Fabrication of hyper-islet by microcontrol of cellular position
| Project/Area Number |
26390038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nano/Microsystems
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| Research Institution | Yokohama City University |
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Principal Investigator |
Kojima Nobuhiko 横浜市立大学, 国際総合科学部(八景キャンパス), 准教授 (90342956)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 膵島 / インスリン / 糖鎖 / レクチン / 糖尿病 / 移植 / 血糖値 / 自己組織化 / 細胞外マトリクス / 組織工学 / マイクロシステム / 再生医療 |
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| Outline of Final Research Achievements |
According to the present study, self-organized cell positioning of pancreatic α and β cells in reconstructed pancreatic islets is caused by sugar chain (β-galactoside). Inhibition of the self-organization by a carbohydrate-specific lectin downregulate the insulin secretion activity of the islet. Highly functionalized islets (hyper-islets) which have enhanced insulin secretion activity by α cells have been found to efficiently reduce the blood glucose level of diabetes model mice. These findings indicate the importance of "designing" of islets for islet transplantation.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] Control of Islet Organization in Vitro.2015
Author(s)
Kamitori, S., Ozeki, Y. and Kojima, N.
Organizer
2015 Taiwan-Japan Forum on Additive Manufacturing and Bioengineering
Place of Presentation
National Formosa University, Yunlin, Taiwan
Year and Date
2015-09-01
Related Report
Int'l Joint Research
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