Development of magnetic nanoparticle imaging system with high sensitivity and spatial resolution for in-vivo diagnostic

• Project/Area Number: 26820159
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering
• Research Institution: Kyushu University
• Principal Investigator: Yoshida Takashi 九州大学, システム情報科学研究科(研究院, 准教授 (30380588)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 磁気計測 / 磁性ナノ粒子 / 磁気粒子イメージング / バイオセンシング / 磁気ナノ粒子 / ブラウン緩和 / ニール緩和 / イメージング

Outline of Final Research Achievements

Magnetic particle imaging (MPI) is a promising medical imaging modality. In MPI, magnetic nanoparticles (MSPs) that are accumulated at disease sites are minimally-invasively detected from the surface of the body.
In this study, we developed a highly-sensitive MPI system with high spatial resolution based on an evaluation method of magnetic properties of MNPs and a highly-sensitive detection method of MNPs. We succeeded in obtaining a clear 3-D MPI imaging of two MNPs samples which contains 50 ug (Fe) of MNPs and are separated by 30 mm.

Research Products

• [Journal Article] Narrow-Band Magnetic Nanoparticle Imaging using Orthogonal Gradient Field (2015)
  • Author(s): S. Bai, A. Hirokawa, K. Tanabe, T. Sasayama, T. Yoshida and K. Enpuku
  • Journal Title: Journal of the Magnetics Society of Japan Volume: 39 Issue: 5 Pages: 216-219
  • DOI: 10.3379/msjmag.1508R009
  • NAID: 130005102241
  • ISSN: 1882-2924, 1882-2932
  • Peer Reviewed / Open Access
• [Journal Article] Narrowband Magnetic Particle Imaging Utilizing Electric Scanning of Field Free Point (2015)
  • Author(s): S. Bai, A. Hirokawa, K. Tanabe, T. Sasayama, T. Yoshida, and K. Enpuku
  • Journal Title: IEEE TRANSACTIONS ON MAGNETICS Volume: 51 Issue: 11 Pages: 5101404-5101404
  • DOI: 10.1109/tmag.2015.2438029
  • Peer Reviewed
• [Journal Article] Evaluation of Complex Harmonic Signals From Magnetic Nanoparticles for Magnetic Particle Imaging (2015)
  • Author(s): T. Yoshida, N. Tsujimura, K. Tanabe,T. Sasayama, and K. Enpuku
  • Journal Title: IEEE TRANSACTIONS ON MAGNETICS Volume: 51 Issue: 11 Pages: 5101704-5101704
  • DOI: 10.1109/tmag.2015.2441750
  • Peer Reviewed
• [Journal Article] Effect of viscosity on harmonic signals from magnetic fluid (2015)
  • Author(s): Takashi Yoshida, Shi Bai, Aiki Hirokawa, Kazuhiro Tanabe, Keiji Enpuku
  • Journal Title: Journal of Magnetism and Magnetic Materials Volume: 380 Pages: 105-110
  • DOI: 10.1016/j.jmmm.2014.10.044
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effect of Neel relaxation on the properties of the third harmonic signal of magnetic nanoparticles for use in narrow-band magnetic particle imaging (2014)
  • Author(s): K. Enpuku, S. Bai, A. Hieokawa, K. Tanabe, T. Sasayama and T. Yoshida
  • Journal Title: Jpn. J. Appl. Phys. Volume: 53 Issue: 10 Pages: 103002-103002
  • DOI: 10.7567/jjap.53.103002
  • Peer Reviewed
• [Presentation] Dynamic Magnetization of Immobilized Magnetic Nanoparticles for Cases with Aligned and Randomly Oriented Easy Axes (2016)
  • Author(s): T. Yoshida, T. Viereck, T. Sasayama, K. Enpuku, M. Schilling, and F. Ludwig
  • Organizer: 6th International Workshop on Magnetic Particle Imaging (IWMPI 2016)
  • Place of Presentation: Lübeck, Germany
  • Year and Date: 2016-03-16
  • Int'l Joint Research
• [Presentation] 磁気粒子イメージングにおける固相磁気ナノ粒子の高調波磁化特性 (2016)
  • Author(s): 松木優樹、辻村尚貴、笹山瑛由、吉田敬、圓福敬二
  • Organizer: 電気学会マグネティックス研究会
  • Place of Presentation: 東北大学
  • Year and Date: 2016-03-07
• [Presentation] Characterization of magnetic nanoparticles for magnetic particle imaging (2015)
  • Author(s): T. Yoshida, N. Tsujimura, T. Sasayama, and K. Enpuku
  • Organizer: Workshop on Magnetic-fluids and Magnetic Particle Imaging 2015 (WMMPI2015)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-22
  • Int'l Joint Research / Invited
• [Presentation] 第三高調波磁化信号を用いた三次元磁気粒子イメージングシステムの開発 (2015)
  • Author(s): 辻村 尚貴、吉田 敬、圓福 敬二
  • Organizer: 日本磁気学会学術講演会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-09-09
• [Presentation] Evaluation of Complex Harmonic Signals from Magnetic Nanoparticles for Magnetic Particle Imaging (2015)
  • Author(s): T. Yoshida, N. Tsujimura, K. Tanabe, T. Sasayama, and K. Enpuku
  • Organizer: International Magnetic Conference (INTERMAG 2015)
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-05-11
  • Int'l Joint Research
• [Presentation] 磁気微粒子イメージングにおける磁気ナノ粒子の磁化動特性 (2014)
  • Author(s): 吉田 敬，白 石，廣川 愛生，田辺 一博，辻村 尚貴，笹山 瑛由，圓福 敬二
  • Organizer: 電気学会マグネティックス研究会
  • Place of Presentation: 岡山大学（岡山県岡山市北区津島中）
  • Year and Date: 2014-12-03
• [Presentation] Dynamic Behavior of Magnetic Nanoparticles in Solution -From a viewpoint of biomedical applications- (2014)
  • Author(s): Takashi Yoshida
  • Organizer: 3rd International Conference of AUMS
  • Place of Presentation: Haikou, China
  • Year and Date: 2014-10-28 – 2014-11-02
  • Invited
• [Presentation] Effect of Viscosity on Harmonic Signals from Magnetic Fluid (2014)
  • Author(s): Takashi Yoshida, Seki Bai, and Keiji Enpuku
  • Organizer: 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2014-06-10 – 2014-06-14
• [Presentation] 磁気緩和の基礎と応用 (2014)
  • Author(s): 吉田 敬
  • Organizer: ナノバイオ磁気工学専門研究会
  • Place of Presentation: 中央大学駿河記念館（東京都千代田区駿河台）
  • Year and Date: 2014-05-19
  • Invited