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Effect of incretin related drugs on glucose metabolism and insulin secretion in cats

Research Project

Project/Area Number 26850201
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

Akihiro Mori  日本獣医生命科学大学, 獣医学部, 講師 (60549559)

Research Collaborator SAKO Toshinori  
ODA Hitomi  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords猫 / グルコース / インスリン / インクレチン / 肥満 / 糖尿病
Outline of Final Research Achievements

Impact of carbohydrate sources on short-term post-prandial serum glucose, insulin, and non-esterified fatty acid (NEFA) concentrations was investigated with obese cats. Maltose appears to be capable of inducing experimentally induced postprandial hyperglycemia in obese cats. Next, effect on short-term post-prandial serum glucose, insulin, and incretin hormone concentrations in healthy cats treated by acarbose and sitaglipt and its combination therapy were investigated, following ingestion of a meal with maltose. Combination therapy offers great potential for treating diabetic cats.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2014

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (1 results)

  • [Journal Article] Evaluation of portable blood glucose meters using canine and feline pooled blood samples.2016

    • Author(s)
      Mori A, Oda H, Onozawa E, Shono S, Takahashi T, Yamashita S, Fujimoto H, Sako T
    • Journal Title

      Pol J Vet Sci

      Volume: 19 Issue: 4 Pages: 707713-707713

    • DOI

      10.1515/pjvs-2016-0089

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of various carbohydrate sources on postprandial glucose, insulin and NEFA concentrations in obese cats2016

    • Author(s)
      Akihiro Mori, Kaori Ueda, Peter Lee, Hitomi Oda, Katsumi Ishioka、 Toshinori Sako
    • Journal Title

      Polish journal of veterinary sciences

      Volume: 未定

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of Acarbose, Sitagliptin and combination therapy on blood glucose, insulin, and incretin hormone concentrations in experimentally induced postprandial hyperglycemia of healthy cats2016

    • Author(s)
      Akihiro Mori, Kaori Ueda, Peter Lee, Hitomi Oda, Katsumi Ishioka, Toshiro Arai、 Toshinori Sako
    • Journal Title

      Research in veterinary science

      Volume: 未定

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Preliminary Study Characterizing the Use of Sitagliptin for Glycemic Control in Healthy Beagle Dogs with Normal Gluco-Homeostasis2014

    • Author(s)
      Oda H, Mori A, Lee P, Saeki K, Arai T, Sako T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 10 Pages: 1383-1387

    • DOI

      10.1292/jvms.13-0590

    • NAID

      130004704116

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 健常猫におけるアカルボースおよびシタグリプチンの糖代謝への影響2014

    • Author(s)
      森 昭博、上田香織、小田民美、左向 敏紀
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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