Research in the regulation of feeding behavior - the role of central dopamine neurons -
| Project/Area Number |
26430024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Hoshi University |
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Principal Investigator |
IKEDA Hiroko 星薬科大学, 薬学部, 准教授 (70297844)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 摂食調節 / ドパミン神経 / ドパミン受容体 / 視床下部 / 摂食調節ペプチド |
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| Outline of Final Research Achievements |
The present study examined the role of dopaminergic functions in the lateral hypothalamus (LH) in the regulation of feeding behavior. The results in the present study have indicated that dopamine neurons in the LH are activated by food intake, which inhibits food intake by activating dopamine D1 and D2 receptors. In addition, it is suggested that dopamine D1 and D2 receptors in the LH have an inhibitory role in the regulation of feeding behavior through agouti-related peptide (AgRP) / neuropeptide Y (NPY) neurons and orexin neurons, respectively.
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Report
(4 results)
Research Products
(9 results)
