| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
MHC region including HLA is promising candidate region for schizophrenia based on genome-wide association studies (GWASs). In this study, we focused on the classical HLA, and conducted association analysis using relatively large sample size (2500 schizophrenia and 3000 controls in the Japanese population). However, we could not detect significant association between specific HLA allele and schizophrenia.
In summary we speculate that the GWAS signal in the MHC region may not point the classical HLA, but non-HLA genes as risk genes for schizophrenia.
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