Functional analysis of placenta-specific mRNA/microRNA and their clinical application

• Project/Area Number: 26462495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagasaki University
• Principal Investigator: MIURA Kiyonori 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 胎盤 / 胎児 / mRNA / microRNA / 胎盤機能 / 分子マーカー / 母体血漿 / 産科疾患 / 産婦人科 / C19MC / 基準値 / トランスクリプト－ム / C14MC

Outline of Final Research Achievements

In this study, placenta-specific miRNAs were clearly detected in mesenchymal stem cells (MSC) from fetal part of placental tissues, suggesting that primarily expanded MSCs may serve as useful tools for uncovering the molecular mechanism on pregnant disorders. Subsequently, by transfection of chorionic villi (CV)-MSCs with the miR-518b mimic, some miR-518b target genes were previously demonstrated to associate with preeclampsia. In addition, we could construct the reference values for circulating C19MC pregnancy-associated miRNAs in maternal plasma throughout pregnancy, and confirm their possibility of clinical significance in obstetric management. Finally, circulating level of placenta-specific microRNAs in maternal plasma were associated with pregnancy-associated disorders and abnormal pregnancy, suggesting that plasma concentrations of placenta-specific microRNAs may be potential biomarkers to predict and/or estimate the abnormal conditions of pregnancy.

Research Products

• [Journal Article] Fetiform teratoma was a parthenogenetic tumour arising from a mature ovum (2017)
  • Author(s): Miura K, Kurabayashi T, Satoh C, Sasaki K, Ishiguro T, Yoshiura KI and Masuzaki H
  • Journal Title: Journal of Human Genetics Volume: 印刷中 Issue: 9 Pages: 803-808
  • DOI: 10.1038/jhg.2017.45
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders (2017)
  • Author(s): Fuchi N, Miura K, Doi H, Li TS, Masuzaki H
  • Journal Title: Scientific Reports Volume: － Issue: 1 Pages: 46220-46220
  • DOI: 10.1038/srep46220
  • NAID: 120006987524
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Circulating levels of pregnancy-associated, placenta-specific microRNAs in pregnant women with placental abruption (2017)
  • Author(s): Miura K, Higashijima A, Murakami Y, Fuchi N, Tsukamoto O, Abe S, Hasegawa Y, Miura S, Masuzaki H
  • Journal Title: Reproductive Science Volume: 24 Pages: 148-155
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Factors affecting parental decisions to terminate pregnancy in the presence of chromosome abnormalities: a Japanese multicenter study (2016)
  • Author(s): Nishiyama M, Sekizawa A, Ogawa K, Sawai H, Nakamura H, Samura O, Suzumori N, Nakayama S, Yamada T, Ogawa M, Katagiri Y, Murotsuki J, Okamoto Y, Namba A, Hamanoue H, Ogawa M, Miura K, Izumi S, Kamei Y, Sago H
  • Journal Title: Prenatal Diagnosis Volume: 36 Issue: 12 Pages: 1121-1126
  • DOI: 10.1002/pd.4947
  • Peer Reviewed
• [Journal Article] A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan. (2016)
  • Author(s): Yotsumoto J, Sekizawa A, Suzumori N, Yamada T, Katagiri Y, Takeshita N, Ogawa M, Okai T, Izumi S, Hamanoue H, Inuzuka M, Haino K, Hamajima N, Nishizawa H, Okamoto Y, Nakamura H, Kanagawa T, 他28名; Japan NIPT Consortium.
  • Journal Title: J Hum Genet. Volume: 61 Issue: 12 Pages: 995-1001
  • DOI: 10.1038/jhg.2016.96
  • Peer Reviewed
• [Journal Article] A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population. (2016)
  • Author(s): Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe S, Higashijima A, Fuchi N, Miura S, Yoshiura KI, Masuzaki H.
  • Journal Title: J Hum Genet. Volume: 61(9) Issue: 9 Pages: 793-796
  • DOI: 10.1038/jhg.2016.50
  • NAID: 40020938176
  • Peer Reviewed
• [Journal Article] Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy 18 (2016)
  • Author(s): N. Suzumori, T. Ebara, T. Yamada, O. Samura O, J. Yotsumoto, M. Nishiyama, K. Miura K, H. Sawai H, J. Murotsuki J, M. Kitagawa M, Y. Kamei Y, H. Masuzaki, F. Hirahara F, JS. Saldivar , N. Dharajiya, H. Sago, A. Sekizawa A; Japan NIPT Consortium, H. Masuyama,
  • Journal Title: J Hum Genet Volume: 印刷中 Issue: 7 Pages: 647-652
  • DOI: 10.1038/jhg.2016.25
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Survey of prenatal testing for genetic disorders in Japan: Recent report (2016)
  • Author(s): Nobuzane T, Yamada T, Miura K, Sawai H, Masuzaki H, Kudo Y
  • Journal Title: The Journal of Obstetrics and Gynaecology Research Volume: 42 Issue: 4 Pages: 375-379
  • DOI: 10.1111/jog.12948
  • Peer Reviewed
• [Journal Article] Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier (2016)
  • Author(s): Fuchi N, Miura K, Imaizumi Y, Hasegawa H, Yanagihara K, Miyazaki Y, Masuzaki H
  • Journal Title: The Journal of Obstetrics and Gynaecology Research Volume: 42 Issue: 3 Pages: 336-340
  • DOI: 10.1111/jog.12904
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan (2016)
  • Author(s): Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K
  • Journal Title: Early Human Development Volume: 92 Pages: 33-36
  • DOI: 10.1016/j.earlhumdev.2015.10.022
  • Peer Reviewed
• [Journal Article] Estrogen deficiency heterogeneously affects tissue specific stem cells in mice. (2015)
  • Author(s): Kitajima Y, Doi H, Ono Y, Urata Y, Goto S, Kitajima M, Miura K, Li TS, Masuzaki H.
  • Journal Title: Sci Rep. 2015 Aug 6;5:12861 Volume: 5 Issue: 1 Pages: 12861-12861
  • DOI: 10.1038/srep12861
  • NAID: 120006986975
  • Peer Reviewed
• [Journal Article] Increased levels of cell-free miR-517a and decreased levels of cell-free miR-518b in maternal plasma samples from placenta previa pregnancies at 32 weeks gestation (2015)
  • Author(s): Hasegawa Y, Miura K, Higashijima A, Abe S, Miura S, Yoshiura KI, Masuzaki H
  • Journal Title: Reproductive Sciences Volume: 22 Issue: 12 Pages: 1569-1576
  • DOI: 10.1177/1933719115589407
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Circulating levels of C19MC-cluster microRNAs in pregnant women with severe pre-eclampsia. (2015)
  • Author(s): Miura K, Higashijima A, Murakami Y, Tsukamoto O, Hasegawa Y, Abe S, Naoki Fuchi N, Miura S, Kaneuchi M, Masuzaki H
  • Journal Title: The Journal of Obstetrics and Gynaecology Research Volume: 41 Issue: 10 Pages: 1526-1532
  • DOI: 10.1111/jog.12749
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pregnancy-associated microRNAs in plasma as potential molecular markers of ectopic pregnancy (2015)
  • Author(s): Miura K, Higashijima A, Mishima H, Miura S, Kitajima M, Kaneuchi M, Yoshiura K, Masuzaki H
  • Journal Title: Fertility and Sterility Volume: 印刷中 Issue: 5 Pages: 1202-1208
  • DOI: 10.1016/j.fertnstert.2015.01.041
  • Peer Reviewed
• [Journal Article] Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight. (2015)
  • Author(s): Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Fuchi N, Murakami Y, Kinoshita A, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H.
  • Journal Title: Prenatal Diagnosis Volume: 35 Issue: 5 Pages: 509-511
  • DOI: 10.1002/pd.4509
  • Peer Reviewed
• [Journal Article] Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs (2015)
  • Author(s): Morisaki S, Miura K, Higashijima A, Abe S, Miura S, Hasegawa Y, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H
  • Journal Title: Prenat Diagn Volume: 35 Issue: 1 Pages: 44-50
  • DOI: 10.1002/pd.4479
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Circulating levels of C19MC-cluster microRNAs in pregnant women with severe pre-eclampsia (2015)
  • Author(s): Miura K, Higashijima A, Murakami Y, Tsukamoto O, Hasegawa Y, Abe S, Naoki Fuchi N, Miura S, Kaneuchi M, Masuzaki H
  • Journal Title: The Journal of Obstetrics and Gynaecology Research Volume: 99 Pages: 9999-9999
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical applications of analysis of plasma circulating complete hydatidiform mole pregnancy-associated miRNAs in gestational trophoblastic neoplasia: A preliminary investigation. (2014)
  • Author(s): Miura K, Hasegawa Y, Abe S, Higashijima A, Miura S, Mishima H, Kinoshita A, Kaneuchi M, Yoshiura K, Masuzaki H.
  • Journal Title: Placenta Volume: 35 (9) Issue: 9 Pages: 787-789
  • DOI: 10.1016/j.placenta.2014.06.004
  • Peer Reviewed
• [Journal Article] Circulating levels of maternal plasma cell-free pregnancy-associated placenta-specific microRNAs are associated with placental weight. (2014)
  • Author(s): Miura K, Morisaki S, Abe S, Higashijima A, Hasegawa Y, Miura S, Tateishi S, Mishima H, Yoshiura K, Masuzaki H.
  • Journal Title: placenta Volume: 35 (10) Issue: 10 Pages: 848-851
  • DOI: 10.1016/j.placenta.2014.06.002
  • Peer Reviewed
• [Journal Article] Genome-wide association study of HPV-associated cervical cancer in Japanese women. (2014)
  • Author(s): Miura K, Mishima H, Kinoshita A, Hayashida C, Abe S, Tokunaga K, Masuzaki H, Yoshiura KI.
  • Journal Title: Journal of Medical Virology Volume: 86 (7) Issue: 7 Pages: 1153-1158
  • DOI: 10.1002/jmv.23943
  • Peer Reviewed
• [Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US. (2014)
  • Author(s): Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H.
  • Journal Title: Journal of Human Genetics Volume: 59 (5) Issue: 5 Pages: 251-255
  • DOI: 10.1038/jhg.2014.9
  • Peer Reviewed
• [Journal Article] Identification of endometrioid endometrial carcinoma-associated microRNAs in tissue and plasma. (2014)
  • Author(s): Tsukamoto O, Miura K, Mishima H, Abe S, Kaneuchi M, Higashijima A, Miura S, Kinoshita A, Yoshiura K, Masuzaki H.
  • Journal Title: Gynecologic Oncology Volume: 132 (3) Issue: 3 Pages: 715-721
  • DOI: 10.1016/j.ygyno.2014.01.029
  • Peer Reviewed
• [Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome (2014)
  • Author(s): Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura KI, Masuzaki H.
  • Journal Title: Prenatal Diagnosis Volume: 34 Issue: 4 Pages: 345-349
  • DOI: 10.1002/pd.4307
  • Peer Reviewed
• [Journal Article] Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition (2014)
  • Author(s): Minakami, H. Maeda, T. Fujii, T. Hamada, H. Iitsuka, Y. Itakura, A. Itoh, H. Iwashita, M. Kanagawa, T., et al.
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 6 Pages: 1469-1499
  • DOI: 10.1111/jog.12419
  • Peer Reviewed
• [Journal Article] Placental mesenchymal dysplasia differentially diagnosed from molar pregnancy by 3-D inversion mode rendering: A case report (2014)
  • Author(s): Minekawa-Mehandjiev R, Masuda K, Yamamoto K, Miura K, Nakayama M, Murata Y
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 1 Pages: 284-287
  • DOI: 10.1111/jog.12152
  • Peer Reviewed
• [Journal Article] 母体血を用いた胎児診断 (2014)
  • Author(s): 三浦清徳、増崎英明
  • Journal Title: 日本産婦人科・新生児血液学会誌 Volume: 23 Pages: 9-18
  • Peer Reviewed
• [Journal Article] アレイCGHを用いた胎児診断 (2014)
  • Author(s): 三浦清徳
  • Journal Title: 日本医師会誌 Volume: 143 Pages: 1164-1165
  • Peer Reviewed
• [Journal Article] 出生前診断としての染色体検査・遺伝子検査の実施上の留意点 (2014)
  • Author(s): 三浦清徳, 増﨑英明
  • Journal Title: 臨床婦人科産科 Volume: 68 Pages: 763-770
  • Peer Reviewed
• [Journal Article] クリニカルカンファランス13（周産期）1.胎児発育・形態評価 (2014)
  • Author(s): 三浦清徳
  • Journal Title: 日本産科婦人科学会誌 Volume: 66 Pages: 2167-2171
  • Peer Reviewed
• [Presentation] 日本人における子宮頸がん関連遺伝子多型の関与に関する検討 (2016)
  • Author(s): 三浦清徳、金内優典、阿部修平、吉浦孝一郎、増崎英明
  • Organizer: 第58回日本婦人科腫瘍学会
  • Place of Presentation: 米子コンベンションセンター、鳥取県米子市
  • Year and Date: 2016-07-08
• [Presentation] HTLV-1母子感染防止対策 (2016)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第26回日本産婦人科・新生児血液学会
  • Place of Presentation: 長崎大学医学部良順会館、長崎県長崎市
  • Year and Date: 2016-07-01
  • Invited
• [Presentation] Uniparental disomy analysis in trios using genome-wide SNP array and whole-genome sequencing data imply the segmental uniparental isodisomy in general populations (2016)
  • Author(s): Miura K, Yoshiura KI, Masuzaki H
  • Organizer: 第68回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム、東京都千代田区
  • Year and Date: 2016-04-21
• [Presentation] 胎児画像診断は，胎児の表現型をどこまで捉えるのか (2016)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第40回日本遺伝カウンセリング学会
  • Place of Presentation: 京都国際会議場、京都府京都市
  • Year and Date: 2016-04-03
  • Invited
• [Presentation] 出生前診断 (2015)
  • Author(s): 三浦清徳
  • Organizer: 第115回九州医師会医学会 第3分科会
  • Place of Presentation: 長崎県医師会館、長崎
  • Year and Date: 2015-11-15
  • Invited
• [Presentation] 胎盤特異的microRNAの同定とその臨床的意義 (2015)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第23回日本胎盤学会学術集会
  • Place of Presentation: JA共済ビルカンファレンスホール、東京
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] Pregnancy-associated microRNAs in plasma as potential molecular markers of ectopic pregnancy (2015)
  • Author(s): Kiyonori Miura, Ai Higashijima , Yuri Hasegawa, Shoko Miura, Atsushi Yoshida, Masanori Kaneuchi, and Hideaki Masuzaki
  • Organizer: The 19th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] 出生前遺伝学的検査 (2015)
  • Author(s): 三浦清徳、増﨑英明
  • Organizer: 第51回日本周産期・新生児医学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク、福岡
  • Year and Date: 2015-07-10
  • Invited
• [Presentation] 日本におけるNIPTの現状 (2015)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第62回日本小児保健協会学術集会
  • Place of Presentation: 長崎ブリックホール、長崎
  • Year and Date: 2015-06-18
  • Invited
• [Presentation] 出生前診断の何が問題か？ (2014)
  • Author(s): 三浦清徳
  • Organizer: 第59回日本人類遺伝学会
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2014-11-19 – 2014-11-22
  • Invited
• [Presentation] 母体血漿中への妊娠関連胎盤特異的microRNAの流入量および分娩後の消失速度と陣痛との関連について (2014)
  • Author(s): 森崎慎太郎、三浦清徳、東島 愛、阿部修平、三浦生子、長谷川ゆり、吉田 敦、金内優典、吉浦孝一郎、増崎英明
  • Organizer: 第59回日本人類遺伝学会
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 母体血と比較して胎児血で高発現するmicro RNAの同定 (2014)
  • Author(s): 東島愛、三浦清徳、三島博之、木下晃、塚本大空、阿部修平、長谷川ゆり、吉田 敦、吉浦孝一郎、増崎英明
  • Organizer: 第59回日本人類遺伝学会
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 母体血漿中miR-517aおよびmiR518bは前置胎盤に対する帝王切開の出血量に関連する (2014)
  • Author(s): 長谷川ゆり、三浦清徳、東島 愛、阿部修平、三浦生子、吉田 敦、金内優典、吉浦孝一郎、増崎英明
  • Organizer: 第59回日本人類遺伝学会
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 母体血漿中cell-free microRNA流入量と母体のbody mass indexおよび新生児出生体重との関連 (2014)
  • Author(s): 淵 直樹、三浦清徳、東島 愛、長谷川ゆり、阿部修平、三浦生子、村上優子、三嶋博之、木下 晃、金内優典、吉浦孝一郎、増崎英明
  • Organizer: 第59回日本人類遺伝学会
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 双胎間輸血症候群発症予測における母体血漿中胎盤特異的cell-free mRNAの有用性に関する検討 (2014)
  • Author(s): 村上優子、三浦清徳、東島 愛、長谷川ゆり、阿部修平、三浦生子、三嶋博之、木下 晃、金内優典、吉浦孝一郎、増崎英明
  • Organizer: 第59回日本人類遺伝学会
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 診断できる疾患できない疾患 (2014)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第37回日本母体胎児医学会
  • Place of Presentation: 長崎ハウステンボス、長崎
  • Year and Date: 2014-11-07 – 2014-11-08
  • Invited
• [Presentation] 長崎県におけるHTLV-1キャリア妊婦が選択した栄養法の年次推移と医療者に対する啓発活動の重要性に関する調査 (2014)
  • Author(s): 三浦清徳、築山尚史、淵直樹、三浦生子、増崎英明
  • Organizer: 第29回日本女性医学医学会学術集会
  • Place of Presentation: 都市センターホテル、東京
  • Year and Date: 2014-11-01 – 2014-11-02
• [Presentation] 腹腔鏡手術で診断された原発性卵管癌の一例 (2014)
  • Author(s): 三浦清徳、松本亜由美、渕 直樹、金内優典、増崎英明
  • Organizer: 第27回日本内視鏡外科学会総会
  • Place of Presentation: マリオス:盛岡地域交流センター、岩手
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] 腹腔鏡下手術で摘出した卵巣成熟嚢胞性奇形腫に卵巣カルチノイドを認めた一例 (2014)
  • Author(s): 三浦清徳、松本亜由美、高野 玲、淵 直樹、増崎英明
  • Organizer: 第54回日本産科婦人科内視鏡学会
  • Place of Presentation: 城山観光ホテル、鹿児島
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 妊婦HTLV-1スクリーニングの母子感染予防効果に関する検討 (2014)
  • Author(s): 淵 直樹、三浦清徳、築山尚史、上平 憲、長谷川寛雄、柳原克紀、森内浩幸、吉浦孝一郎、増崎英明
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京大学医科学研究所1号館講堂、東京
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] Microarray screening of amniotic fluid-specific genes in maternal plasma (2014)
  • Author(s): Miura K, Higashijima A, Hasegawa Y, Miura S, Yoshiura KI, Masuzaki H
  • Organizer: 18th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Brisbene, Australia
  • Year and Date: 2014-07-20 – 2014-07-23
• [Presentation] 存続絨毛症における胞状奇胎特異的microRNAの臨床的有用性に関する検討 (2014)
  • Author(s): 三浦清徳、長谷川ゆり、阿部修平、金内優典、増﨑英明
  • Organizer: 第56回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 栃木県総合文化センター、栃木
  • Year and Date: 2014-07-17 – 2014-07-19
• [Presentation] HTLV-1キャリア妊婦末梢血中および出生児臍帯血中のHTLV-1プロウイルス量およびHTLV-1抗体に関する検討 (2014)
  • Author(s): 築山尚史、三浦清徳、淵直樹、森内浩幸、増崎英明
  • Organizer: 第50回日本周産期新生児学会学術集会
  • Place of Presentation: シェラトン・グランデ・トーキョーベイホテル,千葉
  • Year and Date: 2014-07-13 – 2014-07-15
• [Presentation] 切迫早産治療中に無顆粒球症を発症した1例 (2014)
  • Author(s): 宮崎恭子、河野通晴、阿部修平、谷口 憲、三浦清徳、増崎英明
  • Organizer: 第24回日本産婦人科・新生児血液学会
  • Place of Presentation: ワークピア横浜、神奈川
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] 妊婦HTLV-1スクリーニング～長崎県における27年間の取り組みとその成果 (2014)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第31回日本産婦人科感染症研究会学術集会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2014-06-07 – 2014-06-08
  • Invited
• [Presentation] 出生前遺伝学的検査と超音波検査 (2014)
  • Author(s): 三浦清徳、増崎英明
  • Organizer: 第87回日本超音波医学会学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2014-05-09 – 2014-05-11
  • Invited
• [Presentation] 生涯研修プログラム クリニカルカンファレンス13（周産期） 1.胎児発育・形態評価 (2014)
  • Author(s): 三浦清徳
  • Organizer: 第66回日本産婦人科学会学術講演会
  • Place of Presentation: 東京フォーラム、東京
  • Year and Date: 2014-04-18 – 2014-04-20
  • Invited
• [Remarks] 長崎大学医学部産婦人科
  • URL: http://www.med.nagasaki-u.ac.jp/gyneclgy/
• [Remarks] 長崎大学病院産婦人科
  • URL: http://www.med.nagasaki-u.ac.jp/gyneclgy/