子どものメンタルヘルスの大規模疫学調査及び脳機能研究-情動と社会性発達の観点から

• 研究課題/領域番号: 19390303
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 精神神経科学
• 研究機関: 浜松医科大学
• 研究代表者: 武井 教使 浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937)
• 研究分担者: 土屋 賢治 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (20362189) ; 中村 和彦 浜松医科大学, 医学部, 准教授 (80263911) ; 宮地 泰士 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60444345) ; 岩田 康秀 (岩田 泰秀) 浜松医科大学, 医学部附属病院, 講師 (10285025) ; 吉原 雄二郎 浜松医科大学, 医学部附属病院, 助教 (00529464) ; 杉原 玄一 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (70402261)
• 研究期間 (年度): 2007 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 18,070千円 (直接経費: 13,900千円、間接経費: 4,170千円); 2009年度: 3,640千円 (直接経費: 2,800千円、間接経費: 840千円); 2008年度: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2007年度: 9,750千円 (直接経費: 7,500千円、間接経費: 2,250千円)
• キーワード: 子ども / メンタルヘルス / 社会性 / 疫学 / 脳発達 / 自閉症 / 脳画像

研究概要

小学5年から高校3年生(1,412人)を対象に、共感性と情動の安定性を評価した。社会性・情動は成長に伴って向上することが確認された。また、共感性・社会性が低いほど、攻撃性が高く、抑うつ傾向が高いことが分かった。一方、社会性に障害をみる自閉症者に対する脳画像研究(PET画像)を実施した。その結果、自閉症者では、広汎な脳部位でマイクログリアの活性が亢進していることが認められ、脳の神経炎症が障害の形成に関与していることが示唆された。

研究成果

• [雑誌論文] Brain Serotonin and Dopamine Transporter Bindings in Adults with High-Functioning Autism. (2010)
  • 著者名/発表者名: Nakamura K., Sekine Y., Ouchi Y., Tsujii M., Yoshikawa E., Futatsubashi M., Tsuchiya K.J., Sugihara G., Iwata Y., Suzuki K., Matsuzaki H., Suda S., Sugiyama T., Takei N., Mori N.
  • 雑誌名: Arch Gen Psychiatry 67(1) ページ: 59-68
  • 査読あり
• [雑誌論文] Decreased serum levels of adiponectin in subjects with autism. (2010)
  • 著者名/発表者名: Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 13
  • 査読あり
• [雑誌論文] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. (2010)
  • 著者名/発表者名: Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 34(1) ページ: 154-8
  • 査読あり
• [雑誌論文] Brain Serotonin and Dopamine Transporter Bindings in Adults with High-Functioning Autism (2010)
  • 著者名/発表者名: Nakamura K., Sekine Y., Ouchi Y., Tsujii M., Yoshikawa E., Futatsubashi M., Tsuchiya K.J., Sugihara G., Iwata Y., Suzuki K., Matsuzaki H., Suda S., Sugiyama T., Takei N., Mori N.
  • 雑誌名: Arch Gen Psychiatry 67(1) ページ: 59-68
  • 査読あり
• [雑誌論文] Decreased serum levels of adiponectin in subjects with autism (2010)
  • 著者名/発表者名: Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 34(3) ページ: 455-8
  • 査読あり
• [雑誌論文] Serum levels of platelet-derived growth factor BB homodimers are in creased in male children with autism (2010)
  • 著者名/発表者名: Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 34(1) ページ: 154-8
  • 査読あり
• [雑誌論文] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism (2010)
  • 著者名/発表者名: Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiya KJ, Matsumoto K, Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
  • 雑誌名: Int J Neuropsychopharmacol 13(4) ページ: 529-34
  • NAID: 120005305395
  • 査読あり
• [雑誌論文] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. (2009)
  • 著者名/発表者名: Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
  • 雑誌名: Am J Med Genet B Neuropsychiatr Gene 150B(7) ページ: 967-76
  • 査読あり
• [雑誌論文] Preliminary genome-wide association study of bipolar disorder in the Japanese population. (2009)
  • 著者名/発表者名: Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishik
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet
  • 査読あり
• [雑誌論文] An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. (2009)
  • 著者名/発表者名: Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
  • 雑誌名: Neurosci Lett 455(2) ページ: 120-3
  • 査読あり
• [雑誌論文] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism. (2009)
  • 著者名/発表者名: Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiya KJ, Matsumoto K, Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
  • 雑誌名: Int J Neuropsychopharmacol 9 ページ: 1-6
  • NAID: 120005305395
  • 査読あり
• [雑誌論文] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder (2009)
  • 著者名/発表者名: Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
  • 雑誌名: Am J Med Genet B Neuropsychiatr Gene 150B(7) ページ: 967-76
  • 査読あり
• [雑誌論文] Preliminary genome-wide association study of bipolar disorder in the Japanese population (2009)
  • 著者名/発表者名: Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T.
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet. 150B(8) ページ: 1110-7
  • 査読あり
• [雑誌論文] An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis (2009)
  • 著者名/発表者名: Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
  • 雑誌名: Neurosci Lett 455(2) ページ: 120-3
  • 査読あり
• [雑誌論文] Gene and Expression Analyses Reveal Enhanced Expression of Pericentrin 2 (PCNT2) in Bipolar Disorder. (2008)
  • 著者名/発表者名: Anitha A., Nakamura K., Yamada K., Iwayama Y., Toyota T., Takei N., Iwata Y., Suzuki K., Sekine Y., Matsuzaki H., Kawai M., Miyoshi K., Katayama T., Matsuzaki S., Baba K., Honda A., Hattori T., Shimizu S., Kumamoto N., Tohyama M., Yoshikawa T., Mori N.
  • 雑誌名: Biol Psychiatr 63(7) ページ: 678-85
  • 査読あり
• [雑誌論文] Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. (2008)
  • 著者名/発表者名: Suzuki K., Nakamura K., Iwata Y., Sekine Y., Kawai M., Sugihara G., Tsuchiya K.J., Suda S., Matsuzaki H., Takei N., Hashimoto K., Mori N.
  • 雑誌名: Schizophr Res 98(1-3) ページ: 148-56
  • 査読あり
• [雑誌論文] Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism. (2008)
  • 著者名/発表者名: Anitha A., Nakamura K., Yamada K., Suda S., Thanseem I., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G.I., Ouchi Y., Sugiyama T., Koizumi K., Higashida H., Takei Anitha A., Nakamura K.
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet 147B(7) ページ: 1019-27
  • 査読あり
• [雑誌論文] Irradiation in Adulthood as a New Model of Schizophrenia. (2008)
  • 著者名/発表者名: Iwata Y., Suzuki K., Wakuda T. 1, Seki N., Thanseem I., Matsuzaki H., Mamiya T., Ueki T., Mikawa S., Sasaki T., Suda S., Yamamoto S., Tsuchiya K.J., Sugihara G., Nakamura1 K., Sato K., Takei N., Hashimoto K., Mori N.
  • 雑誌名: PLoSone 3(5)
  • NAID: 120005313164
  • 査読あり
• [雑誌論文] Methamphetamine causes microglial activation in the brains of human abusers. (2008)
  • 著者名/発表者名: Sekine Y., Ouchi Y., Sugihara G., Takei N., Yoshikawa E., Nakamura K., Iwata Y., Tsuchiya K.J., Suda S., Suzuki K., Kawai M., Takebayashi K., Yamamoto S., Matsuzaki H., Ueki T., Mori N., Gold M.S., Cadet J.L.
  • 雑誌名: J Neurosci 28(22) ページ: 5756-61
  • 査読あり
• [雑誌論文] Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism. (2008)
  • 著者名/発表者名: Nakamura K., Anitha A., Yamada K., Tsujii M., Iwayama Y., Hattori E., Toyota T., Suda S., Takei N., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K.J., Sugihara G.I., Ouchi Y., Sugiyama T., Yoshikawa T., Mori N.
  • 雑誌名: Int J Neuropsychopharmacol 11(8) ページ: 1073-84
  • 査読あり
• [雑誌論文] Paternal age at birth and high-functioning autism spectrum disorder in the offspring. (2008)
  • 著者名/発表者名: Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S, Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
  • 雑誌名: Bri J Psychiar 193(4) ページ: 316-21
  • 査読あり
• [雑誌論文] Serum levels of P-selectin in men with high-functioning autism. (2008)
  • 著者名/発表者名: Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • 雑誌名: Bri J Psychiar 193(4) ページ: 338-9
  • 査読あり
• [雑誌論文] Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. (2008)
  • 著者名/発表者名: Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto S, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N.
  • 雑誌名: PLoS ONE 3(11)
  • 査読あり
• [雑誌論文] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers. (2008)
  • 著者名/発表者名: Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, Kawai M, Takebayashi K, Suzuki K, Takei N, Iyo M, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
  • 雑誌名: Ann N Y Acad Sci 1139 ページ: 49-56
  • 査読あり
• [雑誌論文] Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia. (2008)
  • 著者名/発表者名: Yoshihara Y, Sugihara G, Matsumoto H, Suckling J, Nishimura K, Toyoda T, Isoda H, Tsuchiya KJ, Takebayashi K, Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N.
  • 雑誌名: Ann Gen Psychiatry 7 ページ: 25-25
  • NAID: 120005314220
  • 査読あり
• [雑誌論文] Voxel-based structural magnetic resonance imaging (MRI)study of patients with early onset schizophrenia. (2008)
  • 著者名/発表者名: Yoshihara Y, Sugihara G, Mats umoto H, Suckling J, Nishimura K, Toyoda T, Isoda H, Tsuchiya KJ, Takebayashi K, Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N
  • 雑誌名: Ann Gen Psychiatry 22 ; 7:25 ページ: 1-11
  • NAID: 120005314220
  • 査読あり
• [雑誌論文] Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. (2008)
  • 著者名/発表者名: Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto s, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takci N, Mori N.
  • 雑誌名: PLoS ONE. 3(11) ページ: 1-6
  • 査読あり
• [雑誌論文] Serum levels of P-selectin in men with high-functioning autism. (2008)
  • 著者名/発表者名: Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • 雑誌名: Br J Psychiatry. 193(4) ページ: 338-9
  • 査読あり
• [雑誌論文] Paternal age at birth and high-functioning autistic-spectrum disorder in offspring. (2008)
  • 著者名/発表者名: Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S, Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
  • 雑誌名: Br J Psychiatry. 193(4) ページ: 316-21
  • 査読あり
• [雑誌論文] Electroconvulsive therapy for burning mouth syndrome. (2008)
  • 著者名/発表者名: Suda S, Takagai S, Inoshima-Takahashi K, Sugihara G, Mori N, Takei N.
  • 雑誌名: Acta Psychiatr Scand. 118 (6) ページ: 503-4
  • 査読あり
• [雑誌論文] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism. (2008)
  • 著者名/発表者名: Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E. Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
  • 雑誌名: Int J Neuropsychopharmacol. 11(8) : 1073-84 11 (8) ページ: 1073-84
  • 査読あり
• [雑誌論文] Irradiation in adulthood as a new model of schizophrenia. (2008)
  • 著者名/発表者名: Iwata Y, Suzuki K, Wakuda T, Seki N, Thanseem I, Matsuzaki H, Mamiya T, Ueki T, Mikawa S, Sasaki T, Suda S, Yamamoto S, Tsuchiya KJ, Sugihara G, Nakamura K, Sato K, Takei N. Hashimoto K. Mori N.
  • 雑誌名: PLoS ONE. 3 (5) ページ: 1-8
  • NAID: 120005313164
  • 査読あり
• [雑誌論文] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism (2008)
  • 著者名/発表者名: Anithia A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N. Yoshikawa T. Mori N.
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet 147B (7) ページ: 1019-27
  • 査読あり
• [雑誌論文] Increased serum soluble L-selectin levels in unmedicated schizophrenia. (2007)
  • 著者名/発表者名: Iwata Y, Suzuki K, Nakamura K, Matsuzaki H, Sekine Y, Tsuchiya KJ, Sugihara G, Kawai M, Minabe Y, Takei N, Mori N
  • 雑誌名: Schizophr Res 89(1-3) ページ: 154-60
  • 査読あり
• [雑誌論文] Decreased serum levels of transforming growth factor-beta1 in patients with autism. (2007)
  • 著者名/発表者名: Okada K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 31 ページ: 187-190
  • 査読あり
• [雑誌論文] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism. (2007)
  • 著者名/発表者名: Sugihara G., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suzuki K., Suda S., Matsuzaki H., Kawai M., Minabe Y., Yagi A., Takei N., Sugiyama T., Mori N.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatr 31(2) ページ: 412-415
  • 査読あり
• [雑誌論文] Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia. (2007)
  • 著者名/発表者名: Iwata Y, Nakajima M, Yamada K, Nakamura K, Sekine Y, Tsuchiya KJ, Sugihara G, Matsuzaki H, Suda S, Suzuki K, Takei N, Mori N, Iwayama Y, Takao H, Yoshikawa T, Riley B, Makoff A, Sham P, Chen R, Collier D.
  • 雑誌名: Neurosci Res 57(2) ページ: 194-202
  • NAID: 10021188681
  • 査読あり
• [雑誌論文] Decreased serum levels of PECAM-1 in subjects with high-functioning autism: a negative correlation with head circumference at birth. (2007)
  • 著者名/発表者名: Tsuchiya K.J., Hashimoto K., Iwata Y., Tsujii M., Sekine Y., Sugihara G., Matsuzaki H., Suda S., Kawai M., Nakamura K., Minabe Y., Yagi A., Iyo M., Takei N., Mori N.
  • 雑誌名: Biol Psychiatr Nov 1 62(9) ページ: 1056-8
  • 査読あり
• [雑誌論文] Disruption of Reelin signaling attenuates methamphetamine-induced hyperlocomotion. (2007)
  • 著者名/発表者名: Matsuzaki H., Minabe Y., Nakamura K., Suzuki K., Iwata Y., Sekine Y., Tsuchiya K.J., Sugihara G., Suda S., Takei N., Nakahara D., Hashimoto K., Nairn A.C., Mori N., Sato K.
  • 雑誌名: Eur J Neurosci 25(11) ページ: 3376-84
  • 査読あり
• [雑誌論文] SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism. (2007)
  • 著者名/発表者名: Toyoda T., Nakamura K., Yamada K., Thanseem I., Anitha A., Suda S., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Ouchi Y., Sugiyama T., Takei N., Yoshikawa T., Toyoda
  • 雑誌名: Biochem Biophys Res Commun 360(4) ページ: 715-20
  • 査読あり
• [雑誌論文] Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism. (2007)
  • 著者名/発表者名: Nishimura K., Nakamura K., Anitha A., Yamada K., Tsujii M., Iwayama Y., Hattori E., Toyota T., Takei N., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Suda S., Ouchi Y., Sugiyama T., Yoshikawa T., Mori N.
  • 雑誌名: Biochem Biophys Res Commun 356(1) ページ: 200-206
  • 査読あり
• [雑誌論文] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. (2007)
  • 著者名/発表者名: Suzuki K., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suda S., Sugihara G., Matsuzaki H., Sugiyama T., Kawai M., Minabe Y., Takei N., Mori N.
  • 雑誌名: Biol Psychiatr 62(3) ページ: 267-269
  • 査読あり
• [雑誌論文] Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia. (2007)
  • 著者名/発表者名: Iwata Y., Suzuki K., Nakamura K., Matsuzaki H., Sekine Y., Tsuchiya K.J., Sugihara G., Kawai M., Minabe Y., Takei N., Mori N.
  • 雑誌名: Schizophr Res 89(1-3) ページ: 154-160
  • 査読あり
• [雑誌論文] Poor mental health associated with job dissatisfaction among school teachers in Japan. (2007)
  • 著者名/発表者名: Nagai M., Tsuchiya K.J., Toulopoulou T., Takei N.
  • 雑誌名: J Occup Health Nov 49(6) ページ: 515-22
  • 査読あり
• [雑誌論文] Increased serum soluble L-selectin levels in unmedicated schizophrenia (2007)
  • 著者名/発表者名: Iwata Y., Suzuki K., Nakamura K., Minabe Y., Takei N., Mori N.
  • 雑誌名: Schizophr Res 89(1-3) ページ: 154-60
  • 査読あり
• [雑誌論文] Decreased serum levels of transforming growth factor-betal in patients with autism (2007)
  • 著者名/発表者名: Okada K, Haslumoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatry 31 ページ: 187-190
  • 査読あり
• [雑誌論文] Decreased serum levels of hepatocyte growth factor in male adults with high-functioIling autism (2007)
  • 著者名/発表者名: Sugihara G., Hashimoto K., Iwata Y., Nakamura k., Tsujii M., Tsuchiya K.J., Sekine Y., Yagi A., Takei N., Sugiyama T., Mori N.
  • 雑誌名: Prog Neuropsycchopharmacol Biol Psychiatr 31(2) ページ: 412-415
  • 査読あり
• [雑誌論文] Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia (2007)
  • 著者名/発表者名: Iwata Y, Nakajima M, Yamada K, Nakamura K, Sekine Y, Tsuchiya KJ, Sugihara G, Matsuzaki H, Suda S, Suzuki K, Takei N, Mori N, Iwayama Y, Takao H, Yoshikawa T, Riley B, Makoff A, Sham P, Chen R, Collier D.
  • 雑誌名: Neurosci Res 31(2) ページ: 412-415
  • NAID: 10021188681
  • 査読あり
• [雑誌論文] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism (2007)
  • 著者名/発表者名: Sugihara G, Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suzuki K., Such S., MatsuzakiH., Kawai M., Minabe Y., Yagi A., Takei N., Sugiyama T., Mori N.
  • 雑誌名: Prog Neuropsychopharmacol Biol Psychiatr 57(2) ページ: 194-202
  • 査読あり
• [雑誌論文] Decreased serum levels of PECAM-1 in subjects with high-functioning autism:a negative correlation with head circumference at birth (2007)
  • 著者名/発表者名: Tsuchiya K.J., Hashimoto K., I wata Y., Tsujii M., Sekine Y., Sugihara G., Matsuzaki H., Suda S., Kawai M., Nakamura K., Minabe Y., Yagi A., Iyo M., Takei N., Mori N.
  • 雑誌名: Biol Psychiatry 62(9) ページ: 1056-8
  • 査読あり
• [雑誌論文] Disruption of Reelin signaling attenuates methamphetamine-induced hy perlocomotion (2007)
  • 著者名/発表者名: Matsuzaki H., Minabe Y., NakamuraK., Suzuki K., Iwata Y., Sekine Y., Tsuchiya K.J., Sugihara G, Suda S., Takei IV., Nakahara D., Haslumoto K., NairnA.C., Mori N., Sato K.
  • 雑誌名: Eur J Neurosci 25(11) ページ: 3376-84
  • 査読あり
• [雑誌論文] SNP analyses of growth factor genes EGF,TGFbeta-1,and HGF reve al haplotypic association of EGF with autism (2007)
  • 著者名/発表者名: Toyoda T., Nakamura K., Yamada K., Thanseem I, Anitha A., Suds. S., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyaclu T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Ouchi Y., Sugiyama T., Takei N., Yoshikawa T., Mori N.
  • 雑誌名: Biochenm Biophys Res Commun 360(4) ページ: 715-20
  • 査読あり
• [雑誌論文] Genetic analyses of the brain-derived neurotrophic factor(BDNF)gene in autism (2007)
  • 著者名/発表者名: Nishimura K, Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota. T, Takei N, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Suds. S, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
  • 雑誌名: Biochem Biophys Res Commun 356(1) ページ: 200-206
  • 査読あり
• [雑誌論文] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism (2007)
  • 著者名/発表者名: Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suds. S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
  • 雑誌名: Biol Psychiatry 62(3) ページ: 267-269
  • 査読あり
• [雑誌論文] Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia (2007)
  • 著者名/発表者名: Iwata Y, Suzuki K, Nakamura K, Matsuzaki H, Sekine Y, Tsuchiya KJ, Sugihara G, Kawai M, Minabe Y, Takei N, Mori N.
  • 雑誌名: Schizophr Res 89(1-3) ページ: 154-160
  • 査読あり
• [雑誌論文] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism (2007)
  • 著者名/発表者名: Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
  • 雑誌名: Biol Psychiatry 62(3) ページ: 267-269
  • 査読あり
• [雑誌論文] Poor mental hea1th associated with job dissatisfaction among school teachers in Japan (2007)
  • 著者名/発表者名: Nagai M, Tsuchiya KJ, Toulopoulou T, Takei N.
  • 雑誌名: J Occup Health. 49(6) ページ: 515-22
  • 査読あり
• [学会発表] Genetic and expression analysis of serotonergic factors in autism. (2009)
  • 著者名/発表者名: Nakamura K., Miyachi T., Ayyappan A., Tsujii M., Suda S., Thanseem I., Tsuchiya K., Matsuzaki H., Yamada K., Iwayama Y., Toyota T., Hattori E., Sugiyama T., Takei N., Yoshikawa T., Mori N.
  • 学会等名: The 8th Annual International Meeting for Autism Research
  • 発表場所: Chicago, May
• [学会発表] Searching for causes and effects of an increase in LBW children in Japan: The Hamamatsu Birth Cohort for Mothers and Children (HBC) (2009)
  • 著者名/発表者名: Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Itoh H, Kanayama N, Hirano K, Ohzeki T, Takei N.
  • 学会等名: The 6th World Congress on Developmental Origins of Health and Disease
  • 発表場所: Santiago, Chile
• [学会発表] Unwanted pregnancy and its detrimental effect on early language development in the offspring: the HBC Study. (2009)
  • 著者名/発表者名: Matsumoto K, Tsuchiya KJ, Miyachi T, Itoh H, Kanayama N, Takei N.
  • 学会等名: The 6th World Congress on Developmental Origins of Health and Disease
  • 発表場所: Santiago, Chile
• [学会発表] Machanisms underlying methamphatamine psychoses (2009)
  • 著者名/発表者名: 武井教使
  • 学会等名: Collegium Internationale Neuro -Psychopharamacologicum (CINP)
  • 発表場所: Edinburgh, Scotland, UK.
• [学会発表] Wide-spread decreases of serum growth factors levels in male with high-functioning autism. (2008)
  • 著者名/発表者名: Matsuzaki H., Iwata Y., Tsuchiya J.K., Sugihara G., Suda S., Suzuki K., Nakamura K., Tsujii M., Takei N. Hashimoto K., Mori N.
  • 学会等名: The 38th annual meting of the Societry for Neuroscience
  • 発表場所: Washington
• [学会発表] Serotonin transporter and serotonin related gene expression in autism. (2008)
  • 著者名/発表者名: Suda S., Iwata K., Anitha A., Thanseem I., Nakamura K., Matsuzaki H., Iwata Y., Yamamoto S., Suzuki K., Takei N., Koizumi K., Mori N.
  • 学会等名: The 38th annual meting of the Societry for Neuroscience
  • 発表場所: Washington
• [学会発表] Genetic analysis of serotonergic factors in autism. (2008)
  • 著者名/発表者名: Nakamura K., Matsuzaki H., Tsujii M., Ayyappan A., Yamada K., Suda S., Iwayama Y., Miyachi T., Tsuchiya K., Sugiyama T., Takei N., Yoshikawa T., Mori N.
  • 学会等名: The 7th Annual International Meeting for Autism Research
  • 発表場所: London
• [学会発表] Voxel-based structural MRI study of patients with early-onset schizophrenia. (2008)
  • 著者名/発表者名: Yoshihara Y., Sugihara G., Takei N.
  • 学会等名: 1st Schizophrenia Intrernational Research Society Conference
  • 発表場所: Venice, Italy
• [学会発表] Decreased serum levels of MMPs in ault subjects with high-functioning autism. (2007)
  • 著者名/発表者名: Suda S., Matsuzaki H., Iwata Y., Sugihara G., Tsuchiya J.K., Nakamura K., Takei N., Mori N.
  • 学会等名: The 37th annual meting of the Societry for Neuroscience
  • 発表場所: Washington
• [図書] Recent epidemiological studies of psychiatric disorders in Japan.
  • 著者名/発表者名: Kawai M., Tsuchiya K. J.., Takei N.
  • 出版者: In: Textbook in Psychiatric Epidemiology. Eds P Jones, M Tsuang. Wiley, London(In press)
• [図書] Disturbed growth in early life and later neurocognitive development related especially to psychiatric disorders.
  • 著者名/発表者名: Suda S., Takei N.
  • 出版者: In: International Handbook of Behavior, Diet and Nutrition. Eds Victor R Preedy, Colin Martin and Ronald Ross Watson. Springer, London(In press)
• [備考]
  • URL: http://rccmd.org/modules/staff/index.php?content_id=3