Prediction of primary treatment outcome and prognosis by viral infection and tumor activity in head and neck cancer

• Project/Area Number: 26462610
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: Suzuki Mikio 琉球大学, 医学(系)研究科(研究院), 教授 (00226557)
• Co-Investigator(Kenkyū-buntansha): 上原 貴行 琉球大学, 医学部附属病院, 助教 (00644402) ; 真栄田 裕行 琉球大学, 医学(系)研究科(研究院), 准教授 (40264501) ; Deng Zeyi (DENG Zeyi) 琉球大学, 医学(系)研究科(研究院), 外国人客員研究員 (50723863)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 頭頸部癌 / ウイルス感染 / 生物学的活性 / 生活習慣 / 予後 / ヒト乳頭腫ウイルス / Epstein-Bar ウイルス / Epstein-Barr ウイルス

Outline of Final Research Achievements

Both of p16 immunohistochemistry and PCR for detecton of HPV-DNA/HPV insitu hybridization are needed to determine human papillomavirus (HPV)-related cancer. EB virus infection was only noted in nasopharyngeal cancer of various head and neck cancers. Metabolic tumor volume in PET study was related to prognosis of oropharyngeal cancer in treatment of concurrent chemoradiotherapy. Of various causes, laryngeal cancer was affected by smoking habit, and hypopharyngeal cancer by alcohol intake. De-escalation study about HPV-related cancer is now underway for patients with oropharyngeal cancer.

Research Products

• [Journal Article] Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma (2016)
  • Author(s): 3.Hirakawa H, Hanai N, Ozawa T, Suzuki H, Nishikawa D, Matayoshi S, Suzuki M, Hasegawa Y
  • Journal Title: Head Neck Volume: 38 Issue: S1
  • DOI: 10.1002/hed.24217
  • Peer Reviewed
• [Journal Article] 喉頭乳頭腫におけるヒト乳頭腫ウイルス感染と臨床経過 (2016)
  • Author(s): 喜友名朝則、喜瀬乗基、真栄田裕行、又吉 宣、比嘉麻乃、鈴木幹男
  • Journal Title: 喉頭 Volume: 28 Pages: 24-30
  • NAID: 130005249916
  • Peer Reviewed
• [Journal Article] 頭頸部癌の診断と治療 (2016)
  • Author(s): 鈴木幹男
  • Journal Title: 沖縄県医師会報 Volume: 52 Pages: 804-809
• [Journal Article] 【中咽頭癌-HPVの視点からみた大きな変化】 疫学と病態 中咽頭癌と子宮頸癌のHPVの違いは? (2016)
  • Author(s): 鈴木幹男、上原貴行
  • Journal Title: JOHNS Volume: 32 Pages: 287-292
• [Journal Article] 当科における下咽頭・頸部食道癌治療の妥当性に関する検討 (2015)
  • Author(s): 真栄田裕行，杉田早知子，喜瀬乗基，喜友名朝則，鈴木幹男
  • Journal Title: 口腔・咽頭科 Volume: 28 Pages: 165-170
  • NAID: 130005438167
  • Peer Reviewed
• [Journal Article] 頭頸部癌に対する姑息的照射治療 (2015)
  • Author(s): 上原貴行，真栄田裕行，山下懐，長谷川昌宏，安慶名信也，鈴木幹男
  • Journal Title: 耳鼻咽喉科臨床 Volume: 108 Pages: 475-481
  • NAID: 130005072171
  • Peer Reviewed
• [Journal Article] 喉頭癌の発症要因 (2015)
  • Author(s): 鈴木幹男
  • Journal Title: JOHNS Volume: 31 Pages: 405-408
• [Journal Article] Is there a higher prevalence of human papillomavirus infection in Chinese laryngeal cancer patients? A systematic review and meta-analysis. (2014)
  • Author(s): Zhang C, Deng Z, Chen Y, Suzuki M, Xie M.
  • Journal Title: European Archives of Otorhinolaryngology Volume: epub Issue: 2 Pages: 295-303
  • DOI: 10.1007/s00405-014-3345-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epstein-Barr virus and human papillomavirus infections and genotype distribution in head and neck cancers (2014)
  • Author(s): Deng, Suzuki et al
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e113702-e113702
  • DOI: 10.1371/journal.pone.0113702
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prediction of concurrent chemoradiotherapy outcome in advanced oropharyngeal cancer. (2014)
  • Author(s): Hasegawa M, Maeda H, Deng Z, Kiyuna A, Ganaha A, Yamashita Y, Matayoshi S, Agena S, Toita T, Uehara T, Suzuki M.
  • Journal Title: Int J Oncol Volume: 45 Issue: 3 Pages: 1017-26
  • DOI: 10.3892/ijo.2014.2504
  • Peer Reviewed / Open Access
• [Journal Article] A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous cell carcinoma. (2014)
  • Author(s): Deng Z, Suzuki M, et al
  • Journal Title: Int J Oncol Volume: 45 Issue: 1 Pages: 67-76
  • DOI: 10.3892/ijo.2014.2440
  • Peer Reviewed / Open Access
• [Journal Article] 鼻副鼻腔腫瘍の診断と病理 (2014)
  • Author(s): 鈴木幹男
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 117 Pages: 1212-1215
  • NAID: 130004696910
• [Journal Article] ヒト乳頭腫ウイルス感染の現状と新しい展開 (2014)
  • Author(s): 鈴木幹男
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 117 Pages: 769-774
  • NAID: 130003373053
• [Presentation] Branchiogenic carcinoma with high-risk type human papillomavirus infection (2016)
  • Author(s): Suzuki, M, et al
  • Organizer: Eurogin 2016
  • Place of Presentation: Salzburg, Austria
  • Year and Date: 2016-06-15
  • Int'l Joint Research
• [Presentation] Clinical importance of HPV testing in advanced oropharyngeal carncer (2016)
  • Author(s): Suzuki M, et al
  • Organizer: 16th Japan-Korea Joint Meeting of Otorhinolaryngology, Head and Neck Surgery
  • Place of Presentation: ハイアットリージェンシー東京，新宿区，東京都
  • Year and Date: 2016-03-28
  • Int'l Joint Research / Invited
• [Presentation] HPV-related head and neck cancer (2016)
  • Author(s): Suzuki, M, et al
  • Organizer: 10th Anniversary Symposium of the Otolaryngology-Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
  • Int'l Joint Research / Invited
• [Presentation] 頭頸部癌におけるＥｐｓｔｅｉｎ－Ｂａｒｒウイルスとヒト乳頭腫ウイルス感染と治療予後について (2015)
  • Author(s): 鈴木幹男，他
  • Organizer: 日本癌治療学会
  • Place of Presentation: 京都（国立京都国際会議場・グランドプリンスホテル京都
  • Year and Date: 2015-10-29
• [Presentation] Prediction of concurrent chemoradiotherapy effect in advanced oropharngeal cancer (2015)
  • Author(s): Mikio Suzuki
  • Organizer: 13th Asia-Oceania ORL-HNS Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-03-19 – 2015-03-22
• [Presentation] HPV (+) and/or p16INK4a overexpression vs HPV (-) and/or p16INK4a non-overexpression for the prognosis of HNSCC (2014)
  • Author(s): Mikio Suzuki
  • Organizer: IFHNOS 2014
  • Place of Presentation: New York, USA
  • Year and Date: 2014-07-27 – 2014-07-30
• [Remarks] https://ent-ryukyu.jp/results.html
• [Remarks] 琉球大学医学部耳鼻咽喉科業績
  • URL: http://ent-ryukyu.jp/results.html
• [Remarks] 研究紹介
  • URL: http://ent-ryukyu.jp/research.html
• [Remarks] 業績
  • URL: http://ent-ryukyu.jp/results.html