Clinicopathological study on the pulmonary vasculopathy and right heart morphology/function in lung disease-associated pulmonary hypertension

• Project/Area Number: 26461150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: TSUJINO Ichizo 北海道大学, 医学研究科, 特任教授 (00344507)
• Co-Investigator(Kenkyū-buntansha): 今野 哲 北海道大学, 医学研究科, 准教授 (20399835) ; 谷野 美智枝 北海道大学, 医学研究科, 講師 (90360908)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 肺高血圧症 / 病理組織学的解析 / 心臓MRI / 胸部CT / 肺疾患合併肺高血圧症 / 右心形態 / 右心機能 / 肺疾患 / 右心形態・機能 / 肺血管拡張薬 / 心臓ＭＲＩ / ＣＴ / 病理 / 右心 / フォスフォジエステラーゼ5 / エンドセリン / プロスタサイクリン / COPD / 間質性肺炎 / 呼吸器疾患 / 右心系 / CT

Outline of Final Research Achievements

We studied cases with lung disease-associated pulmonary hypertension and demonstrated remodeling of the pulmonary vasculature as well as the expression of target proteins of pulmonary vasodilators. The expression was also shown in myocardial tissue, suggesting favorable effects of pulmonary vasodilating treatment. In the clinical study, we showed significant improvement in the pulmonary vascular resistance and right heart morphology/function (published in the journal Pulmonary Circulation, 2017). We also notably shown elevations of blood insulin level, index of insulin resistance, and plasma concentration of BDNF, one of the myokines, in pulmonary hypertension patients. Lastly, in our study, clinical relevance of chest computed tomography-derived indices of pulmonary vascular system was examined and we found their usefulness in the diagnosis and hemodynamic evaluation of pulmonary hypertension.

Research Products

• [Journal Article] Representative Chest Auscultation Findings in Pulmonary Hypertension: Phonocardiograms and Sound Clips (2017)
  • Author(s): Sato, T. Ohira, H. Tsujino, I.
  • Journal Title: Ann Am Thorac Soc Volume: － Issue: 5 Pages: e1-e3
  • DOI: 10.1513/annalsats.201612-1031le
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The effects of pulmonary vasodilating agents on right ventricular parameters in severe group 3 pulmonary hypertension: a pilot study (2016)
  • Author(s): Sato, T. Tsujino, I. Sugimoto, A. Nakaya, T. Watanabe, T. Ohira, H. Suzuki, M. Konno, S. Oyama-Manabe, N. Nishimura, M.
  • Journal Title: Pulm Circ Volume: 6 Issue: 4 Pages: 524-531
  • DOI: 10.1086/688712
  • NAID: 120006366484
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bi-ventricular interplay in patients with systemic sclerosis-associated pulmonary arterial hypertension: Detection by cardiac magnetic resonance (2016)
  • Author(s): Noguchi, A. Kato, M. Kono, M. Ohmura, K. Ohira, H. Tsujino, I. Oyama-Manabe, N. Oku, K. Bohgaki, T. Horita, T. Yasuda, S. Nishimura, M. Atsumi, T.
  • Journal Title: Mod Rheumatol Volume: - Issue: 3 Pages: 1-8
  • DOI: 10.1080/14397595.2016.1218597
  • NAID: 120006470966
  • Peer Reviewed / Open Access
• [Presentation] 呼吸器疾患に伴うPHのメカニズムと血管拡張薬の意義 (2017)
  • Author(s): 辻野一三
  • Organizer: 第2回肺高血圧・肺循環学会
  • Place of Presentation: ホテル札幌芸文館（札幌市）
  • Year and Date: 2017-06-02
• [Presentation] 肺動脈性肺高血圧症の右室機能・肺動脈連関の評価と臨床的意義 (2017)
  • Author(s): 中谷資隆、辻野一三ほか
  • Organizer: 第2回肺高血圧・肺循環学会
  • Place of Presentation: ホテル札幌芸文館（札幌市）
  • Year and Date: 2017-06-02
• [Presentation] 肺動脈性肺高血圧症におけるCT指標を用いた診断・血行動態評価 (2017)
  • Author(s): 清水薫子、辻野一三ほか
  • Organizer: 第2回肺高血圧・肺循環学会
  • Place of Presentation: ホテル札幌芸文館（札幌市）
  • Year and Date: 2017-06-02
• [Presentation] 肺高血圧における肺拡散能力低下と静脈病変の関連についての検討 (2017)
  • Author(s): 杉本絢子、辻野一三ほか
  • Organizer: 第2回肺高血圧・肺循環学会
  • Place of Presentation: ホテル札幌芸文館（札幌市）
  • Year and Date: 2017-06-02
• [Presentation] 肺高血圧症におけるインスリン抵抗性の上昇とその臨床的意義 (2017)
  • Author(s): 高階知紗、辻野一三ほか
  • Organizer: 第2回肺高血圧・肺循環学会
  • Place of Presentation: ホテル札幌芸文館（札幌市）
  • Year and Date: 2017-06-02
• [Presentation] Utility of computed tomography-derived measurements of (2016)
  • Author(s): Kaoruko Shimizu, Ichizo Tsujino, Hiroshi Ohira, Taku Watanabe, Toshitaka Nakaya, Masaharu Nishimura
  • Organizer: Joint Meeting combining the 1st Asia Oceania Workshop of Pulmonary Functional Imaging (AOWPFI) and the 8th meeting of the Japanese Society of Pulmonary Functional Imaging (JSPFI)
  • Place of Presentation: Awaji, Japan
  • Year and Date: 2016-01-29
  • Int'l Joint Research
• [Presentation] Amelioration of right ventricular morphology and systolic function in patients with severe group 3 pulmonary hypertension treated with pulmonary vasodilators (2015)
  • Author(s): Junichi Nakamura, Ichizo Tsuzino, Takahiro Sato, Hiroshi Ohira, Satoshi Itaya, Chisa Takasina-Goto, Taku Watanabe, Masaru Suzuki, Satoshi Konno, Masaharu Nishimura
  • Organizer: ERS International Congress - Amsterdam 2015
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-09-29
  • Int'l Joint Research
• [Presentation] Increased right ventricular diastolic stiffness and reduced ejection fraction in pulmonary hypertension (2015)
  • Author(s): Toshitaka Nakaya, Ichizo Tsujino, Takahiro Sato, Noriko Oyama-Manabe, Hiroshi Ohira, Masaharu Nishimura
  • Organizer: ERS International Congress - Amsterdam 2015
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-09-29
  • Int'l Joint Research