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Construction of bioavailability evaluation system of natural folate in food stuff and its application

Research Project

Project/Area Number 26350140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition (2015-2016)
National Institute of Health and Nutrition (2014)

Principal Investigator

UMEGAKI Keizo  国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 情報センター, センター長 (60191920)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords葉酸 / 生体利用率 / 緑茶 / 茶カテキン / 放射線防御 / バイオアッセイ法 / 生体利用性
Outline of Final Research Achievements

To evaluate bioavailability of various food folates, a folate depletion/repletion mice model was constructed. In the model, 4-week-old mice fed a folate deficient diet for 4 weeks were supplied with food folate for 7 days, and then the folate bioavailability was evaluated in terms of changes in folate level in plasma, liver, and bone marrow and decrease in plasma homocysteine level. Based on this model, we showed that tea catechin in green tea, which is considered a major folate source of Japanese, did not influence absorption of spinach folate, and had no practical impact on folate analysis in green tea, using the general microbiological assay. In addition, we showed that spinach folate as well as synthetic folic acid attenuated the chromosomal damage in bone marrow induced by total body irradiation of X-ray.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Effect of Tea Catechins on Folate Analysis in Green Tea by Microbiological Assay2016

    • Author(s)
      Umegaki K, Sekine Y, Sato Y, Chiba T, Sonoda M.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 62 Issue: 2 Pages: 134-138

    • DOI

      10.3177/jnsv.62.134

    • NAID

      130005154251

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of tea catechins on folate analysis in green tea by microbiological assay2016

    • Author(s)
      Keizo Umegaki, Yuki Sekine, Yoko Sato, Tsuyoshi Chiba, Masaru Sonoda
    • Journal Title

      J Nutr Sci Vitaminol,

      Volume: 62 Pages: 137-141

    • NAID

      130005154251

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] X線全身照射マウスの骨髄染色体損傷に対する合成型葉酸と天然型葉酸の防御作用2016

    • Author(s)
      尾関彩、小林悦子、佐藤陽子、千葉剛、梅垣敬三
    • Organizer
      第63回日本栄養改善学会
    • Place of Presentation
      青森市
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] バイオアッセイ法による緑茶の葉酸定量に対する茶カテキンの影響2015

    • Author(s)
      関根有希、薗田勝、尾関彩、千葉剛、佐藤陽子、梅垣敬三
    • Organizer
      日本ビタミン学会67回大会
    • Place of Presentation
      奈良市
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] バイオアッセイ法による緑茶中の葉酸定量に対する茶カテキンの影響2015

    • Author(s)
      関根有希、薗田勝、尾関彩、千葉剛、佐藤陽子、梅垣敬三
    • Organizer
      日本ビタミン学会第67回大会
    • Place of Presentation
      奈良市
    • Year and Date
      2015-06-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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