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Identification of therapeutic targets for motor impairment resulting from Prothymosin alpha deficiency

Research Project

Project/Area Number 25893178
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionNagasaki University

Principal Investigator

SASAKI Keita  長崎大学, 医歯薬学総合研究科(薬学系), 研究員 (80711598)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsCerebral ischemia / 一過性中大脳動脈閉塞 / 線条体 / ドパミン / 神経保護 / 運動障害 / 病態モデル動物 / 加齢 / 薬理学 / 神経生理学 / 生物系薬学 / 創薬 / 行動薬理学
Outline of Final Research Achievements

Prothymosin alpha (ProTa) is widely expressed in the brain and plays multiple functions including cell survival. But, it has remained to identify the intrinsic neuroprotective roles of ProTa. Here, I attempted to characterize the physiological, pathological, and neuropharmacological features of mice-specific deficiency of ProTa in the striatum (ProTa cKO mice). ProTa cKO mice exhibited age-dependent deficiency in rotarod behavior. I hypothesized that dopamine D1 receptor agonist SKF38393 would reverse the behavioral abnormality caused by aging in cKO mice. Indeed, the rotarod deficiency was reversed by SKF38393 under single administration. Moreover, ProTa cKO mice have been shown to display increased brain injury and decreased survival ratio following transient middle cerebral artery occlusion. These finding suggest that ProTa has a key role in maintaining motor function, and lack of ProTa is more susceptible to ischemic neuronal damage in the striatum.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] プロサイモシンαの脳血管保護作用の検討2014

    • Author(s)
      前田詩織、近藤秀春、佐々木恵太、植田弘師
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      産業医科大学(北九州市)
    • Year and Date
      2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢性脳卒中後疼痛におけるLPAシグナルの関与と治療戦略2014

    • Author(s)
      佐々木恵太、前田詩織、近藤秀春、久保泰隆、植田弘師
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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