|Budget Amount *help
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2015: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2014: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
|Outline of Final Research Achievements
Elucidation of cancer metastasis mechanism and development of metastasis regulating drugs for cancer treatment are being conducted all over the world. However, no effective method of controlling metastasis has not found so far. In this study, we focused on the cell adhesion mechanism associated with β catenin among cancer metastasis mechanisms in the cell lines of oral squamous cell carcinoma (OSCC). Furthermore, we identified the metastasis inhibitors and determined their effects. As a result, we could identify three cascades involved in candidate drugs for cancer metastasis. Inhibition of cancer metastasis in vitro and in vivo could be achieved by suppressing these functions. Our results are considered to be very useful data for development of the metastasis suppressive treatment drugs for oral cancer.