| Project/Area Number |
25463135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Maeda Shigeru 岡山大学, 大学病院, 准教授 (50253000)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Hitoshi 岡山大学, 大学病院, 講師 (30423320)
TOMOYASU Yumiko 岡山大学, 医歯薬学総合研究科, 助教 (40594809)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDOH Tsugunobu 富山大学, 医学薬学研究部, 准教授 (50333498)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | レミフェンタニル / 中枢神経系 / 炎症 / インターロイキン６ / サイトカイン / ストレス反応 |
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| Outline of Final Research Achievements |
In a perioperative management, a control of inflammation is important. Especially, controlling the reaction is significant since the inflammatory reaction in CNS is deeply related with post-operative cognitive dysfunction. Remifentanil, an intravenous opioid used for general anesthesia, acts on mu-opioid receptor in the CNS although its anti-inflammatory effect in the CNS remains unclear. Therefore, in this study, the anti-inflammatory effect of remifentanil in the CNS was validated. Remifentanil inhibited IL-6 mRNA reaction in CNS from animal model of systemic acute inflammation. Using C6, originating from astrocyte, remifentanil suppressed a reaction of IL-6 mRNA to LPS. Remifentanil also suppressed cAMP reaction to LPS in C6 while cAMP increased the reaction of IL-6 mRNA to LPS. Thus, it is suggested that remifentanil suppressed inflammatory reaction in CNS, throught inhibits the reaction of cAMP against LPS in astrocyte, at least in part.
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