CD26の自己免疫病、免疫異常症の先端治療法としての分子標的療法の基礎的研究

• 研究課題/領域番号: 17109011
• 研究種目: 基盤研究(S)
• 配分区分: 補助金
• 研究分野: 膠原病・アレルギー・感染症内科学
• 研究機関: 東京大学
• 研究代表者: 森本 幾夫 東京大学, 医科学研究所, 教授 (30119028)
• 研究分担者: 細野 治 東京大学, 医科学研究所, 助教 (50190210) ; 岩田 哲史 東京大学, 医科学研究所, 特任講師 (00396871) ; 矢持 忠徳 東京大学, 医科学研究所, 産学官連携研究員 (80306844) ; 河崎 寛 東京大学, 医科学研究所, 助教 (80280957) ; 大沼 圭 東京大学, 医科学研究所, 助教 (10396872) ; 池田 哲朗 東京大学, 医科学研究所, 特任研究員 (10360489)
• 研究期間 (年度): 2005 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 112,060千円 (直接経費: 86,200千円、間接経費: 25,860千円); 2009年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2008年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2007年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2006年度: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2005年度: 37,180千円 (直接経費: 28,600千円、間接経費: 8,580千円)
• キーワード: 膠原病 / リウマチ学 / 臨床免疫学 / CD26 / caveolin-1 / 共刺激分子 / DPPIV / 自己免疫疾患 / CD8T細胞 / Xeno-GVHD / CD28 / caveolin.1 / DPPIV酵素 / ヒト化CD26抗体 / 異種GVHDマウス / CD26陽性T細胞 / TIA-1陽性T細胞 / エフェクターT細胞 / メモリーT細胞 / CD86 / 共刺激リガンド / CARMA-1 / Caveolin-1 / Tollip / IRAK-1

研究概要

CD26の共刺激リガンドとしてcaveolin-1を同定し、82-101残基はCD26の201-211残基及びDPPIV活性中心の630残基のセリンを介して結合した。CD26にCARMA-1が会合して共刺激シグナルの誘導に関わっていた。ヒトPBLをSCIDマウスに移植すると異種GVHDが生じ、ヒトT細胞がエフェクターであるが、CD26抗体を投与すると臨床症状の顕著な改善が認められたことから、CD26抗体がGVHDなどの免疫病治療に有効なことを示唆した。

研究成果

• [雑誌論文] Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4 (+) T-cell differentiation (2010)
  • 著者名/発表者名: Arimoto-Miyamoto K, Kadowaki N, Kitawaki T, Iwata S, Morimoto C, Uchiyama T.
  • 雑誌名: Immunology
• [雑誌論文] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin. (2010)
  • 著者名/発表者名: Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C
  • 雑誌名: Rheumatol Int. (in press)
  • 査読あり
• [雑誌論文] Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation. (2010)
  • 著者名/発表者名: Arimoto-Miyamoto K, Kadowaki N, Kitawaki T, Iwata S, Morimoto C, Uchiyama T
  • 雑誌名: Immunology. (in press)
  • 査読あり
• [雑誌論文] Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin (2009)
  • 著者名/発表者名: Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C.
  • 雑誌名: Rheumatol Int.
• [雑誌論文] CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion (2009)
  • 著者名/発表者名: Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH.
  • 雑誌名: Br J Cancer. 101 ページ: 983-91
• [雑誌論文] Caveolin-1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma (2009)
  • 著者名/発表者名: Amatya VJ, Takeshima Y, Kohno H, Kushitani K, Yamada T, Morimoto C, Inai K.
  • 雑誌名: Histopathology 55 ページ: 10-9
• [雑誌論文] The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4+ T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans (2009)
  • 著者名/発表者名: Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T.
  • 雑誌名: Int Immunol. 21 ページ: 891-904
  • NAID: 10025387511
• [雑誌論文] Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4 (+) T cells (2009)
  • 著者名/発表者名: Ohnuma K, Uchiyama M, Hatano R, Takasawa W, Endo Y, Dang NH, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun. 386 ページ: 327-32
• [雑誌論文] Histamine Hl-receptor antagonists with immunomodulating activities : potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases (2009)
  • 著者名/発表者名: Okamoto T, Iwata S, Ohnuma K, Dang NH, Morimoto C.
  • 雑誌名: Clin Exp Immunol. 157 ページ: 27-34
• [雑誌論文] Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect (2009)
  • 著者名/発表者名: Yamada K, Hayashi M, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T.
  • 雑誌名: Cancer Cell Int. ページ: 9-17
• [雑誌論文] CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells (2009)
  • 著者名/発表者名: Yamazaki H, Nishida H, Iwata S, Dang NH, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun. 383 ページ: 172-7
• [雑誌論文] SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration (2009)
  • 著者名/発表者名: Yo K, Iwata S, Hashizume Y, Kondo S, Nomura S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun. 382 ページ: 210-4
• [雑誌論文] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells (2009)
  • 著者名/発表者名: Nishida H, Yamazaki H, Yamada T, Iwata S, Dang NH, Inukai T, Sugita K, Ikeda Y, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun. 382 ページ: 57-62
• [雑誌論文] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy (2009)
  • 著者名/発表者名: Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C.
  • 雑誌名: Mod Rheumatol. 19 ページ: 73-9
  • NAID: 10025112125
• [雑誌論文] An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy. (2009)
  • 著者名/発表者名: Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C
  • 雑誌名: Mod Rheumatol. 19 ページ: 73-79
  • NAID: 10025112125
  • 査読あり
• [雑誌論文] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. (2009)
  • 著者名/発表者名: Nishida H, Yamazaki H, Yamada T, Iwata S, Dang NH, Inukai T, Sugita K, Ikeda Y, Morimoto C
  • 雑誌名: Biochem Biophys Res Commun. 382 ページ: 57-62
  • 査読あり
• [雑誌論文] CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. (2009)
  • 著者名/発表者名: Yo K, Iwata S, Hashizume Y, Kondo S, Nomura S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C
  • 雑誌名: Biochem Biophys Res Commun. 382 ページ: 210-214
  • 査読あり
• [雑誌論文] CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells. (2009)
  • 著者名/発表者名: Yamazaki H, Nishida H, Iwata S, Dang NH, Morimoto C
  • 雑誌名: Biochem Biophys Res Commun. 383 ページ: 172-177
  • 査読あり
• [雑誌論文] Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect. (2009)
  • 著者名/発表者名: Yamada K, Hayashi M, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T.
  • 雑誌名: Cancer Cell Int. 9 ページ: 17-17
  • 査読あり
• [雑誌論文] Histamine H1-receptor antagonists with immunomodulating activities : potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases. (2009)
  • 著者名/発表者名: Okamoto T, Iwata S, Ohnuma K, Dang NH, Morimoto C
  • 雑誌名: Clin Exp Immunol. 157 ページ: 27-34
  • 査読あり
• [雑誌論文] Caveolin-1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma. (2009)
  • 著者名/発表者名: Amatya VJ, Takeshima Y, Kohno H, Kushitani K, Yamada T, Morimoto C, Inai K
  • 雑誌名: Histopathology. 55 ページ: 10-19
  • 査読あり
• [雑誌論文] Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4(+)T cells. (2009)
  • 著者名/発表者名: Ohnuma K, Uchiyama M, Hatano R, Takasawa W, Endo Y, Dang NH, Morimoto C
  • 雑誌名: Biochem Biophys Res Commun. 386 ページ: 327-332
  • 査読あり
• [雑誌論文] The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4+T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. (2009)
  • 著者名/発表者名: Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T
  • 雑誌名: Int Immunol. 21 ページ: 891-904
  • NAID: 10025387511
  • 査読あり
• [雑誌論文] CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion. (2009)
  • 著者名/発表者名: Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH
  • 雑誌名: Br J Cancer. 101 ページ: 983-991
  • 査読あり
• [雑誌論文] CD9 Correlates with cancer stem cell potentials in human B-acute lymphoblastic leutemes cells. (2009)
  • 著者名/発表者名: Hihida H, Yamazaki H, Yamada T, Iwata S, Dang NH, Imukai T, Sugita K, Ikeda Y, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun in press
  • 査読あり
• [雑誌論文] Revisiting an old acquaintance : CD26 and its molecular mechanisms in T cell function (2008)
  • 著者名/発表者名: Ohnuma K, Dang NH, Morimoto C.
  • 雑誌名: Trends Immunol. 29 ページ: 295-301
• [雑誌論文] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function (2008)
  • 著者名/発表者名: Ohnuma K, Takahashi N, Yamochi T, Hosono O, Dang NH, Morimoto C.
  • 雑誌名: Front Biosci. 13 ページ: 2299-310
• [雑誌論文] Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood (2008)
  • 著者名/発表者名: Fujimaki W, Takahashi N, Ohnuma K, Nagatsu M, Kurosawa H, Yoshida S, Dang NH, Uchiyama T, Morimoto C.
  • 雑誌名: Clin Dev Immunol. 2008 ページ: 305859-305859
• [雑誌論文] Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1 (2008)
  • 著者名/発表者名: Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, Suematsu M, Sawai T, Morimoto C, Tanaka H.
  • 雑誌名: Mol Endocrinol. 22 ページ: 2609-23
• [雑誌論文] Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5 (2008)
  • 著者名/発表者名: Harima A, Nakaseko C, Yokota A, Kitagawa M, Morimoto C, Harigaya K, Saito Y.
  • 雑誌名: Hematology 13 ページ: 236-43
• [雑誌論文] Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression (2008)
  • 著者名/発表者名: Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
  • 雑誌名: Biochem Biophys Res Commun. 371 ページ: 44-9
• [雑誌論文] SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity (2008)
  • 著者名/発表者名: Yamochi T, Ohnuma K, Hosono O, Tanaka H, Kanai Y, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun. 370 ページ: 195-9
• [雑誌論文] The role of CD26/dipeptidyl peptidase IV in cancer (2008)
  • 著者名/発表者名: Havre PA, Abe M, Urasaki Y, Ohnuma K, Morimoto C, Dang NH.
  • 雑誌名: Front Biosci. 13 ページ: 1634-45
• [雑誌論文] SSA/Ro52 autoantigen interacts with Dcp2 to cnhance its decapping actibity. (2008)
  • 著者名/発表者名: Yamodhi T, Ohmuma K, Hosono O, Tanaka H, Kanai Y, Morinoto C.
  • 雑誌名: Biochem Biophys Res Commun. 370 ページ: 195-199
  • 査読あり
• [雑誌論文] Role of the hinge region of glucocorticoid receptor for HEXIMI-mediated trans criprional repression. (2008)
  • 著者名/発表者名: Yohikawa N, Shimizu N, Sano M, Ohmuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Taanaka H.
  • 雑誌名: Biochem Biophys Res Commun. 371 ページ: 44-49
  • 査読あり
• [雑誌論文] Fibromectin promotes cell proliferation of human pre-B cell line via irs interactions with VLA-4 and VLA-5 (2008)
  • 著者名/発表者名: Harima A, Morimoto C, Harigara K, Saito Y,et al
  • 雑誌名: Hematology 13 ページ: 236-243
  • 査読あり
• [雑誌論文] Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes gy hexamethylene bisacetamide-inducible protein 1. (2008)
  • 著者名/発表者名: Shimizu M, Yoshikawa N, Morimoto C, Tanaka H, et al
  • 雑誌名: Mol Endocrinol. 22 ページ: 2609-2623
  • 査読あり
• [雑誌論文] Comparative study of regulaltory Tcell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood. (2008)
  • 著者名/発表者名: Fujimaki W, Takahashi N, Ohmuma K, Makatsu M, Kurosawa H, Yodhida S, Dang NH, Uchiyama T, Morimoto C.
  • 雑誌名: Clin Dev Immunol. 2008 ページ: 305859-305859
  • 査読あり
• [雑誌論文] Role of CD26/dipepridyl peptidase IV in human T cell activation and function (2008)
  • 著者名/発表者名: Ohmuma k, Takahashi N, Yamochi T, Hodono O, Dang NH, Morimoto C.
  • 雑誌名: Fromt Biosci 13 ページ: 2299-2310
  • 査読あり
• [雑誌論文] Revisiting an old acquaintance:CD26 and its molecular mechanisms in T cell function (2008)
  • 著者名/発表者名: Ohmuma K, Morimoto C.
  • 雑誌名: Trends Immunol 29 ページ: 295-301
  • 査読あり
• [雑誌論文] The role of CD26/dipeptidyl peptidase IV in cancer (2008)
  • 著者名/発表者名: Havre PA, Morimoto C, Dang NH, et. al.
  • 雑誌名: Front Biosci 13 ページ: 1634-1645
  • 査読あり
• [雑誌論文] Role of CD26/dipeptidyl peptidase IV in human T cell activation and function (2008)
  • 著者名/発表者名: Ohnuma K, Hosono O, Dang NH, Morimoto C, et. al.
  • 雑誌名: Front Biosci 13 ページ: 2299-2310
  • 査読あり
• [雑誌論文] Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/lymphoma (2007)
  • 著者名/発表者名: Kayo H, Yamazaki H, Nishida H, Dang NH, Morimoto C.
  • 雑誌名: Biochem Biophys Res Commun. 364 ページ: 808-14
• [雑誌論文] Could serum antibody to poly (ADP-ribose) and/or histone H1 be marker for senile dementia of Alzheimer type? (2007)
  • 著者名/発表者名: Kanai Y, Akatsu H, Iizuka H, Morimoto C.
  • 雑誌名: Ann N Y Acad Sci. 1109 ページ: 338-44
• [雑誌論文] Humanized Anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors (2007)
  • 著者名/発表者名: Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
  • 雑誌名: Clin Cancer Res. 13 ページ: 4191-200
• [雑誌論文] Transcriptional upregulation of ipas gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells (2007)
  • 著者名/発表者名: Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
  • 雑誌名: J Biol Chem. 282 ページ: 14073-82
• [雑誌論文] Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1 (2007)
  • 著者名/発表者名: Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
  • 雑誌名: J Biol Chem. 282 ページ: 10117-31
• [雑誌論文] Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells (2007)
  • 著者名/発表者名: Ohnuma-Ishikawa K, Morio T, Yamada T, Sugawara Y, Ono M, Nagasawa M, Yasuda A, Morimoto C, Ohnuma K, Dang NH, Hosoi H, Verdin E, Mizutani S.
  • 雑誌名: Cancer Res. 67 ページ: 1019-29
• [雑誌論文] Crk-associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7 (2007)
  • 著者名/発表者名: Inamoto S, Iwata S, Inamoto T, Nomura S, Sasaki T, Urasaki Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
  • 雑誌名: Oncogene 26 ページ: 893-904
• [雑誌論文] Transcriptional upregulation of ipas gene expression by HIF-1:A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells (2007)
  • 著者名/発表者名: Makino Y, Morimoto C, et. al.
  • 雑誌名: J Biol Chem 282 ページ: 14073-14082
  • 査読あり
• [雑誌論文] Humanized Anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors (2007)
  • 著者名/発表者名: Inamoto T, Modmoto C, et. al.
  • 雑誌名: Clin Cancer Res 13 ページ: 4191-4200
  • 査読あり
• [雑誌論文] Could serum antibody to poly(ADP-ribose)and/or histone Hl be marker for senile dementia of Alzheimer type? (2007)
  • 著者名/発表者名: Kanai Y, Akatsu H, Iizuka H, Morimoto C
  • 雑誌名: Ann N Y Acad Sci 1109 ページ: 338-344
  • 査読あり
• [雑誌論文] Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/Imhoma (2007)
  • 著者名/発表者名: Kayo H, Yamazaki H, Nishida H, Dang NH, Morimoto C
  • 雑誌名: Biochem Biophys Res Commun 364 ページ: 808-14
  • 査読あり
• [雑誌論文] Crk-associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7 (2007)
  • 著者名/発表者名: Inamoto S, morimoto C, et al.
  • 雑誌名: Oncogene 26 ページ: 893-904
• [雑誌論文] Knockdown of XAB2 enhances all-trans retionic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells (2007)
  • 著者名/発表者名: Ohnuma-Ishikawa K, Morimoto C, et al.
  • 雑誌名: Cancer Res. 67 ページ: 1019-29
• [雑誌論文] Caveolin-1 triggers T-cell activation via CD26 in association with CARMAl (2007)
  • 著者名/発表者名: Ohnuma K, Morimoto C, et al.
  • 雑誌名: J Biol Chem. 282 ページ: 10117-31
• [雑誌論文] Transcriptional upregulation of ipas gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells (2007)
  • 著者名/発表者名: Makino Y, Morimoto C, et al.
  • 雑誌名: J Biol Chem. in press
• [雑誌論文] CD26 Plays a Role in Malignant Mesothelioma Tumor Growth and is a novel Target for Treatment of Malignant Mesothelioma (2007)
  • 著者名/発表者名: Inamoto T, Morimoto C, et al.
  • 雑誌名: Clin Cancer Res. in press
• [雑誌論文] Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27 (kipl) enhancement, and disruption of binding to the extracellular matrix (2006)
  • 著者名/発表者名: Inamoto T, Yamochi T, Ohnuma K, Iwata S, Kina S, Inamoto S, Tachibana M, Katsuoka Y, Dang NH, Morimoto C.
  • 雑誌名: Clin Cancer Res. 12 ページ: 3470-7
• [雑誌論文] Anti-CD26 monoclonal antibody-mediated GI-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kipl)enhancement,and disruption of binding to the extracellular matrix (2006)
  • 著者名/発表者名: Inamoto T, Morimoto C, et al.
  • 雑誌名: Clin cancer Res. 12 ページ: 3470-7
• [雑誌論文] Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats : possible involvement of Nedd9 in the differentiation of neurons after ischemia (2005)
  • 著者名/発表者名: Sasaki T, Iwata S, Okano HJ, Urasaki Y, Hamada J, Tanaka H, Dang NH, Okano H, Morimoto C.
  • 雑誌名: Stroke 36 ページ: 2457-62
• [雑誌論文] CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells (2005)
  • 著者名/発表者名: Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
  • 雑誌名: Mol Cell Biol. 25 ページ: 7743-57
• [雑誌論文] CD26 regulates p38 mitogen-activated protein kinase-dependent phosphorylation of integrin betal, adhesion to extracellular matrix, and tumorigenicity of T-anaplastic large cell lymphoma Karpas 299 (2005)
  • 著者名/発表者名: Sato T, Yamochi T, Yamochi T, Aytac, Ohnuma K, McKee KS, Morimoto C, Dang NH.
  • 雑誌名: Cancer Res. 65 ページ: 6950-6
• [雑誌論文] CD26 T cells in the pathogenesis of asthma (2005)
  • 著者名/発表者名: Ohnuma K, Yamochi T, Hosono O, Morimoto C.
  • 雑誌名: Clin Exp Immunol. 139 ページ: 13-16
• [雑誌論文] Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin (2005)
  • 著者名/発表者名: Yamochi T, Yamochi T, Aytac U, Sato T, Sato K, Ohnuma K, McKee KS, Morimoto C, Dang NH.
  • 雑誌名: Cancer Res. 65 ページ: 1973-83
• [雑誌論文] HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L) (2005)
  • 著者名/発表者名: Iwata S, Souta-Kuribara A, Yamakawa A, Sasaki T, Shimizu T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe T, Arima N, Morimoto C.
  • 雑誌名: Oncogene 24 ページ: 1262-71
• [雑誌論文] HTLV-I Tax induces and associates with Ork-associated substrate lymphocyte type (Cas-L). (2005)
  • 著者名/発表者名: Iwata S, Morimoto C, et al.
  • 雑誌名: Oncogene 24 ページ: 1262-1271
• [雑誌論文] Regulation of p38 phosphorylation and topoisomerase llalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin. (2005)
  • 著者名/発表者名: Yamochi T, Morimoto C, et al.
  • 雑誌名: Cancer Res. 65 ページ: 1973-1983
• [雑誌論文] CD26 T cells in the pathogenesis of asthma. (2005)
  • 著者名/発表者名: Ohnuma K, Yamochi T, Hosono O, Morimoto C.
  • 雑誌名: Clin Exp Immunol. 139 ページ: 13-16
• [雑誌論文] CD26 regulates p38 mitogen-activated protein kinase-dependeni phosphorylation of integrin betal, adhesion to extracellular matrix, and tumorigenicity of T-anaplastic large cell lymphoma Karpas 299. (2005)
  • 著者名/発表者名: Sato T, et al.
  • 雑誌名: Cancer Res. 65 ページ: 6950-6956
• [雑誌論文] CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells. (2005)
  • 著者名/発表者名: Ohnuma K, Morimoto C, et al.
  • 雑誌名: Mol Cell Biol. 25 ページ: 7743-7757
• [雑誌論文] Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats : possible involvement of Nedd9 in the differentiation of neurons after ischemia (2005)
  • 著者名/発表者名: Sasaki T, Morimoto C, et al.
  • 雑誌名: Stroke 36 ページ: 2457-2462
• [学会発表] A Novel Function of CD26-Madiate Costimulation in the Cytotoxic Activity of Human CD8+ T cells in Xenogeneic Chronic Graft-Versus-Host Disease (cGVHD) and GVL Mice Model (2009)
  • 著者名/発表者名: Hatano R, Ohnuma K, Yamada T, et al, Morimoto C.
  • 学会等名: 第51回アメリカ血液学会 (ASH)
  • 発表場所: Morial Convention Center (New Orleans, U. S. A.)
  • 年月日: 2009-12-07
• [学会発表] A Novel Function of CD26-Madiate Costimulation in the Cytotoxic Activity of Human CD8+T cells in Xenogeneic Chronic Graft-Versus-Host Disease(cGVHD)and GVL Mice Model. (2009)
  • 著者名/発表者名: Hatano R, Ohnuma K, Yamada T, et al, Morimoto C.
  • 学会等名: 第51回アメリカ血液学会(ASH)
  • 発表場所: Morial Convention Center(New Orleans, U.S.A.)
  • 年月日: 2009-12-07
• [学会発表] CD26/DPPIVのヒトT細胞機能と活性化 : ベンチからベッドまで (2009)
  • 著者名/発表者名: 森本幾夫, 大沼圭
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸国際展示場
  • 年月日: 2009-10-21
• [学会発表] CD26/DPP IVのヒトT細胞機能と活性化:ベンチからベッドまで (2009)
  • 著者名/発表者名: 森本幾夫、大沼圭
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸国際展示場
  • 年月日: 2009-10-21
• [学会発表] CD26分子を用いたトランスレーショナルリサーチ (2008)
  • 著者名/発表者名: 森本幾夫
  • 学会等名: 第29回日本炎症・再生医学会教育講演
  • 発表場所: 都市センターホテル
  • 年月日: 2008-07-09
• [学会発表] ヒト化CD26抗体の難治性免疫疾患(クローン病、GVHDなど)への治療法開発 (2008)
  • 著者名/発表者名: 森本 幾夫
  • 学会等名: 厚生労働科学研究費補助金「基礎研究成果の臨床応用研究事業」トランスレーショナル研究成果発表会
  • 発表場所: (財)がん研究振興財団国際研究交流会館国際会議場
  • 年月日: 2008-02-26
• [備考]
  • URL: http://www.ims.u-tokyo.ac.jp/cimmuno/
• [備考]
  • URL: http://www.ims.u-tokyo.ac.jp/cimmuno/
• [産業財産権] 細胞表面分子CD26を標的とした悪性中皮腫の治療法 (2007)
  • 発明者名: 森本幾夫, 大沼圭, 稲元輝生
  • 権利者名: 国立大学法人東京大学
  • 出願年月日: 2007-03-14
• [産業財産権] caveolin-1-Fc γ1融合タンパク質及びその使用 (2006)
  • 発明者名: 森本幾夫, 大沼圭
  • 権利者名: 国立大学法人東京大学
  • 産業財産権番号: 2006-351154
  • 出願年月日: 2006-12-27
• [産業財産権] 免疫調整剤のスクリーニング方法 (2006)
  • 発明者名: 森本幾夫, 大沼圭
  • 権利者名: 国立大学法人東京大学
  • 産業財産権番号: 2006-351173
  • 出願年月日: 2006-12-17
• [産業財産権] caveolin-1-Fcγ 1融合タンパク質及びその使用 (2006)
  • 発明者名: 森本幾夫, 大沼圭
  • 権利者名: 東京大学
  • 産業財産権番号: 2006-351154
  • 出願年月日: 2006-12-27