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Examination of neuropsychological developmental characteristics and mechanism of juvenile mice administered with drug at fetal stage

Research Project

Project/Area Number 25860909
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

SAWAI Chihiro  滋賀医科大学, 医学部, 特任講師 (30599824)

Research Collaborator TOYODA Atsushi  
MATSUKAWA Noriko  
KAWASE Takahiro  
TSUKAHARA Takamitsu  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経発達障害 / DOHaD仮説 / マウス / リトドリン塩酸塩 / 発生神経毒性試験 / 行動解析 / ミクログリア解析 / 免疫組織化学 / モノアミン解析 / DoHaD仮説
Outline of Final Research Achievements

In this study, to investigate the cause of neurodevelopmental disorder, neuropsychological developmental characteristics and immunohistological examination were carried out on juvenile mice, by using drugs at fetal period commonly prescribed for human pregnancy.
Suppressant of uterine contraction (β2 agonist) ritodrine and antidepressant were oral administered in maternal mouse. Open field test and forced swimming test were performed on juvenile mice, and then the brains were removed. Brain derived neurotrophic factor and microglia immunostaining were performed in the prefrontal cortex and hippocampas. In the group treated with ritodrine, behavioral tests suggested a high level of anxiety. Administration of maternal drugs in fetal period may affect behavior during juvenile age. Morphologically, abnormal layer structure of the cerebral cortex and focal atrophy were not clear, and significant changes could not be confirmed by local quantitative analysis of microglia.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (16 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] 神経発達障害児における尿失禁への心理社会的問題の影響2017

    • Author(s)
      澤井ちひろ、上仁数義、西倉紀子、阪上由子、小林憲市、河内明宏
    • Journal Title

      夜尿症研究

      Volume: 22

    • NAID

      40021582388

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders.2016

    • Author(s)
      Inoue R, Sakaue Y, Sawai C, Sawai T, Ozeki M, Gustavo A. Romero-Perez, Tsukahara T.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 80 Issue: 12 Pages: 2450-2458

    • DOI

      10.1080/09168451.2016.1222267

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful every-other-day liothyronine therapy for severe resistance to thyroid hormone beta with a novel THRB mutation; case report.2016

    • Author(s)
      Maruo Y, Mori A, Morioka Y, Sawai C, Mimura Y, Matui K, Takeuchi Y.
    • Journal Title

      BMC Endocr Disord.

      Volume: 16 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12902-015-0081-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 神経発達障害における尿失禁への心理社会的問題の影響2016

    • Author(s)
      澤井ちひろ、上仁数義、阪上由子、西倉紀子、高萩恭子、竹内義博、小林憲市、河内明宏
    • Organizer
      第27回日本夜尿症学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Impact of psychosociological problems on incontinence in neurodevelopmental disorders2016

    • Author(s)
      Chihiro SAWAI, Kazuyoshi JOHNIN, Noriko NISHIKURA, Yuko SAKAUE, Kenichi KOBAYASHI, Akihiro KAWAUCHI
    • Organizer
      International Children’s Continence Society
    • Place of Presentation
      Kyoto, JAPAN
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発達障害の病態と生理 薬物療法の実際2016

    • Author(s)
      澤井ちひろ
    • Organizer
      草津市立発達支援センター医療相談連絡会
    • Place of Presentation
      滋賀県草津市
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 滋賀県における発達障害をもつ子どもの支援体制について-小児科発達外来の診療を通して-2016

    • Author(s)
      澤井ちひろ
    • Organizer
      滋賀県精神保健福祉協会の一般科・精神科連携事業講演会
    • Place of Presentation
      滋賀県栗東市
    • Year and Date
      2016-02-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 発達障害を有する児の夜尿症・遺尿症2015

    • Author(s)
      澤井ちひろ
    • Organizer
      第74回日本小児科学会滋賀地方会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] よく見て、伝えて、ほめるコツ~ペアレント・トレーニングの手法から~2015

    • Author(s)
      澤井ちひろ
    • Organizer
      草津市発達障害支援に関わる事業
    • Place of Presentation
      滋賀県草津市
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 思春期の育ちに向けて~ペアレント・トレーニングの手法から~2015

    • Author(s)
      澤井ちひろ
    • Organizer
      草津市発達障害支援に関わる事業
    • Place of Presentation
      滋賀県草津市
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 後期早産児の認知機能の発達について2015

    • Author(s)
      澤井ちひろ
    • Organizer
      第73回日本小児科学会滋賀地方会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 親子教室通所児におけるDESC乳幼児社会的認知発達チェックリスト評価の有用性2015

    • Author(s)
      澤井ちひろ
    • Organizer
      第118回日本小児科学会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-04-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 発達外来受診児の身体症状の検討2014

    • Author(s)
      澤井ちひろ
    • Organizer
      第32回日本小児心身医学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 発達障害児の早期徴候の検討2014

    • Author(s)
      澤井ちひろ,西倉紀子,阪上由子,高野知行,竹内義博
    • Organizer
      第117回日本小児科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 実験的多小脳回症における介在神経細胞のGAP43発現上昇2013

    • Author(s)
      高野知行, 龍神布紀子, 西倉紀子, 吉岡誠一郎, 阪上由子, 澤井ちひろ, 竹内義博
    • Organizer
      第55回日本小児神経学会
    • Place of Presentation
      大分
    • Related Report
      2013 Research-status Report
  • [Presentation] 乳幼児健診で異常を指摘されず, 学童期に発達障害と診断された症例の検討2013

    • Author(s)
      阪上由子, 澤井ちひろ, 吉岡誠一郎, 西倉紀子, 龍神布紀子, 高野知行, 岡田眞子, 竹内義博
    • Organizer
      第55回日本小児神経学会
    • Place of Presentation
      大分
    • Related Report
      2013 Research-status Report
  • [Presentation] 発達外来受診児の身体症状

    • Author(s)
      澤井ちひろ, 西倉紀子, 阪上由子, 小池由香里, 木虎隆志, 岡田眞子, 高野知行, 竹内義博
    • Organizer
      第41回滋賀県学校保健学会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児期発症の特発性てんかんが認知発達に及ぼす影響について

    • Author(s)
      西倉紀子, 吉岡誠一郎, 阪上由子, 澤井ちひろ, 高野知行, 竹内義博, 小池由香里, 木虎隆志, 岡田眞子
    • Organizer
      第27回近畿小児科学会
    • Place of Presentation
      奈良
    • Related Report
      2013 Research-status Report
  • [Presentation] 発達外来の現場から不登校を考える

    • Author(s)
      澤井ちひろ
    • Organizer
      第28回こどもの健康週間記念公開講座
    • Place of Presentation
      滋賀
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 子どもの保健改訂第3版2015

    • Author(s)
      澤井ちひろ(共著)竹内義博・大矢紀昭編
    • Total Pages
      234
    • Publisher
      ミネルヴァ書房
    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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