Activation of anti-tumor immune responses by the control of regulatory T cells

• Project/Area Number: 26290054
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Nagoya University (2016); National Cancer Center Japan (2015); Osaka University (2014)
• Principal Investigator: Nishikawa Hiroyoshi 名古屋大学, 医学(系)研究科(研究院), 教授 (10444431)
• Co-Investigator(Renkei-kenkyūsha): DOKI Yuichiro 大阪大学, 大学院医学研究科, 教授 (20291445) ; TANEMURA Atsushi 大阪大学, 大学院医学研究科, 助教 (50457016)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: がん / 免疫制御 / がん免疫療法 / 制御性T細胞 / エフェクターT細胞 / 免疫学 / トランスレーショナルリサーチ / 免疫共抑制分子

Outline of Final Research Achievements

FoxP3+CD25+CD4+ regulatory T (Treg) cells, crucial for the maintenance of immunological self-tolerance, are abundant in tumors and inhibit anti-tumor immune responses. To address the Treg suppression to tumor antigens particularly derived from self-antigens, Melan-A -specific CD8+ T cells were stimulated in the presence of Treg cells. Treg cells rendered Melan-A-specific T cells anergic (i.e., hypo-proliferative and cytokine hypo-producing upon antigen re-stimulation). Then, developing novel strategies to control Treg cells, particularly in cancers that do not contain large numbers of neoantigens is important for effective cancer immunotherapies.

Research Products

• [Journal Article] ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori. (2017)
  • Author(s): 長瀬 博次
  • Journal Title: Int J Cancer Volume: 140(3) Issue: 3 Pages: 686-695
  • DOI: 10.1002/ijc.30475
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] NY-ESO-1 Protein Cancer Vaccine With Poly-ICLC and OK-432: Rapid and Strong Induction of NY-ESO-1-specific Immune Responses by Poly-ICLC (2017)
  • Author(s): Takeoka T, Nagase H, Kurose K, Ohue Y, Yamasaki M, Takiguchi S, Sato E, Isobe M, Kanazawa T, Matsumoto M, Iwahori K, Kawashima A, Morimoto-Okazawa A, Nishikawa H, Oka M, Pan L, Venhaus R, Nakayama E, Mori M, Doki Y, Wada H.
  • Journal Title: J Immunother Volume: epub Issue: 4 Pages: 140-147
  • DOI: 10.1097/cji.0000000000000162
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody (2017)
  • Author(s): Hamano Y, Kida H, Ihara S, Murakami A, Yanagawa M, Ueda K, Honda O, Tripathi LP, Arai T, Hirose M, Hamasaki T, Yano Y, Kimura T, Kato Y, Takamatsu H, Otsuka T, Minami T, Hirata H, Inoue K, Nagatomo I, Takeda Y, Mori M, Nishikawa H, Mizuguchi K, Kijima T, Kitaichi T, Tomiyama N, Inoue Y, Kumanogoh A
  • Journal Title: Scientific Reports Volume: 23 Issue: 1 Pages: 43201-43201
  • DOI: 10.1038/srep43201
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. (2016)
  • Author(s): Saito, T., Nishikawa, H., Wada, H., Nagano, Y., Sugiyama, D., Atarashi, K., Maeda, Y., Hamaguchi, M., Ohkura, N., Sato, E., Nagase, H., Nishimura, J., Yamamoto, H., Takiguchi, S., Tanoue, T., Suda, W., Morita, H., Hattori, M., Honda, K., Mori, M., Doki, Y., Sakaguchi, S.
  • Journal Title: Nat. Med Volume: 22 Issue: 6 Pages: 679-684
  • DOI: 10.1038/nm.4086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles of regulatory T cells in cancer immunity. (2016)
  • Author(s): Takeuchi Y, Nishikawa H
  • Journal Title: Int Immunol Volume: 28(8) Issue: 8 Pages: 401-409
  • DOI: 10.1093/intimm/dxw025
  • NAID: 120005905585
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fecal microbiota transplantation for patients with steroid-resistant/dependent acute graft-versus-host disease of the gut (2016)
  • Author(s): Kakihana K, Fujioka Y, Suda W, Najima Y, Kuwata G, Sasajima S, Mimura I, Morita H, Sugiyama D, Nishikawa H, Hattori M, Hino Y, Ikegawa S, Yamamoto K, Toya T, Doki N, Koizumi K, Honda K, Ohashi K
  • Journal Title: Blood Volume: 128 Issue: 16 Pages: 2083-2088
  • DOI: 10.1182/blood-2016-05-717652
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Antibody to CMRF35-Like Molecule 2, CD300e A Novel Biomarker Detected in Patients with Fulminant Type 1 Diabetes. (2016)
  • Author(s): Haseda F, Imagawa A, Nishikawa H, Mitsui S, Tsutsumi C, Fujisawa R, Sano H, Murase-Mishiba Y, Terasaki J, Sakaguchi S, Hanafusa T.
  • Journal Title: PLOS ONE Volume: 11 Issue: 8 Pages: e0160576-e0160576
  • DOI: 10.1371/journal.pone.0160576
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia. (2016)
  • Author(s): UreshinoH,ShindoT,NishikawaH,WatanabeN,WatanabeE,SatohN,KitauraK,KitamuraH,DoiK,NagaseK,Kimura H, Samukawa M, Kusunoki S, Miyahara M, Shin-I T, Suzuki R, Sakaguchi S, Kimura S
  • Journal Title: Cancer Immunol Res Volume: 4(8) Pages: 644-649
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Report on the use of nonclinical studies in the regulatory evaluation of oncology drugs (2016)
  • Author(s): Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao Y, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T
  • Journal Title: Cancer Sci Volume: 107(2) Issue: 2 Pages: 189-202
  • DOI: 10.1111/cas.12857
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of Novel and Noninvasive Biomarkers of Acute Cellular Rejection After Liver Transplantation by Protein Microarray. (2016)
  • Author(s): Okubo K, Wada H, Tanaka A, Eguchi H, Hamaguchi M, Tomokuni A, Tomimaru Y, Asaoka T, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Nagano H, Sakaguchi N, Nishikawa H, Doki Y, Mori M, Sakaguchi S
  • Journal Title: Transplant Direct Volume: 2(12)
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hypomethylation of the Treg-specific demethylated region in FOXP3 is a hallmark of the regulatory T-cell subtype in adult T-cell leukemia (2016)
  • Author(s): Shimazu Y, Shimazu Y, Hishizawa M, Hamaguchi M, Nagai Y, Sugino N, Fujii S, Kawahara M, Kadowaki N, Nishikawa H, Sakaguchi S, Takaori-Kondo A
  • Journal Title: Cancer Immunol Res Volume: 4 Issue: 2 Pages: 136-145
  • DOI: 10.1158/2326-6066.cir-15-0148
  • Peer Reviewed
• [Journal Article] Overview: New Modality for Cancer Treatment. (2015)
  • Author(s): Nishikawa H.
  • Journal Title: Oncology Volume: Nov;8 9 Suppl 1 Issue: Suppl. 1 Pages: 33-35
  • DOI: 10.1159/000431063
  • Peer Reviewed
• [Journal Article] Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients. (2015)
  • Author(s): 2.Kurose K, Ohue Y, Wada H, Iida S, Ishida T, Kojima T, Doi T, Suzuki S, Isobe M, Funakoshi T, Kakimi K, Nishikawa H, Udono H, Oka M, Ueda R, Nakayama E.
  • Journal Title: Clin Cancer Res. Volume: 21 Issue: 19 Pages: 4327-36
  • DOI: 10.1158/1078-0432.ccr-15-0357
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulatory T cells in cancer; can they be controlled? (2015)
  • Author(s): Adeegbe DO, Nishikawa H.
  • Journal Title: Immunotherapy Volume: 7(8) Issue: 8 Pages: 843-846
  • DOI: 10.2217/imt.15.52
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans. (2015)
  • Author(s): Miyara, M., et al.
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 112 Issue: 23 Pages: 7225-7230
  • DOI: 10.1073/pnas.1508224112
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Detection of self-reactive CD8⁺ T cells with an anergic phenotype in healthy individuals. (2014)
  • Author(s): Maeda Y, Nishikawa H, Sugiyama D, Ha D, Hamaguchi M, Saito T, Nishioka M, Wing JB, Adeegbe D, Katayama I, Sakaguchi S.
  • Journal Title: Science Volume: 346 Issue: 6216 Pages: 1536-40
  • DOI: 10.1126/science.aaa1292
  • Peer Reviewed
• [Journal Article] Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. (2014)
  • Author(s): Mastumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nut, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T., and Baba, Y.
  • Journal Title: Immunity Volume: 41 Issue: 6 Pages: 1040-1051
  • DOI: 10.1016/j.immuni.2014.10.016
  • Peer Reviewed / Open Access
• [Journal Article] Regulatory T cells in cancer immunotherapy (2014)
  • Author(s): Nishikawa H, Sakaguchi S
  • Journal Title: Curr Opin Immunol Volume: 27 Pages: 1-7
  • DOI: 10.1016/j.coi.2013.12.005
  • NAID: 130004696113
  • Peer Reviewed
• [Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease. (2014)
  • Author(s): Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
  • Journal Title: Science Volume: 346 Issue: 6207 Pages: 363-8
  • DOI: 10.1126/science.1259077
  • Peer Reviewed
• [Journal Article] High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine (2014)
  • Author(s): Saito T, Wada H, Yamasaki M, Miyata H, Nishikawa H, Sato E, Kageyama S, Shiku H, Mori M, Doki Y.
  • Journal Title: Vaccine Volume: 32 Issue: 45 Pages: 5901-5907
  • DOI: 10.1016/j.vaccine.2014.09.002
  • Peer Reviewed
• [Journal Article] Vaccination With NY-ESO-1 Overlapping Peptides Mixed With Picibanil OK-432 and Montanide ISA-51 in Patients With Cancers Expressing the NY-ESO-1 Antigen (2014)
  • Author(s): Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Oka M, Doki Y, Nakayama E.
  • Journal Title: J Immunother Volume: 37(2) Issue: 2 Pages: 84-92
  • DOI: 10.1097/cji.0000000000000017
  • Peer Reviewed
• [Presentation] Targeting immuno-suppressive cancer microenvironment is critical for successful cancer immunotherapy (2017)
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: The 5th International Symposium of Training Plan for Oncology Professionals
  • Place of Presentation: シェラトン都ホテル大阪（大阪府・大阪市）
  • Year and Date: 2017-03-11
  • Int'l Joint Research / Invited
• [Presentation] Targeting FoxP3+ T cells in Cancers; Friends or Foes? (2017)
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: New York Academy of Science; Frontiers in Cancer Immunotherapy
  • Place of Presentation: The New York Academy of Sciences, New York, USA
  • Year and Date: 2017-02-27
  • Int'l Joint Research / Invited
• [Presentation] Role of FoxP3+ T cells in cancer immunology (2017)
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: International Symposium on Immune Diversity and Cancer Therapy Kobe 2017
  • Place of Presentation: 神戸ポートピアホテル（兵庫県・神戸市）
  • Year and Date: 2017-01-26
  • Int'l Joint Research / Invited
• [Presentation] EGFR遺伝子変異陽性非小細胞肺癌で細胞障害性Tリンパ球浸潤が減少する分子学的機序 (2016)
  • Author(s): 竹内美子・冨樫庸介・杉山栄里・木島貴志・熊ノ郷淳・新谷康・奥村明之進・青景圭樹・菱田智之・石井源一郎・坪井正博・西川博嘉
  • Organizer: 第57回日本肺癌学会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市)
  • Year and Date: 2016-12-19
• [Presentation] Control of regulatory T cells for effective cancer immunotherapy (2016)
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: 第45回日本免疫学会総会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県・宜野湾市）
  • Year and Date: 2016-12-05
  • Invited
• [Presentation] The next steps of immune checkpoint inhibitors (2016)
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: 第29回日本放射線腫瘍学会
  • Place of Presentation: 国立京都国際会館（京都府・京都市)
  • Year and Date: 2016-11-25
  • Invited
• [Presentation] がん免疫療法におけるprecision medicine (2016)
  • Author(s): 西川博嘉
  • Organizer: 第75回日本癌学会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-06
  • Invited
• [Presentation] Regulatory T-cell induced anergic CD8+ T cells with suppressive function are novel targets of anti-CTLA-4 mAb (2016)
  • Author(s): Danbee Ha, Hiroyoshi Nishikawa, Daisuke Sugiyama, Yuka Maeda, Dennis Adeegbe, Eichi Sato, Atsushi Tanemura, Ichiro Katayama, Shimon Sakaguchi
  • Organizer: 第75回日本癌学会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-06
• [Presentation] Perspective of T cell responses as prodictive markers in cancer immunotherapy, (2016)
  • Author(s): Yuka Maeda, Hiroyoshi Nishikawa, Hiroyuki Mano
  • Organizer: 第75回日本癌学会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-06
  • Invited
• [Presentation] がん患者における免疫病態の最新知見とがん治療への応用 (2016)
  • Author(s): 西川博嘉
  • Organizer: 第44回日本臨床免疫学会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] Regulatory T cells as a target of cancer immunotherapy (2016)
  • Author(s): 西川博嘉
  • Organizer: 第14回日本臨床腫瘍学会
  • Place of Presentation: 神戸国際展示場（兵庫県・神戸市)
  • Year and Date: 2016-07-28
  • Invited
• [Presentation] がん免疫療法でのバイオマーカーとしての免疫抑制細胞 (2016)
  • Author(s): 西川博嘉
  • Organizer: 第20回日本がん免疫学会
  • Place of Presentation: 大阪国際交流センター（大阪府・大阪市)
  • Year and Date: 2016-07-27
  • Invited
• [Presentation] Critical Role of Regulatory T cells in Cancer Immunotherapy for Hematologic Malignancies, (2016)
  • Author(s): 西川博嘉
  • Organizer: The 5th JCA-AACR Special Joint Conference
  • Place of Presentation: 東京ベイ舞浜ホテル（千葉県・浦安市)
  • Year and Date: 2016-07-13
  • Int'l Joint Research / Invited
• [Presentation] がん免疫療法で誘導される免疫応答と免疫抑制の関連 (2016)
  • Author(s): 西川博嘉
  • Organizer: 第20回日本がん分子標的治療学会
  • Place of Presentation: 別府国際コンベンションセンター（大分県・別府市）
  • Year and Date: 2016-05-30
  • Invited
• [Presentation] Cell-depleting anti-CCR4 mAb therapy (2016)
  • Author(s): 西川博嘉
  • Organizer: The 7th JSH International Symposium
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県・淡路市)
  • Year and Date: 2016-05-13
  • Int'l Joint Research / Invited
• [Presentation] 制御性T細胞による免疫寛容誘導機構 -腫瘍免疫からのレッスン- (2016)
  • Author(s): 西川博嘉
  • Organizer: 第34回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 三重県鳥羽市
  • Year and Date: 2016-02-04
  • Invited
• [Presentation] Cancer Immunotherapy (2016)
  • Author(s): 西川博嘉
  • Organizer: 5th Japan Taiwan Oncology Phase I Trail Conference
  • Place of Presentation: Evergreen International Convention Center, Taiwan
  • Int'l Joint Research / Invited
• [Presentation] 臨床の場におけるがん免疫療法 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第148回日本医学会シンポジウム 新しいがん免疫療法
  • Place of Presentation: 東京都文京区
  • Year and Date: 2015-12-25
  • Invited
• [Presentation] Regulatory T-cell suppression in tumors (2015)
  • Author(s): 西川博嘉
  • Organizer: 第44回日本免疫学会総会学術集会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2015-11-20
• [Presentation] 制御性T細胞を標的とするがん免疫治療の新たな展望 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2015-10-31
• [Presentation] 慢性特発性間質性肺炎の新たなentityを形成する抗Mx1自己抗体の意義 (2015)
  • Author(s): 濱野芳匡、木田博、井原祥一、Lokesh Tripthi、広瀬雅樹、西川博嘉、本多修、水口賢司、富山憲幸、井上義一、熊ノ郷淳
  • Organizer: 第43回日本臨床免疫学会総会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-10-22
• [Presentation] 腫瘍免疫と制御性T細胞 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第43回日本臨床免疫学会総会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-10-22
• [Presentation] CD4+Tregの病態への関与と疾患制御の可能性 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第43回日本臨床免疫学会総会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-10-22
• [Presentation] Accelerates Immuno-Oncology Research to Combat Cancers (2015)
  • Author(s): 西川博嘉
  • Organizer: Asia-Pacific Educational Center of Hematology and Oncology 2015 (APECHO 2015, Taiwan）
  • Place of Presentation: 台北
  • Year and Date: 2015-10-18
  • Invited
• [Presentation] 固形がん患者におけるTreg -ヒト化抗CCR4抗体投与による除去効果を中心に- (2015)
  • Author(s): 和田尚、土岐祐一郎、西川博嘉、中山睿一、上田龍三
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-10-09
• [Presentation] レナリドマイドは制御性T細胞の機能を抑制し抗腫瘍免疫応答を増強させる (2015)
  • Author(s): 杉山大介、竹内美子、西川博嘉
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-10-09
• [Presentation] 大腸癌に対する免疫応答の複雑性 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-10-09
• [Presentation] Anti-tumor immune responses in cancer therapy（がん治療における抗腫瘍免疫応答） (2015)
  • Author(s): 西川博嘉
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-10-09
• [Presentation] 制御性T細胞コントロールによる効果的ながん免疫療法開発 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第7回血液疾患免疫療法研究会学術集会
  • Place of Presentation: 東京都文京区
  • Year and Date: 2015-09-26
• [Presentation] 3+CD4+T-cell subpopulations distinctly control the prognosis of colorectal cancers. (2015)
  • Author(s): Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi
  • Organizer: The Inaugural International Cancer Immunotherapy Conference Translating Science Into Survival
  • Place of Presentation: 米国 ニューヨーク市
  • Year and Date: 2015-09-18
  • Int'l Joint Research
• [Presentation] Self-tumor-antigen-specific CD8 T cells were suppressed by regulatory T cells. (2015)
  • Author(s): Yuka Maeda, Hiroyoshi Nishikawa, Shimon Sakaguchi
  • Organizer: The Inaugural International Cancer Immunotherapy Conference Translating Science Into Survival
  • Place of Presentation: 米国 ニューヨーク市
  • Year and Date: 2015-09-18
  • Int'l Joint Research
• [Presentation] Phase la study of FoxP3+ CD4 Treg depletion by infusion of a humanized anti-CCR4 antibody,KW-0761,in cancer patients (2015)
  • Author(s): Koji Kurose, Yoshihiro Ohue, Hisashi Wada, Toshihiko Doi, Hiroyoshi Nishikawa, Mikio Oka, Ryuzo Ueda
  • Organizer: The Inaugural International Cancer Immunotherapy Conference Translating Science Into Survival
  • Place of Presentation: 米国 ニューヨーク市
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] Role of regulatory T cell in inflammation-associated colorectal cancer;Friends or foes? (2015)
  • Author(s): 西川博嘉
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2015-09-09
  • Invited
• [Presentation] Regulatory T cells in tumor immunity and autoimmune disorders (2015)
  • Author(s): 西川博嘉
  • Organizer: Biomedicum, Helsinki Educational Seminar
  • Place of Presentation: フィンランド ヘルシンキ
  • Year and Date: 2015-08-31
  • Invited
• [Presentation] 大腸癌に影響を与えるFoxP3+T細胞と腸内細菌 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-07-21
• [Presentation] 免疫チェックポイントの基礎 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2015-07-18
• [Presentation] 制御性T細胞の新たなコントロール法 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2015-07-16
• [Presentation] がん免疫療法の新展開 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第101回 日本消化器病学会総会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2015-04-24
• [Presentation] がん免疫療法と制御性T細胞 (2015)
  • Author(s): 西川博嘉
  • Organizer: 第10回日本がん分子標的治療学会 トランスレーショナルリサーチワークショップ
  • Place of Presentation: 東京都
  • Year and Date: 2015-01-20
  • Invited
• [Presentation] がん免疫療法における制御性T細胞 (2014)
  • Author(s): 西川博嘉
  • Organizer: 第27回日本バイオセラピィ学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2014-12-04 – 2014-12-05
  • Invited
• [Presentation] 制御性T細胞とがん免疫療法 (2014)
  • Author(s): 西川博嘉
  • Organizer: 第63回日本血液学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2014-10-31 – 2014-11-02
  • Invited
• [Presentation] Regulatory T cells in anti-tumor immunity: Can they be controlled? (2014)
  • Author(s): Nishikawa Hiroyoshi
  • Organizer: 22nd Annual Cancer Immmunotherapy Symposium
  • Place of Presentation: 米国 ニューヨーク市
  • Year and Date: 2014-10-05 – 2014-10-07
  • Invited
• [Presentation] TCR repertoire reshaping emanating from therapeutic modalities involving Treg depletion and/or immune checkpoint blockade. (2014)
  • Author(s): Adeegbe D, Sugiyama D, Maeda Y, Ha D, Matsutani T, Nishikawa H and Sakaguchi S
  • Organizer: 22nd Annual Cancer Immmunotherapy Symposium
  • Place of Presentation: 米国 ニューヨーク市
  • Year and Date: 2014-10-05 – 2014-10-07
• [Presentation] Association between FoxP3+ T cells and regulatory T cells in colorectal cancer (2014)
  • Author(s): SaitoT, Nishikawa H, Wada H, Mori M, Doki Y and Sakaguchi S
  • Organizer: 22nd Annual Cancer Immmunotherapy Symposium
  • Place of Presentation: 米国 ニューヨーク市
  • Year and Date: 2014-10-05 – 2014-10-07
• [Presentation] 網羅的抗体反応測定法を用いた抗腫瘍免疫応答のモニタリング (2014)
  • Author(s): 西川博嘉
  • Organizer: 第42回日本臨床免疫学会
  • Place of Presentation: 東京都
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] Tregs in Cancer Immunotherapy (2014)
  • Author(s): Nishikawa Hiroyoshi
  • Organizer: 第73回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] 制御性T細胞は腫瘍抗原特異的CD8+T細胞に特徴的なアネルギー状態を誘導する (2014)
  • Author(s): 杉山大介、前田優香、西塔拓郎、西岡めぐみ、Danbee H、西川博嘉、坂口志文
  • Organizer: 第73回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] メラノーマ患者および健常人PBMC中のCD4+T細胞の単一細胞レベルでのレパートリー解析 (2014)
  • Author(s): 岸裕幸、小林英治、杉山大介、西川博嘉、坂口志文、村口篤
  • Organizer: 第73回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 大腸癌での制御性T細胞の予後への影響 (2014)
  • Author(s): 西塔拓郎、西川博嘉、和田 尚、坂口志文,森正樹、土岐裕一郎
  • Organizer: 第73回日本癌学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Regulatory T cellを介したがん免疫応答制御の克服の可能性 (2014)
  • Author(s): 西川博嘉
  • Organizer: 第34回日本分子腫瘍マーカー研究会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-09-24
  • Invited
• [Presentation] Importance of controlling regulatory T cells for successful cancer immunotherapy (2014)
  • Author(s): Hiroyoshi Nishikawa
  • Organizer: 第18回日本がん免疫学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2014-07-30 – 2014-08-01
  • Invited
• [Presentation] 制御性T細胞は腫瘍抗原特異的CD8+T細胞に特徴的なアネルギー状態を誘導する (2014)
  • Author(s): 前田優香、西川博嘉、杉山大介、西塔拓郎、西岡めぐみ、Danbee H、坂口志文
  • Organizer: 第18回日本がん免疫学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2014-07-30 – 2014-08-01
• [Presentation] Promotion of T cell dysfunction by regulatory T cells in tumor; mechanisms and insights (2014)
  • Author(s): Adeegbe D, Sugiyama D, Maeda Y, Ha D, Matsutani T, Nishikawa H and Sakaguchi S
  • Organizer: 第18回日本がん免疫学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2014-07-30 – 2014-08-01
• [Presentation] 制御性T細胞を標的としたがん免疫療法 (2014)
  • Author(s): 西川博嘉
  • Organizer: 第18回日本がん分子標的治療学会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2014-06-25 – 2014-06-27
  • Invited
• [Book] がん免疫療法ハンドブック (2016)
  • Author(s): 西川 博嘉
  • Total Pages: 223
  • Publisher: メディカルレビュー社
• [Remarks] 名古屋大学大学院医学系研究科ホームページ
  • URL: https://www.med.nagoya-u.ac.jp/medical_J/laboratory/basic-med/micro-immunology/immunology/
• [Remarks] 自己免疫疾患を回避する免疫系のシステムを解明
  • URL: http://www.ifrec.osaka-u.ac.jp/jpn/research/2014/12/20141219-Science.php
• [Patent(Industrial Property Rights)] 腫瘍免疫又は免疫感染を増強させる免疫増強剤 (2014)
  • Inventor(s): 西川博嘉、坂口志文、田中淳
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-146031
  • Filing Date: 2014-07-16