2016 Fiscal Year Final Research Report
Fabrication of hyper-islet by microcontrol of cellular position
Project/Area Number |
26390038
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nano/Microsystems
|
Research Institution | Yokohama City University |
Principal Investigator |
Kojima Nobuhiko 横浜市立大学, 国際総合科学部(八景キャンパス), 准教授 (90342956)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 膵島 / インスリン / 糖鎖 / レクチン / 糖尿病 / 移植 / 血糖値 / 自己組織化 |
Outline of Final Research Achievements |
According to the present study, self-organized cell positioning of pancreatic α and β cells in reconstructed pancreatic islets is caused by sugar chain (β-galactoside). Inhibition of the self-organization by a carbohydrate-specific lectin downregulate the insulin secretion activity of the islet. Highly functionalized islets (hyper-islets) which have enhanced insulin secretion activity by α cells have been found to efficiently reduce the blood glucose level of diabetes model mice. These findings indicate the importance of "designing" of islets for islet transplantation.
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Free Research Field |
組織工学・細胞生物学
|