• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Integrated genome-phenome analysis of biomechanisms which cause disharmony in jaw growth

Research Project

Project/Area Number 26253093
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Moriyama Keiji  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20262206)

Co-Investigator(Kenkyū-buntansha) 小林 起穂  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (20596233)
稲澤 譲治  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
小川 卓也  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (50401360)
東堀 紀尚  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50585221)
Research Collaborator KADOTA Chiho (WATANABE Chiho)  
Project Period (FY) 2014-06-27 – 2018-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Keywords下顎後退症 / 進行性下顎頭吸収 / モデル動物 / エピジェネティクス / ゲノム・エピゲノム / 歯学 / エピゲノム
Outline of Final Research Achievements

This study aimed to clarify epigenetic regulation of gene expression and signal transduction mechanisms related to pathogenesis of mandibular retrognathia. Based on the animal model analysis and the patient's clinical information, we determined the internal and external factors surrounding patients with mandibular retrognathia. In the analysis using animal models, we elucidated the effects of combination of hormones and excessive mechanical stress on temporomandibular joint osteoarthritis which causes acquired mandibular retrusion. Furthermore, we elucidated that Setdb1, a histone methylation enzyme, is essential in the developmental process of the mandible. By using clinical information of patients with mandibular retrognathia, we investigated morphological changes of soft and hard tissues before and after orthognathic treatment. These results were presented in various meetigs and published in an international academic journal.

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、歯科矯正学的観点から集積した臨床症状と、動物モデルから得られた情報との統合的研究であり、多数の遺伝子・遺伝子産物の質や量の違いをもとに、これまで不明点が多かった下顎後退症発症メカニズムの分子機構を内的・外的要因の相互作用も含めて明らかにした。得られた知見は、下顎後退症発症機構に基づいた診断・治療・予防法の開発へと発展すると考えられる。

Report

(5 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (88 results)

All 2019 2018 2017 2016 2015 2014

All Journal Article (24 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 23 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (62 results) (of which Int'l Joint Research: 18 results,  Invited: 7 results) Book (2 results)

  • [Journal Article] Combination of estrogen deficiency and excessive mechanical stress aggravates temporomandibular joint osteoarthritis in vivo.2019

    • Author(s)
      Wu Y, Kadota-Watanabe C, Ogawa T, Moriyama K.
    • Journal Title

      Archives of oral biology

      Volume: 102 Pages: 39-46

    • DOI

      10.1016/j.archoralbio.2019.03.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency of missing teeth and reduction of mesiodistal tooth width in Japanese patients with tooth agenesis2018

    • Author(s)
      Higashihori Norihisa、Takada Jun-ichi、Katayanagi Minami、Takahashi Yuki、Moriyama Keiji
    • Journal Title

      Progress in Orthodontics

      Volume: 19(1) Issue: 1 Pages: 30-30

    • DOI

      10.1186/s40510-018-0222-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Examination of craniofacial morphology in Japanese patients with congenitally missing teeth: a cross-sectional study2018

    • Author(s)
      Takahashi Yuki、Higashihori Norihisa、Yasuda Yuko、Takada Jun-ichi、Moriyama Keiji
    • Journal Title

      Progress in Orthodontics

      Volume: 19 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s40510-018-0238-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear import of transcriptional corepressor BCOR occurs through interaction with karyopherin α expressed in human periodontal ligament.2018

    • Author(s)
      Myat AB, Ogawa T, Kadota-Watanabe C, Moriyama K.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 507 Issue: 1-4 Pages: 67-73

    • DOI

      10.1016/j.bbrc.2018.10.158

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of distraction force in maxillary distraction osteogenesis for cleft lip and palate.2017

    • Author(s)
      Sawada H, Ogawa T, Kataoka K, Baba Y, Moriyama K.
    • Journal Title

      Journal of Craniofacial Surgery.

      Volume: 28(2) Issue: 2 Pages: 406-412

    • DOI

      10.1097/scs.0000000000003327

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression2017

    • Author(s)
      Shoji-Matsunaga Ayumi、Ono Takehito、Hayashi Mikihito、Takayanagi Hiroshi、Moriyama Keiji、Nakashima Tomoki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8753-8753

    • DOI

      10.1038/s41598-017-09326-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Profilin1 is expressed in osteocytes and regulates cell shape and migration.2017

    • Author(s)
      Lin W, Izu Y, Smriti A, Kawasaki M, Pawaputanon C, Bottcher RT, Costell M, Moriyama K, Noda M, Ezura Y.
    • Journal Title

      J Cell Physiol.

      Volume: 印刷中 Issue: 1 Pages: 259-268

    • DOI

      10.1002/jcp.25872

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development.2017

    • Author(s)
      Yahiro K, Higashihori N, Moriyama K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 482(4) Issue: 4 Pages: 883-888

    • DOI

      10.1016/j.bbrc.2016.11.128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A preliminary investigation of the effect of relaxin on bone remodeling in suture expansion2016

    • Author(s)
      Duarte C, Kobayashi Y, Morita J, Kawamoto T, Moriyama K
    • Journal Title

      European Journal of Orthodontics

      Volume: 0 Pages: 0-0

    • DOI

      10.1093/ejo/cjw037

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between maternal education and malocclusion in Mongolian adolescents: a cross-sectional study.2016

    • Author(s)
      Tumurkhuu T, Fujiwara T, Komazaki Y, Kawaguchi Y, Tanaka T, Inazawa J, Ganburged G, Bazar A, Ogawa T, Moriyama K.
    • Journal Title

      BMJ Open.

      Volume: 6(11) Issue: 11 Pages: e012283-e012283

    • DOI

      10.1136/bmjopen-2016-012283

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Systemic and maxillofacial characteristics of eleven Japanese children with Russell–Silver syndrome.2016

    • Author(s)
      Sato C, Ogawa T, Tsuge R, Shiga M, Tsuji M, Baba Y, Kosaki K, Moriyama K.
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: - Issue: 5 Pages: 217-225

    • DOI

      10.1111/cga.12162

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 東京医科歯科大学歯科講演会『顎顔面矯正学の現在と未来-顎顔面矯正学分野のめざすもの』-2: 顎変形症患者への外科的矯正治療.2016

    • Author(s)
      東堀紀尚.
    • Journal Title

      矯正臨床ジャーナル

      Volume: 32(6) Pages: 11-20

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Profilin expression is regulated by bone morphogenetic protein (BMP) in osteoblastic cells.2016

    • Author(s)
      Lin W, Ezura Y, Izu Y, Smriti A, Kawasaki M, Pawaputanon C, Moriyama K, Noda M.
    • Journal Title

      J Cell Biochem

      Volume: 117 Pages: 621-628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system2016

    • Author(s)
      Morishita M, Muramatsu T, Suto Y, Hirai M, Konishi T, Hayashi S, Shigemizu D, Tsunoda T, Moriyama K, Inazawa J
    • Journal Title

      Oncotarget

      Volume: 7(9) Issue: 9 Pages: 10182-92

    • DOI

      10.18632/oncotarget.7186

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of blood flow and electromyographic activity in the perioral muscles.2016

    • Author(s)
      Dei A, Miyamoto JJ, Takada JI, Ono T, Moriyama K.
    • Journal Title

      Eur J Orthod

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of nuclear localization signals within the human BCOR protein.2015

    • Author(s)
      Surapornsawasd T, Ogawa T, Moriyama K.
    • Journal Title

      FEBS Lett

      Volume: 589 Issue: 21 Pages: 3313-3320

    • DOI

      10.1016/j.febslet.2015.05.046

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional analysis of hard and soft tissue changes in patients with facial asymmetry undergoing 2-jaw surgery.2015

    • Author(s)
      Suzuki-Okamura E, Higashihori N, Kawamoto T, Moriyama K.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol.

      Volume: 120 Issue: 3 Pages: 299-306

    • DOI

      10.1016/j.oooo.2015.05.020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcification of MC3T3-E1 cells on titanium and zirconium2015

    • Author(s)
      Umezawa T, Chen P, Tsutsumi Y, Doi H, Ashida M, Suzuki S, Moriyama K, Hanawa T.
    • Journal Title

      Dental Materials Journal

      Volume: 34 Issue: 5 Pages: 713-718

    • DOI

      10.4012/dmj.2015-018

    • NAID

      130005101716

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Tooth Restoration Utilising Split Germs Through Re-regionalisation of the Tooth-forming Field.2015

    • Author(s)
      Yamamoto N, Oshima M, Tanaka C, Ogawa M, Nakajima K, Ishida K, Moriyama K, Tsuji T.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 1-10

    • DOI

      10.1038/srep18393

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term intermittent administration of parathyroid hormone facilitates osteogenesis by different mechanisms in cancellous and cortical bone.2015

    • Author(s)
      Ogura K, Iimura T, Makino Y, Sugie-Oya A, Takakura A, Takao-Kawabata R, Ishizuyae T, Moriyama K, Yamaguchi A.
    • Journal Title

      Bone Reports

      Volume: 5 Pages: 7-14

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上顎前歯部歯槽骨切り術を適応した骨格性下顎後退症患者の側貌軟組織変化2015

    • Author(s)
      三上智彦,福岡裕樹,東堀紀尚,川元龍夫,森山啓司
    • Journal Title

      日本顎変形症学会雑誌

      Volume: 25(1) Pages: 17-31

    • NAID

      130005066071

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dentomaxillofacial characteristics of ectodermal dysplasia.2015

    • Author(s)
      Nakayama Y, Baba Y, Tsuji M, Fukuoka H, Ogawa T, Ohkuma M, Moriyama K
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 55(1) Issue: 1 Pages: 42-48

    • DOI

      10.1111/cga.12073

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis.2015

    • Author(s)
      Liu S, Higashihori N, Yahiro K, Moriyama K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 13;458(3) Issue: 3 Pages: 525-530

    • DOI

      10.1016/j.bbrc.2015.01.148

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro.2014

    • Author(s)
      Duarte C, Kobayashi Y, Kawamoto T, Moriyama K
    • Journal Title

      Bone

      Volume: 65 Pages: 92-101

    • DOI

      10.1016/j.bone.2014.05.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] A case of Angle Class II malocclusion with dental crowding in a growing patient2018

    • Author(s)
      Koda N, Ogawa T, Moriyama K
    • Organizer
      2nd APOS Residents Forum(The 11th Asian Pacific Orthodontic Conference(APOC 2018))
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨格性下顎後退症患者の側貌軟組織変化:下顎骨前方移動術と上顎前歯部歯槽骨切り術との比較2018

    • Author(s)
      木下理恵、東堀紀尚、門田千穂、疋田理奈、高橋由記、秋山咲子、伊藤洋介、森山啓司
    • Organizer
      第28回日本顎変形症学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Osteocyte-derived RANKL is a Key Regulator of Orthodontic Tooth Movement2018

    • Author(s)
      Shoji-Matsunaga A, Ono T, Nakashima T, Moriyama K
    • Organizer
      96th General Session & Exhibition of International Association for Dental Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顎関節形成不全の重症度により分類したoculo-auriculo-vertebral spectrum患者の顎顔面形態に関する検討2018

    • Author(s)
      仁木佑紀、東堀紀尚、上園将慶、五十嵐七瀬、稲垣有美、井上雅葵、会坂善也、バダラフノミン、小林起穂、辻美千子、森山啓司
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Le Fort Ⅰ型骨切り術および下顎骨前方移動術により睡眠呼吸障害の改善を認めた骨格性Ⅱ級不正咬合の一症例2018

    • Author(s)
      小笠原毅、松本力、宮崎貴行、馬場優里、伊藤洋介、樺沢勇司、森山啓司
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Combination of estrogen deficiency and excessive mechanical stress exacerbates TMJ-OA in mice2018

    • Author(s)
      Wu Y, Kadota-Watanabe C, Ogawa T, Moriyama K
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Early Treatment of Class II Malocclusion - Lessons Learned from our Clinical Experience2018

    • Author(s)
      Moriyama K
    • Organizer
      2018 Taiwan International Orthodontic Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 東京医科歯科大学歯学部附属病院顎口腔変形疾患外来の取り組み2017

    • Author(s)
      森田圭一、壬生美智子、乙丸貴史、島崎一夫、小川卓也、立川敬子、宮新美智世、小野卓史、森山啓司、谷口尚、原田浩之
    • Organizer
      第41回日本口蓋裂学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格性上顎前突症患者におけるモーションキャプチャーを用いた発音時口唇動態解析の試み2017

    • Author(s)
      高橋由紀、東堀紀尚、伊藤洋介、上園将慶、門田千穂、 秋山咲子、疋田理奈、鈴木聖一、森山啓司
    • Organizer
      第27回日本顎変形症学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 顎顔面先天異常患者に対する歯科矯正学的なアプローチ2017

    • Author(s)
      森山啓司
    • Organizer
      第60回中・四国矯正歯科学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 外科的矯正治療による顎顔面形態と機能の調和2017

    • Author(s)
      東堀紀尚
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 骨格性Ⅱ級不正咬合患者の発音時における口腔周囲軟組織動態の解析2017

    • Author(s)
      高橋由記、東堀紀尚、舩橋健太、松村健二郎、伊藤洋介、上園将慶、門田千穂、秋山咲子、疋田理奈、鈴木聖一、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メッケル軟骨の発生過程に及ぼすヒストンメチル化酵素Setdb1の影響とBMPシグナルの関与2017

    • Author(s)
      八尋浩平、東堀紀尚、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成長終了後に下顎頭肥大を呈したStickler症候群の1症例2017

    • Author(s)
      富永千慧、幸田直己、高橋由記、門脇佳緒里、小倉健司、辻美千子、小林起穂、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment of a Novel Murine Model of Temporomandibular Joint Osteoarthritis 2017

    • Author(s)
      Wu Y, Kadota-Watanabe C, Ogawa T, Moriyama K
    • Organizer
      The 30th Taiwan Association of Orthodontists Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨格性下顎前突症を伴う一卵性双生児の外科学的矯正治療例.2016

    • Author(s)
      浅見拓也、伊藤洋介、秋山秀平、平林恭子、小笠原毅、黒原一人、森山啓司.
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 副甲状腺ホルモンの間欠投与による骨形成促進作用について.2016

    • Author(s)
      小倉健司、飯村忠浩、山口朗、森山啓司.
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 顎顔面発生過程におけるヒストンメチル化酵素Setdb1の役割.2016

    • Author(s)
      八尋浩平、東堀紀尚、森山啓司.
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頭蓋縫合早期癒合症(Craniosynostosis)患者の顎顔面形態の解析―アペール症候群とクルーゾン症候群の比較.2016

    • Author(s)
      小林起穂、辻美千子、疋田理奈、小倉健司、森山啓司.
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 矯正用インプラントアンカー(仮称)を併用し治療を行った下顎頭変形症を伴うハイアングルII級症例.2016

    • Author(s)
      髙橋由記、東堀紀尚、森山啓司.
    • Organizer
      第75 回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頭蓋縫合早期癒合症発症および頭蓋骨縫合部発生に関与するmicro RNAの同定.2016

    • Author(s)
      小林起穂、森山啓司.
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dental Equilibrium Revisited : Soft Tissue Considerations in Treatment of Dentofacial Deformity.2016

    • Author(s)
      Moriyama K.
    • Organizer
      The 10th Asia Pacific orthodontic Conference and 11th Annual Meeting of the Indonesian Association of Orthodontists
    • Place of Presentation
      Bali,Indonesia
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Long-term changes in clinical crown height after surgical orthodontic treatment for mandibular prognathism.2016

    • Author(s)
      Ito Y, Takahashi Y, Hikita R, Watanabe C, Akiyama S, Higashihori N, Moriyama K.
    • Organizer
      The 10th Asia Pacific orthodontic Conference and 11th Annual Meeting of the Indonesian Association of Orthodontists
    • Place of Presentation
      Bali,Indonesia
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surgical-orthodontic treatment for facial asymmetry patient whose occlusal plane canted opposite to the mandibular deviation.2016

    • Author(s)
      Higashihori N, Hikita R, Moriyama K.
    • Organizer
      The 10th Asia Pacific orthodontic Conference and 11th Annual Meeting of the Indonesian Association of Orthodontists
    • Place of Presentation
      Bali,Indonesia
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 短期間の副甲状腺ホルモンの間欠投与は海綿骨と皮質骨で異なるメカニズムにより骨形成を促進する.2016

    • Author(s)
      小倉健司、飯村忠浩、牧野祐司、杉江綾乃、高倉綾、高尾亮子、石津谷俊則、森山啓司、山口朗.
    • Organizer
      第34回日本骨代謝学会学術大会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 硬軟組織シミュレー ションを導入して外科的矯正治療を施行した顔面非対称症例の術後硬軟組織の三次元的検討.2016

    • Author(s)
      小笠原毅、伊藤洋介、浅見拓也、東堀紀尚、鈴木聖一、樺沢勇司、原田浩之、森山啓司.
    • Organizer
      第75回東京矯正歯科学会学術大会
    • Place of Presentation
      有楽町朝日ホール(東京都千代田区)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多数歯欠損を伴う顎変形症に対する治療計画の立案.2016

    • Author(s)
      東堀紀尚.
    • Organizer
      第26回日本顎変形症学会総会・学術大会
    • Place of Presentation
      学術総合センター・一ツ橋講堂(東京都千代田区)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 上下顎移動術を施行した顔面非対称を伴う顎変形症患者の鼻形態に対する三次元解析.2016

    • Author(s)
      秋山咲子、東堀紀尚、疋田理奈、渡辺千穂、高橋由記、伊藤洋介、森山啓司.
    • Organizer
      第26回日本顎変形症学会総会・学術大会
    • Place of Presentation
      学術総合センター・一ツ橋講堂(東京都千代田区)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 長期術後経過からみた骨格性下顎前突症例の臨床的歯冠長変化-下顎枝矢状分割術単独と上下顎移動術の比較.2016

    • Author(s)
      伊藤洋介、高橋由記、疋田理奈、渡辺千穂、秋山咲子、東堀紀尚、森山啓司.
    • Organizer
      第26回日本顎変形症学会総会・学術大会
    • Place of Presentation
      学術総合センター・一ツ橋講堂(東京都千代田区)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 顎変形患者に対して下顎枝矢状分割術に下顎骨体部骨切りを併用した2症例.2016

    • Author(s)
      石川心介、山崎安晴、杉本孝之、池本繁弘、山下理絵、宮本順、森山啓司、稲毛滋白、武田啓.
    • Organizer
      第26回日本顎変形症学会総会・学術大会
    • Place of Presentation
      学術総合センター・一ツ橋講堂(東京都千代田区)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of Profilin1 in BMP-induced Activities in Skeletal Cells.2016

    • Author(s)
      Lin W, Ezura Y, Izu Y, Moriyama K, Noda M.
    • Organizer
      94th General Session & Exhibition of International Association for Dental Research.
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顎矯正手術後の骨格安定度を科学する.2016

    • Author(s)
      小川卓也.
    • Organizer
      第70回NPO法人日本口腔科学会学術集会.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Systemic and cranimaxillofacial characteristics of patients with Williams syndrome.2016

    • Author(s)
      Hikita R, Matsuno S, Asami T, Ogawa T, Baba Y, Tsuji M, Moriyama K.
    • Organizer
      International Congress of Human Genetics 2016.
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maxillofacial morphological characteristics of two Japanese patients with chromosome 18p deletion syndrome.2016

    • Author(s)
      Tsuji M, Ogura K, Hikita R, Kobayashi Y, Moriyama K.
    • Organizer
      International Congress of Human Genetics 2016.
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒストンメチル化酵素SETDB1が顎顔面発生過程に及ぼす影響.2015

    • Author(s)
      八尋浩平、東堀紀尚、森山啓司.
    • Organizer
      第80回口腔病学会学術大会学術大会
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2015-12-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Consideration of soft tissue in treatment of case with dentoskeletal discrepancies2015

    • Author(s)
      Moriyama K.
    • Organizer
      28th TAO annual meeting & 2015 APOS residents forum
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Correction of a high-angle class II malocclusion with condylar resorption using a skeletal anchorage system.2015

    • Author(s)
      Takahashi Y, Higashihori N, Moriyama K.
    • Organizer
      28th TAO annual meeting & 2015 APOS residents forum
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PTH Facilitates Osteogenesis by Different Mechanisms between Cancellous- and Cortical-bones.2015

    • Author(s)
      Ogura K, Ishizuya T, Moriyama K, Yamaguchi A.
    • Organizer
      第63回国際歯科研究学会日本部会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Oculofaciocardiodental syndrome における変異BCORの機能解析による核移行シグナルの同定.2015

    • Author(s)
      小川卓也、スラポンサワッド タンヤポン、森山啓司.
    • Organizer
      第60回日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Intermittent administration of parathyroid hormone facilitates osteogenesis by different mechanisms in cancellous and cortical bone.2015

    • Author(s)
      Ogura K, Ishizuya T, Moriyama K, Yamaguchi A.
    • Organizer
      ASBMR Annual Meeting
    • Place of Presentation
      Washington, USA
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between volumetric measurements of mandibular morphology and condylar movement in facial asymmetry subjects.2015

    • Author(s)
      Ikeda M, Miyamoto J, Takada J, Moriyama K.
    • Organizer
      8th International Orthodontic Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-term observations after surgical orthodontic treatment for mandibular prognathism with facial asymmetry.2015

    • Author(s)
      Watanabe C, Higashihori N, Hikita R, Matsumoto T, Ito Y, Kawamoto T, Moriyama K.
    • Organizer
      8th International Orthodontic Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional analysis of lower lip movement during articulation in patients with mandibular prognathism by motion capture system.2015

    • Author(s)
      Matsumoto T, Higashihori N, Hikita R, Watanabe C, Miyamoto J, Kawamoto T, Suzuki S, Moriyama K.
    • Organizer
      8th International Orthodontic Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A case of Apert syndrome treated by bimaxillary orthognathic surgery after Le Fort III distraction.2015

    • Author(s)
      Tsuji M, Naganishi H, Torikai K, Moriyama K.
    • Organizer
      The 16th Congress of International Society of Craniofacial Surgery
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒストンメチル化酵素Whsc1はレチノイン酸による口蓋裂発症に関与する.2015

    • Author(s)
      東堀紀尚、劉世頴、八尋浩平、森山啓司.
    • Organizer
      第55回日本先天異常学会学術大会
    • Place of Presentation
      パシフィコ横浜会議センター(神奈川県横浜市)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 上顎前歯部歯槽骨切り術によって上顎の著しい前突感が改善された1症例-三次元再構築画像を用いた軟組織変化の検討-.2015

    • Author(s)
      上園将慶,松本力,東堀紀尚,鈴木聖一,樺沢勇司,原田清,森山啓司.
    • Organizer
      第74回東京矯正歯科学会学術大会
    • Place of Presentation
      ベルサール新宿グランド(東京都新宿区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 外科的矯正治療に伴う呼吸器能動態に舌の位置変化が与える影響.2015

    • Author(s)
      疋田理奈、東堀紀尚、宮本順、福岡裕樹、高橋由記、渡辺千穂、伊藤洋介、松本力、川元龍夫、森山啓司.
    • Organizer
      第25回日本顎変形症学会学術大会
    • Place of Presentation
      ベルサール神田(東京都千代田区)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下顎枝矢状分割術を施行した骨格性下顎前突症例の長期術後経過からみた臨床的歯冠長の変化.2015

    • Author(s)
      高橋由記、伊藤洋介、東堀紀尚、松本力、疋田理奈、渡辺千穂、松本力、川元龍夫、森山啓司.
    • Organizer
      第25回日本顎変形症学会学術大会
    • Place of Presentation
      ベルサール神田(東京都千代田区)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 顎変形症治療における併発症の要因とその予防法~矯正歯科医の立場から~2015

    • Author(s)
      東堀紀尚.
    • Organizer
      第25回日本顎変形症学会学術大会
    • Place of Presentation
      ベルサール神田(東京都千代田区)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] “Give Thy Thoughts with Tongue” -The Tongue is An Eloquent Organ in Orthodontics2015

    • Author(s)
      Moriyama K.
    • Organizer
      2015 American Association of Orthodontists Annual Session
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顎顔面成長発育疾患の新たな治療戦略の開発を目指して2014

    • Author(s)
      森山啓司
    • Organizer
      第 8回硬組織疾患ゲノムセンターシンポジウム
    • Place of Presentation
      東京医科歯科大学M&Dタワー(東京都文京区)
    • Year and Date
      2014-12-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identificationofthe classical nuclearlocalizationsignalsof BCOR gene.2014

    • Author(s)
      Surapornsawasd T, Ogawa T, Moriyama K.
    • Organizer
      62th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKRホテル大阪(大阪市)
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis.2014

    • Author(s)
      劉世頴、東堀紀尚、森山啓司
    • Organizer
      62th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKRホテル大阪(大阪市)
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上顎前歯部歯槽骨切り術と下顎枝矢状分割術の併用により外科的矯正治療を行った骨格性II 級不正咬合の一症例2014

    • Author(s)
      伊藤洋介,森下真紀,澤田紘美,東堀紀尚,川元龍夫,森山啓司
    • Organizer
      第73 回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Le Fort III 型骨切り・ 骨延長術後の上下顎移動術により咬合改善を行ったApert 症候群の矯正治療症例2014

    • Author(s)
      松本静、辻美千子、長西裕樹、鳥飼勝行、森山啓司
    • Organizer
      第73 回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウィリアムズ症候群患者の臨床症状に関する検討(第1 報).全身および頭蓋顎顔面形態の特徴について2014

    • Author(s)
      松野さほり,疋田理奈,林婉婷,佐藤麻緒,松本力,辻美千子,馬場祥行,森山啓司
    • Organizer
      第73 回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウィリアムズ症候群患者の臨床症状に関する検討(第2 報).口腔内の特徴について2014

    • Author(s)
      浅見拓也,松本力,庄司あゆみ,疋田理奈,辻美千子,馬場祥行,森山啓司
    • Organizer
      第73 回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 馬蹄形骨切り併用上下顎移動術を行い長期にわたり良好な咬合状態を維持した骨格性II 級ハイアングル症例2014

    • Author(s)
      駒﨑裕子,高橋由記,東堀紀尚,川元龍夫,森山啓司
    • Organizer
      第73 回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 嚥下時舌運動の経時的評価に対するMRI movie の有用性2014

    • Author(s)
      エクプラチャヤクン・ イサリア,高田潤一,井上マリステラ小百合,宮本順,誉田栄一,倉林亨,森山啓司
    • Organizer
      第73 回日本矯正歯科学会大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Considerations on craniofacial anomalies from orthodontic and orthognathic viewpoints.2014

    • Author(s)
      Moriyama K
    • Organizer
      9th APOC and 20th MAOISCTE
    • Place of Presentation
      クチン(マレシーア)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Exploration of mechanisms for chromothripsis; the new mechanism of oncogenesis.2014

    • Author(s)
      森下真紀,村松智暉,林深,数藤由美子,小西輝昭,森山啓司,稲澤譲治
    • Organizer
      第73 回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨格性下顎前突患者の発音時における口腔周囲軟組織動態の検討2014

    • Author(s)
      松本力,川元龍夫,東堀紀尚,疋田理奈,宮本順,鈴木聖一,森山啓司
    • Organizer
      第73 回東京矯正歯科学会大会
    • Place of Presentation
      有楽町朝日ホール(東京都千代田区)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Book] Biomarkers in Bone Disease. Part of the series Biomarkers in Disease: Methods, Discoveries and Applications.2016

    • Author(s)
      Kobayashi Y, Duarte C, Moriyama K.
    • Publisher
      Springer Netherlands
    • Related Report
      2016 Annual Research Report
  • [Book] 骨ペディア(Bonepedia, 骨疾患・骨代謝キーワード事典)2015

    • Author(s)
      森山啓司 他(分担執筆)
    • Total Pages
      328
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi