Mechanism of host organs and tumor microenvironment that related tumor recurrence after liver transplantation
Project/Area Number |
25462092
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | The University of Tokushima |
Principal Investigator |
IMURA Sarotu 徳島大学, 大学病院, 特任教授 (90380021)
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Co-Investigator(Kenkyū-buntansha) |
SHIMADA Mitsuo 徳島大学, 大学院医歯薬学研究部, 教授 (10216070)
MORINE Yuji 徳島大学, 大学院医歯薬学研究部, 講師 (60398021)
IKEMOTO Tetsuya 徳島大学, 大学院医歯薬学研究部, 助教 (20398019)
IWAHASHI Shuichi 徳島大学, 病院, 特任助教 (30531751)
BANDO Yoshimi 徳島大学, 病院, 准教授 (00238239)
UTSUNOMIYA Toru 徳島大学, 大学院医歯薬学研究部, 准教授 (30304801)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 肝癌 / 肝切除 / 肝移植 / 再発 / 腫瘍微小環境 |
Outline of Final Research Achievements |
We studied the mechanism of hepatocellular carcinoma (HCC) progression focused on cancer microenvironment. In HCC, (1) transcription factor STAT4 expression is an index of the cancer immunity and is a poor prognostic factor, (2) cancer stem cell marker CD44 gene expression in non-tumor liver tissue is involved in multicentric recurrence and intrahepatic metastases, (3) cancer suppressive gene Fbxw7 expression decreased in HCC. In the analysis of Fbxw7 expression in non-tumor tissues, the multicentric recurrence was more frequent in the low expression group than that in the high expression group. Low Fbxw7 expression may be associated with hepatocancerogenesis, (4) overexpression of the cell growth factor Nek2 gene was recurrent risk factor associated with tumor grade, (5) by co-cultivation of cancer cells with hepatic stellate cell, proliferation, invasion, and migration abilities of cancer cells was increased via IL-6 or MMP-9 pathway.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma.2014
Author(s)
Enkhbold C, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y, Ishikawa D, Shimada M.
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Journal Title
Hepatol Res.
Volume: -
Issue: 14
DOI
Related Report
Peer Reviewed
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[Journal Article] Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy.2014
Author(s)
Yamada S, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y, Takasu C, Ishikawa D, Shimada M.
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Journal Title
Ann Surg Oncol.
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Specific miRNA expression profiles of non-tumor liver tissue predict a risk for recurrence of hepatocellular carcinoma.2014
Author(s)
Utsunomiya T, Ishikawa D, Asanoma M, Yamada S, Iwahashi S, Kanamoto M, Arakawa Y, Ikemoto T, Morine Y, Imura S, Ishibashi H, Takasu C, Shimada M.
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Journal Title
Hepatol Res.
Volume: 印刷中
Issue: 6
Pages: 631-638
DOI
Related Report
Peer Reviewed
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[Journal Article] The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma.2014
Author(s)
Tovuu LO , Utsunomiya T, Imura S, Morine Y, Ikemoto T, Arakawa Y, Mori H, Hanaoka J, Kanamoto M, Sugimoto K, Saito Y, Yamada S, Asanoma M, Shimada M.
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Journal Title
Int J Clin Oncol.
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Beneficial effects of green tea catechin on massive hepatectomy model in rats2014
Author(s)
Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M
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Journal Title
J Gastroenterol
Volume: 49(4)
Issue: 4
Pages: 692-701
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma.2013
Author(s)
Tovuu LO, Imura S, Utsunomiya T, Morine Y, Ikemoto T, Arakawa Y, Mori H, Hanaoka J, Kanamoto M, Sugimoto K, Iwahashi S, Saito Y, Yamada S, Asanoma M, Miyake H, Shimada M.
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Journal Title
Int J Clin Oncol
Volume: 18
Issue: 4
Pages: 651-656
DOI
Related Report
Peer Reviewed
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[Presentation] 肝発癌母地に着目した肝細胞癌の治療戦略 -DNA, miRNA, Methylationアレイを用いた非癌部肝組織の解析より-2013
Author(s)
齋藤裕, 宇都宮徹, 島田光生, 居村暁, 森根裕二 ,池本哲也, 森大樹, 荒川悠佑, 金本真美, 岩橋衆一, 山田眞一郎, 淺野間理仁,
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
マリンメッセ福岡(福岡県)
Related Report
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[Presentation] 肝細胞癌の癌部・非癌部における細胞周期調節因子Fbxw7の発現低下は独立予後規定因子である2013
Author(s)
石川大地, 島田光生, 山田眞一郎, 齋藤裕, 岩橋衆一, 金本真美, 荒川悠佑, 池本哲也, 森根裕二, 居村暁, 宇都宮徹
Organizer
第49回日本肝癌研究会
Place of Presentation
京王プラザホテル(東京都)
Related Report
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[Presentation] 肝細胞癌の癌部と非癌部の両方におけるFbxw7高発現は術後再発の独立危険因子である2013
Author(s)
宇都宮徹, 島田光生, 石川大地, 山田眞一郎, 齋藤裕, 岩橋衆一, 金本真美, 荒川悠佑, 池本哲也, 森根裕二, 居村暁
Organizer
第24回日本消化器癌発生学会総会
Place of Presentation
石川県立音楽堂(石川県)
Related Report
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[Presentation] ゲノムワイドなDNAメチル化解析に基づく非B非C肝癌例の非癌部肝組織におけるDNAメチル化異常の特徴2013
Author(s)
宇都宮徹, 島田光生, 居村暁, 森根裕二, 池本哲也, 金本真美, 荒川悠佑, 岩橋衆一, 齋藤裕, 山田眞一郎, 石川大地, 田嶋敦,
Organizer
第72回日本癌学会総会
Place of Presentation
パシフィコ横浜(神奈川県)
Related Report