Innate immunity in the pathogenesis of rheumatoid arthritis

• Project/Area Number: 26293235
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Teikyo University
• Principal Investigator: Hajime Kono 帝京大学, 医学部, 准教授 (60585074)
• Co-Investigator(Kenkyū-buntansha): 南木 敏宏 帝京大学, 医学部, 准教授 (00282749) ; 関根 知世子 帝京大学, 医学部, 助教 (40392005)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: インフラマソーム / リウマチ学 / 自然炎症 / IL-1 / NLRP3

Outline of Final Research Achievements

IL-1 plays important role in the pathogenesis of rheumatoid arthritis or other sterile inflammation. IL-1 activation is mediated by inflammasome activation. We have developed an cell based assay to visualize inflammasome activation. By utilizing a genome-wide expression library, we identified several genes that activate or suppress inflammasome activation.

Research Products

• [Journal Article] Independent Association of HLA-G 3’ Untranslated Region 14bp Indel Polymorphism with Systemic Lupus Erythematosus in a Japanese Population: a Case-control Association Study. (2017)
  • Author(s): Hachiya Y, Kawasaki A, Oka S, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T,Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S, Furukawa H, Tsuchiya N.
  • Journal Title: PLoS One. Volume: 11 Pages: 22-22
  • DOI: 10.1371/journal.pone.0158065
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01. (2016)
  • Author(s): Furukawa H, Tohma S, Tsuchiya N, et al
  • Journal Title: PLoS One Volume: 11(4)
  • DOI: 10.1371/journal.pone.0154255
  • NAID: 120007135446
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe-/- mice. (2015)
  • Author(s): Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 194 Pages: 773-780
  • DOI: 10.4049/jimmunol.1302841
  • Peer Reviewed / Open Access
• [Journal Article] Inflammasome activation in response to dead cells and their metabolites (2014)
  • Author(s): Kono H, Kimura Y, Latz E
  • Journal Title: Curr Opin Immunol. Volume: 30 Pages: 91-98
  • DOI: 10.1016/j.coi.2014.09.001
  • Acknowledgement Compliant
• [Journal Article] Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses (2014)
  • Author(s): Kataoka H, Kono H, Patel Z, Kimura Y, Rock KL
  • Journal Title: Plos One Volume: 9
  • DOI: 10.1371/journal.pone.0104741
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular determinants of sterile inflammation (2014)
  • Author(s): Kono H, Onda A, Yanagida T
  • Journal Title: Curr Opin Immunol Volume: (Epub 2014 Jan 7) Pages: 147-156
  • DOI: 10.1016/j.coi.2013.12.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3 (2014)
  • Author(s): De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E
  • Journal Title: Nat Immunol Volume: 15(2)(Epub 2013 Dec 8) Pages: 152-160
  • DOI: 10.1038/ni.2784
  • Peer Reviewed / Open Access