| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Outline of Final Research Achievements |
The present study aims to elucidate the mechanism to regulate flow in an avian lung. The X-ray visualization demonstrated the presence of a stenosis proximal to the first branch of the main trachea. The flow simulations using an anatomically realistic model of a bird lung revealed the stenosis caused acceleration of inflow by vena contracta. As a consequence, the inflow is mostly directed towards posterior air sacs during an inspiration period, corroborating the inspiratory aerodynamic valving hypothesis stated in the earlier studies. Flow simulation studies also demonstrated that thickening of the air sac wall induces a harmonic mismatch between the inflating and deflating behavior of the air sac and the intra-pleural pressure. This brings difficulties in expansion of air sacs to draw in airs during inspiration, suggesting that a phasic match between flow and the behavior of air sacs is important for the flow regulation in avian lungs.
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