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Elucidation of effectiveness of early vitrectomy and onset mechanism of epiretinal membrane

Research Project

Project/Area Number 26462649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNihon University

Principal Investigator

NAKASHIZUKA Hiroyuki  日本大学, 医学部, 准教授 (10372997)

Co-Investigator(Kenkyū-buntansha) 藤田 京子  日本大学, 医学部, 助教 (30297824)
島田 宏之  日本大学, 医学部, 教授 (40162680)
山本 篤志  日本大学, 医学部, 助教 (00738213)
Research Collaborator KINUKAWA Noriko  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords黄斑上膜 / 変視症 / 不等像視 / 大視症 / 中心窩網膜厚 / 視力 / 硝子体手術
Outline of Final Research Achievements

We performed a prospective study who underwent vitrectomy for ERM and whose preoperative VA was better than 0.046 logMAR (0.9 in decimal units)(Good VA group). And we compared these clinical results and pathological findings with ERM whose preoperative VA was under 0.8(Normal VA group).
Results: Horizontal metamorphopsia score decreased significantly in both group 3 months and 6 months after surgery. The amount of macropsia got worse in normalVA group, after surgery while deterioration of macropsia has been prevented in good VA group. Good VA group showed significantly better visual acuity outcome after surgery. The results of VFQ-25 showed improvement of feelings of health and quality of vision. There were no apparent difference between two groups in pathological findings, therefore we could not elucidate the mechanisms of ERM development.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Experimental visualization and quantification of vitreous contamination following intravitreal injections.2016

    • Author(s)
      Nakashizuka H, Shoji J, Shimada H, Yuzawa M.
    • Journal Title

      Retina

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vitrectomy using 0.025% povidone-iodine in balanced salt solution plus for the treatment of postoperativeendophthalmitis.2016

    • Author(s)
      Nakashizuka H, Shimada H, Hattori T, Noguchi T, Kokubo N, Yuzawa M
    • Journal Title

      Retina

      Volume: 35 Issue: 6 Pages: 1087-94

    • DOI

      10.1097/iae.0000000000000634

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vitrectomy using Balanced Salt Solution PLUS containing 0.025% povidone-iodine for the treatment of postoperative endophthalmitis2015

    • Author(s)
      Hiroyuki Nakashizuka, Hiroyuki Shimada,Takayuki Hattori, Takayasu Noguchi , Naomi Kokubo, Mitsuko Yuzawa
    • Journal Title

      RETINA

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 黄斑疾患に対する25ゲージ硝子体手術後網膜剥離の頻度2015

    • Author(s)
      中静裕之,島田宏之,服部隆幸,山本篤志、田中公二、北川順久、湯澤美都子
    • Journal Title

      日本眼科学会雑誌

      Volume: 119

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 眼内炎に対する硝子体内濃度0.025%ポビドンヨード灌流液の硝子体内注射2015

    • Author(s)
      中静裕之,島田宏之,服部隆幸,山本篤志,田中公二,北川順久,眞鍋歩,湯澤美都子.
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場 愛知県名古屋市
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 術後眼内炎に対する0.025%ポビドンヨード・BSS Plusを用いた硝子体手術2015

    • Author(s)
      中静裕之,島田宏之,服部隆幸,野口敬康,小久保直美,湯澤美都子
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌 北海道 札幌市
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 術後眼内炎に対する0.025%ポビドンヨード・BSS Plusを用いた硝子体手術2015

    • Author(s)
      中静裕之、島田宏之、服部隆幸、野口敬康、小久保直美、湯澤美都子
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      さっぽろ芸文館(北海道札幌市)
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Experimental visualization and quantification of vitreous contamination following intravitreal injections.2015

    • Author(s)
      Nakashizuka H, Shoji J, Ihimori A, Yuzawa M.
    • Organizer
      Asia ARVO
    • Place of Presentation
      横浜パシフィコ(神奈川県横浜市)
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 小切開硝子体手術における眼内炎予防と治療2015

    • Author(s)
      中静裕之
    • Organizer
      第38回日本眼科手術学会総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-01-30 – 2015-02-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 視力0.9以上の黄斑上膜症例に対する硝子体手術の効果2014

    • Author(s)
      中静裕之,島田宏之,服部隆幸,山本篤志,田中公二,北川順久,湯澤美都子
    • Organizer
      第53回日本網膜硝子体学会総会・第31回日本眼循環学会 合同学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-11-28 – 2014-11-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 術後眼内炎に対する0.025%ポビドンヨード含有BSS Plusを用いた硝子体手術2014

    • Author(s)
      中静裕之
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Intraoperative surface irrigation with 0.25% povidone-iodine.2014

    • Author(s)
      Hiroyuki Nakashizuka
    • Organizer
      American Academy of Ophthalmology 2014
    • Place of Presentation
      Chicago(U.S.A)
    • Year and Date
      2014-10-18 – 2014-10-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 水晶体嚢を温存した眼内レンズ嚢内強膜縫着術の有用性.2014

    • Author(s)
      中静裕之,山本篤志, 服部隆幸, 田中公二, 大久保裕子, 北川順久, 古谷公一, 若月 優, 小野江 元, 島田宏之, 湯澤美都子
    • Organizer
      第112回日大眼科症例検討会
    • Place of Presentation
      駿河台日本大学病院(東京都千代田区)
    • Year and Date
      2014-06-19
    • Related Report
      2014 Research-status Report
  • [Book] 硝子体手術入門-これだけわかれば始められる2014

    • Author(s)
      中静裕之
    • Total Pages
      243
    • Publisher
      メジカルビュー社
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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