Development and developmental potential of beta5t-expressing thymic epithelial cells
| Project/Area Number |
25860361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OHIGASHI Izumi 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (00596588)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胸腺 / 獲得免疫 / 胸腺上皮細胞 / 髄質上皮細胞 / β5t / 細胞分化 |
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| Outline of Final Research Achievements |
Medullary thymic epithelial cells (mTECs) are derived from cortico-medullary common thymic epithelial progenitors (pTECs) that transiently transcribe cortical thymic epithelial cells (cTECs)-specific molecule β5t. By in vivo fate-mapping analysis of cells that transcribe β5t during a given period in mice, we examined how β5t+ pTECs contribute the maintenance and regeneration of adult mTECs. In adult mice, most mTECs were derived from cells that transcribed β5t during embryogenesis and neonatal period up to one week of age. The contribution of adult β5t+ pTECs was minor even during injury-triggered thymic regeneration. Our results further demonstrate that adult mTEC-restricted stem cells were also derived from perinatal β5t+ progenitors. These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.2014
Author(s)
Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
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Journal Title
J Immunol
Volume: 192
Issue: 2
Pages: 630-640
DOI
Related Report
Peer Reviewed
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[Journal Article] TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development2013
Author(s)
Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ.
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Journal Title
Proc Natl Acad Sci USA
Volume: 110
Issue: 52
Pages: 21107-21112
DOI
Related Report
Peer Reviewed
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[Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.2013
Author(s)
Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
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Journal Title
Proc Natl Acad Sci USA
Volume: 110
Issue: 24
Pages: 9885-9890
DOI
Related Report
Peer Reviewed
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