Study on comparison of health effects of living environment factors and low dose radiation focusing on oxidative stress
Project/Area Number |
26420872
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nuclear engineering
|
Research Institution | Okayama University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
片岡 隆浩 岡山大学, 保健学研究科, 助教 (40509832)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 自己組織化マップ / ラドン / X線 / アルコール / 酸化ストレス / 肝臓 / 環境酸化ストレス / Nrf2 / NIK |
Outline of Final Research Achievements |
We compared liver damage by radiation with by alcohol which is living environment factor to dispel the fear of low-dose radiation. We analyzed liver function and anti-oxidative function in liver using self-organizing maps. The results showed that the effects of radon inhalation at a concentration of up to 2000 Bq/m3 or X-irradiation at a dose of up to 2.0 Gy were comparable with the effect of alcohol administration at 0.5 g/kg bodyweight. According to our result of clustering, their different patterns of liver damage caused by different factors. We found that the effects of low-dose X-irradiation or radon inhalation was extremely small and highly individual.
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Report
(4 results)
Research Products
(12 results)