrease of liver injury.
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