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Innate immunity in the pathogenesis of rheumatoid arthritis

Research Project

Project/Area Number 26293235
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionTeikyo University

Principal Investigator

Hajime Kono  帝京大学, 医学部, 准教授 (60585074)

Co-Investigator(Kenkyū-buntansha) 南木 敏宏  帝京大学, 医学部, 准教授 (00282749)
関根 知世子  帝京大学, 医学部, 助教 (40392005)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywordsインフラマソーム / リウマチ学 / 自然炎症 / IL-1 / NLRP3
Outline of Final Research Achievements

IL-1 plays important role in the pathogenesis of rheumatoid arthritis or other sterile inflammation. IL-1 activation is mediated by inflammasome activation. We have developed an cell based assay to visualize inflammasome activation. By utilizing a genome-wide expression library, we identified several genes that activate or suppress inflammasome activation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(7 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results)

  • [Journal Article] Independent Association of HLA-G 3’ Untranslated Region 14bp Indel Polymorphism with Systemic Lupus Erythematosus in a Japanese Population: a Case-control Association Study.2017

    • Author(s)
      Hachiya Y, Kawasaki A, Oka S, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T,Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S, Furukawa H, Tsuchiya N.
    • Journal Title

      PLoS One.

      Volume: 11 Pages: 22-22

    • DOI

      10.1371/journal.pone.0158065

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01.2016

    • Author(s)
      Furukawa H, Tohma S, Tsuchiya N, et al
    • Journal Title

      PLoS One

      Volume: 11(4)

    • DOI

      10.1371/journal.pone.0154255

    • NAID

      120007135446

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe-/- mice.2015

    • Author(s)
      Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 194 Pages: 773-780

    • DOI

      10.4049/jimmunol.1302841

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammasome activation in response to dead cells and their metabolites2014

    • Author(s)
      Kono H, Kimura Y, Latz E
    • Journal Title

      Curr Opin Immunol.

      Volume: 30 Pages: 91-98

    • DOI

      10.1016/j.coi.2014.09.001

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses2014

    • Author(s)
      Kataoka H, Kono H, Patel Z, Kimura Y, Rock KL
    • Journal Title

      Plos One

      Volume: 9

    • DOI

      10.1371/journal.pone.0104741

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular determinants of sterile inflammation2014

    • Author(s)
      Kono H, Onda A, Yanagida T
    • Journal Title

      Curr Opin Immunol

      Volume: (Epub 2014 Jan 7) Pages: 147-156

    • DOI

      10.1016/j.coi.2013.12.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF32014

    • Author(s)
      De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E
    • Journal Title

      Nat Immunol

      Volume: 15(2)(Epub 2013 Dec 8) Pages: 152-160

    • DOI

      10.1038/ni.2784

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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