| Project/Area Number |
26860033
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
Funami Kenji 北海道大学, 医学(系)研究科(研究院), 博士研究員 (00421983)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | TICAM-1 / TLR3 / 自然免疫 / インターフェロン / dsRNA |
|---|
| Outline of Final Research Achievements |
TLR3 recognizes double-stranded RNA and mediate innate immune response. TICAM-1 acts as adaptor molecule for TLR3-mediated downstream signaling. In this study, we searched components of TICAM-1-signalosome, which is a protein complex acted as scaffold for TICAM-1-mediated innate immune signal transduction. Some proteins was identified as TICAM-1-signalosome components. From these, 14-3-3-zeta, a cytosolic proteins, was indispensable for TICAM-1-mediated inflammatory cytokine production and type I interferon production. Furthermore, 14-3-3-zeta is associated with TICAM-1-signalosome formation. These result suggested that 14-3-3-zeta is a novel component in TICAM-1-signalosome.
|
