Evaluation and clinical application of exercise program by using a novel measuring method for myocardial triglyceride conten

• Project/Area Number: 26350588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Juntendo University
• Principal Investigator: Shimada Kazunori 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (60327814)
• Co-Investigator(Renkei-kenkyūsha): TAMURA Yoshifumi 順天堂大学, 大学院 医学研究科, 准教授 (80420834)
• Research Collaborator: YAMASHITA Haruyo 順天堂大学, 大学院 医学研究科, 助教 (90534892) ; SAI Eiryu 順天堂大学, 大学院 医学研究科, 助教 (30747415)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心筋内中性脂肪 / 異所性脂肪 / 心筋MRS法 / 心臓リハビリテーション / MRS法 / MRスペクトロスコピー / 異所性脂肪蓄積 / 肥大型心筋症 / 高血圧性心疾患

Outline of Final Research Achievements

Proton magnetic resonance spectroscopy (1H-MRS) enables to assess ectopic fat. We evaluated myocardial triglyceride (MTG) content measured by 1H-MRS in apparently healthy subjects and patients with left ventricular (LV) hypertrophy. The mean MTG content was 0.85% in healthy subjects. The MTG content was significantly associated with the percent body fat and serum TG, anaerobic threshold, and LV end-systolic volume. The MTG content was significantly higher in the hypertensive heart disease (HHD) group than in the hypertrophic cardiomyopathy (HCM) group. In a multivariate analysis, LV mass volume and diagnosis of HCM or HHD were independent factors of the MTG content. Cardiac rehabilitation could reduce MTG content. 1H-MRS may be useful for assessing the associations between the MTG content and various clinical parameters, including those reflecting obesity, metabolic disorders, cardiac morphology and exercise capacity, noninvasively.

Research Products

• [Journal Article] Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy. (2017)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Journal Title: Heart Vessels Volume: 32 Pages: 166-174
  • DOI: 10.1007/s00380-016-0844-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Balance of Omega-3 Polyunsaturated Fatty Acids for Reducing Residual Risks in Patients with Coronary Artery Disease. (2017)
  • Author(s): Nishizaki Y, Shimada K, Daida H.
  • Journal Title: Acta Cardiologica. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Are There Any “Ultimate” Practices for Preventing Atherosclerotic Diseases? (2016)
  • Author(s): Shimada K, Daida H.
  • Journal Title: Juntendo Medical Journal Volume: 62 Issue: 3 Pages: 217-223
  • DOI: 10.14789/jmj.62.217
  • NAID: 130005277377
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Current Status and Future Directions for Cardiac Rehabilitation in Japan. (2016)
  • Author(s): Daida H, Nishitani-Yokoyama M, Shimada K.
  • Journal Title: Juntendo Medical Journal. Volume: 62 (Supple 1) Pages: 29-37
  • NAID: 130005865676
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Myocardial Triglyceride Content in Patients with Left Ventricular Hypertrophy: Comparison between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy. (2016)
  • Author(s): Sai E, ShimadaK, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Journal Title: Heart Vessels. Volume: 31
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of Phase II Comprehensive Cardiac Rehabilitation on Coronary Plaque Volume After Acute Coronary Syndrome (2016)
  • Author(s): Nishitani-Yokoyama M, Miyauchi K, Shimada K, Miyazaki T, Ogita M, Okazaki S, Shioya M, Koba S, Tsujita H, Kobayashi Y, Daida H.
  • Journal Title: Int. Heart J. Volume: 56 Issue: 6 Pages: 597-604
  • DOI: 10.1536/ihj.15-049
  • NAID: 130005113055
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome. (2015)
  • Author(s): Alshahi H, Shimada K, Miyauchi K, Yoshihara T, Sai E, Shiozawa T, Naito R, Aikawa T, Ouchi S, Kadoguchi T, Miyazaki T, Daida H.
  • Journal Title: Int J Vasc Med. Volume: 805375 Pages: 805375-805375
  • DOI: 10.1155/2015/805375
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation (2015)
  • Author(s): Yoshihara T, Shimada K, Fukao K, Sai E, Sato-Okabayashi Y, Matsumori R, Shiozawa T, Alshahi H, Miyazaki T, Tada N, Daida H
  • Journal Title: Circ J Volume: 79 Issue: 7 Pages: 1470-1478
  • DOI: 10.1253/circj.cj-14-0471 10.1253/circj.CJ-14-0471
  • NAID: 130005083946
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sudden cardiovascular events and comprehensive cardiac rehabilitation: come back from a bolt out of the blue. (2015)
  • Author(s): Shimada K.
  • Journal Title: J Cardiol Cases. Volume: 11 Pages: 164-165
  • DOI: 10.1016/j.jccase.2015.03.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of Myocardial Triglyceride Accumulation Assessed on ¹H-Magnetic Resonance Spectroscopy in Apparently Healthy Japanese Subjects (2015)
  • Author(s): Sai E, Shimada K, Yokoyama T, Sato S, Nishizaki Y, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Journal Title: Intern. Med. Volume: 54 Issue: 4 Pages: 164-172
  • DOI: 10.2169/internalmedicine.54.3024
  • NAID: 130004903049
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Voluntary exercise ameliorates cardiac inflammation and improves left ventricular function after myocardial infarction in a mouse model. (2017)
  • Author(s): Al Shahi H, Shimada K, Kadoguchi T, Akita K, Takahashi S, Shiozawa T, Aikawa T, Ouchi S, Matsushita S, Isoda K, Miyazaki T, Daida H.
  • Organizer: 81th Annual Meeting of JCS
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] The Validity of the "Kihon Check-list" as an Index of frailty and fatty Acids in Elderly Patients Participating Cardiac Rehabilitation. (2017)
  • Author(s): Yokoyama M, Shimada K, Hoshino Y, Takahashi S, Shiozawa T, Aikawa T, Ouchi S, Fukao K, Iwata H, Miyazaki T, Shimada A, Yamamoto T, Amano A, Daida H.
  • Organizer: 81th Annual Meeting of JCS
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] Decreased circulating DGLA levels and DGLA/AA are associated with total mortality in patients with acute decompensated heart failure. (2017)
  • Author(s): Ouchi S, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Murata A, Kato T, Aikawa T, Suda S, Shiozawa T, Hiki M, Takahashi S, Kasai T, Miyauchi K, Daida H.
  • Organizer: 81th Annual Meeting of JCS
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] Inhibition of NAD(P)H Oxidase 4 Ameliorates Angiotensin II-Induced Protein Degradation via Improving Mitochondrial Dysfunction in Skeletal Myocytes. (2016)
  • Author(s): Kadoguchi T, Shimada K, Shiozawa T, Takahashi S, Hamad Al Shahi, Aikawa T, Ouchi S, Sugita Y, Miyazaki T, Akita K, Isoda K, Daida H.
  • Organizer: American Heart Association Scientifc Sessions 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] Decreased Circulating Omega-6 Fatty Acid Levels Are Associated With Total Mortality in Patients Admitted to Cardiac Intensive Care Unit. (2016)
  • Author(s): Ouchi S, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Murata A, Kato T, Aikawa T, Suda S, Shiozawa T, Hiki M, Takahashi S, Kasai T, Miyauchi K, Daida H.
  • Organizer: American Heart Association Scientifc Sessions 2016
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] 回復期心臓リハビリテーション患者における血管機能指標と運動耐容能との検討. (2016)
  • Author(s): 國本充洋, 島田和典, 横山美帆, 星野祐里子, 高橋秀平, 塩澤知之, 相川達郎, 山田みき, 塩澤 知之, 本澤晶雄, 深尾宏祐, 代田浩之.
  • Organizer: 第27回日本臨床スポーツ医学会
  • Place of Presentation: 千葉 幕張
  • Year and Date: 2016-11-05
• [Presentation] アンジオテンシンIIに依存した酸化ストレスは骨格筋タンパク分解を引き起こす. (2016)
  • Author(s): 門口智泰, 島田和典, 塩澤知之, 高橋秀平, Hamad AlShahi, 大内翔平, 相川達郎, 秋田耕嗣, 磯田菊生, 宮﨑哲朗, 代田浩之.
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-23
• [Presentation] 回復期心臓リハビリテーション患者における血管機能指標と運動耐容能との検討 (2016)
  • Author(s): 國本充洋, 島田和典, 横山美帆, 星野祐里子, 高橋秀平, 塩澤知之, 相川達郎, 山田みき, 本澤晶雄, 深尾宏祐, 代田浩之.
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-23
• [Presentation] Decreased circulating omega-6 fatty acids levels, but not omega-3 fatty acids levels, are associated with total mortality in patients admitted to cardiac intensive care unit. (2016)
  • Author(s): Ouchi S, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Aikawa T, Kato T, Suda S, Hiki M, Takahashi S, Kasai T, Miyauchi K, Daida H.
  • Organizer: European Society of Cardiology Congress 2016
  • Place of Presentation: Rome
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] NAD(P)H oxidase 4 plays a key role in angiotensin II-induced protein degradation in skeletal muscle cells. (2016)
  • Author(s): Kadoguchi T, Shimada K, Shiozawa T, Takahashi S, Al Shahi H, Miyazaki T, Akita K, Isoda K, H. Daida H.
  • Organizer: European Society of Cardiology Congress 2016
  • Place of Presentation: Rome
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] スポーツのもたらす循環器系の効果：サッカーと心臓リハビリテーションとの接点. (2016)
  • Author(s): 島田和典, 深尾宏祐, 塩澤知之, 塩崎正幸, 福島理文, 横山美帆, 池田浩, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 冠血行再建術の進歩と新規二次予防戦略. (2016)
  • Author(s): 宮内克己, 島田和典, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 回復期心臓リハビリテーション患者における「基本チェックリスト」を用いたフレイル判定とその特徴. (2016)
  • Author(s): 横山美帆, 島田和典, 星野祐里子, 高橋秀平, 塩澤知之, 相川達郎, 國本充洋, 深尾宏祐, 山田みき, 本澤晶雄, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 回復期心臓リハビリテーション患者におけるフレイル診断指標と血管機能検査との検討. (2016)
  • Author(s): 星野祐理子, 横山美帆, 島田和典, 高橋秀平, 塩澤知之, 相川達郎, 國本充洋, 深尾宏祐, 山田みき, 本澤晶雄, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 冠動脈バイパス術後患者の急性期心臓リハビリテーションにおけるリハビリ遅延要因の検討. (2016)
  • Author(s): 菊地佑太, 吉野このか, 山崎優太, 諏訪太一, 渡邉英孝, 豊島和可子, 佐藤和命, 保苅吉秀, 山田みき, 本沢晶雄, 横山美帆, 島田和典, 嶋田晶江, 山本平, 天野篤, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 当院における回復期外来心臓リハビリテーションの継続因子に関する検討. (2016)
  • Author(s): 本沢晶雄, 島田和典, 横山美帆, 高橋秀平, 塩澤知之, 星野祐里子, 山田みき, 佐藤裕之, 嶋田晶江, 山本平, 天野篤, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 回復期心臓リハビリテーション患者における血管機能指標と運動耐容能との検討. (2016)
  • Author(s): 國本充洋, 島田和典, 横山美帆, 星野祐里子, 高橋秀平, 塩澤知之, 相川達郎, 深尾宏祐, 山田みき, 本澤晶雄, 代田浩之.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 身体的虚弱と重複障害を考慮し術前介入を行った2度の開胸術既往のある仮性大動脈瘤の1例. (2016)
  • Author(s): 山崎優太, 杉野佑子, 渡邉英孝, 佐藤和命, 北原エリ子, 保苅吉秀, 長岡正範, 山田みき, 本沢晶雄, 横山美帆, 島田和典, 代田浩之, 長濱明日香, 高橋幸子, 嶋田晶江, 山本平, 天野篤.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-16
• [Presentation] 骨格筋タンパク合成および分解調節におけるNAD(P)H oxidase 4の役割の検討. (2016)
  • Author(s): 門口智泰, 島田和典, 塩澤知之, 高橋秀平, Al Shahi Hamad, 大内翔平, 相川達郎, 秋田耕嗣, 宮崎哲朗, 磯田菊生, 代田浩之.
  • Organizer: 第48回日本動脈硬化学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] Effects of First Session of Phase II Cardiac Rehabilitation on Novel Markers of Arterial Stiffness in Patients with Cardiovascular Diseases. (2016)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Hoshino Y, Takahashi S, Shiozawa T, Yamamoto T, Amano A, Daida H.
  • Organizer: EuroPREVENT 2016
  • Place of Presentation: Sofia Antipolis
  • Year and Date: 2016-06-14
  • Int'l Joint Research
• [Presentation] 糖尿病患者における心臓リハビリテーションの有効性とその課題. (2016)
  • Author(s): 島田和典, 横山美帆, 蔡榮龍, 比企誠, 宮崎哲朗, 代田浩之.
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
• [Presentation] 心血管疾患予防における多価不飽和脂肪酸の臨床的有用性. (2016)
  • Author(s): 島田和典.
  • Organizer: 第50回日本成人病（生活習慣病）学会学術集会.
  • Place of Presentation: 都市センターホテル（東京都千代田区）
  • Year and Date: 2016-01-06
• [Presentation] 大学生アスリートにおける持久的運動と循環代謝マーカーの特徴. (2015)
  • Author(s): 深尾 宏祐, 島田 和典, 福島 理文, 塩澤 知之, 塩崎 正幸, 代田 浩之.
  • Organizer: 第26回日本臨床スポーツ医学会学術総会
  • Place of Presentation: 神戸国際会議場（神戸市中央区）
  • Year and Date: 2015-11-07
• [Presentation] 当院における外来心臓リハビリテ―ション継続因子の検討. (2015)
  • Author(s): 本沢晶雄, 島田和典, 横山美帆, 松森理枝, 高橋秀平, 久米淳美, 正木克由規, 深尾宏祐, 塩谷みき, 佐藤裕之, 代田浩之.
  • Organizer: 第21回日本心臓リハビリテーション学会学術集会.
  • Place of Presentation: 福岡国際会議場（福岡市博多区）
  • Year and Date: 2015-07-19
• [Presentation] Myocardial triglyceride content in patients with hypertensive heart disease and hypertrophic cardiomyopathy; assessed by 1H-Magnetic Resonance Spectroscopy. (2015)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Miyazak T, Fujimoto S, Daida H.
  • Organizer: 79th Annual Meeting of JCS
  • Place of Presentation: 大阪国際会議場（大阪府大阪市北区）
  • Year and Date: 2015-04-26
• [Presentation] Myocardial triglyceride content in patients with hypertensive heart disease and hypertrophic cardiomyopathy; assessed by 1H-Magnetic Resonance Spectroscopy. (2015)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Miyazak T, Fujimoto S, Daida H.
  • Organizer: 79th Annual Meeting of JCS
  • Place of Presentation: Ohsaka
  • Year and Date: 2015-04-26
• [Presentation] Myocardial Triglyceride Content in Patients with Left Ventricular Hypertrophy: Comparison between Hypertensive Heart and Hypertrophic Cardiomyopathy (2015)
  • Author(s): Sai E, Shimada K, Yokoyama T, Sato S, Nishizaki Y, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Organizer: SCMR/Euro CMR Meetings 2015
  • Place of Presentation: Nice, France
  • Year and Date: 2015-02-05
• [Presentation] 入退院を繰り返していた慢性心不全患者に回復期心臓リハビリテーションの導入が有用であった一症例. (2014)
  • Author(s): 塩谷みき, 横山美帆, 島田和典, 正木克由規, 久米淳美, 深尾宏祐, 蔡栄龍, 吉原琢磨, 佐藤裕之, 河合祥雄, 代田浩之.
  • Organizer: 第20回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2014-07-20
• [Presentation] 日本心臓リハビリテーション学会レジストレーションシステム：初年度の結果報告と今後の展望. (2014)
  • Author(s): 島田和典, 代田浩之, 横山美帆, 安達仁, 及川恵子, 長山雅俊, 齊藤正和, 大宮一人, 後藤葉一, 伊東春樹.
  • Organizer: 第20回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2014-07-19
• [Presentation] 急性冠症候群患者の冠動脈プラーク退縮と体重変化との関連. (2014)
  • Author(s): 横山美帆, 宮内克己, 島田和典, 蔡栄龍, 荻田学, 久米淳美, 深尾宏祐, 吉原琢磨, 岡崎真也, 塩谷みき, 代田浩之.
  • Organizer: 第20回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2014-07-19
• [Presentation] 高齢冠動脈疾患患者における心臓リハビリテーションの有用性. (2014)
  • Author(s): 横山美帆, 島田和典, 代田浩之.
  • Organizer: 日本老年医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-13
• [Book] 心血管疾患予防における多価不飽和脂肪酸の臨床的有用性. (2016)
  • Author(s): 1.島田和典, 西﨑祐史, 吉原琢磨, 相川達郎, 大内翔平, 塩澤知之, 門口智泰, 高橋秀平, 住吉克彦, 宮崎哲朗,代田浩之.
  • Total Pages: 5
  • Publisher: 成人病と生活習慣病
• [Book] Journal of Clinical Rehabilitation. (2015)
  • Author(s): 島田和典, 高橋秀平, 横山美帆.
  • Publisher: 医歯薬出版
• [Book] 呼吸と循環. (2015)
  • Author(s): 島田和典, 門口智泰, Al Shahi, 塩澤知之.
  • Publisher: 医学書院
• [Book] J-ISCP 会誌心血管薬物療法. (2015)
  • Author(s): 島田和典, Al Shahi H, 塩澤知之.
  • Publisher: J-ISCP 学会誌
• [Book] 心不全患者に寄り添う包括的心臓リハビリテーションを極める. (2015)
  • Author(s): 島田和典.
  • Publisher: 文光堂