Clinical significance of cancer-related protein expression

Research Project

Project/Area Number	26830097
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor diagnostics
Research Institution	Tokyo Medical University
Principal Investigator	Kawate Takahiko 東京医科大学, 医学部, 助教 (30532303)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	乳癌 / DJ-1 / 術前化学療法 / 病理学的完全奏効 / 癌関連タンパク / ELISA法 / 血清 / 効果予測因子 / 乳がん / 化学療法 / 免疫染色 / トリプルネガティブ乳癌 / DJ-1タンパク / プロテオーム解析 / 癌関連蛋白
Outline of Final Research Achievements	This study reported that DJ-1, a cancer-related protein, is a predictive factor for preoperative chemotherapy treatment effectiveness, and comprehensively　analyzed whether it could be a predictive factor of effectiveness, with a view　to practical clinical application. In our report, we focused on the expression of DJ-1 protein and the therapeutic　effect of preoperative chemotherapy of triple-negative breast cancer, and we　wanted clinical application, and we measured DJ-1 protein in serum, And　detected cancer-specific isoform.