大規模コホートからの経時データを用いた心不全リスク要因のネットワーク解析

• 研究課題/領域番号: 16K00039
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 統計科学
• 研究機関: 東北大学
• 研究代表者: 宮田 敏 東北大学, 医学系研究科, 准教授 (60360343)
• 研究分担者: 坂田 泰彦 東北大学, 医学系研究科, 准教授 (90379206)
• 研究協力者: 三浦 正暢 ; 山内 毅 ; 小野瀬 剛史 ; 辻 薫菜子 ; 及川 卓也 ; 笠原 信太郎
• 研究期間 (年度): 2016-04-01 – 2019-03-31
• 研究課題ステータス: 完了 (2018年度)
• 配分額: 4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円); 2018年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円); 2017年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2016年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
• キーワード: コホート研究 / ネットワーク解析 / 関数主成分分析 / 慢性心不全 / 生物統計学 / 構造方程式モデル / 構造方程式モデリング / 関数データ解析 / アンケート調査 / 統計数学

研究成果の概要

本研究では，2006~2010年に東北地区24基幹病院において登録された10,219名の慢性心不全及びその高リスク症例の観察研究（CHART-2研究）の登録データを用いた。リスク層別のため、経時データを関数データとして用いた関数主成分分析を開発し、生存時間イベントをアウトカムとした教師あり学習モデルとしてリスク層別を行った。
モデルの臨床的意義について循環器内科専門医による医学的検討を行い、妥当な結果との結論を得た。

研究成果の学術的意義や社会的意義

本研究の結果，膨大なコホートデータに蓄積された経時データを関数主成分分析によって解析することにより、心不全患者の発症リスクを効果的に判別することに成功した。
研究の成果は，約30編の原著論文（査読あり）と多数の国際学会において報告した．

研究成果

• [雑誌論文] Cardiac Lymphatic Dysfunction Causes Drug-Eluting Stent?Induced Coronary Hyperconstricting Responses in Pigs In Vivo (2019)
  • 著者名/発表者名: Amamizu Hirokazu、Matsumoto Yasuharu、Morosawa Susumu、Ohyama Kazuma、Uzuka Hironori、Hirano Michinori、Nishimiya Kensuke、Gokon Yusuke、Watanabe-Asaka Tomomi、Hayashi Moyuru、Miyata Satoshi、Kamei Takashi、Kawai Yoshiko、Shimokawa Hiroaki
  • 雑誌名: Arteriosclerosis, Thrombosis, and Vascular Biology 巻: 39 号: 4 ページ: 741-753
  • DOI: 10.1161/atvbaha.119.312396
  • 査読あり / オープンアクセス
• [雑誌論文] Conversion formula from B-type natriuretic peptide to N-terminal proBNP values in patients with cardiovascular diseases. (2019)
  • 著者名/発表者名: Kasahara S, Sakata Y, Nochioka K, Miura M, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • 雑誌名: International Journal of Cardiology 巻: 280 ページ: 184-189
  • DOI: 10.1016/j.ijcard.2018.12.069
  • 査読あり / オープンアクセス
• [雑誌論文] Gender differences in prognostic relevance of self-care behaviors on mortality and hospitalization in patients with heart failure ? A report from the CHART-2 Study (2019)
  • 著者名/発表者名: Abe Ruri、Sakata Yasuhiko、Nochioka Kotaro、Miura Masanobu、Oikawa Takuya、Kasahara Shintaro、Sato Masayuki、Aoyanagi Hajime、Shiroto Takashi、Sugimura Koichiro、Takahashi Jun、Miyata Satoshi、Shimokawa Hiroaki
  • 雑誌名: Journal of Cardiology 巻: 73 号: 5 ページ: 370-378
  • DOI: 10.1016/j.jjcc.2018.11.006
  • 査読あり / オープンアクセス
• [雑誌論文] Prognostic impact of residual stenosis after percutaneous coronary intervention in patients with ischemic heart failure ? A report from the CHART-2 study (2019)
  • 著者名/発表者名: Hao Kiyotaka、Takahashi Jun、Sakata Yasuhiko、Miyata Satoshi、Shiroto Takashi、Nochioka Kotaro、Miura Masanobu、Oikawa Takuya、Abe Ruri、Sato Masayuki、Kasahara Shintaro、Aoyanagi Hajime、Shimokawa Hiroaki
  • 雑誌名: International Journal of Cardiology 巻: 278 ページ: 22-27
  • DOI: 10.1016/j.ijcard.2018.10.062
  • 査読あり / オープンアクセス
• [雑誌論文] The 3A3B score: The simple risk score for heart failure with preserved ejection fraction - A report from the CHART-2 Study (2019)
  • 著者名/発表者名: Kasahara Shintaro、Sakata Yasuhiko、Nochioka Kotaro、Tay Wan Ting、Claggett Brian Lee、Abe Ruri、Oikawa Takuya、Sato Masayuki、Aoyanagi Hajime、Miura Masanobu、Shiroto Takashi、Takahashi Jun、Sugimura Koichiro、Teng Tiew-Hwa Katherine、Miyata Satoshi、Shimokawa Hiroaki
  • 雑誌名: International Journal of Cardiology 巻: 284 ページ: 42-49
  • DOI: 10.1016/j.ijcard.2018.10.076
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia-Crucial roles of endothelial nitric oxide synthase (2018)
  • 著者名/発表者名: Eguchi Kumiko、Shindo Tomohiko、Ito Kenta、Ogata Tsuyoshi、Kurosawa Ryo、Kagaya Yuta、Monma Yuto、Ichijo Sadamitsu、Kasukabe Sachie、Miyata Satoshi、Yoshikawa Takeo、Yanai Kazuhiko、Taki Hirofumi、Kanai Hiroshi、Osumi Noriko、Shimokawa Hiroaki
  • 雑誌名: Brain Stimulation 巻: 11 号: 5 ページ: 959-973
  • DOI: 10.1016/j.brs.2018.05.012
  • 査読あり / オープンアクセス
• [雑誌論文] Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction (2018)
  • 著者名/発表者名: Kagaya Yuta、Ito Kenta、Takahashi Jun、Matsumoto Yasuharu、Shiroto Takashi、Tsuburaya Ryuji、Kikuchi Yoku、Hao Kiyotaka、Nishimiya Kensuke、Shindo Tomohiko、Ogata Tsuyoshi、Kurosawa Ryo、Eguchi Kumiko、Monma Yuto、Ichijo Sadamitsu、Hatanaka Kazuaki、Miyata Satoshi、Shimokawa Hiroaki
  • 雑誌名: Coronary Artery Disease 巻: 29 号: 4 ページ: 294-300
  • DOI: 10.1097/mca.0000000000000577
  • 査読あり / オープンアクセス
• [雑誌論文] Comparable prognostic impact of BNP levels among HFpEF, Borderline HFpEF and HFrEF: a report from the CHART-2 Study. (2018)
  • 著者名/発表者名: Kasahara S, Sakata Y, Nochioka K, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • 雑誌名: Heart Vessels 巻: － 号: 9 ページ: 1-11
  • DOI: 10.1007/s00380-018-1150-4
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension. (2018)
  • 著者名/発表者名: Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Siddique MAH, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
  • 雑誌名: Circulation 巻: 138 号: 6 ページ: 600-623
  • DOI: 10.1161/circulationaha.117.033113
  • 査読あり / オープンアクセス
• [雑誌論文] Prognostic Significance of PR Interval Prolongation in Adult Patients With Total Correction of Tetralogy of Fallot (2018)
  • 著者名/発表者名: Kimura Yoshitaka、Fukuda Koji、Nakano Makoto、Hasebe Yuhi、Fukasawa Kyoshiro、Chiba Takahiko、Miki Keita、Tatebe Shunsuke、Miyata Satoshi、Ota Hideki、Kimura Masato、Adachi Osamu、Saiki Yoshikatsu、Shimokawa Hiroaki
  • 雑誌名: Circulation: Arrhythmia and Electrophysiology 巻: 11 号: 11 ページ: 1-11
  • DOI: 10.1161/circep.118.006234
  • 査読あり / オープンアクセス
• [雑誌論文] Effects of Hepatitis C Virus Antibody-Positivity on Cardiac Function and Long-Term Prognosis in Patients With Adult Congenital Heart Disease (2018)
  • 著者名/発表者名: Konno Ryo、Tatebe Shunsuke、Sugimura Koichiro、Satoh Kimio、Aoki Tatsuo、Miura Masanobu、Yamamoto Saori、Sato Haruka、Kozu Katsuya、Terui Yosuke、Miyata Satoshi、Adachi Osamu、Kimura Masato、Saiki Yoshikatsu、Shimokawa Hiroaki
  • 雑誌名: The American Journal of Cardiology 巻: 122 号: 11 ページ: 1965-1971
  • DOI: 10.1016/j.amjcard.2018.08.045
  • 査読あり / オープンアクセス
• [雑誌論文] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension. (2018)
  • 著者名/発表者名: Kozu K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Shimizu T, Nochioka K, Sato H, Konno R, Satoh K, Miyata S, Shimokawa H.
  • 雑誌名: Heart Vessels. 巻: in press 号: 8 ページ: 939-947
  • DOI: 10.1007/s00380-018-1140-6
  • 査読あり / オープンアクセス
• [雑誌論文] Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells (2018)
  • 著者名/発表者名: Nogi Masamichi、Satoh Kimio、Sunamura Shinichiro、Kikuchi Nobuhiro、Satoh Taijyu、Kurosawa Ryo、Omura Junichi、Elias-Al-Mamun Md.、Abdul Hai Siddique Mohammad、Numano Kazuhiko、Kudo Shun、Miyata Satoshi、Akiyama Masatoshi、Kumagai Kiichiro、Kawamoto Shunsuke、Saiki Yoshikatsu、Shimokawa Hiroaki
  • 雑誌名: Circulation 巻: 138 号: 21 ページ: 2413-2433
  • DOI: 10.1161/circulationaha.118.035648
  • 査読あり / オープンアクセス
• [雑誌論文] Sex Differences in Patients With Chronic Heart Failure With Reference to Left Ventricular Ejection Fraction (2018)
  • 著者名/発表者名: Sakata Yasuhiko、Miyata Satoshi、Nochioka Kotaro、Miura Masanobu、Shiroto Takashi、Shimokawa Hiroaki
  • 雑誌名: Gender and the Genome 巻: 2 号: 1 ページ: 27-42
  • DOI: 10.1177/2470289718787115
  • 査読あり / オープンアクセス
• [雑誌論文] Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice (2018)
  • 著者名/発表者名: Sunamura Shinichiro、Satoh Kimio、Kurosawa Ryo、Ohtsuki Tomohiro、Kikuchi Nobuhiro、Elias-Al-Mamun Md.、Shimizu Toru、Ikeda Shohei、Suzuki Kota、Satoh Taijyu、Omura Junichi、Nogi Masamichi、Numano Kazuhiko、Siddique Mohammad Abdul Hai、Miyata Satoshi、Miura Masahito、Shimokawa Hiroaki
  • 雑誌名: Proceedings of the National Academy of Sciences 巻: 115 号: 30
  • DOI: 10.1073/pnas.1721298115
  • 査読あり / オープンアクセス
• [雑誌論文] Structural brain abnormalities and cardiac dysfunction in patients with chronic heart failure. (2018)
  • 著者名/発表者名: Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa.
  • 雑誌名: European Journal of Heart Failure 巻: 20 号: 5 ページ: 936-938
  • DOI: 10.1002/ejhf.1104
  • 査読あり / オープンアクセス
• [雑誌論文] Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. (2018)
  • 著者名/発表者名: Oikawa T, Sakata Y, Nochioka K, Miura M, Tsuji K, Onose T, Abe R, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART‐2 invesigators.
  • 雑誌名: J Am Heart Assoc. 巻: － 号: 6 ページ: 1-21
  • DOI: 10.1161/jaha.117.007524
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Sex differences in post-traumatic stress disorder in cardiovascular patients after the Great East Japan Earthquake: a report from the CHART-2 Study. (2017)
  • 著者名/発表者名: Onose T, Sakata Y, Nochioka K, Miura M, Yamauchi T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Miyata S, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • 雑誌名: Eur Heart J Qual Care Clin Outcomes 巻: 3 号: 3 ページ: 224-233
  • DOI: 10.1093/ehjqcco/qcx009
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Characterization of heart failure patients with mid-range left ventricular ejection fraction-a report from the CHART-2 Study. (2017)
  • 著者名/発表者名: Tsuji K, Sakata Y, Nochioka K, Miura M, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • 雑誌名: Eur J Heart Fail 巻: 19 号: 10 ページ: 1258-1269
  • DOI: 10.1002/ejhf.807
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Long-term prognostic impact of the Great East Japan Earthquake in patients with cardiovascular disease - Report from the CHART-2 Study. (2017)
  • 著者名/発表者名: Miyata S, Sakata Y, Miura M, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Nochioka K, Shiroto T, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • 雑誌名: J Cardiol. 巻: 70 号: 3 ページ: 286-296
  • DOI: 10.1016/j.jjcc.2016.10.018
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Prognostic Impact of Atrial Fibrillation and New Risk Score of Its Onset in Patients at High Risk of Heart Failure ― A Report From the CHART-2 Study ― (2017)
  • 著者名/発表者名: Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators
  • 雑誌名: Circulation Journal 巻: 81 号: 2 ページ: 185-194
  • DOI: 10.1253/circj.CJ-16-0759
  • NAID: 130005298633
  • ISSN: 1346-9843, 1347-4820
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Influence of Left Ventricular Ejection Fraction on the Effects of Supplemental Use of Angiotensin Receptor Blocker Olmesartan in Hypertensive Patients With Heart Failure (2016)
  • 著者名/発表者名: Miura M, Sakata Y, Miyata S, Shiba N, Takahashi J, Nochioka K, Takada T, Saga C, Shinozaki T, Sugi M, Nakagawa M, Sekiguchi N, Komaru T, Kato A, Fukuchi M, Nozaki E, Hiramoto T, Inoue K, Goto T, Ohe M, Tamaki K, Ibayashi S, Ishide N, Maruyama Y, Tsuji I, Shimokawa H; SUPPORT Trial Investigators
  • 雑誌名: Circulation Journal 巻: 80 号: 10 ページ: 2155-2164
  • DOI: 10.1253/circj.CJ-16-0577
  • NAID: 130005419074
  • ISSN: 1346-9843, 1347-4820
  • 査読あり / オープンアクセス / 国際共著
• [雑誌論文] Prognostic Impact of Loop Diuretics in Patients With Chronic Heart Failure – Effects of Addition of Renin-Angiotensin-Aldosterone System Inhibitors and β-Blockers – (2016)
  • 著者名/発表者名: Miura M, Sugimura K, Sakata Y, Miyata S, Tadaki S, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Takahashi J, Shimokawa H; CHART-2 Investigators
  • 雑誌名: Circulation Journal 巻: 80 号: 6 ページ: 1396-1403
  • DOI: 10.1253/circj.CJ-16-0216
  • NAID: 130005153602
  • ISSN: 1346-9843, 1347-4820
  • 査読あり / オープンアクセス / 国際共著
• [学会発表] Prognostic impact of diabetes mellitus in patients with chronic heart failure -With special references to ischemic heart disease and nephropathy- (2018)
  • 著者名/発表者名: Miura M, Sakata Y, Sato M, Abe R, Kasahara S, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Nochioka K, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: Heart Failure Seoul 2018 (Seoul, Korea)
  • 国際学会
• [学会発表] SmgGDS prevents thoracic aortic aneurysm formation and rupture by phenotypic preservation of aortic smooth muscle cells (2018)
  • 著者名/発表者名: Nogi M, Satoh K, Kudo S, Sunamura S, Kikuchi N, Satoh T, Kurosawa R, Omura J, Al-Mamun E, Siddique MA, Numano K, Miyata S, Akiyama M, Kumagai S, Saiki Y, Shimokawa H.
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Prognostic impacts of soluble basigin in patients with chronic heart failure -the novel aspect of the multifunctional inflammatory protein (2018)
  • 著者名/発表者名: Satoh K, Miyata S, Ohtsuki T, Nochioka K, Miura M, Shiroto T, Sunamura S, Nogi M, Kurosawa R, Kikuchi N, Satoh T, Sakata Y, Shimokawa H
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Clinical characteristics, prognosis and prognostic factors of elderly patients with chronic heart failure: A report from the CHART-2 Study (2018)
  • 著者名/発表者名: Sato M, Sakata Y, Nochioka K, Miura M, Kasahara S, Aoyanagi H, Fujihashi T, Yamanaka S, Abe R, Oikawa T, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Benefit and risk of antithrombotic therapy in patients with atrial fibrillation -A report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Shiroto T, Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Yamanaka S, Fujihashi T, Miura M, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Elevated serum triglyceride level as a significant residual risk for acute myocardial infraction in patients with stable ischemic heart disease under statin treatment -A report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Suzuki K, Oikawa T, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Sakata Y, Shimokawa H
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Prognostic impacts of serum levels of selenoprotein P in patients with pulmonary arterial hypertension (2018)
  • 著者名/発表者名: Kikuchi N, Satoh K, Tanaka M, Kato S, Omura J, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Miyata S, Misu H, Saito Y, Shimokawa H.
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Simple risk model for heart failure with preserved ejection fraction -A report from the CHART-2 Study (2018)
  • 著者名/発表者名: Kasahara S, Sakata Y, Nochioka K, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Miura M, Shiroto T, Takahashi J, Sugimura K, Miyata S, Shimokawa H.
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Prognostic impacts of impaired coronary vasodilator function and enhanced vasoconstriction responses in patients with angina and unobstructive coronary arteries (2018)
  • 著者名/発表者名: Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Ikeda S, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Prognostic impact of temporal changes in left ventricular ejection fraction in patients with stage B heart failure (2018)
  • 著者名/発表者名: Aoyanagi H, Sakata Y, Nochioka K, Miura M, Shiroto T, Abe R, Kasahara S, Sato M, Fujihashi T, Yamanaka S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • 国際学会
• [学会発表] Development of useful conversion equation between B-type natriuretic peptide and N-terminal pro BNP levels. (2018)
  • 著者名/発表者名: Kasahara S, Sakata Y, Nochioka K, Abe R, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Sugimura K, Miyata S, Shimokawa H.
  • 学会等名: 22nd Annual Scientific Meeting of Heart Failure Society of America (HFSA) (Nashville, USA)
  • 国際学会
• [学会発表] Prognostic impacts of soluble form of basigin in patients with chronic heart failure -from a prospective large clinical trial with 1,147 patients- (2018)
  • 著者名/発表者名: Satoh K, Miyata S, Miura M, Ohtsuki T, Nochioka K, Sunamura S, Nogi M, Kurosawa R, Kikuchi N, Satoh T, Aoki T, Tatebe S, Sugimura K, Sakata Y, Shimokawa H.
  • 学会等名: ESC Congress 2018 (Munich, Germany)
  • 国際学会
• [学会発表] Prognostic impacts of impaired coronary vasodilatation and enhanced coronary vasoconstricting responses in patients with angina and unobstructive coronary arteries. (2018)
  • 著者名/発表者名: Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H.
  • 学会等名: ESC Congress 2018 (Munich, Germany)
  • 国際学会
• [学会発表] Clinical impacts of wide ORS morphologies on deterioration of left ventricular ejection fraction and fatal arrhythmias in patients with relatively preserved left ventricular ejection function. (2018)
  • 著者名/発表者名: Kimura Y, Nakano M, Sakata Y, Nochioka K, Hasebe Y, Abe R, Chiba T, Fukasawa K, Oikawa T, Kasahara S, Miki K, Sato M, Shiroto T, Miyata S, Shimokawa H.
  • 学会等名: ESC Congress 2018 (Munich, Germany)
  • 国際学会
• [学会発表] Impact of temporal changes in left ventricular ejection fraction in patients at risk for heart failure. (2018)
  • 著者名/発表者名: Aoyanagi H, Sakata Y, Nochioka K, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: ESC Congress 2018 (Munich, Germany)
  • 国際学会
• [学会発表] Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation and diabetes mellitus -A report from the CHART-2 Study (2018)
  • 著者名/発表者名: Sakata Y, Oikawa T, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: Heart Failure 2018 (Vienna, Austria)
  • 国際学会
• [学会発表] Sex differences in temporal changes in left ventricular ejection fraction among patients with heart failure -A report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Tsuji K, Sakata Y, Nochioka K, Miura M, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: Heart Failure 2018 (Vienna, Austria)
  • 国際学会
• [学会発表] Association between impaired glucose tolerance and prognosis according to presence of microalbuminuria in patients with chronic heart failure (2018)
  • 著者名/発表者名: Nochioka K, Sakata Y, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: Heart Failure 2018 (Vienna, Austria)
  • 国際学会
• [学会発表] Derivation and validation of a conversion equation between B-type natriuretic peptide and N-terminal pro BNP levels (2018)
  • 著者名/発表者名: Kasahara S, Sakata Y, Nochioka K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: Heart Failure 2018 (Vienna, Austria)
  • 国際学会
• [学会発表] Antithrombotic therapy improves long-term prognosis in patients with atrial fibrillation and heart failure -A report from the CHART-2 Study (2018)
  • 著者名/発表者名: Shiroto T, Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: Heart Failure 2018 (Vienna, Austria)
  • 国際学会
• [学会発表] Evidence for Sex Differences in Japanese Patients with Chronic Heart Failure -A Report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Transition of Left Ventricular Ejection Fraction in Heart Failure: Is HFmrEF Closer to HFpEF than to HFrEF? (2018)
  • 著者名/発表者名: Sakata Y, Nochioka K, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Prognostic Impact of Impaired Glucose Tolerance in Relation with Microalbuminuria in Patients with Chronic Heart Failure: The SUPPORT Trial Subanalysis (2018)
  • 著者名/発表者名: Nochioka K, Sakata Y, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Aoyanagi H, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Development of a Conversion Formula between B-type Natriuretic Peptide and N-terminal Pro BNP Levels (2018)
  • 著者名/発表者名: Kasahara S, Sataka Y, Nochioka K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Impact of Transition of Left Ventricular Ejection Fraction in Patients at Risk for Heart Failure: Report from the CHART-2 Study (2018)
  • 著者名/発表者名: Aoyanagi H, Sakata Y, Nochioka K, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Differences in Health Consciousness and Prognosis of Patients with Chronic Heart Failure -A Report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Abe R, Sakata Y, Nochioka K, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Clinical Characteristics and Prognostic Factors in Elderly Patients with Chronic Heart Failure -A Report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Sato M, Sakata Y, Oikawa T, Abe R, Kasahara S, Aoyanagi H, Miura M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Prognostic Impact of Triglycerides Levels in the Secondary Prevention of Patients with Myocardial Infarction -A Report from the CHART-2 Study- (2018)
  • 著者名/発表者名: Oikawa T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • 国際学会 / 招待講演
• [学会発表] Prognostic Impact of and Risk Score for the Onset of Atrial Fibrillation in Patients at High Risk for Heart Failure -A Report From the CHART-2 Study- (2016)
  • 著者名/発表者名: Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka N, Takahashi J, Shiroto T, Miyata S, Shimokawa H.
  • 学会等名: American Heart Association (AHA) Scientific Sessions
  • 発表場所: New Orleans , USA
  • 年月日: 2016-11-12
  • 国際学会
• [学会発表] Unique Clinical Features of Patients With Heart Failure With Preserved Ejection Fraction -Insights From the CHART-2 Study- (2016)
  • 著者名/発表者名: Tsuji K, Sakata Y, Miura M, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Nochioka K, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: American Heart Association (AHA) Scientific Sessions
  • 発表場所: New Orleans , USA
  • 年月日: 2016-11-12
  • 国際学会
• [学会発表] Comparable Prognostic Impacts of B-type Natriuretic Peptide Levels bBetween Heart Failure With Reduced and Preserved Ejection Fraction -a Report From the CHART-2 Study- (2016)
  • 著者名/発表者名: Kasahara S, Sakata Y, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Sato M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: American Heart Association (AHA) Scientific Sessions
  • 発表場所: New Orleans , USA
  • 年月日: 2016-11-12
  • 国際学会
• [学会発表] Differences in clinical characteristics and prognosis between heart failure with preserved ejection fraction and that with reduced ejection fraction -Insights from the CHART-2 Study- (2016)
  • 著者名/発表者名: Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H.
  • 学会等名: The 20th Annual Scientific Meeting of the Heart Failure Society of America
  • 発表場所: Orlando, FL, USA
  • 年月日: 2016-09-17
  • 国際学会
• [学会発表] Factors influencing daily exercise in patients with chronic heart failure A report from the multicenter prospective cohort study in Japan (2016)
  • 著者名/発表者名: Tadaki S, Sakata Y, Miura Y, Fukumoto Y, Yano M, Kadokami T, Yasuda S, Daida H, Shimokawa H.
  • 学会等名: The 20th Annual Scientific Meeting of the Heart Failure Society of America
  • 発表場所: Orlando, FL, USA
  • 年月日: 2016-09-17
  • 国際学会
• [学会発表] Prognostic risk stratification with plasma B-type natriuretic peptide levels in patients with chronic heart failure - a report from the CHART-2 Study (2016)
  • 著者名/発表者名: Kasahara S, Sakata Y, Miura M, Tadaki S, Tsuji K, Yamauchi T, Abe R, Oikawa T, Takahashi J, Miyata S, Shimokawa H
  • 学会等名: ESC Congress 2016
  • 発表場所: Roma, Italy
  • 年月日: 2016-08-27
  • 国際学会
• [学会発表] Evidence for a distinct entity of heart failure with preserved ejection frcation -A report from the CHART-2 Study- (2016)
  • 著者名/発表者名: Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H.
  • 学会等名: The 8th Asian Pacific Congress of Heart Failure
  • 発表場所: Gyengju, Korea
  • 年月日: 2016-04-15
  • 国際学会
• [学会発表] Plasma B-type natriuretic peptide levels predict long-term prognosis of patients with chronic herat failure -A report from the CHART-2 Study- (2016)
  • 著者名/発表者名: Kasahara S, Sakata Y, Miura M, Tadaki S, Onose T, Tsuji K, Yamauti T, Abe R, Oikawa T, Takahashi J, Miyata S, Shimokawa H.
  • 学会等名: The 8th Asian Pacific Congress of Heart Failure
  • 発表場所: Gyengju, Korea
  • 年月日: 2016-04-15
  • 国際学会