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Development of genetic marker for artemisinin-resistant malaria: Field-genomics analysis

Research Project

Project/Area Number 26305015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Parasitology (including sanitary zoology)
Research InstitutionJuntendo University

Principal Investigator

Mita Toshihiro  順天堂大学, 医学(系)研究科(研究院), 教授 (80318013)

Co-Investigator(Kenkyū-buntansha) 大橋 順  東京大学, 大学院理学系研究科(理学部), 准教授 (80301141)
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsマラリア / アルテミシニン / 薬剤耐性 / 遺伝子マーカー / 早期診断 / 分子疫学 / 耐性進化 / K13 / Kelch13 / 分子マーカー / 耐性
Outline of Final Research Achievements

The aim of this research is to develop genetic maker(s) that is useful for the containment strategy of resistant parasites. We achieved, 1) first identification of artemisinin-resistant parasites in Africa and identification of potential resistant marker, and 2) detection of malaria parasites harboring mutant PfKelch13 allele (C580Y) and elucidation of its origin and route of their spread. These achievement would greatly contribute the practical application toward the surveillance of resistant parasites.

Academic Significance and Societal Importance of the Research Achievements

マラリアは世界3大感染症の一つである。その根絶のために抗マラリア薬は不可欠であるが、容易に耐性化する。本研究でアフリカでの有用性が期待される新規候補マーカーが明らかになった。今後のさらなる検討によって、その有用性が確認されれば、今後はアフリカにおける耐性原虫の出現と拡散を簡便に評価することが可能になる。これは、耐性マラリア原虫の封じ込め対策へ大きく貢献する。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(70 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (11 results) Journal Article (20 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 17 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results) Presentation (39 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results)

  • [Int'l Joint Research] グル大学/St Mary Hospital, Lacor(ウガンダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] デバイン大学/ウエワク総合病院(パプアニューギニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学/サンガー研究所(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マヒドン大学(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] マヒドン大学(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] グル大学/St.Mary Lacor病院(ウガンダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] デバインワード大学(パプアニューギニア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] グル大学/Lacor病院(Uganda)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] デバイン大学(Papua New Guinea)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 国際保健研究所(ミャンマー)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【微生物と人類の闘いと共存】 薬剤耐性マラリア原虫の進化 第一選択薬アルテミシニンへの耐性メカニズムから紐解く進化と適応.2018

    • Author(s)
      美田敏宏
    • Journal Title

      生物の科学

      Volume: 遺伝: Pages: 382-8

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 薬剤耐性マラリアの最新疫学知見2018

    • Author(s)
      美田敏宏
    • Journal Title

      病原微生物検出情報

      Volume: 1 Pages: 173-4

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea2018

    • Author(s)
      Sekihara M, Tachibana S-I, Yamauchi M, Yatsushiro S, Tiwara S, Fukuda N, Ikeda M, Mori T, Hirai M, Hombhanje F, Mita T
    • Journal Title

      Malaria Journal

      Volume: 17 Issue: 1 Pages: 434-434

    • DOI

      10.1186/s12936-018-2585-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human migration and the spread of malaria parasites to the New World.2018

    • Author(s)
      Rodrigues PT, et al 15/25.
    • Journal Title

      Scientific reports.

      Volume: 8 Issue: 1 Pages: 1993-1993

    • DOI

      10.1038/s41598-018-19554-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rapid selection of sulphadoxine-resistant Plasmodium falciparum and its effect on within-population genetic diversity in Papua New Guinea.2018

    • Author(s)
      Mita T, Hombhanje F, Takahashi N, Sekihara M, Yamauchi M, Tsukahara T, Kaneko A, Endo H, Ohashi J. (Corresponding author)
    • Journal Title

      Scientific reports.

      Volume: 8 Issue: 1 Pages: 5565-5565

    • DOI

      10.1038/s41598-018-23811-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014-20162018

    • Author(s)
      Ikeda M, Kaneko M, Tachibana S-I, Balikagala B, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Yamauchi M, Sekihara M, Hashimoto M, Katuro OT, Olia A, Obwoya PS, Auma MA, Anywar DA, Odongo-Aginya EI, Okello-Onen J, Hirai M, Ohashi J, Palacpac NMQ, Kataoka M, Tsuboi T, Kimura E, Horii T, Mita T.
    • Journal Title

      Emerging Infectious Diseases

      Volume: 24 Issue: 4 Pages: 718-726

    • DOI

      10.3201/eid2404.170141

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 【今、蚊を考える-蚊媒介感染症に関する最近の話題】 蚊媒介感染症に関する最近の話題 マラリア2017

    • Author(s)
      美田敏宏
    • Journal Title

      臨床と微生物

      Volume: マラリア Pages: 263-8

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Absence of in vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda.2017

    • Author(s)
      Balikagala B, Mita T, Ikeda M, Sakurai M, Yatsushiro S, Takahashi N, Tachibana SI, Auma M, Ntege EH, Ito D, Takashima E, Palacpac NM, Egwang TG, Onen JO, Kataoka M, Kimura E, Horii T, Tsuboi T.
    • Journal Title

      Malar J.

      Volume: 16(1) Issue: 1 Pages: 1-23

    • DOI

      10.1186/s12936-016-1663-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Absence of in-vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda.2017

    • Author(s)
      Balikagala B, Mita T*, Ikeda M, Sakurai M, Yatsushiro S, Takahashi N, Tachibana SI, Auma M, Ntege EH, Ito D, Takashima E, Palacpac NM, Egwang TG, Ohashi J, Kataoka M, Kimura E, Horii T and Tsuboi T.
    • Journal Title

      Malaria J

      Volume: 16 Pages: 23-23

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Honma H, Niikura M, Kobayashi F, Horii T, Mita T, Endo H and Hirai M.2016

    • Author(s)
      Honma H, Niikura M, Kobayashi F, Horii T, Mita T, Endo H and Hirai M.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 36971-36971

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Household clustering of asymptomatic malaria infections in Xepon district, Savannakhet province, Lao PDR.2016

    • Author(s)
      Pongvongsa T, Nonaka D, Iwagami M, Nakatsu M, Phongmany P, Nishimoto F, Kobayashi J, Hongvanthon B, Brey PT, Moji K, Mita T, Kano S.
    • Journal Title

      Malar J.

      Volume: 15 Pages: 508-508

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria in Uganda.2016

    • Author(s)
      Yatsushiro S, Yamamoto T, Yamamura S, Abe K, Obana E, Nogami T, Hayashi T, Sesei T, Oka H, Okello-Onen J, Odongo-Aginya EI, Alai MA, Olia A, Anywar D, Sakurai M, Palacpac NM, Mita T, Horii T, Baba Y and Kataoka M.
    • Journal Title

      Scientific reports

      Volume: 6 Pages: 30136-30136

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Little polymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction of artemisinin combination therapies.2016

    • Author(s)
      Mita T*, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Bjorkman A, Endo H, Ohashi J.
    • Journal Title

      Antimicrobial agents and chemotherapy

      Volume: 60 Pages: 3340-3347

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Plasmodium falciparum Kelch 13: A potential molecular marker for tackling artemisinin-resistant malaria parasites.2016

    • Author(s)
      Mita T*, Tachibana S, Hashimoto M, Hirai M.
    • Journal Title

      Expert Rev Anti Infect Ther

      Volume: 14 Pages: 125-135

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Little polymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction of artemisinin combination therapies.2016

    • Author(s)
      Mita, T, R Culleton, N Takahashi, M Nakamura, T Tsukahara, CW Hunja, ZZ Win, WW Htike, AS Marma and L Dysoley.
    • Journal Title

      Antimicrobial agents and chemotherapy

      Volume: 1 Pages: 1-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Challenging malaria control: do our new genetic tools pave the way for malaria eradication?2015

    • Author(s)
      Hirai M, Mita T.
    • Journal Title

      Juntendo Med J

      Volume: 61 Pages: 370-377

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current research topics in Tropical disease; toward the successful control and elimination; Introduction.2015

    • Author(s)
      Mita T*.
    • Journal Title

      Juntendo Med J

      Volume: 61 Pages: 358-359

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patterns and dynamics of genetic diversity in Plasmodium falciparum: what past Human migrations tell us about malaria.2015

    • Author(s)
      Mita T*, Jombart, T.
    • Journal Title

      Parasitol Int.

      Volume: 64(3) Issue: 3 Pages: 238-243

    • DOI

      10.1016/j.parint.2014.09.007

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global distribution of polymorphisms associated with delayed Plasmodium falciparum parasite clearance following artemisinin treatment: genotyping of archive blood samples.2014

    • Author(s)
      Murai K, Culleton R, Hisaoka T, Endo H, Mita T*.
    • Journal Title

      Parasitol Int.

      Volume: 64(3) Issue: 3 Pages: 267-273

    • DOI

      10.1016/j.parint.2014.11.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasmodium falciparum: Genetic diversity and complexity of infections in an isolated village in western Thailand2013

    • Author(s)
      K. Tanabe, G. Zollner, J. A. Vaughan, J. Sattabongkot, B. Khuntirat, H. Honma, T. Mita, T. Tsuboi and R. Coleman
    • Journal Title

      Parasitol Int

      Volume: pii: S1383-5769(13) Issue: 3 Pages: 142-146

    • DOI

      10.1016/j.parint.2013.09.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] フィールドで何が起こっているのかをもっと知りたい-Comprehensiveな薬剤耐性研究.2018

    • Author(s)
      美田敏宏
    • Organizer
      第87回日本寄生虫学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Altered gut microbiota composition in Plasmodium falciparum patients in Uganda.2018

    • Author(s)
      Taniguchi T, Miyauchi E, Olia A, Nagayasu E, Osbert K, Suzue K, Imai T, Shimokawa C, Onishi R, Odongo-Aginya E, Palacpac N, Maruyama H, Kimura E, Mita T, Ohno H, Horii T, Hisaeda H.
    • Organizer
      14th International congress of parastiology.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Global issue of drug resistant malaria and population structure of malaria parasites for global malaria control.2018

    • Author(s)
      Mita T, Tachibana S, Sekihara M, Yamauchi M, Hombhanje F, Ohashi J.
    • Organizer
      14th International congress of parastiology.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of Artemisinin-resistant Plasmodium falciparum with High Survival Rates in Uganda.2018

    • Author(s)
      Mita T, Ikeda M, Kaneko M, Tachibana S, Balikagala B, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Yamauchi M, Sekihara M, Hashimoto M, Obwoya P, Auma M, Anywar D, Odongo-Aginya E, Hirai M, Ohashi J, Palacpac N, Kataoka M, Tsuboi T, Kimura E, Horii T.
    • Organizer
      14th International congress of parastiology.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of artemisinin-resistant Plasmodium falciparum isolates with ex-vivo ring-stage survival assay in Uganda.2017

    • Author(s)
      Mita T, Ikeda M, Kaneko M, Balikagala B, Tachibana S-I, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Hashimoto M, Katuro O, Olia A, Obwoya P, Auma M, Anywar D, Odongo-Aginya E, Hirai M, Palacpac N, Kataoka M, Tsuboi T, Kimura E,Horii T.
    • Organizer
      Keystone Symposia Conference: Malaria: From Innovation to Eradication.
    • Place of Presentation
      Speke Resort & Conference Centre, Kampala. Uganda
    • Year and Date
      2017-02-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 原虫学・寄生虫学が現代のトップサイエンスにもたらす貢献 マラリアミューテーター マラリア原虫薬剤耐性進化解明の新たな研究ツール.2017

    • Author(s)
      平井誠, 池田美恵, 橘真一郎, 美田敏宏.
    • Organizer
      生命科学系学会合同年次大会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 人類を助ける進化学研究:進化し続ける薬剤耐性マラリアの克服.2017

    • Author(s)
      美田敏宏
    • Organizer
      公益信託 進化学振興木村資生基金 “微生物と人類の共存”をゲノムの視点から考える.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] End malaria-マラリアのeliminationをめざして アルテミシニン耐性の評価・検出ツールは出そろったか? 流行地でのフィールド調査から見えてきた問題点.2017

    • Author(s)
      美田敏宏
    • Organizer
      生命科学系学会合同年次大会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウガンダにおけるin vivo薬剤耐性試験およびRSAを用いたアルテミシニン耐性疫学調査.2017

    • Author(s)
      池田美恵, 橘真一郎, 山内祐人, Auma M, 関原誠, 森稔幸, 平井誠, Palacpac N, 木村英作, Aginya E, 堀井俊宏, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウガンダ国の熱帯熱マラリア患者において腸内細菌叢の変化が起こる.2017

    • Author(s)
      谷口委代, 宮内栄治, OliaAlex, 長安英治, OsbertKaturo, 鈴江一友, 今井孝, 下川周子, 大西里咲, I. O-A, PalacpacNirianne, 丸山治彦, 木村英作, 美田敏宏, 大野博司, 堀井俊宏, 久枝一.
    • Organizer
      グローバルヘルス合同大会プログラム・抄録集.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ネズミマラリア原虫の有性生殖関連分子の機能解析.2017

    • Author(s)
      前多晟壮, 森稔幸, 平井誠, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] マラリア原虫有性生殖の透視観察法の開発.2017

    • Author(s)
      森稔幸, 平井誠, 美田敏宏
    • Organizer
      第86回日本寄生虫学会大会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウガンダにおける熱帯熱マラリア原虫キニーネ感受性の実態.2017

    • Author(s)
      山内祐人, 橘真一郎, 池田美恵, 関原誠, Balikagala B, 八代&櫻井美樹, 平井誠, Palacpac N, 木村英作, 堀井俊宏, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫ミトコンドリアのプロテオーム解析 二次元電気泳動法とショットガン質量分析.2017

    • Author(s)
      高宮信三郎, 數野彩子, 峯木礼子, 三浦芳樹, 美田敏宏.
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ascaris suum 成虫およびCaenorhabditis elegans ミトコンドリアのプロテオーム解析: 二次元ゲル電気泳動法とショットガン質量分析法.2017

    • Author(s)
      高宮信三郎, 数野彩子, 峯木礼子, 三浦芳樹, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 宿主内競争による熱帯熱マラリア原虫のクロロキン感受性の回復.2017

    • Author(s)
      橘真一郎, 池田美恵, Balikagala B, 櫻井美樹, 八代聖基, 関原誠, 山内祐人, Auma MA, 平井誠, 森稔幸, Palacpac N, 片岡正俊, 木村英作, 堀井俊宏, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epidemiology of antimalarial drug resistance in Papua New Guinea.2017

    • Author(s)
      関原誠, 橘真一郎, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prerequisite Emergence of Background Mutations For Kelch13-Related Artemisinin-Resistant Plasmodium Falciparum Isolates.2017

    • Author(s)
      Tachibana S-I, Mori T, Hirai M, Mita T,
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of See-Through Imaging Methods for Sexual Reproduction of Malaria Parasites.2017

    • Author(s)
      Mori T, Hirai M, Mita T,
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of artemisinin-resistant Plasmodium falciparum isolates with ex-vivo ring-stage survival assay in Uganda.2017

    • Author(s)
      Mita T, Ikeda M, Kaneko M, Balikagala B, Tachibana S-I, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Hashimoto M, Katuro O, Olia A, Obwoya P, Auma M, Anywar D, Odongo-Aginya E, Hirai M, Palacpac N, Kataoka M, Tsuboi T, Kimura E, Horii T.
    • Organizer
      Keystone Symposia Conference: Malaria
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A mutator Plasmodium berghei model to investigate antimalarial drug resistance.2017

    • Author(s)
      Mita T,
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pb102, A Novel Gene Essential for Female Fertility or Ookinete Maturation of Murine Malaria Parasite, Plasmodium Berghei.2017

    • Author(s)
      Maeta A, Hirai M, Mori T, Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria.2017

    • Author(s)
      Kataoka M, Yatsushiro S, Yamamoto T, Oka H, Okello-Onen J, Odongo-Aginya E, Palacpac N, Mita T, Baba Y, Horii T.
    • Organizer
      Keystone Symposia Conference: Malaria:
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation of Piperaquine Resistant Rodent Malaria Parasite from Mutator Malaria.2017

    • Author(s)
      Hirai M, Ikeda M, Tachibana S-I, Mita T,
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マラリアの脅威とそれに立ち向かう新規技術の開発.2016

    • Author(s)
      美田敏宏
    • Organizer
      第57回日本熱帯医学会総会市民講座「蚊がもたらす感染症から身を守る」
    • Place of Presentation
      一橋大学一橋講堂、東京.
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新規ex-vivo薬剤耐性検出法を用いた高度感染地域におけるアルテミシニン耐性熱帯熱マラリア原虫の検出2016

    • Author(s)
      美田敏宏
    • Organizer
      第15回分子寄生虫マラリア研究フォーラム
    • Place of Presentation
      帯広畜産大学、帯広
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of artemisinin-resistant Plasmodium falciparum isolates using novel ex-vivo assay in Uganda.2016

    • Author(s)
      Mita T.
    • Organizer
      TICAD VI Pre-event; The 3rd International Symposium for the Promotion of Science and Technology Innovation Cooperation between Africa and Japan. -Life Innovation and Green Innovation.
    • Place of Presentation
      JICA Ichigaya Building, Tokyo
    • Year and Date
      2016-07-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 細胞チップを応用した超高感度マラリア診断装置の開発2016

    • Author(s)
      美田敏宏
    • Organizer
      臨床研究情報センターセミナー. 先端医療振興財団
    • Place of Presentation
      臨床研究情報センター、神戸
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アフリカ大陸におけるアルテミシニン耐性マラリアの出現2016

    • Author(s)
      池田 美恵 、金子 恵、橘 真一郎、Mawagali Betty Balikagala、櫻井 美樹 、八代 聖基、 橋本 宗明 、Alex Olia 、Anywar Dennis 、Auma Mary 、Palacpac Nirianne M. Q. 、平井 誠 、 片岡 正俊 、木村 英作 、Aginya Emmanuel 、坪井 敬文 、堀井 俊宏 、美田 敏宏
    • Organizer
      第85回日本寄生虫学会大会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミューテーターマラリア原虫ライブラリーから薬剤耐性原虫の単離2016

    • Author(s)
      平井 誠、池田 美恵、橘 真一郎、美田 敏宏
    • Organizer
      第85回日本寄生虫学会大会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 全世界の熱帯熱マラリア原虫株を用いたアルテミシニン耐性進化の集団遺伝学的解析2016

    • Author(s)
      橘 真一郎、平井 誠、美田 敏宏
    • Organizer
      第85回日本寄生虫学会大会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ウガンダにおけるマラリア対策を見据えた包括的熱帯熱マラリア薬剤耐性研究2015

    • Author(s)
      美田敏宏
    • Organizer
      日本熱帯医学会総会シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Comprehensive analysis of Artemether-Lumefantrine efficacy among children with uncomplicated malaria in Northern Uganda.2015

    • Author(s)
      Betty Balikagala1, Miki Sakurai2, Mie Ikeda3, Yatsushiro Shouki5, Nobuyuki Takahashi 2, Mary Auma6, Edward H. Ntege1, Daisuke Ito1, Eizo Takashima, Nirianne Marie Q Palacpac4, Joseph Okello Onen7, Masatoshi Kataoka 5, Kimura Eisaku4, Toshihiro Horii4, Toshihiro Mita3, Takafumi Tsuboi1
    • Organizer
      64th Annual Meeting American Society of Tropical Medicine and Hygiene
    • Place of Presentation
      Philadelphia
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] マラリアミューテーターを用いたピペラキン耐性原虫の迅速単離と耐性機構の解明2015

    • Author(s)
      池田美恵、平井誠、美田敏宏
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      東京、杏林大学 三鷹キャンパス
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウガンダにおけるex vivo薬剤感受性試験を用いた熱帯熱マラリア原虫のクロロキン感受性の回復2015

    • Author(s)
      櫻井美樹、Mawagali Betty Balikagala、矢代聖基、池田美恵、Ntege Edward、佐伯亜美、本間一、Palacpac Nirianne M.Q.、片岡正俊、坪井敬文、木村英作、遠藤弘良、堀井俊宏、美田敏宏
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      東京、杏林大学 三鷹キャンパス
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Temporal patterns of molecular marker associated with artemisinin resistance before and after the implementation of artemisinin derivatives in Myanmar2015

    • Author(s)
      Win Zin Zayar、上村春樹、Wah Win Htike、Khin San San、北潔、美田敏宏
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      東京、杏林大学 三鷹キャンパス
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルテミシニン耐性熱帯熱マラリア原虫出現以前の大規模検体を用いた耐性候補遺伝子K13-propellerのベースライン多型解析2015

    • Author(s)
      美田敏宏、高橋延之、遠藤弘良、大橋順
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      東京、杏林大学 三鷹キャンパス
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ウガンダにおけるRing Stage Survival Assayを用いたアルテミシニン感受性低下熱帯熱マラリア原虫のスクリーニング2015

    • Author(s)
      金子恵、池田美恵、Mawagali Betty Balikagala、櫻井美樹、矢代聖基、加納永将、佐伯亜美、Palacpac Nirianne M.Q.、片岡正俊、坪井敬文、木村英作、堀井俊宏、美田敏宏
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      東京、杏林大学 三鷹キャンパス
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミューテーターマラリア原虫を用いた突然変異蓄積パターンの解析2015

    • Author(s)
      本間一、平井誠、新倉保、美田敏宏、小林富美恵、堀井俊宏、遠藤弘良
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      東京、杏林大学 三鷹キャンパス
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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