Neural transmission mechanisms of tooth mechanical stimulation -Development of treatment for occlusal dysesthesia patients-

• Project/Area Number: 26293412
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: The University of Tokushima
• Principal Investigator: MATSUKA Yoshizo 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (90243477)
• Co-Investigator(Kenkyū-buntansha): 小川 匠 鶴見大学, 歯学部, 教授 (20267537) ; 山本 由弥子 岡山大学, 医歯薬学総合研究科, 助教 (20403496) ; 丸濱 功太郎 岡山大学, 医歯薬学総合研究科, 助教 (60712792)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: 歯根膜感覚 / 咬合違和感 / PET/CT / ボツリヌス毒素 / fMRI

Outline of Final Research Achievements

Rat premolar teeth were mechanically stimulated and the active part of the brain was measured by PET using FDG. Rats under anesthesia stimulated the right maxillary permolar while measuring the stimulation strength using an electric von Frei device. Before the stimulation of the teeth, FDG was injected from a tail vein and stimulated with a strength of 100, 200, 300 g. The brain PET image was divided into 4 parts (upper right, upper left, lower right, lower left) and the peak value of FDG accumulation was measured. As a result, the stimulation at 300 g showed more FDG accumulation than the 100 or 200 g stimulation. In addition, there were more FDG accumulation was observed in the trigeminal ganglion and the sensory part when the brain was classified into the sensory area, the motor area, hippocampus, trigeminal ganglion and spinal cord.

Research Products

• [Int'l Joint Research] Florida University(米国)
• [Int'l Joint Research] Florida University(米国)
• [Int'l Joint Research] Florida University(米国)
• [Journal Article] Mandibular movement during sleep bruxism associated with current tooth attrition (2017)
  • Author(s): Kazuo Okura, Shuji Shigemoto, Yoshitaka Suzuki, Naoto Noguchi, Katsuhiro Omoto, Susumu Abe, Yoshizo Matsuka
  • Journal Title: Journal of Prosthodontic Research Volume: 61 Issue: 1 Pages: 87-95
  • DOI: 10.1016/j.jpor.2016.06.003
  • NAID: 130005465227
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed
• [Journal Article] Reliability and validity of the patient disability-oriented diagnostic nomenclature system for prosthetic dentistry (2017)
  • Author(s): Matsuka Y, Hagiwara Y, Tamaki K, Takeuchi H, Fujisawa M, Ono T, Tsukiyama Y, Nagao K, Tsuga K, Aita H, Kondo H, Fueki K, Tsukasaki H, Nishigawa K, Ozawa S, Kuwatsuru R, Minakuchi H, Iinuma T et al.
  • Journal Title: Journal of Prosthodontic Research Volume: 61 Issue: 1 Pages: 20-33
  • DOI: 10.1016/j.jpor.2016.06.005
  • NAID: 130005465199
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Japan Prosthodontic Society position paper on ‘‘occlusal discomfort syndrome'' (2016)
  • Author(s): Tamaki K, Ishigaki S, Ogawa T, Oguchi H, Kato T, Suganuma T, Shimada A, Sadamori S, Tsukiyama Y, Nishikawa Y, Masumi S, Yamaguchi T, Aita H, Ono T, Kondo H, Tsukasaki H, Fueki K, Fujisawa M, Matsuka Y, Baba K, Koyano K
  • Journal Title: Journal of Prosthodontic Research Volume: 60 Issue: 3 Pages: 156-166
  • DOI: 10.1016/j.jpor.2015.11.002
  • NAID: 130005172104
  • ISSN: 1883-1958, 1883-9207
  • Year and Date: 2016-07-25
  • Peer Reviewed / Open Access
• [Journal Article] スプリントによる睡眠時ブラキシズムに対する治療効果 : 予備的検討 (2016)
  • Author(s): 大倉一夫，鈴木善貴，重本修伺，大本勝弘，葉山莉香，岩浅匠真，福本美緒，井上美穂，上枝麻友，安陪晋，松香芳三
  • Journal Title: 日本口腔リハビリテーション学会雑誌 Volume: 29 Pages: 21-27
  • NAID: 40021090255
  • Peer Reviewed
• [Journal Article] Preliminary study of neural excitation with positron emission tomography after tooth mechanical stimulation (2016)
  • Author(s): Omoto K, Iwasa T, Afroz S, Ueda M, Okura K, Matsuka Y
  • Journal Title: Journal of Japanese Association of Oral Rehabilitation Volume: 29 Pages: 28-34
  • NAID: 120006765068
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Basic research and clinical investigations of the neural basis of orofacial pain (2015)
  • Author(s): Matsuka Y, Iwata K, Terayama R, Imamura Y, Maruhama K, Shinoda M, Tsuboi Y, Kondo M, Honda K, Katagiri A, Sugimoto T
  • Journal Title: J Oral Biosci Volume: 57 Issue: 1 Pages: 27-36
  • DOI: 10.1016/j.job.2014.09.001
  • NAID: 120006493387
  • Peer Reviewed / Open Access
• [Journal Article] Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission. (2015)
  • Author(s): Omoto K, Maruhama K, Terayama R, Yamamoto Y, Matsushita O, Sugimoto T, Oguma K, Matsuka Y
  • Journal Title: Toxins (Basel) Volume: 7 Issue: 8 Pages: 2906-2917
  • DOI: 10.3390/toxins7082906
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Case report of recurrent temporomandibular joint open lock associated with abrupt reduction of displaced articular disk (2014)
  • Author(s): Nishigawa K, Nakano M, Ishikawa T, Bando E, Matsuka Y
  • Journal Title: Journal of Prosthodontic Research Volume: 58 Issue: 3 Pages: 184-190
  • DOI: 10.1016/j.jpor.2014.04.001
  • NAID: 130004953503
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access
• [Journal Article] Systematic review and recommendations for nonodontogenic toothache (2014)
  • Author(s): Yatani H, Komiyama O, Matsuka Y, Wajima K, Muraoka W, Ikawa M, Sakamoto E, De Laat A , Heir GM
  • Journal Title: J Oral Rehabil Volume: 41 Issue: 11 Pages: 843-852
  • DOI: 10.1111/joor.12208
  • Peer Reviewed / Open Access
• [Journal Article] Effect of an exclusion range of jaw movement data from theintercuspal positionon the estimation of the kinematic axis point (2014)
  • Author(s): Shuji Shigemoto, Nobuyuki Bando, Keisuke Nishigawa, Yoshitaka Suzuki, Toyoko Tajima, Kazuo Okura, Yoshizo Matsuka
  • Journal Title: Medical Engineering & Physics Volume: 36 Issue: 9 Pages: 1162-1167
  • DOI: 10.1016/j.medengphy.2014.06.013
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of platelet serotonin transporter activity in subjects with severe sleep bruxism and control (2014)
  • Author(s): Hajime Minakuchi, Chiharu Sogawa C, Emilio Satoshi Hara, Haruna Miki, Kenji Maekawa, Norio Sogawa, Shigeo Kitayama, Yoshizo Matsuka, Glenn T Clark, Takuo Kuboki
  • Journal Title: Journal of Prosthodontic Research Volume: 58 Issue: 4 Pages: 217-222
  • DOI: 10.1016/j.jpor.2014.06.003
  • NAID: 130004714111
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A multi-institution investigation of the status of patients who complain of occlusal discomfort (2014)
  • Author(s): 澁谷智明，和気裕之, 玉置勝司， 島田淳，古谷野潔，鱒見進一， 窪木拓男，皆木省吾，貞森紳丞， 矢谷博文，藤澤政紀，林 勝彦, 玉井和樹，成田紀之，原 節宏， 馬場一美，尾口仁志，金村清孝， 山口泰彦，西川洋二，塚原宏泰， 松香芳三，葉山莉香
  • Journal Title: Journal of the Japanese Society for the Temporomandibular Joint Volume: 26 Issue: 3 Pages: 196-203
  • DOI: 10.11246/gakukansetsu.26.196
  • NAID: 130004843350
  • ISSN: 0915-3004, 1884-4308
  • Peer Reviewed
• [Presentation] 睡眠中の律動性咀嚼筋活動に関連した酸素および二酸化炭素濃度の変動 (2017)
  • Author(s): 鈴木善貴, ラヴィーンジル, 大倉一夫, 安陪 晋, 松香芳三
  • Organizer: 日本補綴歯科学会
• [Presentation] 口腔顎顔面痛モデル三叉神経節におけるサイトカイン動態 (2017)
  • Author(s): 岩浅匠真, 大島正充, 大倉 一夫, 井上美穂, S.Afroz, 松香芳三
  • Organizer: 日本口腔顔面痛学会
• [Presentation] Up-regulation of inflammatory cytokines in trigeminal ganglia after infraorbital nerve constriction (2017)
  • Author(s): Iwasa T, Arakaki R, Oshima M, Afroz S, Inoue M, Goto N, Ishimaru N, Matsuka Y
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Cytokine released by satellite glial cells and pain transmission in sensory ganglions (2017)
  • Author(s): Afroz S, Iwasa T, Oshima M, Arakaki R, Inoue M, Ishimaru N, Matsuka Y
  • Organizer: Japan Association for Dental Research
  • Int'l Joint Research
• [Presentation] Botulinum toxin mechanisms for orofacial pain management (2017)
  • Author(s): Matsuak Y
  • Organizer: Asian Academy of Craniomandibular Disorders
  • Int'l Joint Research / Invited
• [Presentation] 下顎運動軸の３次元的検討 (2016)
  • Author(s): 重本修伺, 平井真也, 井川知子, 田島登誉子, 松香芳三, 小川 匠
  • Organizer: 日本歯科医学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-21
• [Presentation] 咀嚼能力の総合的な解析に向けた生体信号と食塊粒度の同期記録法の検討 (2016)
  • Author(s): 福永温句, 重本修伺, 大本勝弘, 田島登誉子, 宮本裕司, 皆木省吾, 松香芳三
  • Organizer: 日本補綴歯科学会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2016-07-09
• [Presentation] Pain transmission within peripheral sensory ganglia (2015)
  • Author(s): Omoto K, Maruhama K, Yamamoto Y, Sugimoto T, Matsushita O, Neubert JK, Matsuka Y
  • Organizer: Society for Neuroscience
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-11-17
  • Int'l Joint Research
• [Presentation] 神経障害性疼痛における神経伝達物質遊離抑制と鎮痛効果 (2015)
  • Author(s): 大本勝弘，丸濱功太郎，田中紗友里，大倉一夫，松香芳三
  • Organizer: 補綴若手研究会
  • Place of Presentation: ニューアカオ（静岡県・熱海市）
  • Year and Date: 2015-03-22
• [Presentation] Relationship between neurotransmitter release within sensory ganglia and pain transmission (2015)
  • Author(s): Omoto K, Tanaka S, Suzuki Y, Okura K, Maruhama K, Sugimoto T, Matsuka Y
  • Organizer: . International Association for Dental Research
  • Place of Presentation: Boston, America
  • Year and Date: 2015-03-13
• [Presentation] Neural excitation with positron emission tomography after tooth mechanical stimulation (2014)
  • Author(s): Omoto K, Maruhama K, Sugimoto T, Matsuka Y
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC, America
  • Year and Date: 2014-11-18
• [Presentation] 末梢知覚神経節における神経伝達物質遊離抑制による情報伝達の変化 (2014)
  • Author(s): 大本勝弘, 丸濱功太郎, 田中紗友里, 大倉一夫, 杉本朋貞, 松香芳三
  • Organizer: 日本口腔顔面痛学会
  • Place of Presentation: 東京医科歯科大学（東京都・文京区）
  • Year and Date: 2014-11-01
• [Presentation] 精製A型ボツリヌス毒素の軸索輸送と疼痛抑制効果 (2014)
  • Author(s): 丸濵功太郎，松香芳三，山本由弥子，寺山隆司，杉本朋貞
  • Organizer: 日本神経科学会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-09-11
• [Presentation] 末梢知覚神経節における神経伝達物質遊離抑制と鎮痛効果 (2014)
  • Author(s): 田中紗友里，大本勝弘，丸濱功太郎，杉本朋貞，松香芳三
  • Organizer: 日本補綴歯科学会中国・四国、関西支部合同学術大会
  • Place of Presentation: 倉敷芸文館（岡山県・倉敷市）
  • Year and Date: 2014-09-06
• [Book] 永末書店 (2017)
  • Author(s): 松香芳三
  • Total Pages: 288
  • Publisher: 冠橋義歯補綴学テキスト第2版
  • ISBN: 4816013202