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Longitudinal effects of high-intensity interval training (HIIT) on fat distribution, metabolic parameters and composition of free fatty acids

Research Project

Project/Area Number 26350905
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKeio University

Principal Investigator

KAWAI TOSHIHIDE  慶應義塾大学, 医学部(信濃町), 講師(非常勤) (10276230)

Research Collaborator AZUMA Koichiro  
FUJII Chikako  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords内臓脂肪 / 脂肪酸分画 / リノール酸 / インスリン抵抗性 / 高強度運動 / 運動療法 / 体脂肪分布
Outline of Final Research Achievements

We evaluated the relationships between the composition of free fatty acids (FFA) and metabolic parameters, including body fat distribution. The study subjects were 111 Japanese (54 men/ 57 women) who underwent 75g-OGTT. 24 fractions of serum FFA, lipids, and fat distribution by CT scanning were measured. Our data suggest that linoleic acid level was inversely correlated with accumulation of visceral fat in relation to a reduction of insulin resistance. We evaluated an original treadmill protocol “KEIO-SENIOR” which we developed for patients with diabetes who need life-style modification. The study subjects were 50 Japanese. Based on the results, we made an exercise prescription. After 6 months, we found significant weight reduction, decreased blood pressures and improvement of glycemic control. We showed that a combined leg-cycling high-intensity interval training (HIIT) and arm-cranking-HIIT program improves aerobic capacity and muscle hypertrophy in 12 healthy male subjects.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(15 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] A case of autoimmune polyendocrine syndrome type I with strong positive GAD antibody titer, followed up with glucose tolerance measured by oral glucose tolerance test2017

    • Author(s)
      Murakami R, Kawai T, Meguro S, Hayashi M, Itoh H
    • Journal Title

      Neuro Endocrinol Lett

      Volume: 37 Pages: 540-542

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationships between composition of major fatty acids and fat distribution, and insulin resistance in Japanese2017

    • Author(s)
      Fujii C, Kawai T, Azuma K, Oguma Y, Katsukawa F, Hirose H, Tanaka K, Meguro S, Matsumoto H, Itoh H
    • Journal Title

      J Diabetes Res

      Volume: ID1567467 Pages: 1-9

    • DOI

      10.1155/2017/1567467

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An attempt to design optimal personalized exercise prescriptions using the KEIO-SENIOR treadmill protocol for patients with type 2 diabetes2016

    • Author(s)
      Toshihide Kawai
    • Journal Title

      Personalized Medicine Universe

      Volume: 5 Pages: 27-31

    • DOI

      10.1016/j.pmu.2015.12.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study2014

    • Author(s)
      Osawa Y, Azuma K, Tabata S, Katsukawa F, Ishida H, Oguma Y, Kawai T, Itoh H, Okuda S, Matsumoto H
    • Journal Title

      Open Access J Sports Med

      Volume: 5 Pages: 1-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 血中脂肪酸分画と体組成、経口糖負荷試験(OGTT)時の糖代謝指標との関連2016

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、小熊祐子、松本秀男、伊藤 裕
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中高年肥満者に対する運動処方作成を目的としたトレッドミルプロトコール(KEIO-SENIOR)とその臨床応用2016

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、田畑尚吾、小熊祐子、松本秀男、伊藤 裕
    • Organizer
      第34回日本肥満症治療学会学術集会
    • Place of Presentation
      東京コンベンションホール(東京都中央区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 2型糖尿病患者、個々の症例にふさわしい運動処方の試み2015

    • Author(s)
      河合 俊英
    • Organizer
      第20回国際個別化医療学会学術集会
    • Place of Presentation
      イイノホール(東京都千代田区)
    • Year and Date
      2015-05-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖尿病患者のメディカルチェックのためのトレッドミルプロトコール「KEIO-SENIOR」(K)とBruceプロトコール(B)との対比2015

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、田畑尚吾、堀澤栞里、小熊祐子、勝川史憲、石田浩之、松本秀男、伊藤 裕
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 75g経口糖負荷試験(OGTT)の経時的変化と血中脂肪酸分画、体脂肪分布の関連2015

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、小熊祐子、松本秀男、伊藤 裕
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ(東京都千代田区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 高強度インターバルトレーニングと血中高分子量アディポネクチン濃度との関連2015

    • Author(s)
      東宏一郎、大澤祐介、田畑尚吾、長野雅史、藤井千華子、河合俊英、小口修司、大田敦美、菊池春人、村田 満、伊藤 裕、松本秀男
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ(東京都千代田区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 75g経口糖負荷試験(OGTT)の経時的変化と血中脂肪酸分画、体脂肪分布の関連2015

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、小熊祐子、松本秀男、伊藤 裕
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 高強度インターバルトレーニングと血中高分子量アディポネクチン濃度との関連2015

    • Author(s)
      東宏一郎、大澤祐介、田畑尚吾、長野雅史、藤井千華子、河合俊英、小口修司、大田敦美、菊池春人、村田 満、伊藤 裕、松本秀男
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動処方作成を目的としたトレッドミルプロトコール「KEIO-SENIOR」(K)と心筋虚血の評価を目的とした「Bruce」(B)プロトコールの対比2014

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、小熊祐子、勝川史憲、田畑尚吾、堀澤栞里、石田浩之、松本秀男、伊藤 裕
    • Organizer
      第25回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 健常男性における高強度インターバル運動の効果2014

    • Author(s)
      東宏一郎、大沢祐介、長野雅史、田畑尚吾、堀澤栞里、勝川史憲、小熊祐子、石田浩之、河合俊英、松本秀男
    • Organizer
      第25回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動処方のためのtreadmill protocol 「KEIO-SENIOR(K)」とBruce protocol (B)との対比2014

    • Author(s)
      河合俊英、東宏一郎、藤井千華子、小熊祐子、勝川史憲、田畑尚吾、堀澤栞里、石田浩之、松本秀男、伊藤 裕
    • Organizer
      第35回日本肥満学会学術集会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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