COPDのphenotypingに関する包括的研究

• 研究課題/領域番号: 18209029
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 呼吸器内科学
• 研究機関: 京都大学
• 研究代表者: 三嶋 理晃 京都大学, 大学院・医学研究科, 教授 (60190625)
• 研究分担者: 新實 彰男 京都大学, 大学院・医学研究科, 准教授 (30252513) ; 平井 豊博 京都大学, 大学院・医学研究科, 講師 (20359805) ; 室 繁郎 京都大学, 大学院・医学研究科, 講師 (60344454) ; 小川 恵美子 京都大学, 大学院・医学研究科, 助教 (00378671) ; 小賀 徹 京都大学, 大学院・医学研究科, 講師 (90378670) ; 星野 勇馬 京都大学, 産学官連携研究員 (00378746) ; 中野 恭幸 滋賀医科大学, 医学部, 教授 (00362377)
• 研究期間 (年度): 2006 – 2008
• 研究課題ステータス: 完了 (2008年度)
• 配分額: 50,050千円 (直接経費: 38,500千円、間接経費: 11,550千円); 2008年度: 9,620千円 (直接経費: 7,400千円、間接経費: 2,220千円); 2007年度: 9,620千円 (直接経費: 7,400千円、間接経費: 2,220千円); 2006年度: 30,810千円 (直接経費: 23,700千円、間接経費: 7,110千円)
• キーワード: 画像診断 / 遺伝子多型 / 炎症 / 体重減少 / 胃食道逆流 / 骨そしょう症 / リモデリング / 慢性閉塞性肺疾患 / phenotyping / 動物モデル / 細胞培養 / 肺障害

研究概要

マウスの肺気腫生成に対するチオレドキシンの予防効果を明らかにし、肺気腫自然発症のモデルであるklotho mouseの病理画像がフラクタル構造を呈することを明らかにした。さらに、COPDにおいて、GERD(胃食道逆流)の症状を持つ患者は、有意に急性増悪の頻度が高いこと、CT画像における気腫病変の程度は体重(BMI)や骨塩量(BMD)と有意な相関を認めることを明らかにした。

研究成果

• [雑誌論文] Features of cough variant asthmaand classic asthma duringmethacholine-inducedbrochoconstriction : a cross-sectional study (2009)
  • 著者名/発表者名: Matsumoto H, Niimi A, Takemura M, Ueda T,Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M
  • 雑誌名: Cough
• [雑誌論文] Specific IgE response to trichophyton and asthma severity (2009)
  • 著者名/発表者名: Matsuoka H, Niimi A, Matsumoto H, Ueda T,Takemura M, Yamaguchi M, Jinnai M,, Otsuka K,Oguma T, Takeda T, Ito I, Chin K, Amitani R,Mishima M
  • 雑誌名: Chest 135(4) ページ: 898-903
• [雑誌論文] Eosinophilic airway disorders associated withchronic cough (2009)
  • 著者名/発表者名: Niimi A, Matsumoto H, Mishima M
  • 雑誌名: Pulm Pharmacol Ther 22(2) ページ: 114-20
• [雑誌論文] Body mass index in male patients with COPD : correlation with low attenuation areas on CT. (2009)
  • 著者名/発表者名: Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T,Sato S, Sakai H, Tsukino M, Kinose D, NishiokaM, Niimi A, Chin K, Par 辿 PD, Mishima M.
  • 雑誌名: Thorax 64(1) ページ: 20-5
• [雑誌論文] Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction : a cross-sectional study (2009)
  • 著者名/発表者名: Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
  • 雑誌名: Cough. 9 ; 5:3
  • NAID: 120004770219
• [雑誌論文] Specific IgE response to trichophyton and asthma severity. (2009)
  • 著者名/発表者名: Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, Jinnai M, Otsuka K, Oguma T, Takeda T, I to I, Chin K, Amitani R, Mishima M.
  • 雑誌名: Chest. 135 (4) ページ: 898-903
• [雑誌論文] Eosinophilic airway disorders associated with chronic cough. (2009)
  • 著者名/発表者名: Niimi A, Matsumoto H, Mishima M.
  • 雑誌名: Pulm Pliarmacol Ther. 22(2) ページ: 114-20
• [雑誌論文] Body mass index in male patients with COPD : correlation with low attenuation areas on CT. (2009)
  • 著者名/発表者名: Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M.
  • 雑誌名: Thorax 64(1) ページ: 20-5
• [雑誌論文] Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD (2008)
  • 著者名/発表者名: Ohara T, Hirai T, Muro S, Haruna A, Terada K,Kinose D, Marumo S, Ogawa E, Hoshino Y,Niimi A, Chin K, Mishima M.
  • 雑誌名: Chest 134(6) ページ: 1244-9
• [雑誌論文] Gastroesophagealreflux-associated chronic cough in an adolescentand the diagnostic implications : a case report (2008)
  • 著者名/発表者名: Jinnai M, Niimi A, Takemura M, Matsumoto H,Konda Y, Mishima M.
  • 雑誌名: Cough 15 ページ: 5-5
• [雑誌論文] Impact ofgastro-oesophageal reflux disease symptoms onCOPD exacerbation (2008)
  • 著者名/発表者名: Terada K, Muro S, Sato S, Ohara T, Haruna A,Marumo S, Kinose D, Ogawa E, Hoshino Y,Niimi A, Terada T, Mishima M
  • 雑誌名: Thorax 63(11) ページ: 951-5
• [雑誌論文] Redox-basedtherapeutics for lung diseases (2008)
  • 著者名/発表者名: Hoshino Y, Mishima M
  • 雑誌名: Antioxid Redox Signal 10(4) ページ: 701-4
• [雑誌論文] Sputum levels of transforming growth factor-beta1 in asthma : relation to clinical and computed tomography findings (2008)
  • 著者名/発表者名: Yamaguchi M, Niimi A, Matsumoto H, UedaT, Takemura M, Matsuoka H, Jinnai M, OtsukaK, Oguma T, Takeda T, Ito I, Chin K, MishimaM
  • 雑誌名: J Investig Allergol Clin Immunol 18(3) ページ: 202-6
• [雑誌論文] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography (2008)
  • 著者名/発表者名: Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E,Nakano Y, Hoshino Y, Ito Y, Matsumoto H,Niimi A, Mio T, Chin K, Muro S, Mishima M.
  • 雑誌名: Respirology 13(3) ページ: 372-8
• [雑誌論文] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice (2008)
  • 著者名/発表者名: Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J
  • 雑誌名: J Pharmacol Exp Ther 325(2) ページ: 380-8
• [雑誌論文] TGFB1 promoter polymorphism C-509T andpathophysiology of asthma (2008)
  • 著者名/発表者名: Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
  • 雑誌名: J Allergy ClinImmunol 121(3) ページ: 659-64
• [雑誌論文] Relationship between pulmonary empliysema and osteoporosis assessed by CT in patients with COPD. (2008)
  • 著者名/発表者名: Ohara T, Hirai T, Muro S, Haruna A, Terada K, Kinose D, Marumo S, Ogawa E, Hoshino Y, Niimi A, Chin K, Mishima M.
  • 雑誌名: Chest 134(6) ページ: 1244-9
• [雑誌論文] Gastroesophageal reflux-associated chronic cough in an adolescent and thediagnostic implications : a case report (2008)
  • 著者名/発表者名: Jinnai M, Niimi A, Takemura M, Matsumoto H, Konda Y, Mishima M.
  • 雑誌名: Cough. 15 ; 4:5
• [雑誌論文] Sputum levels of transforming growth factor-betal in asthma : relation to clinical and computed tomography findings. (2008)
  • 著者名/発表者名: Yamaguchi M, Niimi A, Matsumoto H, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Chin K, Mishima M.
  • 雑誌名: J Investig Allergol Clin Immunol. 18(3) ページ: 202-6
• [雑誌論文] Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. (2008)
  • 著者名/発表者名: Terada K, Muro S, Sato S, Ohara T, Haruna A, Marumo S, Kinose D, Ogawa E, Hoshino Y, Niimi A, Terada T, Mishima M.
  • 雑誌名: Thorax 63(11) ページ: 951-5
• [雑誌論文] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography. (2008)
  • 著者名/発表者名: Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
  • 雑誌名: Respirology 13(3) ページ: 372-8
• [雑誌論文] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysemain mice (2008)
  • 著者名/発表者名: Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J.
  • 雑誌名: J Pharmacol Exp Ther. 325(2) ページ: 380-8
• [雑誌論文] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure. (2008)
  • 著者名/発表者名: Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
  • 雑誌名: Antioxid Redox Signal. 10(4) ページ: 715-26
• [雑誌論文] Redox-based therapeutics for lung diseases. (2008)
  • 著者名/発表者名: Hoshino Y, Mishima M.
  • 雑誌名: Antioxid Redox Signal. 10(4) ページ: 701-4
• [雑誌論文] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. (2008)
  • 著者名/発表者名: Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M.
  • 雑誌名: J Allergy Clin Immunol. 121(3) ページ: 659-64
• [雑誌論文] Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography. (2008)
  • 著者名/発表者名: Ohara T, Hirai T, Sato S, Terada K, Kinose D, Haruna A, Marumo S, Nishioka M, Ogawa E, Nakano Y, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Muro S, Mishima M.
  • 雑誌名: Respirology. 13(3) ページ: 372-8
  • 査読あり
• [雑誌論文] Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice (2008)
  • 著者名/発表者名: Sato A, Hoshino Y, Hara T, Muro S, Nakamura H, Mishima M, Yodoi J.
  • 雑誌名: J Pharmacol Exp Ther. 325(2) ページ: 380-8
  • 査読あり
• [雑誌論文] TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. (2008)
  • 著者名/発表者名: Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima
  • 雑誌名: J Allergy Clin Immunol. 121(3) ページ: 659-64
  • 査読あり
• [雑誌論文] Atopic features of cough variantasthma and classic asthma with wheezing (2007)
  • 著者名/発表者名: Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
  • 雑誌名: ClinExp Allergy 37(12) ページ: 1833-9
• [雑誌論文] Corticosteroid-induced myopathy mimickingtherapy-resistant asthma (2007)
  • 著者名/発表者名: Yamaguchi M, Niimi A, Minakuchi M,Matsumoto H, Shimizu K, Chin K, Mishima M.
  • 雑誌名: Ann Allergy AsthmaImmunol 99(4) ページ: 371-4
• [雑誌論文] Analysis of longitudinalchanges in the psychological status of patientswith asthma (2007)
  • 著者名/発表者名: Oga T, Nishimura K, Tsukino M, Sato S,Hajiro T, Mishima M
  • 雑誌名: Respir Med 101(10) ページ: 2133-8
• [雑誌論文] Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1 (2007)
  • 著者名/発表者名: Hoshino Y, Nakamura T, Sato A, Mishima M,Yodoi J, Nakamura H
  • 雑誌名: Am J Respir Cell MolBiol 37(4) ページ: 438-46
• [雑誌論文] Airway wallthickening in patients with cough variant asthmaand nonasthmatic chronic cough (2007)
  • 著者名/発表者名: Matsumoto H, Niimi A, Tabuena RP,Takemura M, Ueda T, Yamaguchi M, MatsuokaH, Jinnai M, Chin K, Mishima M.
  • 雑誌名: Chest 131(4) ページ: 1042-9
• [雑誌論文] Morphological mechanism of the development ofpulmonary emphysema in klotho mice (2007)
  • 著者名/発表者名: Sato A, Hirai T, Imura A, Kita N, Iwano A,Muro S, Nabeshima Y, Suki B,Mishima M.
  • 雑誌名: Proc NatlAcad Sci USA 104(7) ページ: 2361-5
• [雑誌論文] Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population (2007)
  • 著者名/発表者名: Matsumoto H, Niimi A, Takemura M, Ueda T,Yamaguchi M, Matsuoka H, Jinnai M, Chin K,Mishima M.
  • 雑誌名: Cough ページ: 3-1
  • NAID: 120004770220
• [雑誌論文] Longitudinal deteriorations in patient reported outcomes inpatients with COPD (2007)
  • 著者名/発表者名: Oga T, Nishimura K, Tsukino M, Sato S,Hajiro T, Mishima M.
  • 雑誌名: Respir Med 101(1) ページ: 146-53
• [雑誌論文] Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1. (2007)
  • 著者名/発表者名: Hoshino Y, Nakamura T, Sato A, Mishima M, Yodoi J, Nakamura H.
  • 雑誌名: Am J Respir Cell Mol Biol. 37(4) ページ: 438-46
  • 査読あり
• [雑誌論文] Atopic features of cough variant asthma and classic asthma with wheezing (2007)
  • 著者名/発表者名: Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M.
  • 雑誌名: Clin Exp Allergy. 37(12) ページ: 1833-9
  • 査読あり
• [雑誌論文] Elevation of serum thioredoxin in patients with gefitinib-induced interstitial lung disease. (2007)
  • 著者名/発表者名: Sakuma K, Nakamura H, Nakamura T, Hoshino Y, Ueda S, Ichikawa M, Tabata C, Fujita S, Masago K, Yodoi J, Mishima M, Mio T.
  • 雑誌名: Intern Med. 46(23) ページ: 1905-9
  • NAID: 130000078603
  • 査読あり
• [雑誌論文] Corticosteroid-induced myopathy mimicking therapy-resistant asthma. (2007)
  • 著者名/発表者名: Yamaguchi M, Niimi A, Minakuchi M, Matsumoto H, Shimizu K, Chin K, Mishima M.
  • 雑誌名: Ann Allergy Asthma Immunol. 99(4) ページ: 371-4
  • 査読あり
• [雑誌論文] Analysis of longitudinal changes in the psychological status of patients with asthma. (2007)
  • 著者名/発表者名: Oga T, Nishimura K, Tsukino M, Sato S, Hajiro T, Mishima M.
  • 雑誌名: Respir Med. 101(10) ページ: 2133-8
  • 査読あり
• [雑誌論文] Morphological mechanism of the development of pulmonary emphysema in klotho mice. (2007)
  • 著者名/発表者名: Sato A, Hirai T, Imura A, Kita N, Iwano A, Muro S, Nabeshima Y, Suki B, Mishima M
  • 雑誌名: Proc Natl Acad Sci U S A. Feb 13;104 (7)
• [雑誌論文] Role of small airways in asthma : investigation using high-resolution computed tomography (2006)
  • 著者名/発表者名: Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M.
  • 雑誌名: J Allergy Clin Immunol 118(5) ページ: 1019-25
• [雑誌論文] Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking (2006)
  • 著者名/発表者名: Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M, Yodoi J.
  • 雑誌名: Antioxid Redox Signal 8(9-10) ページ: 1891-6
• [雑誌論文] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD (2006)
  • 著者名/発表者名: Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
  • 雑誌名: Respirology 11(5) ページ: 579-85
• [雑誌論文] High sensitivity C-reactive protein in asthma (2006)
  • 著者名/発表者名: Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Muro S,Hirai T, Ito Y, Nakamura T, Mio T, Chin K, Mishima M.
  • 雑誌名: Eur Respir J 27(5) ページ: 908-12
• [雑誌論文] Prognosis of cough variant asthma : a retrospective analysis (2006)
  • 著者名/発表者名: Matsumoto H, Niimi A, Takemura M, Ueda T, Tabuena R, Yamaguchi M, Matsuoka H, Hirai T, Muro S, Ito Y, Mio T, Chin K, Nishiyama H, Mishima M.
  • 雑誌名: J Asthma 43(2) ページ: 131-5
• [雑誌論文] Dyspnoea with activities of dailyliving versus peak dyspnoea during exercise in male patients with COPD (2006)
  • 著者名/発表者名: Oga T, Nishimura K, Tsukino M, Hajiro T, Mishima M.
  • 雑誌名: Respir Med 100(6) ページ: 965-71
• [雑誌論文] Thioredoxin-l suppresses systemic inflammatory responses against cigarette smoking. (2006)
  • 著者名/発表者名: Sato A, Hara T, Nakamura H, Kato N, Hoshino Y, Kondo N, Mishima M
  • 雑誌名: Antioxid Redox Signal 8 (9-10) ページ: 1891-1896
• [雑誌論文] Prognosis of cough variant asthma : a retrospective analysis. (2006)
  • 著者名/発表者名: Motsumoto, H., A.Niimi, M.Takemura, T.Ueda, R.Tabuena, M.Yamaguchi, H.Matsuoka, T.Hirai, S.Muro, Y.Ito, T.Mio, K.Chin, H.Nishiyama, M.Mishima
  • 雑誌名: J Asthma 43 (2) ページ: 131-135
• [雑誌論文] Role of small airways in asthma : Investigation using high-resolution computed tomography. (2006)
  • 著者名/発表者名: Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M
  • 雑誌名: J Allergy Clin Immunol 118 ページ: 1019-1025
• [雑誌論文] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD. (2006)
  • 著者名/発表者名: Ohara T, Hirai T, Sato S, Sato A, Nishioka M, Muro S, Mishima M
  • 雑誌名: Respirology Sep;11 (5) ページ: 579-585
• [雑誌論文] Cough-ReflexSensitivity to Inhaled Capsaicin in ChronicObstructive Pulmonary Disease : the Impact onExacerbation Frequency
  • 著者名/発表者名: Kunihiko Terada, M.D., Shigeo Muro, M.D.,Ph. D., Tadashi Ohara, M.D., Ph. D., AkaneHaruna, M.D., Satoshi Marumo, M.D., MegumiKudo, M.D., Emiko Ogawa, M.D., Ph. D.,Yuma Hoshino, M.D., Ph. D., Toyohiro Hirai,M.D., Ph. D., Akio Niimi, M.D., Ph. D.,Michiaki Mishima, M.D., Ph. D.
  • 雑誌名: Respirology (in press)
• [雑誌論文] Effect of inhaled corticosteroidson small airways in asthma: Investigation usingimpulse oscillometry
  • 著者名/発表者名: Yamaguchi M, Niimi A, Ueda T, TakemuraM, Matsuoka H, Jinnai M, Otsuka K, Oguma T,Takeda T, Ito I, Matsumoto H, Hirai T, Chin K,Mishima M.
  • 雑誌名: Pulm Pharmacol Ther (in press)
• [雑誌論文] Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation.
  • 著者名/発表者名: Kunihiko Terada, Shigeo Muro, Susumu Sato, Tadashi Ohara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yuma Hoshino, Akio Niimi, Michiaki Mishima.
  • 雑誌名: Thorax (in press)
  • 査読あり
• [雑誌論文] M. Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough.
  • 著者名/発表者名: Matsumoto H, Niimi A, Tabuena RP, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima
  • 雑誌名: Chest (in press)
• [学会発表] Regulation of Connective Tissue Growth Factor Gene Expression by Lipopolysaccharide in Bronchial Epithelial Cells (2009)
  • 著者名/発表者名: M. Nishioka, E. Ogawa, T. Hirai, S. Muro, M. Mishima
  • 学会等名: 2006 International Conference of American Thoracic Society
  • 発表場所: San Diego Convention Center, San Diego, California, USA
• [学会発表] Sputum leukocytosis on stable condition predicts chronic obstructive pulmonary disease exacerbations (2008)
  • 著者名/発表者名: Kunihiko Terada, Shigeo Muro, TadashiOhara, Akane Haruna, Satoshi Marumo, Daisuke Kinose, Emiko Ogawa, Yutaka Ito, Satoshi Ichiyama, Michiaki Mishima
  • 学会等名: 2008 International Conferenceof American Thoracic Society
  • 発表場所: Metro Toronto Convention Centre, Toronto, Canada
• [学会発表] Relation between smallairways and patient reported outcomes in chronic obstructive pulmonary disease (2008)
  • 著者名/発表者名: Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Kunihiko Terada, Daisuke Kinose, Satoshi Marumo, Yuma Hoshino, Toyohiro Hirai, Emiko Ogawa, Kazuo Chin, Michiaki Mishima
  • 学会等名: 2008 International Conference of American ThoracicSociety
  • 発表場所: Metro Toronto Convention Centre, Toronto, Canada
• [学会発表] Chest Subcutaneous Fat Mass Measured by Chest Computed Tomography Correlated with Low Attenuation Areas in COPD (2008)
  • 著者名/発表者名: E. Ogawa., T. Ohara, Kinose, Nishioka. Sakai, MD, S. Muro, T. Hirai, Y. Nakano, M. Mishima
  • 学会等名: 2008 International Conference of American Thoracic Society
  • 発表場所: MetroToronto Convention Centre, Toronto, Canada
• [学会発表] Impaired swallowing reflex predisposes to COPD exacerbations (2008)
  • 著者名/発表者名: Kunihiko Terada, Shigeo Muro, TadashiOhara, Megumi Kudo, Emiko Ogawa, YumaHoshino, Toyohiro Hirai, Akio Niimi, MichiakiMishima
  • 学会等名: 18th Annual Conference of European Respiratory Society
  • 発表場所: Messe Sud, Berlin, Germany
• [学会発表] TNF-alpha Modulates Expressions of MMPs and Migratory Function of Human Airway Smooth Muscle Cells (2008)
  • 著者名/発表者名: Ito I, Hamid Q, Niimi A, Matsumoto H,Yamaguchi M, Matsuoka H, Jinnai M, OtsukaK, Takeda T, Nakaji H, Mishima M
  • 学会等名: 2008 International Conference of American Thoracic Society
  • 発表場所: Metro Toronto Convention Centre, Toronto, Canada
• [学会発表] Relationship between Small Airways Function, and Health Status, Dyspneaand Disease Control in Asthma (2008)
  • 著者名/発表者名: Takeda T, Oga T, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Chin K, Mishima M
  • 学会等名: 2008 International Conference of American Thoracic Society
  • 発表場所: Metro Toronto Convention Centre, Toronto, Canada
• [学会発表] Arterial Hypoxia Correlated with the Inflammatory Profile in Induced Sputum from COPD Patients (2007)
  • 著者名/発表者名: Sato, S. Muro, S. Sato, M. Nishioka, Y. Hoshino, E. Ogawa, T. Hirai, H. Nakamura, J. Yodoi, M. Mishima
  • 学会等名: 2007 International Conference of American Thoracic Society
  • 発表場所: Moscone Convention Center, San Francisco, California, USA
• [学会発表] Corticosteroid Suppressed LPS Induced NOD2 Gene Expression in Airway Epithelial Cells/D (2007)
  • 著者名/発表者名: Kinose, E. Ogawa, M. Nishioka, Y. Hoshino, T. Hirai, S. Muro, M. Mishima
  • 学会等名: 2007 International Conference of American Thoracic Society
  • 発表場所: Moscone Convention Center, San Francisco, California, USA
• [学会発表] Thioredoxin Suppressed Cigarette Smoke Induced Emphysema in Mice (2007)
  • 著者名/発表者名: Sato, Y. Hoshino, M. Takenaka, S. Muro, H. Nakamura, J. Yodoi, M. Mishima
  • 学会等名: 2007 International Conference of American Thoracic Society
  • 発表場所: Moscone Convention Center, San Francisco, California, USA
• [学会発表] Respiratory Resistance In COPD Patients Using Impulse Oscillometry (2007)
  • 著者名/発表者名: S. SATO, T. HIRAI, S. MURO AND M. MISHIMA
  • 学会等名: Biomedical Engineering Symposium
  • 発表場所: Losangels, USA
• [学会発表] Morphological Mechanism Of The Development Of ulmonary Emphysema In Klotho Mice (2007)
  • 著者名/発表者名: T. HIRAI, A. SATO, S. MURO, A. IMURA, Y. NABESHIMA AND M. MISHIMA
  • 学会等名: Biomedical Engineering Symposium
  • 発表場所: Losangels, USA.
• [学会発表] Impacts of gastro-oesophageal reflux symptoms on exacerbations of COPD (2007)
  • 著者名/発表者名: K. Terada, S. Muro, A. Niimi, E. Ogawa, Y. Hoshino, S. Sato, T. Ohara, D. Kinose, A. Haruna, S. Marumo, M. Mishima
  • 学会等名: 17th Annual Conference of European Respiratory Society
  • 発表場所: Stockholm International Fair and Congress Center, Stockholm, Sweden
• [学会発表] Geographic Difference in Chronic Cough Etiology : Comparison of Japan with the UK (2007)
  • 著者名/発表者名: Niimi A, Ueda T, Matsumoto H, Chung KF, Mishima M
  • 学会等名: 2007 International Conference of American Thoracic Society
  • 発表場所: Moscone Convention Center, San Francisco, California, USA
• [学会発表] Dynamic Property of Central Airway Walls as Assessed by Computed Tomography (CT) : Correlation with Asthma Pathophysiology. (2007)
  • 著者名/発表者名: Yamaguchi M, Niimi A, Matsumoto H,Ueda T, Takemura M, Matsuoka H, Jinnai M,Mishima M
  • 学会等名: 2007 International Conference of American Thoracic Society
  • 発表場所: Moscone Convention Center, San Francisco, California, USA
• [学会発表] Thioredoxin Prevents Cigarette Smoke Induced Oxidative Stress and Apoptosis (2006)
  • 著者名/発表者名: A. Sato, Y. Hoshino, H. Nakamura, M.Narita, S. Muro, M. Mishima, J. Yodoi
  • 学会等名: 2006 International Conference of American Thoracic Society
  • 発表場所: San Diego Convention Center, San Diego, California, USA
• [学会発表] Annual Changes in Computed Tomography Measurements and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease (2006)
  • 著者名/発表者名: T. Ohara, T. Hirai, S. Sato, E. Ogawa, A. Sato,M. Nishioka, K. Terada, Kinose, S. Muro, M. Mishima
  • 学会等名: 2006 International Conference of American Thoracic Society
  • 発表場所: San Diego Convention Center, San Diego, California, USA
• [学会発表] Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease ; Correlation with Low Attenuation Areas on Computed Tomography (2006)
  • 著者名/発表者名: E. Ogawa, Y. Nakano, S. Muro, H. Sakai, T.Hirai, M. Mishima
  • 学会等名: 2006 International Conference of American Thoracic Society
  • 発表場所: San Diego Convention Center, San Diego, California, USA
• [学会発表] Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD (2006)
  • 著者名/発表者名: Tadashi OHARA, Toyohiro HIRAI, Susumu SATO, Atsuyasu SATO, Michiyoshi NISHIOKA, Shigeo MURO, Michiaki MISHIMA
  • 学会等名: 11th Congress of the Asian Pacific Society of Respirology
  • 発表場所: Kyoto International Conference Hall, Kyoto, Japan
• [学会発表] Longitudinal deteriorations in patient centered versus physiological measurements in patients with COPD (2006)
  • 著者名/発表者名: T. Oga, K. Nishimura, M. Tsukino, S. Sato, T.Hajiro, M. Mishima
  • 学会等名: 16th Annual Congress of European Respiratory Society
  • 発表場所: International Congress Centre Munich, Munich, German
• [備考] Harasawa Memorial Award(Asia Pacific Society of Respiratory Medicine)2008.11