粘膜免疫と自己識別

• 研究領域: 免疫系自己-形成・識別とその異常
• 研究課題/領域番号: 19059003
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京大学
• 研究代表者: 清野 宏 東京大学, 医科学研究所, 教授 (10271032)
• 研究分担者: シドニア ファガラサン (FAGARASAN Sidonia / SIDONIA Fagarasan) 理化学研究所, 免疫アレルギーセンター科学総合研究センター, チームリーダー (00391970)
• 研究期間 (年度): 2007 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 144,000千円 (直接経費: 144,000千円); 2011年度: 28,800千円 (直接経費: 28,800千円); 2010年度: 28,800千円 (直接経費: 28,800千円); 2009年度: 28,800千円 (直接経費: 28,800千円); 2008年度: 28,800千円 (直接経費: 28,800千円); 2007年度: 28,800千円 (直接経費: 28,800千円)
• キーワード: 共生細菌 / パイエル板 / Alcaligenes / フコシル化 / IgA / 孤立リンパ濾胞 / M細胞 / Tfh細胞 / 腸管IgA / 胚中心 / 濾胞性ヘルパーT細胞 / Foxp3+制御性T細胞 / PD-1 / 絨毛上皮細胞 / 自然免疫担当細胞 / 濾胞性樹状細胞 / レチノイン酸 / Alcaligrnes / 孤立性リンパ濾胞 / FoxP3^+制御性T細胞 / 樹状細胞

研究概要

我々の腸管内に共生している腸内細菌の中には、腸管リンパ組織内を生息場所としているものがあった。この細菌群の局在には宿主側の粘膜免疫機構が必要であり、その宿主-細菌間の共生機構の破綻は炎症性腸疾患を始めとする慢性炎症の発症に繋がる事が示唆された。また、粘膜免疫の恒常性維持には、腸内細菌、粘膜免疫担当細胞、上皮細胞の三者間相互作用によって厳密に制御されていることが明らかとなり、これらの相互作用の破綻は粘膜免疫のみにとどまらず、全身免疫系の異常にも繋がっている事が示唆された。

研究成果

• [雑誌論文] Impaired selection of IgA and intestinal dysbiosis associated with PD-1-deficiency (2013)
  • 著者名/発表者名: Maruya, M., Kawamoto, S., Kato, LM., and Fagarasan, S
  • 雑誌名: Gut Microbes 巻: 4(2) ページ: 65-71
• [雑誌論文] Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development (2013)
  • 著者名/発表者名: Takase, M., Iida, R., Maruya, M., Sakaue-Sawano, A., Miyawaki, A., Wakayama, T., Nishigami, S., Fagarasan, S. and Kanagawa O
  • 雑誌名: Int Immunol 巻: 25(3) ページ: 145-56
• [雑誌論文] Nuclear transferred embryonic stem cells for analysis of B1 B-lymphocyte development. (2013)
  • 著者名/発表者名: Takase M, Iida R, Maruya M, Sakaue-Sawano A, Miyawaki A, Wakayama T, Nishigami S, Fagarasan S, Kanagawa O.
  • 雑誌名: International immunology 巻: 25 号: 3 ページ: 145-156
  • DOI: 10.1093/intimm/dxs095
  • 査読あり
• [雑誌論文] Impaired selection of IgA and intestinal dysbiosis associated with PD-1-deficiency (2013)
  • 著者名/発表者名: Maruya M, Kawamoto S, Kato LM, Fagarasan S
  • 雑誌名: Gut Microbes 巻: 4 号: 2 ページ: 165-171
  • DOI: 10.4161/gmic.23595
  • 査読あり
• [雑誌論文] The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut (2012)
  • 著者名/発表者名: Kawamoto, S., Tran, TH., Maruya, M., Suzuki, K., Doi, Y., Tsutsui, Y., Kato, LM., and Fagarasan, S
  • 雑誌名: Science. Apr 巻: 336(6080) ページ: 485-9
• [雑誌論文] The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. (2012)
  • 著者名/発表者名: Shimpei Kawamoto, Thinh H. Tran, Mikako Maruya, Keiichiro Suzuki, Yasuko Doi, Yumi Tsutsui, Lucia M. Kato, Sidonia Fagarasan
  • 雑誌名: Science 巻: 336 号: 6080 ページ: 485-489
  • DOI: 10.1126/science.1217718
  • 査読あり
• [雑誌論文] The airway antigen sampling system: Respiratory M cells as an alternative gateway for inhaled antigens (2011)
  • 著者名/発表者名: Kim, D-Y., Sato, A., Fukuyama, S., Sagara, H, Nagatake, T., Kong, IG., Goda, K., Nochi, T., Kunisawa, J., Sato, S., Yokota, Y., Lee, CH., and Kiyono, H
  • 雑誌名: J. Immunol 巻: 186 ページ: 4253-4262
• [雑誌論文] Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells (2011)
  • 著者名/発表者名: Maruya M, Suzuki K, Fujimoto H, Miyajima M, Kanagawa O, Wakayama T, and Fagarasan, S
  • 雑誌名: Proc Natl Acad Sci U S A 巻: 108(2) ページ: 722-7
• [雑誌論文] Epithelial cell microRNAs in gut immunity (2011)
  • 著者名/発表者名: Goto, Y., and Kiyono, H
  • 雑誌名: Nat Immunol 巻: 12 ページ: 195-197
• [雑誌論文] Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis (2011)
  • 著者名/発表者名: Kunisawa, J., and Kiyono, H
  • 雑誌名: Cell Host Microbe 巻: 9 ページ: 83-84
• [雑誌論文] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress (2011)
  • 著者名/発表者名: Terahara, K., Nochi, T., Yoshida, M., Takahashi, Y., Goto, Y., Hatai, H., Kurokawa, S., Jang, H-M., Kweon, M-N, Domino, SE., Hiroi, T., Yuki, Y., Tsunetsugu-Yokota, Y., Kobayashi, K., and Kiyono, H
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 404 ページ: 822-828
• [雑誌論文] Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. (2011)
  • 著者名/発表者名: Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H.
  • 雑誌名: Biochem Biophys Res Commun. 巻: 404 ページ: 822-8
  • 査読あり
• [雑誌論文] Peaceful mutualism in the gut : revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. (2011)
  • 著者名/発表者名: Kunisawa J, Kiyono H.
  • 雑誌名: Cell Host Microbe. 巻: 17 ページ: 83-4
  • 査読あり
• [雑誌論文] Epithelial cell microRNAs in gut immunity. (2011)
  • 著者名/発表者名: Goto Y, Kiyono H.
  • 雑誌名: Nat Immunol. 巻: 12 ページ: 195-7
  • 査読あり
• [雑誌論文] Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells. (2011)
  • 著者名/発表者名: Maruya M, Suzuki K, Fujimoto H, Miyajima M, Kanagawa O, Wakayama T, Fagarasan S
  • 雑誌名: Proc Nat1 Acad Sci U S A. 巻: 108 ページ: 722-7
  • 査読あり
• [雑誌論文] Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis (2010)
  • 著者名/発表者名: Fagarasan, S., Kawamoto, S., Kanagawa, O and Suzuki, K
  • 雑誌名: Annu Rev Immunol 巻: 28 ページ: 243-73
• [雑誌論文] The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut (2010)
  • 著者名/発表者名: Suzuki, K., Maruya, M., Kawamoto, S., Sitnik, K., Kitamura, H., Agace, WW and Fagarasan, S
  • 雑誌名: Immunity. Jul 巻: 33(1) ページ: 71-83
• [雑誌論文] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines (2010)
  • 著者名/発表者名: Nochi, T., Yuki, Y., Takahashi, H., Sawada, SI., Mejima, M., Kohda, T., Harada, N., Kong, IG., Sato, A., Kataoka, N., Tokuhara, D., Kurokawa, S., Takahashi, Y., Tsukada, H., Kozaki, S., Akiyoshi, K., and Kiyono, H
  • 雑誌名: Nature Mater 巻: 9 ページ: 572-578
• [雑誌論文] Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine (2010)
  • 著者名/発表者名: Tokuhara, D., Yuki, Y., Nochi, T., Kodama, T., Mejima, M., Kurokawa, S., Takahashi, Y., Nanno, M., Nakanishi, U., Takaiwa, F., Honda, T., and Kiyono, H
  • 雑誌名: Proc. Natl. Acad. Sci. USA 巻: 107 ページ: 8794-8799
• [雑誌論文] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis (2010)
  • 著者名/発表者名: Obata, T., Goto, Y., Kunisawa, J., Sato, S., Sakamoto, M., Setoyama, H., Matsuki, T., Nonaka, K., Shibata, N., Gohda, M., Kagiyama, Y., Nochi, T., Yuki, Y., Fukuyama, Y., Mukai, A., Shinzaki, S., Fujihashi, K., Sasakawa, C., Iijima, H., Goto, M., Umesaki, Y., Benno, Y., and Kiyono, H
  • 雑誌名: Proc. Natl. Acad. Sci. USA 巻: 107 ページ: 7419-7424
• [雑誌論文] Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis (2010)
  • 著者名/発表者名: Fagarasan, S. et al.
  • 雑誌名: Adv Immunol 巻: 107
• [雑誌論文] B cell-specific and stimulation-responsive enhancers derepress (2010)
  • 著者名/発表者名: Tran, TH., Nakata, M., Suzuki, K., Begum, NA., Shinkura, R., Fagarasan, S. and Honjo, T and Nagaoka H
  • 雑誌名: Aicda by overcoming the effects of silencers 巻: 11(2) ページ: 148-54
• [雑誌論文] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. (2010)
  • 著者名/発表者名: Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 107 ページ: 7419-24
  • 査読あり
• [雑誌論文] Secretory IgA-mediated protection against V.cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. (2010)
  • 著者名/発表者名: Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 107 ページ: 8794-9
  • 査読あり
• [雑誌論文] Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. (2010)
  • 著者名/発表者名: Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H.
  • 雑誌名: Nat Mater. 巻: 9 ページ: 572-8
  • 査読あり
• [雑誌論文] IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. (2010)
  • 著者名/発表者名: Malamut G, El Machhour R, Montcuquet N, Martin-Lanneree S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B.
  • 雑誌名: J Clin Invest. 巻: 120 ページ: 2131-43
  • 査読あり
• [雑誌論文] In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. (2010)
  • 著者名/発表者名: Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H.
  • 雑誌名: J Immunol. 巻: 185 ページ: 5436-43
  • 査読あり
• [雑誌論文] Mucosal regulatory cells in the gastrointestinal tract and periodontium. (2010)
  • 著者名/発表者名: Takahashi I, Fujihashi K, Kiyono H.
  • 雑誌名: Periodontol 巻: 54 ページ: 247-56
  • 査読あり
• [雑誌論文] Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. (2010)
  • 著者名/発表者名: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S.
  • 雑誌名: J Virol. 巻: 84 ページ: 12703-12
  • 査読あり
• [雑誌論文] High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. (2010)
  • 著者名/発表者名: Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K.
  • 雑誌名: J Biol Chem. 巻: 285 ページ: 30427-35
  • 査読あり
• [雑誌論文] Aberrant interaction of the gut immune system with environmental factors in the development of food allergies. (2010)
  • 著者名/発表者名: Kunisawa J, Kiyono H.
  • 雑誌名: Curr Allergy Asthma Rep. 巻: 10 ページ: 215-21
  • 査読あり
• [雑誌論文] The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. (2010)
  • 著者名/発表者名: Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace WW, Fagarasan S.
  • 雑誌名: Immunity. 巻: 33 ページ: 71-83
  • 査読あり
• [雑誌論文] Adaptive immune regulation in the gut : T cell-dependent and Tcell-independent IgA synthesis. (2010)
  • 著者名/発表者名: Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K.
  • 雑誌名: Annu Rev Immunol 巻: 28 ページ: 243-73
  • 査読あり
• [雑誌論文] Advances in Immunology.Mucosal immunity.Preface. (2010)
  • 著者名/発表者名: Fagarasan S, Cerutti A.
  • 雑誌名: Adv Immunol. 巻: 107
  • 査読あり
• [雑誌論文] GALT : organization and dynamics leading to IgA synthesis. (2010)
  • 著者名/発表者名: Suzuki K, Kawamoto S, Maruya M, Fagarasan S.
  • 雑誌名: Adv Immunol 巻: 107 ページ: 153-85
  • 査読あり
• [雑誌論文] Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity. (2010)
  • 著者名/発表者名: Suzuki K, Maruya M, Kawamoto S, Fagarasan S.
  • 雑誌名: Immunol Rev. 巻: 237 ページ: 180-90
  • 査読あり
• [雑誌論文] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. (2010)
  • 著者名/発表者名: Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.
  • 雑誌名: Nat Immunol. 巻: 12 ページ: 264-70
  • 査読あり
• [雑誌論文] Secretory IgA-mediated protection against V.cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine (2010)
  • 著者名/発表者名: Tokuhara, D., et al.
  • 雑誌名: Proc.Natl.Acad.Sci.USA (in press)
  • 査読あり
• [雑誌論文] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis (2010)
  • 著者名/発表者名: Obata, T., et al.
  • 雑誌名: Proc.Natl.Acad.Sci.USA (in press)
  • 査読あり
• [雑誌論文] Adaptive immune regulation in the gut : T cell-dependent and T cell-in dependent IgA synthesis (2010)
  • 著者名/発表者名: Fagarasan, et al.
  • 雑誌名: Annu Rev Immunol 28 ページ: 243-273
  • 査読あり
• [雑誌論文] B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers (2010)
  • 著者名/発表者名: Tran TH, et al.
  • 雑誌名: Nat Immunol 11 ページ: 148-154
  • 査読あり
• [雑誌論文] Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches (2009)
  • 著者名/発表者名: Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S and Fagarasan, S
  • 雑誌名: Science 巻: 13;323(5920) ページ: 1488-92
• [雑誌論文] Diverse regulatory pathways for IgA synthesis in the gut (2009)
  • 著者名/発表者名: Suzuki, K., and Fagarasan, S
  • 雑誌名: Mucosal Immunol 巻: 2(6) ページ: 468-71
• [雑誌論文] A Rice-based oral cholera vaccine induces macaque-specific systemic neutralizing Abs but does not influence pre-existing intestinal immunity (2009)
  • 著者名/発表者名: Nochi, T., Yuki,Y., Katakai, Y., Shibata, H., Tokuhara,D., Mejima, M., Kurokawa,S., Takahashi,Y., Nakanishi, U., Ono, F., Mimuro, H., Sasakawa, S., Takaiwa, F., Terao, K., and Kiyono, H
  • 雑誌名: J. Immunol 巻: 183 ページ: 6538-6544
• [雑誌論文] Expression of newly identified secretory CEACAM1(a) isoforms in the intestional epithelium (2009)
  • 著者名/発表者名: Terahara, K., Yoshida, M., Taguchi, F., Igarashi, O., Nochi, T., Gotoh, Y., Yamamoto, T., Tsunetsugu-Yokota, Y., Beauchemin, N., and Kiyono, H
  • 雑誌名: Biochem Biophys Res Commun 巻: 383 ページ: 340-346
• [雑誌論文] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium (2009)
  • 著者名/発表者名: Knoop, KA., Kumar, N., Butler, BR., Sakthivel, SK., Taylor, RT., Nochi, T., Akiba, H., Yagita, H., Kiyono, H., and Williams, IR
  • 雑誌名: J. Immunol 巻: 183 ページ: 5738-5747
• [雑誌論文] Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response (2009)
  • 著者名/発表者名: Hase, K., Kawano, K., Nochi, T., Pontes, GS., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Yabashi, A., Waguri, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S., Lowe, AW., Itoh, K., Kiyono, H., and Ohno, H
  • 雑誌名: Nature 巻: 462 ページ: 226-230
• [雑誌論文] Mucosal immunosenescence : New developments and vaccines to control infectious diseases (2009)
  • 著者名/発表者名: Fujihashi, K. and Kiyono, H
  • 雑誌名: Trends Immunol 巻: 30 ページ: 334-343
• [雑誌論文] Id2-, RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity (2009)
  • 著者名/発表者名: Nagatake, T., Fukuyama, S, Kim. D-Y., Goda, K., Igarashi.O., Sato,S., Nochi, T., Sagara, H.,Yokota, Y., Jetten, AM., Kaisho, T., Akira, A., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., and Kiyono, H
  • 雑誌名: J. Exp. Med 巻: 206 ページ: 2351-2364
• [雑誌論文] Id2-, RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity (2009)
  • 著者名/発表者名: Nagatake, T., et al.
  • 雑誌名: J.Exp.Med 206 ページ: 2351-2364
  • 査読あり
• [雑誌論文] Mucosal immunosenescence : New developments and vaccines to contr-olinfectious diseases (2009)
  • 著者名/発表者名: Fujihashi, K., Kiyono, H.
  • 雑誌名: Trends Immunol 30 ページ: 334-343
  • 査読あり
• [雑誌論文] New Horizon of mucosal immunity and vaccine (2009)
  • 著者名/発表者名: Takahashi, T., et al.
  • 雑誌名: Curr.Opin.Immunol 21 ページ: 352-358
  • 査読あり
• [雑誌論文] Uptake through glycoprotein 2 of FimH(+)bacteria by M cells initiates mucosal immune response (2009)
  • 著者名/発表者名: Hase, K., et al.
  • 雑誌名: Nature 462 ページ: 226-230
  • 査読あり
• [雑誌論文] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium (2009)
  • 著者名/発表者名: Knoop, K.A., et al.
  • 雑誌名: J.Immunol 183 ページ: 5738-5747
  • 査読あり
• [雑誌論文] Expression of newly identified secretory CEACAMI(a)isoforms in the intestional epithelium. (2009)
  • 著者名/発表者名: Terahara, K., et al.
  • 雑誌名: Biochem Biophys Res Commun 383 ページ: 340-346
  • 査読あり
• [雑誌論文] A Rice-based oral cholera vaccine induces macaque-specific systemic neutralizing Abs but does not influence pre-existing intestinal immunity (2009)
  • 著者名/発表者名: Nochi, T., et al
  • 雑誌名: J.Immunol 183 ページ: 6538-6544
  • 査読あり
• [雑誌論文] Mucosal vaccines : novel advances in technology and delivery (2009)
  • 著者名/発表者名: Yuki, Y., Kiyono, H.
  • 雑誌名: Expert Rev Vaccines 8 ページ: 1083-1097
  • 査読あり
• [雑誌論文] Diverse regulatory pathways for IgA synthesis in the gut (2009)
  • 著者名/発表者名: Suzuki K, Fagarasan S.
  • 雑誌名: Mucosal Immunol 2 ページ: 468-471
  • 査読あり
• [雑誌論文] Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches (2009)
  • 著者名/発表者名: Tsuji M, et al.
  • 雑誌名: Science 323 ページ: 1488-1492
  • 査読あり
• [雑誌論文] Peyer's patches are required for intestinal IgA responses to Salmonella (2008)
  • 著者名/発表者名: Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, MN., Kiyono, H. and Yamamoto, M
  • 雑誌名: Infect. Immun 巻: 76 ページ: 927-934
• [雑誌論文] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity (2008)
  • 著者名/発表者名: Chang, SY., Cha, HR., Uematsu, S., Akira, S., Igarashi, O., Kiyono, H., and Kweon, M-N
  • 雑誌名: J. Immunol 巻: 180 ページ: 1609-18
• [雑誌論文] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 (2008)
  • 著者名/発表者名: Uematsu, S., Fujimoto, K., Jang, MH., Yang, BG., Jung, YJ., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., Kiyono, H., Miyasaka, M., Ishii, KJ., and Akira, S
  • 雑誌名: Nature Immunol 巻: 9 ページ: 769-776
• [雑誌論文] Comprehensive gene expression analysis among Peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis (2008)
  • 著者名/発表者名: Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, GS., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, AW. and Kiyono, H
  • 雑誌名: J. Immunol 巻: 180 ページ: 7840-7846
• [雑誌論文] The mucosa: at the frontlines of immunity (2008)
  • 著者名/発表者名: Fehervari1, Z., and Kiyono, H
  • 雑誌名: Trends Immunol 巻: 29 ページ: 503-504
• [雑誌論文] Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFκB-inducing kinase in stromal cells. (2008)
  • 著者名/発表者名: Kunisawa, J., Gohda, M., Kurashima, Y., Ishikawa, I., Higuchi, M. and Kiyono, H.
  • 雑誌名: Blood. 111 ページ: 4646-4652
  • 査読あり
• [雑誌論文] Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. (2008)
  • 著者名/発表者名: Gohda, M., Kunisawa, J., Miura, F., Kagiyama, Y., Kurashima, Y., Higuchi, M., Ishika wa, I., Ogahara, I. and Kiyono, H.
  • 雑誌名: J. Immunol. 180 ページ: 5335-5343
  • 査読あり
• [雑誌論文] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. (2008)
  • 著者名/発表者名: Uematsu, S., Fujimoto, K., Jang, MH., Yang, BG., Jung, YJ., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., Kiyono, H., Miyasaka, M., Ishii, KJ., Akira, S.
  • 雑誌名: Nat Immunol 9 ページ: 769-776
  • 査読あり
• [雑誌論文] Cutting edge : Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. (2008)
  • 著者名/発表者名: Chang, SY., Cha, HR., Igarashi, O., Rennert, PD., Kissenpfennig, A., Malissen, B., Nanno, M., Kiyono, H., and Kweon, MN.
  • 雑誌名: J. Immunol. 180 ページ: 4361-4365
  • 査読あり
• [雑誌論文] Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. (2008)
  • 著者名/発表者名: Sun-Young Chang, Hye-Ran Cha, Uematsu, S., Akira, S., Igarashi, 0., Kiyono, H., and Mi-Na Kweon
  • 雑誌名: J. Immunol. 180 ページ: 1609-1618
  • 査読あり
• [雑誌論文] Comprehensive gene expression analysis among peyer's patch M cells, villous M cells and intestinal epithelial cells by DNA microarray analysis. (2008)
  • 著者名/発表者名: Terahara, T., Igarashi, O., Yoshida, M., Nochi, T., Kurokawa, S., Takayama, N., Yuki, Y., Low, AW. and Kiyono, H.
  • 雑誌名: J. Immunol. 180 ページ: 7840-7846
  • 査読あり
• [雑誌論文] Peyer's patches are required for intestinal IgA responses to Salmonella. (2008)
  • 著者名/発表者名: Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, M.N., Kiyono, H. and Yamamoto, M.
  • 雑誌名: Infect Immun. 76 ページ: 927-934
  • 査読あり
• [雑誌論文] Nasal Vaccination with the 40-Kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces lomg-term protective immunity with reduced levels of immunoglobulin E antibodies. (2008)
  • 著者名/発表者名: Momoi, F., Hashizume, T., Kurita-Ochiai, T., Yuki, Y., Kiyono, H., and Yamamoto, M.
  • 雑誌名: Infect Immun. 76 ページ: 7840-7846
  • 査読あり
• [雑誌論文] Tonic B cell activation by radioprotective105/MD-1 promotes diseaseprogression in MRL/lpr mice. (2008)
  • 著者名/発表者名: Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, and Miyake K.
  • 雑誌名: Int Immunol. 20 ページ: 881-891
  • 査読あり
• [雑誌論文] The mucosa : at the frontlines of immunity. (2008)
  • 著者名/発表者名: Fehervaril, Z., and Kiyono, H.
  • 雑誌名: Trends Immunol 29 ページ: 503-504
  • 査読あり
• [雑誌論文] Immunological commonalities and distinctions between airway and digestive immunity. (2008)
  • 著者名/発表者名: Kunisawa, J., Nochi, T. and Kiyono, H.
  • 雑誌名: Trends Immunol. 29 ページ: 505-513
  • 査読あり
• [学会発表] IgA synthesis : a form of functional immune adaptation extending beyond gut (2013)
  • 著者名/発表者名: Sidonia Fagarasan
  • 学会等名: 1. Keystone symposia. XI 2013, B Cell Development & Function
  • 発表場所: Colorado, USA(招待講演)
  • 年月日: 2013-02-12
• [学会発表] PD-1 Defeciency Skews the Gut Microbiota by altering the IgA Selection in Gut (2012)
  • 著者名/発表者名: Sidonia Fagarasan
  • 学会等名: The 2012 Spring Conference of the Korean Association of Immunologists
  • 発表場所: Seoul, Korea(招待講演)
  • 年月日: 2012-04-13
• [学会発表] Mucosal Decisions of Mutualisum and Elimination for Surface barrier system (2012)
  • 著者名/発表者名: Invited Speaker
  • 学会等名: The 6^<th> Annual International Symposium in Institute of Dermatological Science(IDS)
  • 発表場所: Seoul, Korea
• [学会発表] PD-1 Defeciency Skews the Gut Microbiota by altering the IgA Selection in Gut (2012)
  • 著者名/発表者名: Fagarasan, S
  • 学会等名: The 2012 Spring Conference of the Korean Association of Immunologists
  • 発表場所: Seoul, Korea
• [学会発表] Chaperon-Like Antigen Presentaion by Nanogel-Based Vaccine at Nasal Epithelium (2011)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: Avison Biomedical Symposium 2011
  • 発表場所: Seoul, Korea
  • 年月日: 2011-02-25
• [学会発表] The Mucosal Gateway System for Antigen-sampling and Homestatic Niche (2011)
  • 著者名/発表者名: Invited Speaker
  • 学会等名: The 15^<th> International Congress of Mucosal Immunology
  • 発表場所: Paris, France
• [学会発表] New Prospects on the Aerodigestive Immunity for Mucosal Vaccine Development (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: Prato Conference on the Pathogenesis of Bacterial Diseases of Animals
  • 発表場所: Prato, Italy
  • 年月日: 2010-10-09
• [学会発表] Mucosal Nanogel-based Chaperon Vaccine for the induction of protective immunity (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: 4^<th> Vaccine and ISV Annuals Global Congress
  • 発表場所: Vienna, Austria
  • 年月日: 2010-10-04
• [学会発表] Intra-Tissue habitation of commensal bacteria in Peyer's patches for gut immunity (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: 8^<th> German-Japanease Symposium, Regulation of immune response and diseases
  • 発表場所: Cuxhahen, Germany.
  • 年月日: 2010-09-27
• [学会発表] Intra-tissue habitation of intestinal opportunistic bacteria in mammalian gut-associated lymphoid tissues for the creation of a mucosal antibody-mediated symiosis (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: 40^<th> Annual Meeting DGFI German Society for Immunology
  • 発表場所: Leipzig, Germany
  • 年月日: 2010-09-26
• [学会発表] Mucosal chaperoning nanogel vaccine for the induction of protective immunity (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: The 10^<th> Awaji International Forum on Infection and Immunity (United states-Japan Cooperative Medical Science Program 23^<rd> Joint Meeting of the AIDS Panels
  • 発表場所: Awaji, Japan.淡路夢舞台国際会議場
  • 年月日: 2010-09-08
• [学会発表] Role of Intestinal Glycosylation for the Mucosal Immne System and Mucosal Vaccine Development (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: 1^<st> Asia Pacific Workshop on Neurovirology Seoul 2010
  • 発表場所: Seoul, Korea.
  • 年月日: 2010-07-16
• [学会発表] Craniofacial Mucosal Immune Sysem : Uniqueness of lymphoid Organogenesis and Immunological Function for NALT and TALT (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: The 7^<th> Intenational Symposium on Tonsils and Mucosal Barriers of the Upper Airways
  • 発表場所: Asahikawa, Hokkaido旭川グランドホテル
  • 年月日: 2010-07-08
• [学会発表] Mucosal Immunity in the Control of Infectious Diseases (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: Pasteur-Areva Course Anti-Viral Imjmunity
  • 発表場所: Shanghai, China
  • 年月日: 2010-05-28
• [学会発表] Basic principals of immune responces : innate versus adaptive immunity (2010)
  • 著者名/発表者名: HIROSHI KIYONO
  • 学会等名: The 10^<th> International Advanced Course on Vaccinology in Asia Pacific Region
  • 発表場所: Seoul, Korea
  • 年月日: 2010-05-10
• [学会発表] New Prospect for Mucosal Vaccine Development : MucoRiceTM for Refrigeration-and Needle/Shiringe-free vaccine (2010)
  • 著者名/発表者名: 清野宏
  • 学会等名: The 2nd International Symposium of Innovative B-ioproduction Kobe(iBioK)
  • 発表場所: Kobe, Japan
  • 年月日: 2010-01-22
• [学会発表] Novel Strategy for Mucosal Vaccine Development : MucoRice and MucoNanogel (2010)
  • 著者名/発表者名: 清野宏
  • 学会等名: Adaptive and Innate Immune Resposes to Neglected Tropical Disease Conference
  • 発表場所: SanDiego, USA
  • 年月日: 2010-01-10
• [学会発表] Intra-Tissue Habitation of Commensal Bacteria in Peyer's patches for Gut Immunity (2010)
  • 著者名/発表者名: Invited Speaker
  • 学会等名: The 8^<th> German-Japanease International Symposium, Regulation of Immune Response and Diseases
  • 発表場所: Cuxhahen, Germany
• [学会発表] Mucosal Decision of Immunity and Tolerance (2010)
  • 著者名/発表者名: Invited Speaker
  • 学会等名: The 83^<rd> Annunal Meeting of Japanese Society for Bacteriology
  • 発表場所: Yokohama, Japan
• [学会発表] MucoRice : New Horizon for the Development of Oral Vaccine (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: 12th Asia Pacific-International Molecular Biology Network(A-IMBN)Symposium
  • 発表場所: Penang, Malaysia
  • 年月日: 2009-10-27
• [学会発表] New Prospect for Vaccine Development : MucoRice and MucoNanogel (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: 3rd Vaccine Global Congress
  • 発表場所: Singapore Singapore
  • 年月日: 2009-10-04
• [学会発表] The Craniofacial and Mucosal Immune System (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: Japanese Journal of Rhinology
  • 発表場所: 島根, 日本
  • 年月日: 2009-10-03
• [学会発表] Mucosal Harmony for Immunity and Tolerance in Vaccine Development (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: 2nd European Congress of Immunology
  • 発表場所: Berlin, Germany
  • 年月日: 2009-09-14
• [学会発表] 粘膜免疫による腸内細菌共生機構の構築 (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: 第63回日本細菌学会東北支部総会
  • 発表場所: 盛岡, 日本
  • 年月日: 2009-08-20
• [学会発表] Rice-Based Vaccine : New Generation of Mucosal Vacine (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: 14th International Congress of Mucosal Immunol-ogy
  • 発表場所: Boston, USA.
  • 年月日: 2009-07-08
• [学会発表] 粘膜免疫による腸内細菌共生の構築 (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: 第91回日本消化器病学会中国支部例会
  • 発表場所: 岡山, 日本
  • 年月日: 2009-06-13
• [学会発表] Mucosal Decision of Immunity and Tolerance for Creation of Symbiosis (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: The 6th Extraordinary International Symposium on Recent Advances in Otitis Media
  • 発表場所: Seoul, Korea
  • 年月日: 2009-05-06
• [学会発表] Mucosal Immunity : A Driving Force for the Development of New Generation of Oral Vaccine (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: The 13th International Conference on Emerging In fection Dieseases of the Pacific Rum : Focus on Enteric Diseases
  • 発表場所: Kolkata, India
  • 年月日: 2009-04-06
• [学会発表] Session 1"Id2, RORγt, and LTβR independent initiation of TALT genesis in ocular immunity."and Session 2" Indigenous Opportunistic Bacteria Inhabit Mammalian Gut-associated Lymphoid Tissues for Gut Immunity" (2009)
  • 学会等名: Trudeau Institute Mucosal Immunology Workshop
  • 発表場所: New York, USA
• [学会発表] Development of Intestinal Symbiosis by the Mucosal Immune System (2009)
  • 著者名/発表者名: Invited Speaker
  • 学会等名: The 63^<th> Japanese Society for Bacteriology Tohoku District Research Conference
  • 発表場所: Morioka, Japan
• [学会発表] The Mucosal Immune System for the Creation of Gut Symbiosis (2009)
  • 学会等名: The 91^<st> Japanese Association of Gastroenteology, Chugoku Division Meeting
  • 発表場所: Okayama, Japan
• [学会発表] Mucosal Decision of Immunity and Tolerance for Creation of Symbiosis (2009)
  • 著者名/発表者名: Invited Speaker
  • 学会等名: The 6^<th> Extraordinary International Symposium on Recent Advances in Otitis Media
  • 発表場所: Seoul, Korea
• [学会発表] T-dependent and T-independent IgA responses in the gut (2009)
  • 学会等名: Annual Meeting of The Japanese Society for Immunology
  • 発表場所: Osaka
• [学会発表] T-dependent and T-independent IgA responses in the gut (2009)
  • 学会等名: Microanatomy of the Immune Responses in Health and Disease
  • 発表場所: University of Birmingham, UK
• [学会発表] Sessionl "Id2, RORgt, and LTbR independent initiation of TALT genesis in ocular immunity." and Sessionl "Indigenous opportunistic bacteria inhabit mammalian gut associated lymphoid tissues for gut immunity." (2009)
  • 著者名/発表者名: 清野宏
  • 学会等名: Mucosal immunology Workshop at Trudeau Institute
  • 発表場所: New York, USA
• [学会発表] T-dependent and T-independent IgA responses in the gut (2009)
  • 著者名/発表者名: Fagarasan Sidonia
  • 学会等名: 日本免疫学会
  • 発表場所: 大阪
• [図書] 臨床粘膜免疫学 (2010)
  • 著者名/発表者名: 清野宏
  • 総ページ数: 722
  • 出版者: 株式会社シナジー
• [図書] 臨床粘膜免疫学
  • 著者名/発表者名: 清野宏
  • 出版者: (株)シナジー