A new application of photodynamic therapy for oral cancer
| Project/Area Number |
25861979
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University (2013-2014, 2016)
Kyorin University (2015) |
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Principal Investigator |
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| Research Collaborator |
ENOKI Shigenori 株式会社LSIメディエンス
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 局所進行口腔癌 / 組織穿刺型プローブ / 組織内PDT / 再発口腔癌 / 組織内光線力学的治療 / 口腔癌 / iPDT / 新型穿刺プローブ / 改良型Probe / PDlaser / コネクター / taraporfin sodium / 再発頭頸部癌 / QOL |
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| Outline of Final Research Achievements |
Photodynamic therapy is currently used to treat early stage oral cancer. Expanding its application to locally advanced oral cancer may benefit patients. This study investigated the therapeutic effect of intra-tissue photodynamic therapy (interstitial PDT: iPDT) using a prototype tissue puncture probe. A system was established that connected all-around irradiation type probes used for a conventional "PD laser" and that performed iPDT. The antitumor effect of this system was investigated in nude mice that received transplants of human oral tumors. The relative tumor volume differed significantly in the iPDT-treated and non-irradiated groups. These findings suggested that this system might provide antitumor effects.
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Report
(5 results)
Research Products
(1 results)
