| Project/Area Number |
26462461
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SATO Youichi 徳島大学, 大学院医歯薬学研究部(薬学系), 准教授 (10363160)
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| Co-Investigator(Kenkyū-buntansha) |
山内 あい子 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 (30122253)
井本 逸勢 (井本 逸勢(橘逸勢)) 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (30258610)
岩本 晃明 国際医療福祉大学, 大学病院, 教授 (60046117)
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| Co-Investigator(Renkei-kenkyūsha) |
TAJIMA Atsushi 金沢大学, 医薬保健研究域医学系, 教授 (10396864)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 男性不妊症 / 精子濃度 / 次世代シーケンサー / GWAS / アンドロロジー / 男性不妊 |
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| Outline of Final Research Achievements |
To identify novel causative genes of male infertility, we searched for genes related to semen parameters using men from the general population and fertile men. And we tried to search for risk loci for azoospermia using azoospermic patients and their families. We identified a locus associated with sperm motility by genome-wide association studies. And we identified candidate genes responsible for the risk of azoospermia using whole-exome sequencing of families. Moreover, we identified several SNPs significantly associated with male infertility.
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