Molecular basis of the CD47-SIRP alpha signaling system in the regulation of physiological function
Project/Area Number |
26291022
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
|
Research Institution | Kobe University |
Principal Investigator |
Matozaki Takashi 神戸大学, 医学(系)研究科(研究院), 教授 (80252782)
|
Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Hiroshi 群馬大学, 大学院保健学研究科, 教授 (70334125)
MURATA Yoji 神戸大学, 大学院医学研究科, 准教授 (60400735)
SAITO Yasuyuki 神戸大学, 大学院医学研究科, 講師 (40508842)
KOTANI Takenori 神戸大学, 大学院医学研究科, 助教 (40455960)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
Keywords | シグナル伝達 / 生体分子 / 脳・神経 / 免疫学 / 癌 |
Outline of Final Research Achievements |
We have here investigated the molecular basis of the CD47-SIRPα signaling system in the regulation of physiological function in the central nervous system (CNS) as well as in the immune system. In the CNS, we have shown that the protein tyrosine phosphatase Shp-2, which is a downstream molecule of SIRPα, regulates synaptic functions and thereby modulates learning and locomotor activity. In the immune system, we have shown that SIRPα is essential for the maintenance of dendritic cell homeostasis in the secondary lymphoid organs and skin. Furthermore, we have found that anti-SIRPα antibodies appear to be a potential new tool for cancer immunotherapy.
|
Report
(4 results)
Research Products
(42 results)
-
[Journal Article] Anti-SRPα antibodies as a potential new tool for cancer immunotherapy.2017
Author(s)
Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Verjan Garcia N, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T.
-
Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Role of Src family kinases in regulation of intestinal epithelial homeostasis.2016
Author(s)
Imada S, Murata Y, Kotani T, Hatano M, Sun C, Konno T, Park JH, Kitamura Y, Saito Y, Ohdan H, Matozaki T.
-
Journal Title
Mol Cell Biol.
Volume: 36
Pages: 2811-2823
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.2015
Author(s)
Y Murata, T Kotani, Y Supriatna, Y Kitamura, S Imada, K Kawahara, M Nishio, EW Daniwijaya, H Sadakata, S Kusakari, M Mori, Y Kanazawa, Y Saito, K Okawa, M Takeda-Morishita, H Okazawa, H Ohnishi, T Azuma, A Suzuki, T Matozaki
-
Journal Title
Proc Natl Acad Sci USA
Volume: 112
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
[Journal Article] Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium.2015
Author(s)
Washio K, Kotani T, Saito Y, Respatika D, Murata Y, Kaneko Y, Okazawa H, Ohnishi H, Fukunaga A, Nishigori C, Matozaki T.
-
Journal Title
Genes Cells.
Volume: -
Pages: 00-00
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice2015
Author(s)
Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto, M., Matsuzaki, Y., Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H
-
Journal Title
Mol Cell Biol
Volume: 35
Pages: 15571572-15571572
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.2014
Author(s)
Yoshino S, Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano-Toki A, Kakizaki S, Okada S, Shimizu H, Ozawa A, Tuchiya T, Ikota H, Nakazato Y, Mori M, Matozaki T, Sasaki T, Kitamura T, Mori M.
-
Journal Title
Endocrinology
Volume: 155
Pages: 3459-3472
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Essential role of SIRPα on dendritic cells in Homeostatic regulation of the secondary lymphoid organ2015
Author(s)
Datu Respatika, Yasuyuki Saito, Ken Washio, Satomi Komori, Takenori Kotani, Yoji Murata, Yoriaki Kaneko, Hideki Okazawa, Hiroshi Ohnishi, Atsushi Fukunaga, Chikako Nishigori, and Takashi Matozaki
Organizer
2015University of Washington and Kobe University joint symposium 2015神戸大学・ワシントン大学国際合同シンポジウム
Place of Presentation
University of Washington, Seattle (USA)
Year and Date
2015-09-10
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-