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Regulation of aged liver regenerative disorder focused of epigenetic changes

Research Project

Project/Area Number 25462091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

MORINE Yuji  徳島大学, 大学院医歯薬学研究部, 講師 (60398021)

Co-Investigator(Kenkyū-buntansha) SHIMADA Mitsuo  徳島大学, 大学院医歯薬学研究部, 教授 (10216070)
IMURA Satoru  徳島大学, 病院, 特任教授 (90380021)
IKEMOTO Tetsuya  徳島大学, 大学院医歯薬学研究部, 助教 (20398019)
UTSUNOMIYA Toru  徳島大学, 大学院医歯薬学研究部, 准教授 (30304801)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsEpigenetics / HDAC / 肝再生 / 加齢 / 肝切除
Outline of Final Research Achievements

Mechanism of the decreased regenerative capacity of aged liver after hepatectemy and its regulation focused on epigenetic changes were elucidated in this study. In aged liver, the down-regulated of cell cycle and up -regulated of apoptosis-related genes during liver regeneration after hepatectomy were demonstrated. Also the epigenetic regulation with HDAC inhibitor up-regulated cell cycle related genes and differentiation related genes, after hepatectomy resulted in increase of liver regeneration and decrease of liver injury.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (10 results)

  • [Journal Article] Liver regeneration after splenectomy in patients with liver cirrhosis.2016

    • Author(s)
      Yamada S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito Y, Yoshikawa M, Teraoku H, Shimada M.
    • Journal Title

      Hepatolgy research

      Volume: 印刷中 Issue: 5 Pages: 443-449

    • DOI

      10.1111/hepr.12573

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The value of systematic lymph node dissection for intrahepatic cholangiocarcinoma from the viewpoint of liver lymphatics2015

    • Author(s)
      Y.Morine, M.Shimada
    • Journal Title

      Journal of gastroenterology

      Volume: 50 Issue: 9 Pages: 913-927

    • DOI

      10.1007/s00535-015-1071-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical role of Foxp3<sup>+</sup>regulatory T cell in Living donor related liver transplantation for prediction of life-threatening complications2015

    • Author(s)
      Asanoma M, Mori H, Ikemoto T, Utsunomiya T, Imura S, Morine Y, Hanaoka J, Kanamoto M, Saito Y, Yamada S, Shimada M.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 62 Issue: 1.2 Pages: 37-40

    • DOI

      10.2152/jmi.62.37

    • NAID

      130005129689

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysfunction of liver regeneration in aged liver after partial hepatectomy.2015

    • Author(s)
      Enkhbold C1, Morine Y, Utsunomiya T, Imura S, Ikemoto T, Arakawa Y, Saito Y, Yamada S, Ishikawa D, Shimada M.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: - Issue: 7 Pages: 1217-1224

    • DOI

      10.1111/jgh.12930

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery of nutritional metabolism after liver transplantation.2015

    • Author(s)
      Sugihara K, Yamanaka-Okumura H, Teramoto A, Urano E, Katayama T, Morine Y, Imura S, Utsunomiya T, Shimada M, Takeda E.
    • Journal Title

      Nutrition

      Volume: 31 Issue: 1 Pages: 105-110

    • DOI

      10.1016/j.nut.2014.05.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation and management of hepatic injury induced by oxaliplatin-based chemotherapy in patients with hepatic resection for colorectal liver metastasis.2014

    • Author(s)
      Morine Y, Shimada M, Utsunomiya T.
    • Journal Title

      Hepatology Research

      Volume: 44 Issue: 1 Pages: 59-69

    • DOI

      10.1111/hepr.12107

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Senescence-related genes possibly responsible for poor liver regeneration after hepatectomy in elderly patients2014

    • Author(s)
      Zhu C, Ikemoto T, Utsunomiya T, Yamada S, Morine Y, Imura S, Arakawa Y, Takasu C, Ishikawa D, Shimada M
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 29(5) Issue: 5 Pages: 1102-1108

    • DOI

      10.1111/jgh.12468

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asanoma M. Beneficial effects of enteral nutrition containing with hydrolyzed whey peptide on warm ischemia/reperfusion injury in the rat liver2014

    • Author(s)
      Hanaoka J, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Sugimoto K, Saito Y, Yamada S
    • Journal Title

      Hepatol Res

      Volume: 44(1) Issue: 1 Pages: 114-121

    • DOI

      10.1111/hepr.12097

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of green tea catechin on massive hepatectomy model in rats.2014

    • Author(s)
      Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M.
    • Journal Title

      Journal of Gastroenterology

      Volume: -

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features of pancreaticobiliary maljunction: update analysis of 2nd Japan-nationwide survey.2013

    • Author(s)
      Morine Y, Shimada M, Takamatsu H, Araida T, Endo I, Kubota M, Toki A, Noda T, Matsumura T, Miyakawa S, Ishibashi H, Kamisawa T, Shimada H.
    • Journal Title

      Journal of Hepatobiliary Pancreat Science

      Volume: 20 Issue: 5 Pages: 472-480

    • DOI

      10.1007/s00534-013-0606-2

    • NAID

      10031183502

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of sonic hedgehog signaling after massive hepatectomy in a rat.2013

    • Author(s)
      Jun Hanaoka
    • Journal Title

      Surgery Today

      Volume: 50 Issue: 3 Pages: 300-307

    • DOI

      10.1007/s00595-012-0248-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 小胞体ストレス応答に着目した加齢肝再生不全における肝星細胞の役割についての検討2015

    • Author(s)
      荒川悠佑,島田光生,吉川雅登,寺奥大貴,山田眞一郎,,齋藤裕,岩橋衆一,池本哲也,森根裕二,居村暁
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝胆膵外科手術における周術期栄養評価の有用性に関する研究-体成分分析装置と主観的包括的アセスメントSGA-2015

    • Author(s)
      齋藤 裕
    • Organizer
      第52回日本外科代謝栄養学会学術集会
    • Place of Presentation
      きゅりあん(東京都品川区)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝胆膵外科手術におけるNST介入による周術期栄養評価2015

    • Author(s)
      齋藤裕,安井苑子,吉川雅登,寺奥大貴,山田眞一郎,岩橋衆一,荒川悠佑,池本哲也,森根裕二,居村暁,濱田康弘,島田光生
    • Organizer
      第40回日本外科系連合学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝胆膵外科手術における周術期栄養評価の有用性に関する研究‐体成分分析装置と主観的包括的アセスメント-2015

    • Author(s)
      齋藤裕,安井苑子,吉川雅登,寺奥大貴,山田眞一郎,岩橋衆一,荒川悠佑,池本哲也,森根裕二,居村暁,濱田康弘,島田光生
    • Organizer
      第27回日本肝胆膵外科学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京都港区)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脾機能亢進症を合併した肝癌に対する脾摘+肝切除の有用性2015

    • Author(s)
      山田眞一郎,吉川雅登,寺奥大貴,齋藤裕,高須千絵,岩橋衆一,荒川悠佑,東島潤,池本哲也,居村暁,森根裕二,島田光生
    • Organizer
      第27回日本肝胆膵外科学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京都港区)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 加齢肝再生不全における肝星細胞の役割についての検討2015

    • Author(s)
      荒川悠佑,島田光生,寺奥大貴,吉川雅登,石川大地,山田眞一郎,齋藤裕,高須千絵,岩橋衆一,池本哲也,森根裕二,居村暁,東島潤
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝虚血再灌流傷害の発生・進展機序の解明と統合的治療法開発の取り組み2015

    • Author(s)
      髙須千絵,森根裕二,居村暁,荒川悠佑,岩橋衆一,齋藤裕,山田眞一郎,石川大地,島田光生
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高齢者の肝再生不全の機序解明と治療への応用2013

    • Author(s)
      荒川悠佑, 島田光生, 石川大地, 山田眞一郎, 淺野間理仁, 齋藤裕, 岩橋衆一, 金本真美, 森大樹, 池本哲也, 森根裕二, 居村暁,
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪由来幹細胞を用いた肝胆膵領域の再生医療に関するimpactと課題2013

    • Author(s)
      池本哲也 島田光生, 宇都宮徹, 居村暁, 森根裕二, 森大樹, 荒川悠佑, 金本真美, 齋藤裕, 山田眞一郎, 淺野間理仁, 三宅秀則
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 高齢者の肝再生不全の機序解明と治療への応用2013

    • Author(s)
      荒川悠佑, 島田光生, 石川大地, 山田眞一郎, 髙須千絵, 齋藤裕, 岩橋衆一, 金本真美, 池本哲也, 森根裕二, 居村暁, 宇都宮徹,
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      別府湾ロイヤルホテル(大分県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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