認知機能と神経画像を中間表現型とする統合失調症の分子病態解明

• 研究課題/領域番号: 19390304
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 精神神経科学
• 研究機関: 名古屋大学
• 研究代表者: 尾崎 紀夫 名古屋大学, 大学院・医学系研究科, 教授 (40281480)
• 研究分担者: 飯高 哲也 名古屋大学, 大学院・医学系研究科, 准教授 (70324366) ; 吉田 契造 名古屋大学, 大学院・医学系・研究科, 講師 (60323151) ; 岩田 仲生 藤田保健衛生大学, 医学部, 教授 (60312112)
• 連携研究者: 岩田 仲生 藤田保健衛生大学, 医学部, 教授 (60312112)
• 研究期間 (年度): 2007 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 18,330千円 (直接経費: 14,100千円、間接経費: 4,230千円); 2009年度: 5,720千円 (直接経費: 4,400千円、間接経費: 1,320千円); 2008年度: 5,720千円 (直接経費: 4,400千円、間接経費: 1,320千円); 2007年度: 6,890千円 (直接経費: 5,300千円、間接経費: 1,590千円)
• キーワード: 統合失調症 / ゲノム / 認知機能 / 神経画像 / 中間表現型

研究概要

統合失調症の病態を検討するに際して、診断ではなく、神経画像や薬物に対する反応性を指標として、遺伝子解析を行った。その結果、神経画像との関係では、神経成長因子の遺伝子が、脳の構造に影響を与えることが判明した。薬物に対する治療反応性との関係では、脳内伝達物質であるドパミン遺伝子との関連および新たな遺伝子との関連が明らかになった。さらに、薬物による副作用との関係では、脳内伝達物質であるガンマアミノ酪酸遺伝子との関連が確認された。

研究成果

• [雑誌論文] Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures (2010)
  • 著者名/発表者名: Takahashi, M., H. Hayashi, Y. Watanabe, K. Sawamura, N. Fukui, J. Watanabe, T. Kitajima, Y. Yamanouchi, N. Iwata, K. Mizukami, T. Hori, K. Shimoda, H. Ujike, N. Ozaki, K. Iijima, K. Takemura, H. Aoshima, T. Someya
  • 雑誌名: Schizophr Res (in press)
  • 査読あり
• [雑誌論文] Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population (2010)
  • 著者名/発表者名: Kushima, I., B. Aleksic, Y. Ito, Y. Nakamura, K. Nakamura, N. Mori, M. Kikuchi, T. Inada, H. Kunugi, S. Nanko, T. Kato, T. Yoshikawa, H. Ujike, M. Suzuki, N. Iwata, N. Ozaki
  • 雑誌名: J Hum Genet (in press)
  • NAID: 10030733833
  • 査読あり
• [雑誌論文] Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population (2010)
  • 著者名/発表者名: Kushima, I., B. Aleksic, M. Ikeda, Y. Yamanouchi, Y. Kinoshita, Y. Ito, Y. Nakamura, T. Inada, N. Iwata, N. Ozaki
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet (in press)
  • 査読あり
• [雑誌論文] Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population (2010)
  • 著者名/発表者名: Aleksic, B., I. Kushima, Y. Ito, Y. Nakamura, H. Ujike, M. Suzuki, T. Inada, R. Hashimoto, M. Takeda, N. Iwata, N. Ozaki
  • 雑誌名: Schizophr Res (in press)
  • 査読あり
• [雑誌論文] Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches (2010)
  • 著者名/発表者名: Ikeda, M., Y. Tomita, A. Mouri, M. Koga, T. Okochi, R. Yoshimura, Y. Yamanouchi, Y. Kinoshita, R. Hashimoto, H.J. Williams, M. Takeda, J. Nakamura, T. Nabeshima, M.J. Owen, M.C. O'Donovan, H. Honda, T. Arinami, N. Ozaki, N. Iwata
  • 雑誌名: Biol Psychiatry 67(3) ページ: 263-9
  • 査読あり
• [雑誌論文] Copy number variation in schizophrenia in the Japanese population (2010)
  • 著者名/発表者名: Ikeda, M., B. Aleksic, G. Kirov, Y. Kinoshita, Y. Yamanouchi, T. Kitajima, K. Kawashima, T. Okochi, T. Kishi, I. Zaharieva, M.J. Owen, M.C. O'Donovan, N. Ozaki, N. Iwata
  • 雑誌名: Biol Psychiatry 67(3) ページ: 283-6
  • 査読あり
• [雑誌論文] Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population (2010)
  • 著者名/発表者名: Kushima I, et al.
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet 153B(3) ページ: 786-91
  • 査読あり
• [雑誌論文] Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia : Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches (2010)
  • 著者名/発表者名: Ikeda M, et al.
  • 雑誌名: Biol Psychiatry 67(3) ページ: 263-9
  • 査読あり
• [雑誌論文] Copy Number Variation in Schizophrenia in the Japanese Population (2010)
  • 著者名/発表者名: Ikeda M, et al.
  • 雑誌名: Biol Psychiatry 67(3) ページ: 283-6
  • 査読あり
• [雑誌論文] Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population (2010)
  • 著者名/発表者名: Aleksic B, et al.
  • 雑誌名: Schizophr Res (in press)
  • 査読あり
• [雑誌論文] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia (2009)
  • 著者名/発表者名: Takahashi, T., M. Suzuki, M. Tsunoda, N. Maeno, Y. Kawasaki, S.Y. Zhou, H. Hagino, L. Niu, H. Tsuneki, S. Kobayashi, T. Sasaoka, H. Seto, M. Kurachi, N. Ozaki
  • 雑誌名: Psychiatry Res 172(2) ページ: 128-35
  • 査読あり
• [雑誌論文] BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis (2009)
  • 著者名/発表者名: Kawashima, K., M. Ikeda, T. Kishi, T. Kitajima, Y. Yamanouchi, Y. Kinoshita, T. Okochi, B. Aleksic, M. Tomita, T. Okada, H. Kunugi, T. Inada, N. Ozaki, N. Iwata
  • 雑誌名: Schizophr Res 112(1-3) ページ: 72-9
  • 査読あり
• [雑誌論文] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia (2009)
  • 著者名/発表者名: Takahashi T, et al.
  • 雑誌名: Psychiatry Res 172(2) ページ: 128-35
  • 査読あり
• [雑誌論文] Meta-analysis of association between genetic variants in COMT and schizophrenia : an update (2009)
  • 著者名/発表者名: Okochi T, et al.
  • 雑誌名: Schizophr Res 110(1-3) ページ: 140-8
  • 査読あり
• [雑誌論文] Association study of the G72 gene with schizophrenia in a Japanese population : a multicenter study (2009)
  • 著者名/発表者名: Ohi K, et al.
  • 雑誌名: Schizophr Res 109(1-3) ページ: 80-5
  • 査読あり
• [雑誌論文] Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia (2009)
  • 著者名/発表者名: Koga M, et al.
  • 雑誌名: Hum Mol Genet 18(13) ページ: 2483-94
  • 査読あり
• [雑誌論文] Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism (2009)
  • 著者名/発表者名: Hakamata Y, et al.
  • 雑誌名: Psychiatry Res 173(3) ページ: 206-11
  • 査読あり
• [雑誌論文] Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder (2008)
  • 著者名/発表者名: Yoshimi, A., N. Takahashi, S. Saito, Y. Ito, B. Aleksic, H. Usui, Y. Kawamura, Y. Waki, T. Yoshikawa, T. Kato, N. Iwata, T. Inada, Y. Noda, N. Ozaki
  • 雑誌名: Schizophr Res 100(1-3) ページ: 334-41
  • 査読あり
• [雑誌論文] An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population (2008)
  • 著者名/発表者名: Saito, S., N. Takahashi, N. Maeno, Y. Ito, B. Aleksic, H. Usui, T. Iidaka, T. Inada, N. Ozaki
  • 雑誌名: Neuroreport 19(4) ページ: 471-473
  • 査読あり
• [雑誌論文] Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins (2008)
  • 著者名/発表者名: Kuratomi, G., K. Iwamoto, M. Bundo, I. Kusumi, N. Kato, N. Iwata, N. Ozaki, T. Kato
  • 雑誌名: Mol Psychiatry 13(4) ページ: 429-41
  • 査読あり
• [雑誌論文] The Dysbindin Gene (DTNBP1) Is Associated with Methamphetamine Psychosis (2008)
  • 著者名/発表者名: Kishimoto, M., H. Ujike, Y. Motohashi, Y. Tanaka, Y. Okahisa, T. Kotaka, M. Harano, T. Inada, M. Yamada, T. Komiyama, T. Hori, Y. Sekine, N. Iwata, I. Sora, M. Iyo, N. Ozaki, S. Kuroda
  • 雑誌名: Biol Psychiatry 63(2) ページ: 191-196
  • 査読あり
• [雑誌論文] Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population (2008)
  • 著者名/発表者名: Ji, X., N. Takahashi, S. Saito, R. Ishihara, N. Maeno, T. Inada, N. Ozaki
  • 雑誌名: Neurosci Lett 435(2) ページ: 95-8
  • 査読あり
• [雑誌論文] Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia (2008)
  • 著者名/発表者名: Inada, T., M. Koga, H. Ishiguro, Y. Horiuchi, A. Syu, T. Yoshio, N. Takahashi, N. Ozaki, T. Arinami
  • 雑誌名: Pharmacogenet Genomics 18(4) ページ: 317-323
  • 査読あり
• [雑誌論文] Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia (2008)
  • 著者名/発表者名: Ikeda, M., Y. Yamanouchi, Y. Kinoshita, T. Kitajima, R. Yoshimura, S. Hashimoto, M.C. O'Donovan, J. Nakamura, N. Ozaki, N. Iwata
  • 雑誌名: Pharmacogenomics 9(10) ページ: 1437-4
  • 査読あり
• [雑誌論文] Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample (2008)
  • 著者名/発表者名: Ikeda, M., N. Takahashi, S. Saito, B. Aleksic, Y. Watanabe, A. Nunokawa, Y. Yamanouchi, T. Kitajima, Y. Kinoshita, T. Kishi, K. Kawashima, R. Hashimoto, H. Ujike, T. Inada, T. Someya, M. Takeda, N. Ozaki, N. Iwata
  • 雑誌名: Schizophr Res 101(1-3) ページ: 1-8
  • 査読あり
• [雑誌論文] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia (2008)
  • 著者名/発表者名: Ikeda, M., T. Hikita, S. Taya, J. Uraguchi-Asaki, K. Toyo-oka, A. Wynshaw-Boris, H. Ujike, T. Inada, K. Takao, T. Miyakawa, N. Ozaki, K. Kaibuchi, N. Iwata
  • 雑誌名: Hum Mol Genet 7(20) ページ: 3212-22
  • 査読あり
• [雑誌論文] N. o association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population (2008)
  • 著者名/発表者名: Aleksic, B., M. Ikeda, R. Ishihara, S. Saito, T. Inada, N. Iwata, N. Ozaki
  • 雑誌名: J Hum Genet 53(9) ページ: 863-6
  • NAID: 10021929601
  • 査読あり
• [雑誌論文] Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder. (2008)
  • 著者名/発表者名: Yoshimi A, et al
  • 雑誌名: Schizophr Res 100(1-3) ページ: 334-341
  • 査読あり
• [雑誌論文] An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. (2008)
  • 著者名/発表者名: Saito S, et al
  • 雑誌名: Neuroreport 19(4) ページ: 471-473
  • 査読あり
• [雑誌論文] No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population. (2008)
  • 著者名/発表者名: Kishi T, et al
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet 147B(4) ページ: 531-534
  • 査読あり
• [雑誌論文] Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population. (2008)
  • 著者名/発表者名: Ji X, et al
  • 雑誌名: Neurosci Lett 435(2) ページ: 95-98
  • 査読あり
• [雑誌論文] No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population. (2008)
  • 著者名/発表者名: Ito Y, et al
  • 雑誌名: Am J Med Genet B Neuropsychiatr Genet 147B(7) ページ: 1013-1018
  • 査読あり
• [雑誌論文] A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6)gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. (2008)
  • 著者名/発表者名: Ito Y, et al
  • 雑誌名: Neurosci Lett 438(1) ページ: 70-75
  • 査読あり
• [雑誌論文] Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. (2008)
  • 著者名/発表者名: Inada T, et al
  • 雑誌名: Pharmacogenet Genomics 18(4) ページ: 317-323
  • 査読あり
• [雑誌論文] Valiants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. (2008)
  • 著者名/発表者名: Ikeda M, et al
  • 雑誌名: Pharmacogenomics 9(10) ページ: 1437-1443
  • 査読あり
• [雑誌論文] Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample. (2008)
  • 著者名/発表者名: Ikeda M, et al
  • 雑誌名: Schizophr Res 101(1-3) ページ: 1-8
  • 査読あり
• [雑誌論文] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. (2008)
  • 著者名/発表者名: Ikeda M, et al
  • 雑誌名: Hum Mol Genet 17(20) ページ: 3212-3222
  • 査読あり
• [雑誌論文] No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population. (2008)
  • 著者名/発表者名: Aleksic B, et al
  • 雑誌名: J Hum Genet 53(9) ページ: 863-866
  • 査読あり
• [雑誌論文] Identification of Functional Polymorphisms in the Promoter Region of the Human PICK1 Gene and Their Association With Methamphetamine Psychosis (2007)
  • 著者名/発表者名: Matsuzawa, D., K. Hashimoto, R. Miyatake, Y. Shirayama, E. Shimizu, K. Maeda, Y. Suzuki, Y. Mashimo, Y. Sekine, T. Inada, N. Ozaki, N. Iwata, M. Harano, T. Komiyama, M. Yamada, I. Sora, H. Ujike, A. Hata, A. Sawa, M. Iyo
  • 雑誌名: Am J Psychiatry 164(7) ページ: 1105-14
  • 査読あり
• [雑誌論文] Association of SOX10 with schizophrenia in the Japanese population (2007)
  • 著者名/発表者名: Maeno, N., N. Takahashi, S. Saito, X. Ji, R. Ishihara, N. Aoyama, A. Branko, H. Miura, M. Ikeda, T. Suzuki, T. Kitajima, Y. Yamanouchi, Y. Kinoshita, N. Iwata, T. Inada, N. Ozaki
  • 雑誌名: Psychiatr Genet 17(4) ページ: 227-231
  • 査読あり
• [雑誌論文] Association study between the transferrin gene and schizophrenia in the Japanese population (2007)
  • 著者名/発表者名: Maeno, N., N. Takahashi, S. Saito, X. Ji, A. Branko, R. Ishihara, K. Yoshida, T. Inada, T. Iidaka, N. Ozaki
  • 雑誌名: Neuroreport 18(5) ページ: 517-20
  • 査読あり
• [雑誌論文] No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population (2007)
  • 著者名/発表者名: Ikeda, M., N. Ozaki, Y. Yamanouchi, T. Suzuki, T. Kitajima, Y. Kinoshita, T. Inada, N. Iwata
  • 雑誌名: Schizophr Res 91(1-3) ページ: 22-6
  • 査読あり
• [雑誌論文] Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia (2007)
  • 著者名/発表者名: Ikeda, M., N. Ozaki, T. Suzuki, T. Kitajima, Y. Yamanouchi, Y. Kinoshita, T. Kishi, Y. Sekine, M. Iyo, M. Harano, T. Komiyama, M. Yamada, I. Sora, H. Ujike, T. Inada, N. Iwata
  • 雑誌名: Genes Brain Behav 6(1) ページ: 107-12
  • 査読あり
• [雑誌論文] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia (2007)
  • 著者名/発表者名: Hashimoto, R., H. Hashimoto, N. Shintani, S. Chiba, S. Hattori, T. Okada, M. Nakajima, K. Tanaka, N. Kawagishi, K. Nemoto, T. Mori, T. Ohnishi, H. Noguchi, H. Hori, T. Suzuki, N. Iwata, N. Ozaki, T. Nakabayashi, O. Saitoh, A. Kosuga, M. Tatsumi, K. KamijiHashimoto, R., H. Hashimoto, N. Shintani, S
  • 雑誌名: Mol Psychiatry 12(11) ページ: 1026-1032
  • 査読あり
• [雑誌論文] Gap junction coding genes and schizophrenia: a genetic association study (2007)
  • 著者名/発表者名: Aleksic, B., R. Ishihara, N. Takahashi, N. Maeno, X. Ji, S. Saito, T. Inada, N. Ozaki
  • 雑誌名: J Hum Genet 52(6) ページ: 498-501
  • 査読あり
• [雑誌論文] Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions. (2007)
  • 著者名/発表者名: Tomita Y, et. al.
  • 雑誌名: J Biosci Bioeng 103(4) ページ: 303-310
  • 査読あり
• [雑誌論文] Association of SOX10 with schizophrenia in the Japanese population. (2007)
  • 著者名/発表者名: Maeno N, et. al.
  • 雑誌名: Psychiatr Genet 17(4) ページ: 227-231
  • 査読あり
• [雑誌論文] Association study between the transferrin gene and schizophrenia in the Japanese population. (2007)
  • 著者名/発表者名: Maeno N, et. al.
  • 雑誌名: Neuroreport 18(5) ページ: 517-520
  • 査読あり
• [雑誌論文] No association between the glutamate decarboxylase 67 gene(GAD1)and schizophrenia in the Japanese population. (2007)
  • 著者名/発表者名: Ikeda M, et. al.
  • 雑誌名: Schizophr Res 91(1-3) ページ: 22-26
  • 査読あり
• [雑誌論文] Possible association of beta-arrestin 2 gene with methamphetamine usedisorder, but not schizophrenia. (2007)
  • 著者名/発表者名: Ikeda M, et. al.
  • 雑誌名: Genes Brain Behav 6(1) ページ: 107-112
  • 査読あり
• [雑誌論文] Gap junction coding genes and schizophrenia: a genetic association stud y. (2007)
  • 著者名/発表者名: Aleksic B, et. al.
  • 雑誌名: J Hum Genet 52(6) ページ: 498-501
  • 査読あり
• [雑誌論文] Association Study between Vesicle-Associated Membrane Protein 2 Gene Polymorphisms and Fluvoxamine Response in Japanese Major Depressive Patients. (2007)
  • 著者名/発表者名: Saito S, et. al.
  • 雑誌名: Neuropsychobiology 54(4) ページ: 226-230
  • 査読あり
• [雑誌論文] A Promoter Haplotype of the Inositol Monophosphatase 2 Gene(IMPA2)at 18p11.2 Confers a Possible Risk for Bipolar Disorder by Enhancing Transcription. (2007)
  • 著者名/発表者名: Ohnishi T, et. al.
  • 雑誌名: Neuropsychopharmacology 32(8) ページ: 1727-1737
  • 査読あり
• [雑誌論文] Identification of Functional Polymorphisms in the Promoter Region of the Human PICK1 Gene and Their Association With Methamphetamine Psychosis. (2007)
  • 著者名/発表者名: Matsuzawa D, et. al.
  • 雑誌名: Am J Psychiatry 164(7) ページ: 1105-1114
  • 査読あり
• [雑誌論文] PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case-control population. (2007)
  • 著者名/発表者名: Ishiguro H, et. al.
  • 雑誌名: Neurosci Res 58(2) ページ: 145-148
  • 査読あり
• [雑誌論文] Support for association of the PPP3CC gene with schizophrenia. (2007)
  • 著者名/発表者名: Horiuchi Y, et. al.
  • 雑誌名: Mol Psychiatry 12(10) ページ: 891-893
  • 査読あり
• [雑誌論文] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. (2007)
  • 著者名/発表者名: Hashimoto R, et. al.
  • 雑誌名: Mol Psychiatry 12(11) ページ: 1026-1032
  • 査読あり
• [学会発表] DISC1-interacting molecule and schizophrenia (2009)
  • 著者名/発表者名: Ozaki N.
  • 学会等名: 9th World Congress of Biological Psychiatry : Symposium Genetic stratetegies in the search for genes in schizophrenia
  • 発表場所: Paris, France
  • 年月日: 2009-06-28
• [学会発表] DISC1-interacting molecule and schizophrenia (2009)
  • 著者名/発表者名: Ozaki, N
  • 学会等名: in 9th World Congress of Biological Psychiatry: Symposium Genetic stratetegies in the search for genes in schizophrenia
  • 発表場所: Paris, France
• [学会発表] Glia-related gene and schizophrenia: Invited lecture. in The Third Dual Congress on (2008)
  • 著者名/発表者名: Ozaki, N
  • 学会等名: Psychiatry and the Neurosciences
  • 発表場所: Athens
• [学会発表] 統合失調症モデル動物に臨床医が望むこと (2008)
  • 著者名/発表者名: 尾崎紀夫
  • 学会等名: in第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
  • 発表場所: 東京
• [学会発表] From Gene to Phenotype in Schizophrenia: Invited lecture (2008)
  • 著者名/発表者名: Ozaki, N
  • 学会等名: in 2nd WFSBP Asia-Pacific Congress
  • 発表場所: Toyama
• [学会発表] Endophenotype Approach of Mental Disorders: Bridging between Genotype and Phenotype (2008)
  • 著者名/発表者名: Ozaki, N
  • 学会等名: in 2008 International Conference on Pharmacogenomics Symposium :New Paradigm of Pharmacogonomics: to be alone or together Invited
  • 発表場所: Busan, Korea
• [学会発表] Glia-related gene and schizophrenia : Invited lecture (2008)
  • 著者名/発表者名: Ozaki N.
  • 学会等名: The Third Dual Congress on : " Psychiatry and the Neurosciences"
  • 発表場所: Athens, Greece
• [学会発表] From Gene to Phenotype in Schizophrenia : Invited lecture (2008)
  • 著者名/発表者名: Ozaki N.
  • 学会等名: 2nd WFSBP Asia-Pacific Congress
  • 発表場所: 富山
• [学会発表] Endophenotype Approach of Mental Disorders : Bridging between Genotype and Phenotype (2008)
  • 著者名/発表者名: Ozaki N.
  • 学会等名: 2008 International Conference on Phannacogenomics Symposium 10 : New Paradigm of Pharmacogonomics : to be alone or together Invited.
  • 発表場所: Busan, Korea
• [学会発表] 精神障害に関与する遺伝因と環境因をどの様に患者・家族に伝えるべきか:精神科臨床における遺伝カウンセリング. (2007)
  • 著者名/発表者名: 尾崎紀夫
  • 学会等名: 第103回精神神経学会教育講演
  • 発表場所: 東京
  • 年月日: 2007-11-17
• [学会発表] DISC1-interacting molecules and pathogenesis of schizophrenia:Candidate gene approach (2007)
  • 著者名/発表者名: Ozaki, N., , M. Ikeda, S. Taya, K. Kaibuchi, N. Iwata
  • 学会等名: in 2nd WFSBP International Congress of Biological Psychiatry :Symposium Pathogenesis of Schizophrenia
  • 発表場所: Chilli
• [学会発表] Association study between the MPZL1/PZR gene and schizophrenia in the Japanese population. (2007)
  • 著者名/発表者名: Usui H, et. al.
  • 学会等名: 15th World Congress on Psychiatric Genetics
  • 発表場所: New York, USA.
• [学会発表] Association study between the TACR3 gene polymorphisms and Japanese schizophrenia. (2007)
  • 著者名/発表者名: Saito S, et. al.
  • 学会等名: 15th World Congress on Psychiatric Genetics
  • 発表場所: New York, USA.
• [学会発表] シンポジウム「疾患領域横断的遺伝学」統合失調症のゲノム解析:表現型同定とCDCV仮説の問題を中心に. (2007)
  • 著者名/発表者名: 尾崎紀夫
  • 学会等名: 日本人類遺伝学会第52回大会
  • 発表場所: 東京