Comprehensive evaluation with 320-row MDCT for coronary artery stenosis
| Project/Area Number |
26461780
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 千恵次 北海道大学, 保健科学研究院, 教授 (10292012)
納谷 昌直 北海道大学, 大学病院, 講師 (20455637)
玉木 長良 北海道大学, 医学研究科, 特任教授 (30171888)
真鍋 治 北海道大学, 医学研究科, 特任助教 (40443957)
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| Co-Investigator(Renkei-kenkyūsha) |
Kikuchi Yasuka 北海道大学, 医学(系)研究科(研究院), 特任助教 (80783539)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋血流 / 心筋虚血 / 冠動脈 / コンピューター断層撮影 / 機能的狭窄度 / MDCT / 心筋血流定量 |
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| Outline of Final Research Achievements |
By using low-dose dynamic CTP with 320-row multi-detector CT (MDCT), we have developed a comprehensive method to estimate myocardial blood flow derived from CT (MBFCT) and coronary flow reserve derived from CT (CFRCT), validated with 15O-water PET. We also hypothesized that the severity of CAD might inversely correlate with the MBFCT and CFRCT. Quantitative per-patient and per-vessel CFRCT and hyperemic MBFCT assessed with 320-row MDCT, showed a moderately good diagnostic performance for identifying patients with obstructive CAD in a clinical setting. CFRCT and MBFCT are clinically useful for evaluating CAD and may contribute to pathophysiological investigations of CAD.
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Report
(4 results)
Research Products
(18 results)
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[Presentation] 心不全の診断2016
Author(s)
真鍋徳子
Organizer
第35回日本画像医学会
Place of Presentation
ステーションコンファレンス東京（東京都千代田区）
Year and Date
2016-02-27
Related Report
Invited
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[Presentation] Evaluation of myocardial heterogeneity in hypertrophic cardiomyopathy with strain encoded MRI2014
Author(s)
Keita Sakamoto, Noriko Oyama-Manabe, Osamu Manabe, Masanao Naya, Hiroyuki Sugimori, Yasuka Kikuchi, Satoshi Yabusaki, Rie Mimura, Fumi Kato, Noriyuki Miyamoto, Kohsuke Kudo, Nagara Tamaki, Hiroki Shirato
Organizer
The 15th Asian Oceanian Congress of Radiology
Place of Presentation
神戸国際展示場（神戸市）
Year and Date
2014-09-24 – 2014-09-28
Related Report
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