Development of CEST-based molecular MR imaging for brain tumors

• Project/Area Number: 26461827
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: TOGAO Osamu 九州大学, 大学病院, 助教 (10452749)
• Co-Investigator(Kenkyū-buntansha): 樋渡 昭雄 九州大学, 大学病院, 助教 (30444855) ; 吉浦 敬 鹿児島大学, 医歯学域医学系, 教授 (40322747) ; 山下 孝二 九州大学, 大学病院, 助教 (80546565) ; 本田 浩 九州大学, 医学研究院, 教授 (90145433)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: MRI / 脳腫瘍 / 神経膠腫 / CESTイメージング / APTイメージング / グリオーマ / 分子イメージング / 神経膠腫3)脳腫瘍の治療効果判定における有用性

Outline of Final Research Achievements

Toward the clinical application of amide proton transfer (APT) imaging of brain tumors, we developed and optimized APT MR imaging sequences on a clinical MR scanner. We developed the parallel transmission based APT imaging and 3D fast spin echo Dixon method. With this sequence, we evaluated the effect of saturation pulse length on the APT contrast of brain tumors and found that APT contrast of glioma was increased with the length of saturation pulse. APT signal was increased with WHO grade of glioma. APT imaging showed better diagnostic performance in differentiating high-grade from low-grade gliomas compared to contrast enhanced imaging, diffusion-weighted imaging, and perfusion weighted imaging. APT imaging could be a non-invasive clinical tool for assessing brain tumors.

Research Products

• [Journal Article] Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging (2017)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Keupp J, Yoshimoto K, Kuga D, Yoneyama M, Suzuki SO, Iwaki T, Takahashi M, Iihara K, Honda H
  • Journal Title: Eur Radiol Volume: 27(2) Issue: 2 Pages: 578-588
  • DOI: 10.1007/s00330-016-4328-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Amide proton transfer imaging of brain tumors using a self-corrected 3D fast spin-echo Dixon method: Comparison with separate B0 correction (2017)
  • Author(s): Togao O, Keupp J, Hiwatashi A, Yamashita K, Kikuchi K, Yoneyama M, Honda H
  • Journal Title: Magn Reson Med Volume: 印刷中 Issue: 6 Pages: 2272-2279
  • DOI: 10.1002/mrm.26322
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glycosaminoglycan chemical exchange saturation transfer in human lumbar intervertebral discs: Effect of saturation pulse and relationship with low back pain (2017)
  • Author(s): Wada T, Togao O, Tokunaga C, Funatsu R, Yamashita Y, Kobayashi K, Nakamura Y, Honda H
  • Journal Title: J Magn Reson Imaging Volume: 45(3) Issue: 3 Pages: 863-871
  • DOI: 10.1002/jmri.25397
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores (2016)
  • Author(s): Takayama Y, Nishie A, Sugimoto M, Togao O, Asayama Y, Ishigami K, Ushijima Y, Okamoto D, Fujita N, Yokomizo A, Keupp J, Honda H
  • Journal Title: MAGMA Volume: 29(4) Issue: 4 Pages: 671-679
  • DOI: 10.1007/s10334-016-0537-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Amide Proton Transfer Imaging of Diffuse Gliomas: Effect of Saturation Pulse Length in Parallel Transmission-Based Technique (2016)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Yoneyama M, Kruiskamp MJ, Sagiyama K, Takahashi M, Honda H
  • Journal Title: PLoS One Volume: 11(5) Issue: 5 Pages: e0155925-e0155925
  • DOI: 10.1371/journal.pone.0155925
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of the saturation pulse duration on chemical exchange saturation transfer in amide proton transfer MR imaging: a phantom study. (2016)
  • Author(s): Wada T, Togao O, Tokunaga C, Funatsu R, Kobayashi K, Nakamura Y.
  • Journal Title: Radiol Phys Technol. Volume: 9 Issue: 1 Pages: 15-21
  • DOI: 10.1007/s12194-015-0326-1
  • Peer Reviewed
• [Journal Article] Differentiation of high-grade and low-grade diffuse gliomas by intravoxel incoherent motion MR imaging. (2016)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Mizoguchi M, Yoshimoto K, Suzuki SO, Iwaki T, Obara M, Van Cauteren M, Honda H.
  • Journal Title: Neuro Oncol. Volume: 18 Issue: 1 Pages: 132-141
  • DOI: 10.1093/neuonc/nov147
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. (2016)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Keupp J, Yoshimoto K, Kuga D, Yoneyama M, Suzuki SO, Iwaki T, Takahashi M, Iihara K, Honda H.
  • Journal Title: Eur Radiol. Volume: NA
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors (2015)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Suzuki Y, Kruiskamp MJ, SagiyamaK, Takahashi M, Honda H
  • Journal Title: J Magn Reson Imaging Volume: 未定 Issue: 5 Pages: 1346-1353
  • DOI: 10.1002/jmri.24895
  • Peer Reviewed
• [Journal Article] Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors. (2015)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Suzuki Y, Kruiskamp MJ, Sagiyama K, Takahashi M, Honda H.
  • Journal Title: J Magn Reson Imaging. Volume: NA
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effect of the saturation pulse duration on chemical exchange saturation transfer in amide proton transfer MR imaging: a phantom study (2015)
  • Author(s): Wada T, Togao O, Tokunaga C, Funatsu R, Kobayashi K. Nakamura Y.
  • Journal Title: Radiol Phys Technol. Volume: NA
  • Peer Reviewed
• [Journal Article] Amide Proton Transfer（APT）イメージング (2014)
  • Author(s): 栂尾 理，樋渡 昭雄，山下 孝二，菊地 一史，本田 浩
  • Journal Title: 日獨医報 Volume: 59 Pages: 124-137
• [Presentation] Clinical application of CEST/APT Imaging (2017)
  • Author(s): 栂尾 理
  • Organizer: Neuro MR Expert Meeting
  • Place of Presentation: 東京都
  • Invited
• [Presentation] Clinical application of CEST/APT Imaging (2016)
  • Author(s): Togao O
  • Organizer: 第44回日本磁気共鳴医学会大会 KSMRM Joint Session
  • Place of Presentation: 大宮市
  • Year and Date: 2016-09-09
  • Invited
• [Presentation] Amide proton transfer (APT) imaging of brain tumors using a self-corrected 3D fast spin-echo Dixon method: comparison with separate B0 mapping (2016)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoneyama M, Honda H.
  • Organizer: 24th Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Philips ISMRM 2016 Gold Corporate Lunch Symposium: Advanced MR Sequences for Clinical Neuroradiology (2016)
  • Author(s): 栂尾 理
  • Organizer: 24th Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research / Invited
• [Presentation] 脳神経MRIのトピックス：脳腫瘍, 血管, 神経イメージング (2016)
  • Author(s): 栂尾 理
  • Organizer: 第100回 MR研究会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 3D fast spin-echo Dixon法を用いた脳腫瘍のamide proton transfer(APT)イメージング (2015)
  • Author(s): 栂尾 理、樋渡昭雄、山下孝二、菊地一史、鈴木 由里子、Jochen Keupp、本田 浩
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京都
  • Year and Date: 2015-09-10
• [Presentation] Assessment of glycosaminoglycan content in lumbar intervertebral discs with chemical exchange saturation transfer imaging: comparison with T1-rho measurement (2015)
  • Author(s): Togao O, Hiwatashi A, Wada T, Yamashita K, Kikuchi K, Tokunaga C, Suzuki Y, Keupp J, Honda H.
  • Organizer: 23rd Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Differentiation of High-grade and Low-grade Diffuse Gliomas by Intravoxel Incoherent Motion MRI (2015)
  • Author(s): Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Van Cauteren M, Honda H.
  • Organizer: 23rd Scientific Meeting and Exhibition, International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Intravoxel incoherent motion MRIによる低悪性と高悪性度神経膠腫の鑑別 (2015)
  • Author(s): 栂尾 理、樋渡昭雄、山下孝二、菊地一史、本田 浩
  • Organizer: 第74回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-04-16
• [Presentation] Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors. (2014)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Suzuki Y, Sagiyama K, Takahashi M, Honda H.
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milano, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Amide Proton Transferにおける飽和パルスの印加時間がCEST効果に及ぼす影響 (2014)
  • Author(s): 和田達弘、栂尾 理、他
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2014-04-10 – 2014-04-13
• [Book] 臨床画像 (2015)
  • Author(s): 栂尾 理、樋渡 昭雄、山下 孝二、菊地 一史、吉浦 敬、鈴木 由里子、Jochen Keupp、本田 浩
  • Total Pages: 9
  • Publisher: メジカルビュー社
• [Book] CEST - CESTイメージングの臨床応用とその課題 (2014)
  • Author(s): 栂尾 理，樋渡 昭雄，山下 孝二，菊地 一史，本田 浩, 吉浦 敬, 鈴木 由里子, Jochen Keupp
  • Total Pages: 5
  • Publisher: インナービジョン株式会社