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Researches for the pathogenesis and disease models of canine degenerative myelopathy, leptomeningeal histiocytic sarcoma, and multiple myositis.

Research Project

Project/Area Number 26292157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

UCHIDA Kazuyuki  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10223554)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsコーギー犬 / 組織球性肉腫 / Cell line / 樹状細胞 / マクロファージ / ランゲルハンス細胞 / 変性性脊髄症 / 筋疾患 / 炎症性筋症 / ウェルシュコーギー / 犬 / 神経原性筋疾患 / 筋原性筋疾患 / 筋炎 / イヌ / 炎症性筋疾患 / ウェルシュ・コーギー / 多発性筋炎 / 筋萎縮性側索硬化症 / SOD1
Outline of Final Research Achievements

The present study revealed the pathological features of breed specific diseases occurring in Pembroke Welsh Corgi(PWC) dogs, especially histiocytic sarcoma and degenerative myelopathy. Regarding histiocytic sarcomas, cell line derived from leptomeningealhistiocytic sarcomas in a PWC dog was established. Two additional cell lines from synovial histiocytic sarcoma of a flat-coated retriever dog and canine cutaneous Langerhans cell histiocytosis have been successfully established. These three types of cell lines will be exellent tools for the basic researches on tumoregenesis and therapeutic drug development on histiocytic sarcomas, not only in dogs but also in humans. Regarding canine degenerative myelopathy, autophagy abnormality is involved in addition to SOD1 mutation in PWC dogs.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(8 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Immunohistochemical analysis of canine and feline muscle disorders using formalin-fixed, paraffin-embedded tissues.2017

    • Author(s)
      Shiga T, Uchida K, Chambers JK, Nakayama H.
    • Journal Title

      Journal of Veterinary Diagnostic Investigation

      Volume: 29(6): Pages: 805-813

    • DOI

      10.1177/1040638717715287

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Variations in Histiocytic Differentiation of Cell Lines From Canine Cerebral and Articular Histiocytic Sarcomas.2017

    • Author(s)
      Thongtharb A, Uchida K, Chambers JK, Nakayama H.
    • Journal Title

      Veterinary Pathology

      Volume: In press Pages: 395-404

    • DOI

      10.1177/0300985817690211

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo)2016

    • Author(s)
      Thongtharb A, Uchida K, Chambers JK, Miwa Y, Murata Y, Nakayama H
    • Journal Title

      J Vet Diagn Invest.

      Volume: 28 Pages: 165-170

    • DOI

      10.1177/1040638715626485

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas2016

    • Author(s)
      Thongtharb A, Uchida K, Chambers JK, Kagawa Y, Nakayama H
    • Journal Title

      J. Vet. Med. Sci.

      Volume: in press Issue: 4 Pages: 593-599

    • DOI

      10.1292/jvms.15-0627

    • NAID

      130007331496

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of autophagy-related proteins in the spinal cord of pembroke welsh corgi dogs with canine degenerative myelopathy.2015

    • Author(s)
      Ogawa M, Uchida K, Yamato O, Mizukami K, Chambers JK, Nakayama H.
    • Journal Title

      Vet Pathol

      Volume: 未定 Pages: 1099-1107

    • DOI

      10.1177/0300985815570070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of autophagy-related proteins in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy.2015

    • Author(s)
      Ogawa M, Uchida K, Yamato O, Mizukami K, Chambers JK, Nakayama H.
    • Journal Title

      Vet Pathol.

      Volume: In press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Characteristics and Prognostic Factors in Dogs with Histiocytic Sarcomas in Japan2014

    • Author(s)
      Takahashi M1, Tomiyasu H, Hotta E, Asada H, Fukushima K, Kanemoto H, Fujino Y, Ohno K, Uchida K, Nakayama H, Tsujimoto H.
    • Journal Title

      J. Vet. Med. Sci.

      Volume: In press Issue: 5 Pages: 661-666

    • DOI

      10.1292/jvms.13-0414

    • NAID

      130003391271

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Pathological study on primary leptomeningeal histiocytic sarcoma in dogs.2015

    • Author(s)
      A. Thongtharb, K. Uchida, J.K. Chambers, and H. Nakayama
    • Organizer
      2015 ACVP/ASVCP/STP Combined Annual Meeting
    • Place of Presentation
      ミネアポリス、ミネソタ州、アメリカ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2019-03-29  

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