The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.
| Project/Area Number |
26350904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Josai University |
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Principal Investigator |
Keizo Kasono 城西大学, 薬学部, 教授 (90177387)
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| Co-Investigator(Kenkyū-buntansha) |
野部 浩司 昭和大学, 薬学部, 教授 (30276612)
竹之内 康広 城西大学, 薬学部, 助手 (30582233)
大竹 一男 城西大学, 薬学部, 助教 (50337482)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖尿病 / 糖尿病合併症 / n-3系多価不飽和脂肪酸 / エイコサペンタエン酸 / 血管内皮機能 / 脂肪酸 / 血管内皮細胞 / n-3系多可不飽和脂肪酸 / 低酸素トレーニング / 血管内皮機能障害 / EPA / DHA |
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| Outline of Final Research Achievements |
<1> The administration of palmitoleic acid (POA) for 2 weeks improved the insulin resistance and reduced the plasma glucose levels in diabetic model mice (KKA-y). It was speculated that the administration of POA compensatory increased the relaxation response induced by PPAR-δ.<2> Eicosapentaenoic acid (EPA) dose-dependently decreased the up-regulated protein levels of VCAM-1 and ICAM-1 induced by TNF-α in human aortic endothelial cells.<3> It is speculated that fish oil supplementation reduces the cardiovascular loading induced by increase of Ht during hypoxic training without blunting the improvement of endurance performance.
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Report
(4 results)
Research Products
(2 results)
