The study about a differential diagnosis of development disorder and development disorder with a trauma, and an effectiveness in treatment of a trauma.

• Project/Area Number: 25670515
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hirosaki University
• Principal Investigator: NAKAMURA Kazuhiko 弘前大学, 医学(系)研究科(研究院), 教授 (80263911)
• Co-Investigator(Kenkyū-buntansha): SUGIYAMA Toshiro 浜松医科大学, 医学部, 教授 (60216348)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 児童・思春期精神医学 / PET / 発達障害 / 自閉症 / ADHD / トラウマ処理 / ドパミンD１受容体 / ドパミンD1受容体

Outline of Final Research Achievements

We pursued PET study for adults with developmental disorder related to abuse, which shows the symptoms of ASD and ADHD. This study reveals depressed dopamine D1 receptor, which may underpin neurophysiologic mechanism of development disorder related to abuse, and which is useful in differential diagnosis of it.　As treatment of a trauma for developmental disorder related to abuse, we developed a chance-EMDR which takes short period, and found the effectiveness in treatment of a trauma.
In regard to pharmacotherapy with a few dosages, we found the effectiveness in treatment of a trauma with the prescription of herbal medicine by Kandabashi. We also found the effectiveness in treatment of comorbidities with a few dosages of antipychotics.

Research Products

• [Journal Article] Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism. (2014)
  • Author(s): Anitha A, Thanseem I, Nakamura K, Vasu MM, Yamada K, Ueki T, Iwayama Y, Toyota T, Tsuchiya KJ, Iwata Y, Suzuki K, Sugiyama T, Tsujii M, Yoshikawa T, Mori N.
  • Journal Title: J Psychiatry Neurosci. Volume: 39 Pages: 294-303
  • Peer Reviewed / Open Access
• [Journal Article] N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. (2014)
  • Author(s): 1.Iwata K, Matsuzaki H, Tachibana T, Ohno K, Yoshimura S, Takamura H, Yamada K, Matsuzaki S, Nakamura K, Tsuchiya KJ, Matsumoto K, Tsujii M, Sugiyama T, Katayama T, Mori N
  • Journal Title: Molecular Autism Volume: 5(33) Issue: 1 Pages: 2040-2392
  • DOI: 10.1186/2040-2392-5-33
  • Peer Reviewed / Open Access
• [Journal Article] 発達障害への少量処方 (特集 子ども臨床トピックス) -- (児童精神科臨床のトピックス) (2014)
  • Author(s): 杉山 登志郎
  • Journal Title: そだちの科学 Volume: 22 Pages: 54-62
  • NAID: 40020065133
• [Journal Article] Microglial activation in young adults with autism spectrum disorder (2013)
  • Author(s): Suzuki K
  • Journal Title: JAMA Psychiatry Volume: 70 Issue: 1 Pages: 49-58
  • DOI: 10.1001/jamapsychiatry.2013.272
  • Peer Reviewed
• [Journal Article] Reliability and validity of Autism Diagnostic Interview-Revised, Japanese Version (2013)
  • Author(s): Tsuchiya KJ
  • Journal Title: Journal of Autism and Developmental Disorders Volume: 43 Issue: 3 Pages: 643-662
  • DOI: 10.1007/s10803-012-1606-9
  • Peer Reviewed
• [Presentation] 大人のADHDについて (2014)
  • Author(s): 中村和彦
  • Organizer: 第５５回日本児童青年精神医学会総会
  • Place of Presentation: 浜松市
  • Year and Date: 2014-10-11 – 2014-10-13
  • Invited
• [Presentation] 発達障害と子ども虐待との複合症例に対するEMDRを用いた簡易精神療法の試み (2014)
  • Author(s): 杉山登志郎
  • Organizer: 第５５回日本児童青年精神医学会総会
  • Place of Presentation: 浜松市
  • Year and Date: 2014-10-11 – 2014-10-13
• [Book] 子どものこころの医学 (2014)
  • Author(s): 中村和彦編著
  • Total Pages: 261
  • Publisher: 金芳堂
• [Book] 子どものPTSD-診断と治療 (2014)
  • Author(s): 友田明美、杉山登志郎、谷池雅子編集
  • Total Pages: 304
  • Publisher: 診断と治療社