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Impact and response to DNA damage in mitosis

Research Project

Project/Area Number 26550027
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionKyoto University

Principal Investigator

Matsumoto Tomohiro  京都大学, 放射線生物研究センター, 教授 (80212223)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords有糸分裂期 / テロメア / 染色体凝縮 / 酵母 / 放射線感受性 / クロマチン / 損傷修復 / スピンドルチェックポイント
Outline of Final Research Achievements

Mitosis is a cell cycle stage in which the radiation sensitivity is higher than any other stages, but the underlying mechanisms are still unclear. In this research project, we used the fission yeast model system and found the followings:
1) Some of the stress response genes, including DNA repair gene around telomere are normally silenced. 2) This silencing requires a chromosome-condensing factor and a kinase that phosphorylates the condensing factor in mitosis. We therefore found a novel mechanism of gene silencing that likely accounts for a low activity of DNA repair in mitosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] Involvement of S. pombe Aurora kinase in the regulation of heterochromatic imprint at the subtelomere.2014

    • Author(s)
      Masahiro Takado, Tatsuki Kunoh, Yuji Chikashige, Tomohiro Matsumoto
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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