| Project/Area Number |
26461780
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 千恵次 北海道大学, 保健科学研究院, 教授 (10292012)
納谷 昌直 北海道大学, 大学病院, 講師 (20455637)
玉木 長良 北海道大学, 医学研究科, 特任教授 (30171888)
真鍋 治 北海道大学, 医学研究科, 特任助教 (40443957)
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| Co-Investigator(Renkei-kenkyūsha) |
Kikuchi Yasuka 北海道大学, 医学(系)研究科(研究院), 特任助教 (80783539)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋血流 / 心筋虚血 / 冠動脈 / コンピューター断層撮影 / 機能的狭窄度 / MDCT / 心筋血流定量 |
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| Outline of Final Research Achievements |
By using low-dose dynamic CTP with 320-row multi-detector CT (MDCT), we have developed a comprehensive method to estimate myocardial blood flow derived from CT (MBFCT) and coronary flow reserve derived from CT (CFRCT), validated with 15O-water PET. We also hypothesized that the severity of CAD might inversely correlate with the MBFCT and CFRCT. Quantitative per-patient and per-vessel CFRCT and hyperemic MBFCT assessed with 320-row MDCT, showed a moderately good diagnostic performance for identifying patients with obstructive CAD in a clinical setting. CFRCT and MBFCT are clinically useful for evaluating CAD and may contribute to pathophysiological investigations of CAD.
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