Role of Staphylococcus aureus alpha-toxin and IL-22 in the pathogenesis of eosinophilic rhinosinusitis
| Project/Area Number |
25861562
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IL-22 / 好酸球 / MUC１ / 副鼻腔炎 / 鼻茸 / アスピリ不耐 / 黄色ブドウ球菌 / 気道炎症 / MUC1 / アスピリン不耐 / マイクロアレイ / AHR / エンテロトキシン / αトキシン / サイトカイン / 溶血 |
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| Outline of Final Research Achievements |
98.8% of Staphylococcus aureus detected in middle meatus of patients with chronic rhinosinusitis showed alpha-hemolysis, suggesting a high presence of alpha-toxin in the nose. Nasal polyp cells produced substantial amounts of IL-5, IL-13, IFN-gamma, IL-10 and IL-17A in response to alpha-toxin in ICAM-1 dependent manner. In addition, the polyp cells produced IL-22 in response to the toxin. Impairment of alpha-toxin-induced IL-10 production was associated with eosinophilic inflammation and lower airway obstruction. Furthermore, IL-22 induced MUC1 expression by nasal epithelial cells which was dependent on IL-22 receptor expression.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression.2016
Author(s)
Noyama Y, Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Makihara S, Kanai K, Koyama T, Taniguchi M, Ishitoya J, Kanda A, Kobayashi Y, Asako M, Tomoda K, Nishizaki K.
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Journal Title
Allergology International
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps2016
Author(s)
Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.
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Journal Title
Allergology International
Volume: 65
Issue: 1
Pages: 96-102
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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