| Project/Area Number |
26282144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
芳澤 暢子 浜松医科大学, 医学部附属病院, 助教 (10402314)
上田 重人 埼玉医科大学, 医学部, 助教 (20646947)
佐伯 俊昭 埼玉医科大学, 医学部, 教授 (50201512)
小倉 廣之 浜松医科大学, 医学部, 助教 (50402285)
久慈 一英 埼玉医科大学, 医学部, 教授 (90283142)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Yutaka 浜松ホトニクス株式会社, 中央研究所, 研究主幹(理事) (80393982)
UEDA Yukio 浜松ホトニクス株式会社, 中央研究所・第7研究室, 副研究室長 (30393987)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 画像診断システム / 拡散光イメージング / 乳がん / 乳癌 |
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| Outline of Final Research Achievements |
Diffuse optical spectroscopy is used for evaluation of tumor blood volume quantified by tissue hemoglobin concentrations. We investigated whether early changes in tumor total hemoglobin concentration predict a pathological complete response (pCR) to neoadjuvant chemotherapy in patients with operable breast cancer, and we compared the predictive value of pCR between optical spectroscopy and FDG-PET. Although changes in tumor hemoglobin concentration predicted pCR to chemotherapy with moderate accuracy, the diagnostic performance of optical spectroscopy was not superior to that of metabolic response monitored by FDG-PET.
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